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Chemistry

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Also known as: 1968-05-4, Diindolylmethane, Di(1h-indol-3-yl)methane, 3,3'-methylenebis-1h-indole, 3,3'-methylenediindole, Dim
Molecular Formula
C17H14N2
Molecular Weight
246.31  g/mol
InChI Key
VFTRKSBEFQDZKX-UHFFFAOYSA-N
FDA UNII
SSZ9HQT61Z

Diindolylmethane
Diindolylmethane is a phytonutrient and plant indole found in cruciferous vegetables including broccoli, Brussels sprouts, cabbage, cauliflower and kale, with potential anti-androgenic and antineoplastic activities. As a dimer of indole-3-carbinol, diindolylmethane (DIM) promotes beneficial estrogen metabolism in both sexes by reducing the levels of 16-hydroxy estrogen metabolites and increasing the formation of 2-hydroxy estrogen metabolites, resulting in increased antioxidant activity. Although this agent induces apoptosis in tumor cells in vitro, the exact mechanism by which DIM exhibits its antineoplastic activity in vivo is unknown.
1 2D Structure

Diindolylmethane

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
3-(1H-indol-3-ylmethyl)-1H-indole
2.1.2 InChI
InChI=1S/C17H14N2/c1-3-7-16-14(5-1)12(10-18-16)9-13-11-19-17-8-4-2-6-15(13)17/h1-8,10-11,18-19H,9H2
2.1.3 InChI Key
VFTRKSBEFQDZKX-UHFFFAOYSA-N
2.1.4 Canonical SMILES
C1=CC=C2C(=C1)C(=CN2)CC3=CNC4=CC=CC=C43
2.2 Other Identifiers
2.2.1 UNII
SSZ9HQT61Z
2.3 Synonyms
2.3.1 MeSH Synonyms

1. 2,2'-methylenebis(1h-indole)

2. Diindolylmethane

2.3.2 Depositor-Supplied Synonyms

1. 1968-05-4

2. Diindolylmethane

3. Di(1h-indol-3-yl)methane

4. 3,3'-methylenebis-1h-indole

5. 3,3'-methylenediindole

6. Dim

7. Arundine

8. 3-(1h-indol-3-ylmethyl)-1h-indole

9. 1h-indole, 3,3'-methylenebis-

10. Di(3-indolyl)methane

11. 3,3'-di-indolylmethane

12. Plant Indole

13. 3,3'-methylenebis(1h-indole)

14. 3,3,-diindolylmethane

15. Mfcd00195766

16. Ssz9hqt61z

17. Bis-1h-indol-3-ylmethane

18. Chebi:50182

19. 3,3'-methanediylbis(1h-indole)

20. Hb 236

21. 3,3 Inverted Exclamation Marka-diindolylmethane

22. 3-diindolyl Methane

23. 3,3'-diindolymethane

24. Diidolylmethane

25. Infemin

26. Ccris 5806

27. 33diindolylmethyle

28. Di-3-indolylmethane

29. Nsc708486

30. 3-3-diindolylmethane

31. 33'-diindolylmethane

32. Spectrum2_001711

33. Spectrum3_001989

34. Spectrum5_001955

35. Unii-ssz9hqt61z

36. Cbiol_001839

37. Oprea1_472633

38. Oprea1_740951

39. Bspbio_001290

40. Bspbio_003589

41. Cbdive_010856

42. Kbiogr_000010

43. Kbioss_000010

44. Mls006011847

45. Schembl325162

46. Spectrum1505331

47. Spbio_001722

48. 3,3'-di(indol-3-yl)methane

49. Bml3-f11

50. Chembl446452

51. 3,3'-diindolylmethane (dim)

52. Diindolylmethane [vandf]

53. Dtxsid8037047

54. Gtpl11208

55. Kbio2_000010

56. Kbio2_002578

57. Kbio2_005146

58. Kbio3_000019

59. Kbio3_000020

60. Kbio3_003002

61. Bio1_000125

62. Bio1_000614

63. Bio1_001103

64. Bio2_000010

65. Bio2_000490

66. Diindolylmethane, 3,3'-

67. Hms1361a12

68. Hms1791a12

69. Hms1989a12

70. Hms3402a12

71. Zinc187911

72. 3,3'-diindolylmethane, Aldrichcpr

73. Act06989

74. Albb-016048

75. Bcp00470

76. Ccg-39861

77. Gr-207

78. Hsci1_000069

79. S4728

80. Stk263696

81. Akos003627372

82. Am84671

83. Cs-1652

84. Db11875

85. Ks-5266

86. Nsc-708486

87. Sb16901

88. Idi1_033760

89. 3,3'-diindolylmethane [who-dd]

90. Ncgc00095348-01

91. Ncgc00095348-02

92. Ncgc00095348-03

93. Ncgc00095348-04

94. Ncgc00095348-05

95. Ncgc00095348-06

96. Ncgc00095348-07

97. Ac-11611

98. Hy-15758

99. Nci60_038418

100. Smr001828114

101. Sy038972

102. 3,3'-diindolylmethane, >=98% (hplc)

103. 3,3'-diindolylmethane, Analytical Standard

104. Db-011102

105. Ft-0614061

106. M1399

107. A16321

108. D-3720

109. 968d054

110. Q4634053

111. Brd-k37846922-001-05-2

112. Brd-k37846922-001-06-0

113. Brd-k37846922-001-09-4

114. C444299000

2.4 Create Date
2005-03-25
3 Chemical and Physical Properties
Molecular Weight 246.31 g/mol
Molecular Formula C17H14N2
XLogP34.3
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count0
Rotatable Bond Count2
Exact Mass246.115698455 g/mol
Monoisotopic Mass246.115698455 g/mol
Topological Polar Surface Area31.6 Ų
Heavy Atom Count19
Formal Charge0
Complexity286
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count1
4 Pharmacology and Biochemistry
4.1 MeSH Pharmacological Classification

Anticarcinogenic Agents

Agents that reduce the frequency or rate of spontaneous or induced tumors independently of the mechanism involved. (See all compounds classified as Anticarcinogenic Agents.)


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18-Feb-2021
30-Sep-2024
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ABOUT THIS PAGE

Diindolylmethane Manufacturers

A Diindolylmethane manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Diindolylmethane, including repackagers and relabelers. The FDA regulates Diindolylmethane manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Diindolylmethane API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

Diindolylmethane Suppliers

A Diindolylmethane supplier is an individual or a company that provides Diindolylmethane active pharmaceutical ingredient (API) or Diindolylmethane finished formulations upon request. The Diindolylmethane suppliers may include Diindolylmethane API manufacturers, exporters, distributors and traders.

click here to find a list of Diindolylmethane suppliers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PharmaCompass.

Diindolylmethane USDMF

A Diindolylmethane DMF (Drug Master File) is a document detailing the whole manufacturing process of Diindolylmethane active pharmaceutical ingredient (API) in detail. Different forms of Diindolylmethane DMFs exist exist since differing nations have different regulations, such as Diindolylmethane USDMF, ASMF (EDMF), JDMF, CDMF, etc.

A Diindolylmethane DMF submitted to regulatory agencies in the US is known as a USDMF. Diindolylmethane USDMF includes data on Diindolylmethane's chemical properties, information on the facilities and procedures used, and details about packaging and storage. The Diindolylmethane USDMF is kept confidential to protect the manufacturer’s intellectual property.

click here to find a list of Diindolylmethane suppliers with USDMF on PharmaCompass.

Diindolylmethane GMP

Diindolylmethane Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

PharmaCompass offers a list of Diindolylmethane GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Diindolylmethane GMP manufacturer or Diindolylmethane GMP API supplier for your needs.

Diindolylmethane CoA

A Diindolylmethane CoA (Certificate of Analysis) is a formal document that attests to Diindolylmethane's compliance with Diindolylmethane specifications and serves as a tool for batch-level quality control.

Diindolylmethane CoA mostly includes findings from lab analyses of a specific batch. For each Diindolylmethane CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

Diindolylmethane may be tested according to a variety of international standards, such as European Pharmacopoeia (Diindolylmethane EP), Diindolylmethane JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Diindolylmethane USP).

Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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