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1. 2,2-dichloro-4'-hydroxy-n-methylacetanilide 2-furoate
2. 2-furamide
3. Diloxanide
4. Entamide Furoate
5. Furamide
1. 3736-81-0
2. Dichlofurazol
3. Furentomin
4. Histomibal
5. Diloxanid Furoate
6. 4-(2,2-dichloro-n-methylacetamido)phenyl Furan-2-carboxylate
7. [4-[(2,2-dichloroacetyl)-methylamino]phenyl] Furan-2-carboxylate
8. Diloxanidefuroate
9. Mls000028653
10. Amebiazol
11. Diloxanide Furoate [usp]
12. Nsc-759146
13. 2-furoic Acid, Ester With 2,2-dichloro-4'-hydroxy-n-methylacetanilide
14. Smr000058857
15. Chebi:4601
16. Yp4n72iw34
17. Diclofurazol
18. Entamide Furoate
19. Ncgc00016637-07
20. Miforon
21. Cas-3736-81-0
22. Diloxanide Furoate (usp)
23. Dsstox_cid_28925
24. Dsstox_rid_83191
25. 2,2-dichloroacetamido-4-n-methylphenyl 2-furoate
26. Dsstox_gsid_48999
27. Entamide 2-furoate
28. 4-(n-methyl-2,2-dichloroacetamido)phenyl 2-furoate
29. Furamide (amebicide)
30. 2,2-dichloro-n-(4-hydroxyphenyl)-n-methylacetamide 2-furoic Acid Ester
31. 2,2-dichloro-n-[4-hydroxyphenyl]-n-methylacetamide 2-furoic Acid Ester
32. Sr-01000003134
33. Einecs 223-108-1
34. 8073 Cb
35. Unii-yp4n72iw34
36. Diloxanidi Furoas
37. Cb 8073
38. Diloxanide Furoate (tn)
39. 2-furancarboxylic Acid, 4-((dichloroacetyl)methylamino)phenyl Ester
40. Opera_id_1633
41. Prestwick0_000903
42. Prestwick1_000903
43. Prestwick2_000903
44. Prestwick3_000903
45. 4-((dichloroacetyl)methylamino)phenyl 2-furoate
46. Schembl23381
47. Bspbio_000746
48. 2,2-dichloroacetamideo-4-n-methylphenyl 2-furoate
49. 4-(2,2-dichlor-n-methylacetamido)phenyl 2-furoat
50. Cid_19529
51. Mls001148648
52. Spbio_002945
53. 4-(n-methyl-2,2-dichloroacetamideo)phenyl 2-furoate
54. Bpbio1_000822
55. Zinc1300
56. Diloxanide Furoate [mi]
57. Chembl1334860
58. Dtxsid8048999
59. Bdbm70295
60. 4-(2,2-dichlor-n-methylacetamido)phenyl 2-furancarboxylat
61. 4-(2,2-dichlor-n-methylacetamido)phenyl 2-furoat [iupac]
62. Hms1570f08
63. Hms2093n21
64. Hms2097f08
65. Hms2234p06
66. Hms3371i07
67. Hms3714f08
68. Pharmakon1600-01505532
69. Diloxanide Furoate [mart.]
70. Diloxanide Furoate [usp-rs]
71. Diloxanide Furoate [who-dd]
72. Diloxanide Furoate [who-ip]
73. Hy-b1147
74. Tox21_113492
75. 4-(2,2-dichlor-n-methylacetamido)phenyl 2-furancarboxylat [iupac]
76. Nsc759146
77. Akos016014036
78. Tox21_113492_1
79. Ccg-213477
80. Cs-4751
81. Db14638
82. Nsc 759146
83. Diloxanidi Furoas [who-ip Latin]
84. Ncgc00016637-01
85. Ncgc00016637-02
86. Ncgc00016637-03
87. Ncgc00016637-04
88. Ncgc00016637-05
89. Ncgc00016637-06
90. Ncgc00016637-10
91. Ncgc00023178-03
92. Ncgc00023178-04
93. Ncgc00023178-05
94. Diloxanide Furoate [usp Monograph]
95. Sbi-0206798.p001
96. Ab00383052
97. Ft-0752403
98. C07637
99. D02480
100. Ab00383052_13
101. Diloxanide Furoate 100 Microg/ml In Acetonitrile
102. Q799564
103. Q-200989
104. Sr-01000003134-2
105. Sr-01000003134-4
106. Brd-k10974103-001-03-9
107. Brd-k10974103-001-14-6
108. [4-[(2,2-dichloroacetyl)-methyl-amino]phenyl] Furan-2-carboxylate
109. [4-[2,2-bis(chloranyl)ethanoyl-methyl-amino]phenyl] Furan-2-carboxylate
110. 2-furancarboxylic Acid, 4-[(2,2-dichloroacetyl)methylamino]phenyl Ester
111. Diloxanide Furoate, United States Pharmacopeia (usp) Reference Standard
112. 2-furancarboxylic Acid [4-[(2,2-dichloro-1-oxoethyl)-methylamino]phenyl] Ester
113. Furan-2-carboxylic Acid [4-[(2,2-dichloroacetyl)-methyl-amino]phenyl] Ester
| Molecular Weight | 328.1 g/mol |
|---|---|
| Molecular Formula | C14H11Cl2NO4 |
| XLogP3 | 3.4 |
| Hydrogen Bond Donor Count | 0 |
| Hydrogen Bond Acceptor Count | 4 |
| Rotatable Bond Count | 5 |
| Exact Mass | 327.0065132 g/mol |
| Monoisotopic Mass | 327.0065132 g/mol |
| Topological Polar Surface Area | 59.8 Ų |
| Heavy Atom Count | 21 |
| Formal Charge | 0 |
| Complexity | 383 |
| Isotope Atom Count | 0 |
| Defined Atom Stereocenter Count | 0 |
| Undefined Atom Stereocenter Count | 0 |
| Defined Bond Stereocenter Count | 0 |
| Undefined Bond Stereocenter Count | 0 |
| Covalently Bonded Unit Count | 1 |
Diloxanide is used alone as a primary agent in the treatment of asymptomatic (cyst passers) intestinal amebiasis caused by Entamoeba histolytica. Diloxanide may also be used concurrently, or sequentially, with other agents such as the nitroimidazoles (eg. metronidazole) in the treatment of invasive or extraintestinal forms of amebiasis.
Diloxanide is a luminal amebicide, however the mechanism of action of diloxanide is unknown. Diloxanide destroys the trophozoites of E. histolytica that eventually form into cysts. The cysts are then excreted by persons infected with asymptomatic amebiasis. Diloxanide furoate is a prodrug, and is hydrolyzed in the gastrointestinal tract to produce diloxanide, the active ingredient.
Amebicides
Agents which are destructive to amebae, especially the parasitic species causing AMEBIASIS in man and animal. (See all compounds classified as Amebicides.)
Absorption
Bioavailability is 90% (in diloxanide parental form), however diloxanide furoate is slowly absorbed from the gastrointestinal tract.
Route of Elimination
Renal (90%, rapidly excreted as glucuronide metabolite). 10% is excreted in the feces as diloxanide.
Hydrolyzed to furoic acid and diloxanide, which undergoes extensive glucuronidation (99% of diloxanide occurs as glucuronide and 1% as free diloxanide in the systemic circulation).
3 hours
Unknown. Diloxanide may inhibit protein synthesis.
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REF. STANDARDS & IMPURITIES
ABOUT THIS PAGE
A Diloxanide Furoate manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Diloxanide Furoate, including repackagers and relabelers. The FDA regulates Diloxanide Furoate manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Diloxanide Furoate API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.
click here to find a list of Diloxanide Furoate manufacturers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PhamaCompass.
A Diloxanide Furoate supplier is an individual or a company that provides Diloxanide Furoate active pharmaceutical ingredient (API) or Diloxanide Furoate finished formulations upon request. The Diloxanide Furoate suppliers may include Diloxanide Furoate API manufacturers, exporters, distributors and traders.
click here to find a list of Diloxanide Furoate suppliers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PharmaCompass.
A Diloxanide Furoate DMF (Drug Master File) is a document detailing the whole manufacturing process of Diloxanide Furoate active pharmaceutical ingredient (API) in detail. Different forms of Diloxanide Furoate DMFs exist exist since differing nations have different regulations, such as Diloxanide Furoate USDMF, ASMF (EDMF), JDMF, CDMF, etc.
A Diloxanide Furoate DMF submitted to regulatory agencies in the US is known as a USDMF. Diloxanide Furoate USDMF includes data on Diloxanide Furoate's chemical properties, information on the facilities and procedures used, and details about packaging and storage. The Diloxanide Furoate USDMF is kept confidential to protect the manufacturer’s intellectual property.
click here to find a list of Diloxanide Furoate suppliers with USDMF on PharmaCompass.
A Diloxanide Furoate written confirmation (Diloxanide Furoate WC) is an official document issued by a regulatory agency to a Diloxanide Furoate manufacturer, verifying that the manufacturing facility of a Diloxanide Furoate active pharmaceutical ingredient (API) adheres to the Good Manufacturing Practices (GMP) regulations of the importing country. When exporting Diloxanide Furoate APIs or Diloxanide Furoate finished pharmaceutical products to another nation, regulatory agencies frequently require a Diloxanide Furoate WC (written confirmation) as part of the regulatory process.
click here to find a list of Diloxanide Furoate suppliers with Written Confirmation (WC) on PharmaCompass.
Diloxanide Furoate Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.
GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).
PharmaCompass offers a list of Diloxanide Furoate GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Diloxanide Furoate GMP manufacturer or Diloxanide Furoate GMP API supplier for your needs.
A Diloxanide Furoate CoA (Certificate of Analysis) is a formal document that attests to Diloxanide Furoate's compliance with Diloxanide Furoate specifications and serves as a tool for batch-level quality control.
Diloxanide Furoate CoA mostly includes findings from lab analyses of a specific batch. For each Diloxanide Furoate CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.
Diloxanide Furoate may be tested according to a variety of international standards, such as European Pharmacopoeia (Diloxanide Furoate EP), Diloxanide Furoate JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Diloxanide Furoate USP).
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