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Chemistry

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Also known as: 16208-51-8, Tavocept, Sodium 2,2'-disulfanediyldiethanesulfonate, Dimesna [inn], Dimesna-d8, Bnp-7787
Molecular Formula
C4H8Na2O6S4
Molecular Weight
326.4  g/mol
InChI Key
KQYGMURBTJPBPQ-UHFFFAOYSA-L
FDA UNII
230R951Y4D

Dimesna
Dimesna is a synthetic derivative of dithio-ethane sulfonate with uroprotective properties. In the kidney, dimesna undergoes reduction to the free thiol compound, mesna, which reacts chemically with the urotoxic ifosfamide metabolites acrolein and 4-hydroxy-ifosfamide, resulting in their detoxification. This agent also inhibits cyclophosphamide-induced hemorrhagic cystitis.
1 2D Structure

Dimesna

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
disodium;2-(2-sulfonatoethyldisulfanyl)ethanesulfonate
2.1.2 InChI
InChI=1S/C4H10O6S4.2Na/c5-13(6,7)3-1-11-12-2-4-14(8,9)10;;/h1-4H2,(H,5,6,7)(H,8,9,10);;/q;2*+1/p-2
2.1.3 InChI Key
KQYGMURBTJPBPQ-UHFFFAOYSA-L
2.1.4 Canonical SMILES
C(CS(=O)(=O)[O-])SSCCS(=O)(=O)[O-].[Na+].[Na+]
2.2 Other Identifiers
2.2.1 UNII
230R951Y4D
2.3 Synonyms
2.3.1 MeSH Synonyms

1. 2,2'-dithiodiethanesulfonic Acid

2. 2,2'-dithiodiethanesulfonic Acid, Ammonium Salt

3. 2,2'-dithiodiethanesulfonic Acid, Disodium Salt

4. Bnp7787

5. Disodium 2,2'-dithio-bis-ethane Sulfonate

6. Tavocept

2.3.2 Depositor-Supplied Synonyms

1. 16208-51-8

2. Tavocept

3. Sodium 2,2'-disulfanediyldiethanesulfonate

4. Dimesna [inn]

5. Dimesna-d8

6. Bnp-7787

7. Ethanesulfonic Acid, 2,2'-dithiobis-, Disodium Salt

8. Bis(2-sulfoethyl)disulfide Disodium Salt

9. 1189975-43-6

10. Disodium 2,2'-dithiodiethanesulfonate

11. Disodium 2,2'-dithio-bis-ethane Sulfonate

12. Bnp7787

13. Disodium;2-(2-sulfonatoethyldisulfanyl)ethanesulfonate

14. 230r951y4d

15. Nsc-716976

16. Nsc-760345

17. Ethanesulfonic Acid, 2,2'-dithiobis-, Sodium Salt (1:2)

18. Dimesnum

19. Dimesnum [inn-latin]

20. Ccris 5852

21. Bnp 7787

22. Einecs 240-337-2

23. Nsc 716976

24. Bionumerik

25. Disodium 2,2'-dithiobis(ethanesulfonate)

26. Beta,beta'-sulfoethyldisulfide, Disodium Salt

27. Unii-230r951y4d

28. 2,2'-dithiodi-1-ethanesulfonic Acid Disodium Salt

29. Tavocept;bnp7787

30. Dinatrium 3,4-dithiahexan-1,6-disulfonat

31. Dimesna [usan]

32. Dimesna [mi]

33. Dimesna [mart.]

34. Dimesna [who-dd]

35. Schembl18847

36. Dinatrium 3,4-dithiahexan-1,6-disulfonat [iupac]

37. Ethanesulfonic Acid, 2,2'-dithiodi-, Disodium Salt

38. Chembl2104318

39. Dtxsid6066024

40. Hms3264g13

41. Hms3654m20

42. Hms3867m13

43. Hms3884k05

44. Bcp21002

45. Mfcd00868218

46. Akos015833466

47. Ac-1240

48. As-2006

49. Ccg-213814

50. Disodium 2,2'-dithiobisethane Sulfonate

51. Disodium 2,2'-dithiobis-ethane Sulfonate

52. Db-064437

53. Ft-0601551

54. Ft-0667231

55. Sw220298-1

56. Disodium 2,2'-dithiodiethanesulphonate

57. C73103

58. A883003

59. J-009892

60. Q27253698

2.4 Create Date
2005-08-08
3 Chemical and Physical Properties
Molecular Weight 326.4 g/mol
Molecular Formula C4H8Na2O6S4
Hydrogen Bond Donor Count0
Hydrogen Bond Acceptor Count8
Rotatable Bond Count5
Exact Mass325.89991123 g/mol
Monoisotopic Mass325.89991123 g/mol
Topological Polar Surface Area182 Ų
Heavy Atom Count16
Formal Charge0
Complexity268
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count3
4 Pharmacology and Biochemistry
4.1 MeSH Pharmacological Classification

Protective Agents

Synthetic or natural substances which are given to prevent a disease or disorder or are used in the process of treating a disease or injury due to a poisonous agent. (See all compounds classified as Protective Agents.)


ABOUT THIS PAGE

Dimesna Manufacturers

A Dimesna manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Dimesna, including repackagers and relabelers. The FDA regulates Dimesna manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Dimesna API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

Dimesna Suppliers

A Dimesna supplier is an individual or a company that provides Dimesna active pharmaceutical ingredient (API) or Dimesna finished formulations upon request. The Dimesna suppliers may include Dimesna API manufacturers, exporters, distributors and traders.

Dimesna GMP

Dimesna Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

PharmaCompass offers a list of Dimesna GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Dimesna GMP manufacturer or Dimesna GMP API supplier for your needs.

Dimesna CoA

A Dimesna CoA (Certificate of Analysis) is a formal document that attests to Dimesna's compliance with Dimesna specifications and serves as a tool for batch-level quality control.

Dimesna CoA mostly includes findings from lab analyses of a specific batch. For each Dimesna CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

Dimesna may be tested according to a variety of international standards, such as European Pharmacopoeia (Dimesna EP), Dimesna JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Dimesna USP).

Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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