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Chemistry

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Also known as: 5,5-dimethyloxazolidine-2,4-dione, 695-53-4, 5,5-dimethyl-2,4-oxazolidinedione, Dimethadion, Eupractone, Propazone
Molecular Formula
C5H7NO3
Molecular Weight
129.11  g/mol
InChI Key
JYJFNDQBESEHJQ-UHFFFAOYSA-N
FDA UNII
ALU9NPM703

Dimethadione
An anticonvulsant that is the active metabolite of TRIMETHADIONE.
1 2D Structure

Dimethadione

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
5,5-dimethyl-1,3-oxazolidine-2,4-dione
2.1.2 InChI
InChI=1S/C5H7NO3/c1-5(2)3(7)6-4(8)9-5/h1-2H3,(H,6,7,8)
2.1.3 InChI Key
JYJFNDQBESEHJQ-UHFFFAOYSA-N
2.1.4 Canonical SMILES
CC1(C(=O)NC(=O)O1)C
2.2 Other Identifiers
2.2.1 UNII
ALU9NPM703
2.3 Synonyms
2.3.1 MeSH Synonyms

1. 5,5-dimethyl-2,4-oxazolidinedione

2. 5,5-dimethyloxazolidine-2,4-dione

3. Dimethyloxazolidinedione

2.3.2 Depositor-Supplied Synonyms

1. 5,5-dimethyloxazolidine-2,4-dione

2. 695-53-4

3. 5,5-dimethyl-2,4-oxazolidinedione

4. Dimethadion

5. Eupractone

6. Propazone

7. Dimethyloxazolidinedione

8. 5,5-dimethyl-1,3-oxazolidine-2,4-dione

9. 2,4-oxazolidinedione, 5,5-dimethyl-

10. Bax 1400z

11. Ac 1198

12. Nsc-30152

13. 5,5-dimethyloxazolidinedione

14. Nortrimethadione

15. Dmo

16. Bay 1400z

17. 5,5-dwumetylooksazolidyno-2,4-dion

18. Mfcd00005379

19. Alu9npm703

20. Bax-1400z

21. Bay-1400z

22. Nsc30152

23. Ac-1198

24. Ncgc00016532-02

25. Cas-695-53-4

26. Dsstox_cid_478

27. Dsstox_rid_75614

28. Dsstox_gsid_20478

29. Dimetadione [dcit]

30. Dimetadiona

31. Dimetadione

32. Dimethadionum

33. Dimethadione [usan:inn]

34. Dimetadiona [inn-spanish]

35. Dimethadionum [inn-latin]

36. Nsc 30152

37. Dimethyl-oxazolidine-2,4-dione

38. Sr-05000001609

39. Einecs 211-781-4

40. Unii-alu9npm703

41. Brn 0113541

42. Ai3-18201

43. 5,5-dwumetylooksazolidyno-2,4-dion [polish]

44. 5,5-dimethyl-2,4-oxazolidindion

45. Prestwick_55

46. 5,4-oxazolidinedione

47. Spectrum_000801

48. Trimethadion, M(nor-)

49. 5,5-dimethyl-2,4-oxazolidindion [iupac]

50. Prestwick0_000829

51. Prestwick1_000829

52. Prestwick2_000829

53. Prestwick3_000829

54. Spectrum2_000108

55. Spectrum3_000398

56. Spectrum4_000518

57. Spectrum5_000911

58. Dimethadione [mi]

59. Dimethadione (usan/inn)

60. Dimethadione [inn]

61. Dimethadione [usan]

62. Chembl1099

63. Schembl34862

64. Bspbio_000757

65. Bspbio_002215

66. Kbiogr_001095

67. Kbioss_001281

68. Divk1c_000939

69. Spectrum1500253

70. Spbio_000096

71. Spbio_002678

72. Bpbio1_000833

73. Dtxsid2020478

74. Chebi:94613

75. Hms502o21

76. Kbio1_000939

77. Kbio2_001281

78. Kbio2_003849

79. Kbio2_006417

80. Kbio3_001435

81. Ninds_000939

82. Wln: T5ovmv Ehj E1 E1

83. Hms1570f19

84. Hms1920g22

85. Hms2091o10

86. Hms2097f19

87. Hms3714f19

88. Pharmakon1600-01500253

89. Hy-b1348

90. Zinc5762010

91. Tox21_110479

92. Tox21_200496

93. Ccg-38926

94. Nsc756741

95. 5, 5-dimethyloxazolidine-2,4-dione

96. 5,5-dimethyl-oxazolidine-2,4-dione

97. Akos015906843

98. Tox21_110479_1

99. Nsc-756741

100. Idi1_000939

101. 2,4-oxazolidinedione, 5, 5-dimethyl-

102. Ncgc00016532-01

103. Ncgc00016532-03

104. Ncgc00016532-04

105. Ncgc00016532-07

106. Ncgc00094656-01

107. Ncgc00094656-02

108. Ncgc00258050-01

109. As-14715

110. Sy048286

111. Sbi-0051352.p003

112. Db-055297

113. A9197

114. Ab00051972

115. Cs-0013093

116. D0003

117. Ft-0619784

118. Ft-0646768

119. 5,5-dimethyl-1,3-oxazolidine-2,4-dione #

120. 95d534

121. D-5490

122. D03838

123. H10857

124. Ab00051972_04

125. Sr-05000001609-1

126. Sr-05000001609-2

127. Brd-k43687498-001-02-3

128. Q27166437

129. F2173-0915

2.4 Create Date
2005-03-25
3 Chemical and Physical Properties
Molecular Weight 129.11 g/mol
Molecular Formula C5H7NO3
XLogP30.1
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count3
Rotatable Bond Count0
Exact Mass129.042593085 g/mol
Monoisotopic Mass129.042593085 g/mol
Topological Polar Surface Area55.4 Ų
Heavy Atom Count9
Formal Charge0
Complexity173
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count1
4 Pharmacology and Biochemistry
4.1 MeSH Pharmacological Classification

Anticonvulsants

Drugs used to prevent SEIZURES or reduce their severity. (See all compounds classified as Anticonvulsants.)


4.2 Metabolism/Metabolites

Dimethadione is a known human metabolite of trimethadione.

S73 | METXBIODB | Metabolite Reaction Database from BioTransformer | DOI:10.5281/zenodo.4056560


ABOUT THIS PAGE

Dimethadione Manufacturers

A Dimethadione manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Dimethadione, including repackagers and relabelers. The FDA regulates Dimethadione manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Dimethadione API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

Dimethadione Suppliers

A Dimethadione supplier is an individual or a company that provides Dimethadione active pharmaceutical ingredient (API) or Dimethadione finished formulations upon request. The Dimethadione suppliers may include Dimethadione API manufacturers, exporters, distributors and traders.

click here to find a list of Dimethadione suppliers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PharmaCompass.

Dimethadione USDMF

A Dimethadione DMF (Drug Master File) is a document detailing the whole manufacturing process of Dimethadione active pharmaceutical ingredient (API) in detail. Different forms of Dimethadione DMFs exist exist since differing nations have different regulations, such as Dimethadione USDMF, ASMF (EDMF), JDMF, CDMF, etc.

A Dimethadione DMF submitted to regulatory agencies in the US is known as a USDMF. Dimethadione USDMF includes data on Dimethadione's chemical properties, information on the facilities and procedures used, and details about packaging and storage. The Dimethadione USDMF is kept confidential to protect the manufacturer’s intellectual property.

click here to find a list of Dimethadione suppliers with USDMF on PharmaCompass.

Dimethadione GMP

Dimethadione Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

PharmaCompass offers a list of Dimethadione GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Dimethadione GMP manufacturer or Dimethadione GMP API supplier for your needs.

Dimethadione CoA

A Dimethadione CoA (Certificate of Analysis) is a formal document that attests to Dimethadione's compliance with Dimethadione specifications and serves as a tool for batch-level quality control.

Dimethadione CoA mostly includes findings from lab analyses of a specific batch. For each Dimethadione CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

Dimethadione may be tested according to a variety of international standards, such as European Pharmacopoeia (Dimethadione EP), Dimethadione JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Dimethadione USP).

Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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