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    Chemistry

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    Also known as: 107-51-7, Trisiloxane, octamethyl-, Poly(dimethylsiloxane), 1,1,1,3,3,5,5,5-octamethyltrisiloxane, Dimeticone, Dimethyl-bis(trimethylsilyloxy)silane
    Molecular Formula
    C8H24O2Si3
    Molecular Weight
    236.53  g/mol
    InChI Key
    CXQXSVUQTKDNFP-UHFFFAOYSA-N
    FDA UNII
    9G1ZW13R0G
    Dimethicone
    1 2D Structure

    Dimethicone

    2 Identification
    2.1 Computed Descriptors
    2.1.1 IUPAC Name
    dimethyl-bis(trimethylsilyloxy)silane
    2.1.2 InChI
    InChI=1S/C8H24O2Si3/c1-11(2,3)9-13(7,8)10-12(4,5)6/h1-8H3
    2.1.3 InChI Key
    CXQXSVUQTKDNFP-UHFFFAOYSA-N
    2.1.4 Canonical SMILES
    C[Si](C)(C)O[Si](C)(C)O[Si](C)(C)C
    2.2 Other Identifiers
    2.2.1 UNII
    9G1ZW13R0G
    2.3 Synonyms
    2.3.1 MeSH Synonyms

    1. Baysilon

    2. Macroplastique

    3. Poly(dimethylsiloxane)

    4. Polydimethylsiloxane

    5. Rtv S-5392

    6. Silastic

    7. Siliconique

    8. Silikon 1000

    9. Simpa

    2.3.2 Depositor-Supplied Synonyms

    1. 107-51-7

    2. Trisiloxane, Octamethyl-

    3. Poly(dimethylsiloxane)

    4. 1,1,1,3,3,5,5,5-octamethyltrisiloxane

    5. Dimeticone

    6. Dimethyl-bis(trimethylsilyloxy)silane

    7. Dimethicone 350

    8. 63148-62-9

    9. Pentamethyl(trimethylsilyloxy)disiloxane

    10. Dimethylbis(trimethylsiloxy)silane

    11. 9g1zw13r0g

    12. Chebi:9147

    13. Trisiloxane, 1,1,1,3,3,5,5,5-octamethyl-

    14. Dimethylbis(trimethylsilyloxy)silane

    15. Dimethicones

    16. Poly(dimethylsiloxane), Hydroxy Terminated

    17. Mfcd00084411

    18. Mfcd00134211

    19. Mfcd00148360

    20. Ccris 3198

    21. Poly(dimethylsiloxane), Trimethylsiloxy Terminated

    22. Einecs 203-497-4

    23. Dimeticonum

    24. Unii-9g1zw13r0g

    25. Dimeticona

    26. Frd 20

    27. Ctamethyltrisiloxane

    28. Mfcd00008264

    29. Pentamethyl(trimethylsiloxy)disiloxane

    30. Octamethyl-trisiloxane

    31. Pdms

    32. Dimethicone Macromolecule

    33. Volasil Dm-1

    34. Silicon Oil For Oil Bath

    35. Trisiloxane [inci]

    36. Dm-fluid 1.0cs

    37. Ec 203-497-4

    38. Octamethyltrisiloxane, 98%

    39. Dsstox_cid_20710

    40. Dsstox_rid_79558

    41. Dsstox_gsid_40710

    42. Os 20 (siloxane)

    43. Schembl23459

    44. Siliconoil Pharma 100 Cst.

    45. Dimethyl Polysiloxane, Bis(trimethylsilyl)-terminated

    46. Dow Corning High-vacuum Grease

    47. Chembl2142985

    48. Dtxsid9040710

    49. Chebi:31498

    50. Cxqxsvuqtkdnfp-uhfffaoysa-

    51. Kf 96a1

    52. Octamethyltrisiloxane [mi]

    53. Dimethylbis(trimethylsiloxy)siliane

    54. Polydimethylsiloxane, 1000 Cst.

    55. Alpha-(trimethylsilyl)-omega-methylpoly(oxy(dimethylsilylene))

    56. [(ch3)3sio]2si(ch3)2

    57. Tox21_301002

    58. Co9816

    59. Mfcd00165850

    60. Silane, Dimethylbis(trimethylsiloxy)-

    61. Akos015840180

    62. Zinc169747808

    63. Antifoam Compound For Anhydrous Systems

    64. Fs-4459

    65. Ncgc00164100-01

    66. Ncgc00164100-02

    67. Ncgc00254904-01

    68. Cas-107-51-7

    69. Db-040764

    70. Ft-0631598

    71. Ft-0696355

    72. O0257

    73. O9816

    74. C07261

    75. D91850

    76. S12475

    77. A801717

    78. Xiameter(r) Pmx-200 Silicone Fluid 1 Cst

    79. J-001906

    80. Poly(dimethylsiloxane), Viscosity 1.0 Cst (25 C)

    81. Q2013799

    82. Xiameter(r) Pmx-200 Silicone Fluid 20 Cs

    83. 2,2,4,4,6,6-hexamethyl-3,5-dioxa-2,4,6-trisilaheptane

    84. Polydimethylsiloxane, 20,000 Cst. Trimethoxysilyl Terminated

    85. Polydimethylsiloxane, Extreme Low Volatility, Viscosity 1000 Cst.

    86. Intermediate Viscosity Polydimethylsiloxane Antifoam Emulsion, 20% Active, Viscosity 1500cst

    87. Intermediate Viscosity Polydimethylsiloxane Antifoam Emulsion, 30% Active, Viscosity 1500cst

    88. Polydimethylsiloxane, Trimethylsiloxy Terminated, Reduced Volatility, Viscosity 20 Cst.

    89. 28349-86-2

    90. Intermediate Viscosity Polydimethylsiloxane Antifoam Emulsion, 10% Active, Viscosity 1000-2000cst

    91. Intermediate Viscosity Polydimethylsiloxane Antifoam Emulsion, 10% Active, Viscosity 800-2000cst

    92. Intermediate Viscosity Polydimethylsiloxane Antifoam Emulsion, 20% Active, Viscosity 1000-2000cst

    93. Intermediate Viscosity Polydimethylsiloxane Antifoam Emulsion, 30% Active, Viscosity 1000-2000cst

    94. Polydimethylsiloxane, Trimethylsiloxy Terminated, Extreme Low Volatility, Viscosity 12.500 Cst.

    2.4 Create Date
    2005-03-27
    3 Chemical and Physical Properties
    Molecular Weight 236.53 g/mol
    Molecular Formula C8H24O2Si3
    Hydrogen Bond Donor Count0
    Hydrogen Bond Acceptor Count2
    Rotatable Bond Count4
    Exact Mass236.10840961 g/mol
    Monoisotopic Mass236.10840961 g/mol
    Topological Polar Surface Area18.5 Ų
    Heavy Atom Count13
    Formal Charge0
    Complexity149
    Isotope Atom Count0
    Defined Atom Stereocenter Count0
    Undefined Atom Stereocenter Count0
    Defined Bond Stereocenter Count0
    Undefined Bond Stereocenter Count0
    Covalently Bonded Unit Count1
    4 Pharmacology and Biochemistry
    4.1 FDA Pharmacological Classification
    4.1.1 Pharmacological Classes
    Skin Barrier Activity [PE]
    4.2 ATC Code

    P - Antiparasitic products, insecticides and repellents

    P03 - Ectoparasiticides, incl. scabicides, insecticides and repellents

    P03A - Ectoparasiticides, incl. scabicides

    P03AX - Other ectoparasiticides, incl. scabicides

    P03AX05 - Dimeticone

    API Reference Price

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MAHARASHTRA.","supplier":"CRODA INTERNATIONAL PLC","supplierCountry":"UNITED STATES","foreign_port":"NEW YORK - JOHN F. K","customer":"CRODA INTERNATIONAL PLC","customerCountry":"INDIA","quantity":"36.00","actualQuantity":"36","unit":"KGS","unitRateFc":"41.6","totalValueFC":"1876","currency":"USD","unitRateINR":"4370.9","date":"27-Aug-2024","totalValueINR":"157353.58","totalValueInUsd":"1876","indian_port":"Bombay Air","hs_no":"29232090","bill_no":"5268159","productDescription":"API","marketType":"REGULATED MARKET","country":"UNITED STATES","selfForZScoreResived":"Pharma Grade","supplierPort":"NEW YORK - JOHN F. 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    10-Sep-2024
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    Dimethicone Manufacturers

    A Dimethicone manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Dimethicone, including repackagers and relabelers. The FDA regulates Dimethicone manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Dimethicone API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

    click here to find a list of Dimethicone manufacturers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PhamaCompass.

    Dimethicone Suppliers

    A Dimethicone supplier is an individual or a company that provides Dimethicone active pharmaceutical ingredient (API) or Dimethicone finished formulations upon request. The Dimethicone suppliers may include Dimethicone API manufacturers, exporters, distributors and traders.

    click here to find a list of Dimethicone suppliers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PharmaCompass.

    Dimethicone USDMF

    A Dimethicone DMF (Drug Master File) is a document detailing the whole manufacturing process of Dimethicone active pharmaceutical ingredient (API) in detail. Different forms of Dimethicone DMFs exist exist since differing nations have different regulations, such as Dimethicone USDMF, ASMF (EDMF), JDMF, CDMF, etc.

    A Dimethicone DMF submitted to regulatory agencies in the US is known as a USDMF. Dimethicone USDMF includes data on Dimethicone's chemical properties, information on the facilities and procedures used, and details about packaging and storage. The Dimethicone USDMF is kept confidential to protect the manufacturer’s intellectual property.

    click here to find a list of Dimethicone suppliers with USDMF on PharmaCompass.

    Dimethicone JDMF

    The Pharmaceuticals and Medical Devices Agency (PMDA) established the Japan Drug Master File (JDMF), also known as the Master File (MF), to permit Japanese and foreign manufacturers of drug substances, intermediates, excipients, raw materials, and packaging materials (‘Products’) to voluntarily register confidential information about the production and management of their products in Japan.

    The Dimethicone Drug Master File in Japan (Dimethicone JDMF) empowers Dimethicone API manufacturers to present comprehensive information (e.g., production methods, data, etc.) to the review authority, i.e., PMDA (Pharmaceuticals & Medical Devices Agency).

    PMDA reviews the Dimethicone JDMF during the approval evaluation for pharmaceutical products. At the time of Dimethicone JDMF registration, PMDA checks if the format is accurate, if the necessary items have been included (application), and if data has been attached.

    click here to find a list of Dimethicone suppliers with JDMF on PharmaCompass.

    Dimethicone CEP

    A Dimethicone CEP of the European Pharmacopoeia monograph is often referred to as a Dimethicone Certificate of Suitability (COS). The purpose of a Dimethicone CEP is to show that the European Pharmacopoeia monograph adequately controls the purity of Dimethicone EP produced by a given manufacturer. Suppliers of raw materials can prove the suitability of Dimethicone to their clients by showing that a Dimethicone CEP has been issued for it. The manufacturer submits a Dimethicone CEP (COS) as part of the market authorization procedure, and it takes on the role of a Dimethicone CEP holder for the record. Additionally, the data presented in the Dimethicone CEP (COS) is managed confidentially and offers a centralized system acknowledged by numerous nations, exactly like the Dimethicone DMF.

    A Dimethicone CEP (COS) is recognised by all 36 nations that make up the European Pharmacopoeia Convention. Dimethicone CEPs may be accepted in nations that are not members of the Ph. Eur. at the discretion of the authorities there.

    click here to find a list of Dimethicone suppliers with CEP (COS) on PharmaCompass.

    Dimethicone WC

    A Dimethicone written confirmation (Dimethicone WC) is an official document issued by a regulatory agency to a Dimethicone manufacturer, verifying that the manufacturing facility of a Dimethicone active pharmaceutical ingredient (API) adheres to the Good Manufacturing Practices (GMP) regulations of the importing country. When exporting Dimethicone APIs or Dimethicone finished pharmaceutical products to another nation, regulatory agencies frequently require a Dimethicone WC (written confirmation) as part of the regulatory process.

    click here to find a list of Dimethicone suppliers with Written Confirmation (WC) on PharmaCompass.

    Dimethicone NDC

    National Drug Code is a comprehensive database maintained by the FDA that contains information on all drugs marketed in the US. This directory includes information about finished drug products, unfinished drug products, and compounded drug products, including those containing Dimethicone as an active pharmaceutical ingredient (API).

    Finished drug products

    The FDA updates the NDC directory daily. The NDC numbers for Dimethicone API and other APIs are published in this directory by the FDA.

    Unfinished drugs

    The NDC unfinished drugs database includes product listing information submitted for all unfinished drugs, such as active pharmaceutical ingredients (APIs), drugs intended for further processing and bulk drug substances for compounding.

    Pharmaceutical companies that manufacture Dimethicone as an active pharmaceutical ingredient (API) must furnish the FDA with an updated record of all drugs that they produce, prepare, propagate, compound, or process for commercial distribution in the US at their facilities.

    Compounded drug products

    The NDC directory also contains data on finished compounded human drug products that contain Dimethicone and are produced by outsourcing facilities. While these outsourcing facilities are not mandated to assign a Dimethicone NDC to their finished compounded human drug products, they may choose to do so.

    click here to find a list of Dimethicone suppliers with NDC on PharmaCompass.

    Dimethicone GMP

    Dimethicone Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

    GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

    PharmaCompass offers a list of Dimethicone GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Dimethicone GMP manufacturer or Dimethicone GMP API supplier for your needs.

    Dimethicone CoA

    A Dimethicone CoA (Certificate of Analysis) is a formal document that attests to Dimethicone's compliance with Dimethicone specifications and serves as a tool for batch-level quality control.

    Dimethicone CoA mostly includes findings from lab analyses of a specific batch. For each Dimethicone CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

    Dimethicone may be tested according to a variety of international standards, such as European Pharmacopoeia (Dimethicone EP), Dimethicone JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Dimethicone USP).

    Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
    For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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