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Chemistry

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Also known as: Metubine iodide, 7601-55-0, Dimethyl tubocurarine iodide, Metocurine iodide [usan], Dimethylchondrocurarine iodide, O,o'-dimethylchondrocurarine diiodide
Molecular Formula
C40H48I2N2O6
Molecular Weight
906.6  g/mol
InChI Key
DIGFQJFCDPKEPF-OIUSMDOTSA-L
FDA UNII
O0U0E87X7F

Metocurine
Metocurine iodide is a benzylisoquinolinium competitive nondepolarizing neuromuscular blocking agent. It is used as an anesthesia adjunct to induce skeletal muscle relaxation and to reduce the intensity of muscle contractions in convulsive therapy Metocurine iodide has a moderate risk of inducing histamine release and has some ganglion blocking activity. Metocurine iodide can be used most advantageously if muscle twitch response to peripheral nerve stimulation is monitored to assess degree of muscle relaxation. Metocurine Iodide is no longer available on the US market.
1 2D Structure

Metocurine

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
(1S,16R)-9,10,21,25-tetramethoxy-15,15,30,30-tetramethyl-7,23-dioxa-15,30-diazoniaheptacyclo[22.6.2.23,6.18,12.118,22.027,31.016,34]hexatriaconta-3(36),4,6(35),8(34),9,11,18(33),19,21,24,26,31-dodecaene;diiodide
2.1.2 InChI
InChI=1S/C40H48N2O6.2HI/c1-41(2)17-15-27-22-34(44-6)36-24-30(27)31(41)19-25-9-12-29(13-10-25)47-40-38-28(23-37(45-7)39(40)46-8)16-18-42(3,4)32(38)20-26-11-14-33(43-5)35(21-26)48-36;;/h9-14,21-24,31-32H,15-20H2,1-8H3;2*1H/q+2;;/p-2/t31-,32+;;/m0../s1
2.1.3 InChI Key
DIGFQJFCDPKEPF-OIUSMDOTSA-L
2.1.4 Canonical SMILES
C[N+]1(CCC2=CC(=C3C=C2C1CC4=CC=C(C=C4)OC5=C6C(CC7=CC(=C(C=C7)OC)O3)[N+](CCC6=CC(=C5OC)OC)(C)C)OC)C.[I-].[I-]
2.1.5 Isomeric SMILES
C[N+]1(CCC2=CC(=C3C=C2[C@@H]1CC4=CC=C(C=C4)OC5=C6[C@@H](CC7=CC(=C(C=C7)OC)O3)[N+](CCC6=CC(=C5OC)OC)(C)C)OC)C.[I-].[I-]
2.2 Other Identifiers
2.2.1 UNII
O0U0E87X7F
2.3 Synonyms
2.3.1 MeSH Synonyms

1. Dimethyl Dl-curine Dimethochloride

2. Dimethyl-l-curine Dimethochloride

3. Dimethyl-l-curine Dimethoiodide

4. Dimethylchondrocurarine

5. Dimethylcurarine Dimethochloride

6. Dimethylcurine

7. Dmcdm

8. Metocurine

9. Metocurine Dichloride

10. Metocurine Dichloride(1alpha)-isomer

11. Metocurine Dichloride, (1'alpha)-isomer

12. Metocurine Dichloride, (1beta)-(+-)-isomer

13. Metocurine Dihydroxide

14. Metocurine Diiodide

15. Metocurine Diiodide, (1beta)-(+-)-isomer

16. Metocurine Diiodide, (1beta)-isomer

17. Metocurine, (1'alpha)-isomer

18. Metocurine, (1beta)-isomer

19. Metubine

2.3.2 Depositor-Supplied Synonyms

1. Metubine Iodide

2. 7601-55-0

3. Dimethyl Tubocurarine Iodide

4. Metocurine Iodide [usan]

5. Dimethylchondrocurarine Iodide

6. O,o'-dimethylchondrocurarine Diiodide

7. Dimethyltubocurarinium Iodide

8. Tubocuraranium, 6,6',7',12'-tetramethoxy-2,2,2',2'-tetramethyl-, Diiodide

9. Tetrandrini Dimethiodidum

10. (+)-o,o'-dimethylchondrocurarine Diiodide

11. Metocurine Iodide (usan)

12. O0u0e87x7f

13. Metubine

14. Methyl-curarin

15. Dsstox_cid_2944

16. Dimethylether Of D-tubocurarine Iodide

17. Methyl-curarin [german]

18. Dsstox_rid_76799

19. Dsstox_gsid_22944

20. (1s,16r)-9,10,21,25-tetramethoxy-15,15,30,30-tetramethyl-7,23-dioxa-15,30-diazoniaheptacyclo[22.6.2.23,6.18,12.118,22.027,31.016,34]hexatriaconta-3(36),4,6(35),8(34),9,11,18(33),19,21,24,26,31-dodecaene;diiodide

21. Cas-7601-55-0

22. Tubocurarine, O,o'-dimethyl-, Diiodide

23. Metubine Iodide (tn)

24. Nsc-36388

25. Einecs 231-510-3

26. Nsc 36388

27. Unii-o0u0e87x7f

28. Metocurine Iodide [usan:usp]

29. 6,6',7',12'-tetramethoxy-2,2,2',2'-tetramethyltubocuraranium Diiodide

30. Ncgc00181151-01

31. Chembl1739

32. 13h-4,6:21,24-dietheno-8,12-metheno-1h-pyrido(3',2':14,15)(1,11)dioxacycloeicosino(2,3,4-ij)isoquinolinium, 2,3,13a,14,15,16,25,25a-octahydro-9,18,19,29-tetramethoxy-1,1,14,14-tetramethyl-, Diiodide, (13ar-(13ar*,25as*))-

33. Schembl415745

34. Metocurine Iodide [mi]

35. Chebi:6901

36. Dtxsid9022944

37. Metocurine Iodide [vandf]

38. Metocurine Iodide [mart.]

39. Tox21_112755

40. Tox21_112755_1

41. Db00416

42. Metocurine Iodide [orange Book]

43. 2,2,2',2'-tetramethyl-6,6',7',12'-tetrakis(methyloxy)tubocuraran-2,2'-diium Diiodide

44. Ncgc00263444-01

45. 13h-4,6:21,24-dietheno-8,12-metheno-1h-pyrido(3',2':14,15)(1,11)dioxacycloeicosino(2,3,4-ij)isoquinolinium, 2,3,13a,14,15,16,25,25a-octahydro-9,18,19,29-tetramethoxy-1,1,14,14-tetramethyl-, Diiodide, (13ar,25as)-

46. Dimethyltubocurarinium Iodide [who-dd]

47. D00761

48. Q20817012

49. Tubocuraranium,6,6',7',12'-tetramethoxy-2,2,2',2'-tetramethyl-,diiodide

50. 13h-4,6:21,24-dietheno-8,12-metheno-1h-pyrido(3',2':14,15)(1,11)dioxacycloeicosino(2,3,4-ij)isoquinolinium, 2,3,13a,14,15,16,25,25a-octahydro-9,18,19,29-tetramethoxy-1,1,14,14-tetramethyl-, Iodide (1:2), (13ar,25as)-

2.4 Create Date
2005-06-24
3 Chemical and Physical Properties
Molecular Weight 906.6 g/mol
Molecular Formula C40H48I2N2O6
Hydrogen Bond Donor Count0
Hydrogen Bond Acceptor Count8
Rotatable Bond Count4
Exact Mass906.16018 g/mol
Monoisotopic Mass906.16018 g/mol
Topological Polar Surface Area55.4 Ų
Heavy Atom Count50
Formal Charge0
Complexity1060
Isotope Atom Count0
Defined Atom Stereocenter Count2
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count3
4 Drug and Medication Information
4.1 Drug Indication

For use as an anesthesia adjunct to induce skeletal muscle relaxation and to reduce the intensity of muscle contractions in convulsive therapy.


5 Pharmacology and Biochemistry
5.1 Pharmacology

Metocurine iodide is a benzylisoquinolinium competitive nondepolarizing neuromuscular blocking agent. Metocurine iodide has a moderate risk of inducing histamine release and has some ganglion blocking activity. Metocurine iodide can be used most advantageously if muscle twitch response to peripheral nerve stimulation is monitored to assess degree of muscle relaxation. As with other nondepolarizing neuromuscular blockers, the time to onset of paralysis decreases and the duration of maximum effect increases with increasing doses of metocurine iodide. Repeated administration of maintenance doses of metocurine iodide has no cumulative effect on the duration of neuromuscular block if recovery is allowed to begin prior to repeat dosing. Moreover, the time needed to recover from repeat doses does not change with additional doses. Repeat doses can therefore be administered at relatively regular intervals with predictable results.


5.2 MeSH Pharmacological Classification

Neuromuscular Nondepolarizing Agents

Drugs that interrupt transmission at the skeletal neuromuscular junction without causing depolarization of the motor end plate. They prevent acetylcholine from triggering muscle contraction and are used as muscle relaxants during electroshock treatments, in convulsive states, and as anesthesia adjuvants. (See all compounds classified as Neuromuscular Nondepolarizing Agents.)


5.3 Biological Half-Life

3 to 4 hours


5.4 Mechanism of Action

Metocurine iodide antagonizes the neurotransmitter action of acetylcholine by binding competitively with cholinergic receptor sites on the motor end-plate. This antagonism is inhibited, and neuromuscular block reversed, by acetylcholinesterase inhibitors such as neostigmine, edrophonium, and pyridostigmine.


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Metocurine manufacturers, exporters & distributors 1

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PharmaCompass offers a list of Metocurine API manufacturers, exporters & distributors, which can be sorted by GMP, USDMF, JDMF, KDMF, CEP (COS), WC, Price,and more, enabling you to easily find the right Metocurine manufacturer or Metocurine supplier for your needs.

Send us enquiries for free, and we will assist you in establishing a direct connection with your preferred Metocurine manufacturer or Metocurine supplier.

PharmaCompass also assists you with knowing the Metocurine API Price utilized in the formulation of products. Metocurine API Price is not always fixed or binding as the Metocurine Price is obtained through a variety of data sources. The Metocurine Price can also vary due to multiple factors, including market conditions, regulatory modifications, or negotiated pricing deals.

API | Excipient name

Metocurine

Synonyms

Metubine iodide, 7601-55-0, Dimethyl tubocurarine iodide, Metocurine iodide [usan], Dimethylchondrocurarine iodide, O,o'-dimethylchondrocurarine diiodide

Cas Number

7601-55-0

Unique Ingredient Identifier (UNII)

O0U0E87X7F

About Metocurine

Metocurine iodide is a benzylisoquinolinium competitive nondepolarizing neuromuscular blocking agent. It is used as an anesthesia adjunct to induce skeletal muscle relaxation and to reduce the intensity of muscle contractions in convulsive therapy Metocurine iodide has a moderate risk of inducing histamine release and has some ganglion blocking activity. Metocurine iodide can be used most advantageously if muscle twitch response to peripheral nerve stimulation is monitored to assess degree of muscle relaxation. Metocurine Iodide is no longer available on the US market.

Dimethyltubocurarine Iodide Manufacturers

A Dimethyltubocurarine Iodide manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Dimethyltubocurarine Iodide, including repackagers and relabelers. The FDA regulates Dimethyltubocurarine Iodide manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Dimethyltubocurarine Iodide API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

Dimethyltubocurarine Iodide Suppliers

A Dimethyltubocurarine Iodide supplier is an individual or a company that provides Dimethyltubocurarine Iodide active pharmaceutical ingredient (API) or Dimethyltubocurarine Iodide finished formulations upon request. The Dimethyltubocurarine Iodide suppliers may include Dimethyltubocurarine Iodide API manufacturers, exporters, distributors and traders.

click here to find a list of Dimethyltubocurarine Iodide suppliers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PharmaCompass.

Dimethyltubocurarine Iodide USDMF

A Dimethyltubocurarine Iodide DMF (Drug Master File) is a document detailing the whole manufacturing process of Dimethyltubocurarine Iodide active pharmaceutical ingredient (API) in detail. Different forms of Dimethyltubocurarine Iodide DMFs exist exist since differing nations have different regulations, such as Dimethyltubocurarine Iodide USDMF, ASMF (EDMF), JDMF, CDMF, etc.

A Dimethyltubocurarine Iodide DMF submitted to regulatory agencies in the US is known as a USDMF. Dimethyltubocurarine Iodide USDMF includes data on Dimethyltubocurarine Iodide's chemical properties, information on the facilities and procedures used, and details about packaging and storage. The Dimethyltubocurarine Iodide USDMF is kept confidential to protect the manufacturer’s intellectual property.

click here to find a list of Dimethyltubocurarine Iodide suppliers with USDMF on PharmaCompass.

Dimethyltubocurarine Iodide GMP

Dimethyltubocurarine Iodide Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

PharmaCompass offers a list of Dimethyltubocurarine Iodide GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Dimethyltubocurarine Iodide GMP manufacturer or Dimethyltubocurarine Iodide GMP API supplier for your needs.

Dimethyltubocurarine Iodide CoA

A Dimethyltubocurarine Iodide CoA (Certificate of Analysis) is a formal document that attests to Dimethyltubocurarine Iodide's compliance with Dimethyltubocurarine Iodide specifications and serves as a tool for batch-level quality control.

Dimethyltubocurarine Iodide CoA mostly includes findings from lab analyses of a specific batch. For each Dimethyltubocurarine Iodide CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

Dimethyltubocurarine Iodide may be tested according to a variety of international standards, such as European Pharmacopoeia (Dimethyltubocurarine Iodide EP), Dimethyltubocurarine Iodide JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Dimethyltubocurarine Iodide USP).

Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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