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Dimetindene

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ACTIVE PHARMA INGREDIENTS

9 API Suppliers, 4 CEP/COS, 2 EU WC, 7 Listed Suppliers, $ API Reference Price

9 API Suppliers
4 CEP/COS
2 EU WC
7 Listed Suppliers
$ API Reference Price

FINISHED DOSAGE FORMULATIONS

13 FDF Dossiers, 5 Europe, 5 South Africa, 3 Listed Dossiers

13 FDF Dossiers
5 Europe
5 South Africa
3 Listed Dossiers

DIGITAL CONTENT

1 NEWS #PharmaBuzz

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1 NEWS #PharmaBuzz

GLOBAL SALES INFORMATION

1 Finished Drug Prices

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1 Finished Drug Prices

MARKET PLACE

14 APIs, 2 FDF Dossiers

marketPlace
14 APIs
2 FDF Dossiers

REF. STANDARDS & IMPURITIES

1 EDQM , 1 Others

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1 EDQM
1 Others

Synopsis

ACTIVE PHARMA INGREDIENTS

API Suppliers

USDMF

CEP/COS

JDMF

EU WC

KDMF

NDC API

VMF

Listed Suppliers

API REF. PRICE (USD/KG)

$ 4,153

MARKET PLACE

API

FDF

0INTERMEDIATES

FINISHED DOSAGE FORMULATIONS

FDF Dossiers

FDA Orange Book

Europe

Canada

Australia

South Africa

Listed Dossiers

0 DRUGS IN DEVELOPMENT

DRUG PRODUCT COMPOSITIONS

REF. STANDARDS OR IMPURITIES

EDQM

USP

Others

PATENTS & EXCLUSIVITIES

US Patents

US Exclusivities

Health Canada Patents

DIGITAL CONTENT

Data Compilation #PharmaFlow

Stock Recap #PipelineProspector

Weekly News Recap #Phispers

News #PharmaBuzz

GLOBAL SALES INFORMATION

US Medicaid (USD)

Annual Reports (USD Million)

Finished Drug Prices

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0EXCIPIENTS BY APPLICATIONS

Chemistry

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Also known as: Dimetindene maleate, 3614-69-5, Forhistal maleate, Dimethpyrindene maleate, Fenistil-retard, Dimethinden maleate

Molecular Formula

C₂₄H₂₈N₂O₄

Molecular Weight

408.5 g/mol

InChI Key

SWECWXGUJQLXJF-BTJKTKAUSA-N

FDA UNII

6LL60J9E0O

A histamine H1 antagonist. It is used in hypersensitivity reactions, in rhinitis, for pruritus, and in some common cold remedies.

1 2D Structure

Dimetindene

2 Identification

2.1 Computed Descriptors

2.1.1 IUPAC Name

(Z)-but-2-enedioic acid;N,N-dimethyl-2-[3-(1-pyridin-2-ylethyl)-1H-inden-2-yl]ethanamine

2.1.2 InChI

InChI=1S/C20H24N2.C4H4O4/c1-15(19-10-6-7-12-21-19)20-17(11-13-22(2)3)14-16-8-4-5-9-18(16)20;5-3(6)1-2-4(7)8/h4-10,12,15H,11,13-14H2,1-3H3;1-2H,(H,5,6)(H,7,8)/b;2-1-

2.1.3 InChI Key

SWECWXGUJQLXJF-BTJKTKAUSA-N

2.1.4 Canonical SMILES

CC(C1=CC=CC=N1)C2=C(CC3=CC=CC=C32)CCN(C)C.C(=CC(=O)O)C(=O)O

2.1.5 Isomeric SMILES

CC(C1=CC=CC=N1)C2=C(CC3=CC=CC=C32)CCN(C)C.C(=C\C(=O)O)\C(=O)O

2.2 Other Identifiers

2.2.1 UNII

6LL60J9E0O

2.3 Synonyms

2.3.1 MeSH Synonyms

1. Dimethindene

2. Dimethpyrindene

3. Dimetindene

4. Fenistil

5. Forhistal

6. Maleate, Dimethindene

2.3.2 Depositor-Supplied Synonyms

1. Dimetindene Maleate

2. 3614-69-5

3. Forhistal Maleate

4. Dimethpyrindene Maleate

5. Fenistil-retard

6. Dimethinden Maleate

7. Fenistil

8. Su-6518

9. Dimethindene Maleate [usan]

10. Su 6518

11. Dimethindene (maleate)

12. Nsc-107677

13. Mls002704010

14. 6ll60j9e0o

15. 2-(1-(2-(2-(dimethylamino)ethyl)inden-3-yl)ethyl)pyridine Maleate (1:1)

16. Triten

17. (z)-but-2-enedioic Acid;n,n-dimethyl-2-[3-(1-pyridin-2-ylethyl)-1h-inden-2-yl]ethanamine

18. 1h-indene-2-ethanamine, N,n-dimethyl-3-(1-(2-pyridinyl)ethyl)-, (z)-2-butenedioate (1:1)

19. Forthistal Maleate

20. Dimethindene Malenate

21. Dimetindene Maleate (jan)

22. But-2-enedioic Acid;n,n-dimethyl-2-[3-(1-pyridin-2-ylethyl)-1h-inden-2-yl]ethanamine

23. Dimethindene Maleate (usan)

24. Dimetindene Hydrogen Maleate

25. Dimetindene Maleate [jan]

26. N,n-dimethyl-2-(3-(1-(pyridin-2-yl)ethyl)-1h-inden-2-yl)ethanamine Maleate

27. Nsc107677

28. Einecs 222-789-2

29. Nsc 107677

30. Unii-6ll60j9e0o

31. Dimethindenmaleat

32. 2-[1-[2-[2-(dimethylamino)ethyl]inden-3-yl]ethyl]pyridine Maleate (1:1)

33. Dimethindene Maleate [usan:usp]

34. Starbld0026265

35. Forhistal Maleate (tn)

36. 2-(1-(2-(2-(dimethylamino)ethyl)inden-3-yl)ethyl)pyridine Maleate

37. Schembl359490

38. Chembl1870768

39. Chebi:31500

40. Dimethindene Maleate [mi]

41. Dimetindene Maleate [mart.]

42. Dimetindene Maleate [who-dd]

43. Hy-13710a

44. Mfcd00072146

45. Pyridine, 2-(1-(2-(2-(dimethylamino)ethyl)inden-3-yl)ethyl)-, Maleate (1:1)

46. Dimetindene Maleate [ep Monograph]

47. Smr001570719

48. Ws-01911

49. Cs-0015467

50. Z 820

51. D01343

52. F16365

53. W-106641

54. Q27265113

55. 1h-indene-2-ethanamine,n-dimethyl-3-[1-(2-pyridinyl)ethyl]-, (z)-2-butenedioate (1:1)

56. N,n-dimethyl-2-{3-[(rs)-1-(pyridine-2-yl)ethyl]-1h-inden-2-yl}ethanamin-(z)-butendioate

2.4 Create Date

2005-03-26

3 Chemical and Physical Properties

Molecular Formula	C₂₄H₂₈N₂O₄
Molecular Weight	408.5 g/mol
Hydrogen Bond Donor Count	2
Hydrogen Bond Acceptor Count	6
Rotatable Bond Count	7
Exact Mass	408.20490738 g/mol
Monoisotopic Mass	408.20490738 g/mol
Topological Polar Surface Area	90.7 Å²
Heavy Atom Count	30
Formal Charge	0
Complexity	518
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	1
Defined Bond Stereocenter Count	1
Undefined Bond Stereocenter Count	0
Covalently Bonded Unit Count	2

4 Pharmacology and Biochemistry

4.1 MeSH Pharmacological Classification

Antipruritics

Agents, usually topical, that relieve itching (pruritus). (See all compounds classified as Antipruritics.)

Histamine H1 Antagonists

Drugs that selectively bind to but do not activate histamine H1 receptors, thereby blocking the actions of endogenous histamine. Included here are the classical antihistaminics that antagonize or prevent the action of histamine mainly in immediate hypersensitivity. They act in the bronchi, capillaries, and some other smooth muscles, and are used to prevent or allay motion sickness, seasonal rhinitis, and allergic dermatitis and to induce somnolence. The effects of blocking central nervous system H1 receptors are not as well understood. (See all compounds classified as Histamine H1 Antagonists.)

Anti-Allergic Agents

Agents that are used to treat allergic reactions. Most of these drugs act by preventing the release of inflammatory mediators or inhibiting the actions of released mediators on their target cells. (From AMA Drug Evaluations Annual, 1994, p475) (See all compounds classified as Anti-Allergic Agents.)

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API Reference Price

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