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Chemistry

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Also known as: 1,2-dimyristoyl-rac-glycero-3-phosphocholine, 18656-38-7, Dl-dimyristoylphosphatidylcholine, 13699-48-4, Dmpc, 2,3-di(tetradecanoyloxy)propyl 2-(trimethylazaniumyl)ethyl phosphate
Molecular Formula
C36H72NO8P
Molecular Weight
677.9  g/mol
InChI Key
CITHEXJVPOWHKC-UHFFFAOYSA-N
FDA UNII
U86ZGC74V5

Dimyristoyl Lecithin
A synthetic phospholipid used in liposomes and lipid bilayers for the study of biological membranes.
1 2D Structure

Dimyristoyl Lecithin

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
2,3-di(tetradecanoyloxy)propyl 2-(trimethylazaniumyl)ethyl phosphate
2.1.2 InChI
InChI=1S/C36H72NO8P/c1-6-8-10-12-14-16-18-20-22-24-26-28-35(38)42-32-34(33-44-46(40,41)43-31-30-37(3,4)5)45-36(39)29-27-25-23-21-19-17-15-13-11-9-7-2/h34H,6-33H2,1-5H3
2.1.3 InChI Key
CITHEXJVPOWHKC-UHFFFAOYSA-N
2.1.4 Canonical SMILES
CCCCCCCCCCCCCC(=O)OCC(COP(=O)([O-])OCC[N+](C)(C)C)OC(=O)CCCCCCCCCCCCC
2.2 Other Identifiers
2.2.1 UNII
U86ZGC74V5
2.3 Synonyms
2.3.1 MeSH Synonyms

1. 1,2 Dimyristoyl Glycero 3 Phosphorylcholine

2. 1,2 Ditetradecanoyl Glycero 3 Phosphocholine

3. 1,2 Ditetradecyl Glycero 3 Phosphocholine

4. 1,2-dimyristoyl-glycero-3-phosphorylcholine

5. 1,2-ditetradecanoyl-glycero-3-phosphocholine

6. 1,2-ditetradecyl-glycero-3-phosphocholine

7. Dimyristoyllecithin

8. Dimyristoylphosphatidylcholine

9. Dmcp

10. Dmpc

2.3.2 Depositor-Supplied Synonyms

1. 1,2-dimyristoyl-rac-glycero-3-phosphocholine

2. 18656-38-7

3. Dl-dimyristoylphosphatidylcholine

4. 13699-48-4

5. Dmpc

6. 2,3-di(tetradecanoyloxy)propyl 2-(trimethylazaniumyl)ethyl Phosphate

7. Dl-beta,gamma-dimyristoyl-alpha-lecithin

8. Dimyristoyl-phosphatidylcholine

9. U86zgc74v5

10. Chebi:241349

11. Dimyristoyllecithin

12. L-alpha-dimyristoylphosphatidylcholine

13. Ncgc00181029-01

14. (1)-(7-myristoyl-4-oxido-10-oxo-3,5,9-trioxa-4-phosphatricosyl)trimethylammonium 4-oxide

15. 3,5,9-trioxa-4-phosphatricosan-1-aminium, 4-hydroxy-n,n,n-trimethyl-10-oxo-7-((1-oxotetradecyl)oxy)-, Inner Salt, 4-oxide

16. Unii-u86zgc74v5

17. Einecs 242-481-1

18. Soy Bean Phospholipid

19. Dsstox_cid_26816

20. Dsstox_rid_81928

21. 1,2-ditetradecanoyl-rac-glycerol-3-phosphocholine

22. Dsstox_gsid_46816

23. Schembl244839

24. Chembl316257

25. Dtxsid4046816

26. Dimyristoyl-.alpha.-lecithin

27. Tox21_112679

28. Mfcd00066562

29. Akos024418777

30. Db11283

31. Hy-w142596

32. 1,2-dimyristoyl-phosphatidylcholine

33. Cas-18656-38-7

34. Cs-0204636

35. Ft-0625421

36. Ft-0627667

37. Ft-0627775

38. 1,2-dimyristoyl-dl-phosphatidylcholine

39. D-5665

40. D-5667

41. Dimyristoyl Phosphatidylcholine, (+/-)

42. 1,2-dimyristoyl-glycero-3-phosphocholine

43. A839808

44. 1,2-dimyristoyl-phosphatidylcholine, (+/-)

45. 1,2-dimyristoyl-glycero-3-phosphocholine, Dl-

46. 1,2-dimyristoyl-rac-glycero-3-phosphocholine, >=99%

47. Q27225712

48. 1,2-dimyristoyl-glycero-3-phosphocholine, (+/-)-

49. 2,3-bis(1-oxotetradecoxy)propyl 2-(trimethylammonio)ethyl Phosphate

50. 2,3-bis(tetradecanoyloxy)propyl 2-(trimethylammonio)ethyl Phosphate

51. 2,3-bis(tetradecanoyloxy)propyl 2-(trimethylazaniumyl)ethyl Phosphate

52. [2-({[2,3-bis(tetradecanoyloxy)propyl] Phosphonato}oxy)ethyl]trimethylazanium

53. 3,5,9-trioxa-4-phosphatricosan-1-aminium,4-hydroxy-n,n,n-trimethyl-10-oxo-7-[(1-oxotetradecyl)oxy]-, Inner Salt, 4-oxide

54. 3,5,9-trioxa-4-phosphatricosan-1-aminium,4-hydroxy-n,n,n-trimethyl-10-oxo-7-[(1-oxotetradecyl)oxy]-,inner Salt,4-oxide

2.4 Create Date
2005-03-28
3 Chemical and Physical Properties
Molecular Weight 677.9 g/mol
Molecular Formula C36H72NO8P
XLogP311.3
Hydrogen Bond Donor Count0
Hydrogen Bond Acceptor Count8
Rotatable Bond Count36
Exact Mass677.49955525 g/mol
Monoisotopic Mass677.49955525 g/mol
Topological Polar Surface Area111 Ų
Heavy Atom Count46
Formal Charge0
Complexity765
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count1
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count1
4 Drug and Medication Information
4.1 Drug Indication

DL-dimyristoylphosphatidylcholine is not an active pharmaceutical agent and has no indication.


5 Pharmacology and Biochemistry
5.1 Pharmacology

DL-dimyristoylphosphatidylcholine is a water soluble phospholipid used to solubilize drugs for injection.


5.2 MeSH Pharmacological Classification

Indicators and Reagents

Substances used for the detection, identification, analysis, etc. of chemical, biological, or pathologic processes or conditions. Indicators are substances that change in physical appearance, e.g., color, at or approaching the endpoint of a chemical titration, e.g., on the passage between acidity and alkalinity. Reagents are substances used for the detection or determination of another substance by chemical or microscopical means, especially analysis. Types of reagents are precipitants, solvents, oxidizers, reducers, fluxes, and colorimetric reagents. (From Grant and Hackh's Chemical Dictionary, 5th ed, p301, p499) (See all compounds classified as Indicators and Reagents.)


5.3 Mechanism of Action

As a phospholipid, DL-dimyristoylphosphatidylcholine can form a micelle with a hydrophobic core to contain lipophilic drugs while maintaining a hyrophilic outer portion to allow increased solubility of the drug in the aqueous environment of the blood or gastrointestinal tract.


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ABOUT THIS PAGE

Dimyristoyl Lecithin Manufacturers

A Dimyristoyl Lecithin manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Dimyristoyl Lecithin, including repackagers and relabelers. The FDA regulates Dimyristoyl Lecithin manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Dimyristoyl Lecithin API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

Dimyristoyl Lecithin Suppliers

A Dimyristoyl Lecithin supplier is an individual or a company that provides Dimyristoyl Lecithin active pharmaceutical ingredient (API) or Dimyristoyl Lecithin finished formulations upon request. The Dimyristoyl Lecithin suppliers may include Dimyristoyl Lecithin API manufacturers, exporters, distributors and traders.

click here to find a list of Dimyristoyl Lecithin suppliers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PharmaCompass.

Dimyristoyl Lecithin USDMF

A Dimyristoyl Lecithin DMF (Drug Master File) is a document detailing the whole manufacturing process of Dimyristoyl Lecithin active pharmaceutical ingredient (API) in detail. Different forms of Dimyristoyl Lecithin DMFs exist exist since differing nations have different regulations, such as Dimyristoyl Lecithin USDMF, ASMF (EDMF), JDMF, CDMF, etc.

A Dimyristoyl Lecithin DMF submitted to regulatory agencies in the US is known as a USDMF. Dimyristoyl Lecithin USDMF includes data on Dimyristoyl Lecithin's chemical properties, information on the facilities and procedures used, and details about packaging and storage. The Dimyristoyl Lecithin USDMF is kept confidential to protect the manufacturer’s intellectual property.

click here to find a list of Dimyristoyl Lecithin suppliers with USDMF on PharmaCompass.

Dimyristoyl Lecithin GMP

Dimyristoyl Lecithin Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

PharmaCompass offers a list of Dimyristoyl Lecithin GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Dimyristoyl Lecithin GMP manufacturer or Dimyristoyl Lecithin GMP API supplier for your needs.

Dimyristoyl Lecithin CoA

A Dimyristoyl Lecithin CoA (Certificate of Analysis) is a formal document that attests to Dimyristoyl Lecithin's compliance with Dimyristoyl Lecithin specifications and serves as a tool for batch-level quality control.

Dimyristoyl Lecithin CoA mostly includes findings from lab analyses of a specific batch. For each Dimyristoyl Lecithin CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

Dimyristoyl Lecithin may be tested according to a variety of international standards, such as European Pharmacopoeia (Dimyristoyl Lecithin EP), Dimyristoyl Lecithin JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Dimyristoyl Lecithin USP).

Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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