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Valsynthese, part of the SSE Group, is a CDMO focused on highly energetic and highly hazardous chemistry.

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Sichuan Elixir Pharmaceuticals Diosmin

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ACTIVE PHARMA INGREDIENTS

32 API Suppliers, 5 USDMF, 19 CEP/COS, 1 EU WC, 3 KDMF, 16 Listed Suppliers, $ API Reference Price

32 API Suppliers
5 USDMF
19 CEP/COS
1 EU WC
3 KDMF
16 Listed Suppliers
$ API Reference Price

FINISHED DOSAGE FORMULATIONS

38 FDF Dossiers, 31 Europe, 7 Listed Dossiers

38 FDF Dossiers
31 Europe
7 Listed Dossiers

RELATED EXCIPIENT COMPANIES

1 SPI Pharma, 1 DKSH, 2 Faran Shimi Pharmaceutical, 1 Boai NKY Pharmaceuticals Ltd, 8 Gangwal Healthcare, 4 Anhui Sunhere Pharmaceutical Excipients Co.,Ltd, 11 BASF, 3 DFE Pharma, 5 Gangwal Chemicals, 1 Ideal Cures Pvt Ltd, 1 Ingredion Pharma Solutions, 3 Kerry, 5 Microlex e.U, 1 Novo Excipients, 2 Pharmatrans-Sanaq, 2 Pluviaendo, 2 Prachin Chemical, 12 Roquette, 2 Shanghai Shenmei Pharmaceutical Technology Co., Ltd, 9 Sigachi Industries, 2 Vasa Pharmachem

EXCIPIENTS BY APPLICATIONS

25 Fillers, Diluents & Binders, 19 Direct Compression, 15 Disintegrants & Superdisintegrants, 13 Granulation, 12 Thickeners and Stabilizers, 9 Co-Processed Excipients, 7 Coating Systems & Additives, 7 Controlled & Modified Release, 6 Lubricants & Glidants, 6 Film Formers & Plasticizers, 6 Solubilizers, 2 Chewable & Orodispersible Aids, 2 Parenteral, 2 Taste Masking, 2 Rheology Modifiers, 2 Emulsifying Agents, 1 API Stability Enhancers, 1 Topical

excipientsByApplications
25 Fillers, Diluents & Binders
19 Direct Compression
15 Disintegrants & Superdisintegrants
13 Granulation
12 Thickeners and Stabilizers
9 Co-Processed Excipients
7 Coating Systems & Additives
7 Controlled & Modified Release
6 Lubricants & Glidants
6 Film Formers & Plasticizers
6 Solubilizers
2 Chewable & Orodispersible Aids
2 Parenteral
2 Taste Masking
2 Rheology Modifiers
2 Emulsifying Agents
1 API Stability Enhancers
1 Topical

DIGITAL CONTENT

2 NEWS #PharmaBuzz

media
2 NEWS #PharmaBuzz

GLOBAL SALES INFORMATION

28 Finished Drug Prices

globalSalesInformation
28 Finished Drug Prices

MARKET PLACE

25 APIs, 6 FDF Dossiers

marketPlace
25 APIs
6 FDF Dossiers

REF. STANDARDS & IMPURITIES

2 EDQM , 2 USP , 4 Others

otherSolutions
2 EDQM
2 USP
4 Others

ANALYTICAL

1 BioAnalytical Methods

otherMethods
1 BioAnalytical Methods

HTBA Diosmin

Synopsis

ACTIVE PHARMA INGREDIENTS

32

API Suppliers

5

USDMF

19

CEP/COS

CEP/COS Certifications

0

JDMF

1

EU WC

3

KDMF

0

NDC API

0

VMF

16

Listed Suppliers

API REF. PRICE (USD/KG)

$

$ 172

MARKET PLACE

25

API

6

FDF

0INTERMEDIATES

FINISHED DOSAGE FORMULATIONS

38

FDF Dossiers

0

FDA Orange Book

FDA (Orange Book)

31

Europe

0

Canada

0

Australia

0

South Africa

7

Listed Dossiers

0 DRUGS IN DEVELOPMENT

DRUG PRODUCT COMPOSITIONS

REF. STANDARDS OR IMPURITIES

2

EDQM

2

USP

0

JP

4

Others

PATENTS & EXCLUSIVITIES

0

US Patents

0

US Exclusivities

0

Health Canada Patents

DIGITAL CONTENT

0

Data Compilation #PharmaFlow

0

Stock Recap #PipelineProspector

0

Weekly News Recap #Phispers

2

News #PharmaBuzz

GLOBAL SALES INFORMATION

US Medicaid (USD)

NA

Annual Reports (USD Million)

NA

Finished Drug Prices

78 RELATED EXCIPIENT COMPANIES

137EXCIPIENTS BY APPLICATIONS

Chemistry

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Also known as: 520-27-4, Barosmin, Diosimin, Venosmine, Diosmil, Diosmine

Molecular Formula

C₂₈H₃₂O₁₅

Molecular Weight

608.5 g/mol

InChI Key

GZSOSUNBTXMUFQ-YFAPSIMESA-N

FDA UNII

7QM776WJ5N

Diosmin

A bioflavonoid that strengthens vascular walls.

1 2D Structure

Diosmin

2 Identification

2.1 Computed Descriptors

2.1.1 IUPAC Name

5-hydroxy-2-(3-hydroxy-4-methoxyphenyl)-7-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-[[(2R,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyloxan-2-yl]oxymethyl]oxan-2-yl]oxychromen-4-one

2.1.2 InChI

InChI=1S/C28H32O15/c1-10-21(32)23(34)25(36)27(40-10)39-9-19-22(33)24(35)26(37)28(43-19)41-12-6-14(30)20-15(31)8-17(42-18(20)7-12)11-3-4-16(38-2)13(29)5-11/h3-8,10,19,21-30,32-37H,9H2,1-2H3/t10-,19+,21-,22+,23+,24-,25+,26+,27+,28+/m0/s1

2.1.3 InChI Key

GZSOSUNBTXMUFQ-YFAPSIMESA-N

2.1.4 Canonical SMILES

CC1C(C(C(C(O1)OCC2C(C(C(C(O2)OC3=CC(=C4C(=C3)OC(=CC4=O)C5=CC(=C(C=C5)OC)O)O)O)O)O)O)O)O

2.1.5 Isomeric SMILES

C[C@H]1[C@@H]([C@H]([C@H]([C@@H](O1)OC[C@@H]2[C@H]([C@@H]([C@H]([C@@H](O2)OC3=CC(=C4C(=C3)OC(=CC4=O)C5=CC(=C(C=C5)OC)O)O)O)O)O)O)O)O

2.2 Other Identifiers

2.2.1 UNII

7QM776WJ5N

2.3 Synonyms

2.3.1 MeSH Synonyms

1. Barosmin

2. Buchu Resin

3. Daflon

4. Resin, Buchu

5. Venosmine

2.3.2 Depositor-Supplied Synonyms

1. 520-27-4

2. Barosmin

3. Diosimin

4. Venosmine

5. Diosmil

6. Diosmine

7. Flebosten

8. Daflon

9. Tovene

10. Ven-detrex

11. Diovenor

12. Buchu Resin

13. Litosmil

14. Veno-v

15. Flebosmil

16. Diosminum

17. Rioven

18. Diosmetin 7-o-rutinoside

19. Diosven

20. Flebaven

21. Flebavena

22. Hemerven

23. Insuven

24. Varinon

25. Dioven

26. Diosmetin-7-o-rutinoside

27. Diosmin [inn]

28. Diosmetin 7-rutinoside

29. 5-hydroxy-2-(3-hydroxy-4-methoxyphenyl)-7-[(2s,3r,4s,5s,6r)-3,4,5-trihydroxy-6-[[(2r,3r,4r,5r,6s)-3,4,5-trihydroxy-6-methyloxan-2-yl]oxymethyl]oxan-2-yl]oxychromen-4-one

30. 7qm776wj5n

31. Chebi:4631

32. 3',5,7-trihydroxy-4'-methoxyflavone 7-rutinoside

33. 3',5,7-trihydroxy-4'-methoxyflavone-7-rutinoside

34. Diosmin (inn)

35. Nsc-758417

36. 5-hydroxy-2-(3-hydroxy-4-methoxyphenyl)-7-(((2s,3r,4s,5s,6r)-3,4,5-trihydroxy-6-((((2r,3r,4r,5r,6s)-3,4,5-trihydroxy-6-methyltetrahydro-2h-pyran-2-yl)oxy)methyl)tetrahydro-2h-pyran-2-yl)oxy)-4h-chromen-4-one

37. Diosmin, Analytical Standard

38. Dsstox_cid_25892

39. Dsstox_rid_81206

40. Dsstox_gsid_45892

41. 3',5,7-trihydroxy-4'-methoxyflavone-7-(6-o-(-deoxy-alpha-l-mannopyraonsyl)-beta-d-glucopyranoside

42. 5-hydroxy-2-(3-hydroxy-4-methoxy-phenyl)-7-[(2s,3r,4s,5s,6r)-3,4,5-trihydroxy-6-[[(2r,3r,4r,5r,6s)-3,4,5-trihydroxy-6-methyl-tetrahydropyran-2-yl]oxymethyl]tetrahydropyran-2-yl]oxy-chromen-4-one

43. 3',5,7-trihydroxy-4'-methoxyflavone 7-rhamnoglucoside

44. Cas-520-27-4

45. Diosmin [inn:ban]

46. Diosmin [inn-spanish]

47. Diosmine [inn-french]

48. Diosminum [inn-latin]

49. Sr-01000799147

50. Unii-7qm776wj5n

51. Ccris 7915

52. Ncgc00095022-01

53. 4h-1-benzopyran-4-one, 7-((6-o-(6-deoxy-.alpha.-l-mannopyranosyl)-.beta.-d-glucopyranosyl)oxy)-5-hydroxy-2-(3-hydroxy-4-methoxyphenyl)-

54. 4h-1-benzopyran-4-one, 7-[[6-o-(6-deoxy-.alpha.-l-mannopyranosyl)-.beta.-d-glucopyranosyl]oxy]-5-hydroxy-2-(3-hydroxy-4-methoxyphenyl)-

55. Einecs 208-289-7

56. Daflon (tn)

57. Mfcd00009772

58. Diosmin (8)

59. Se 4601

60. Diosmine [inci]

61. Diosmin [dsc]

62. Diosmin [mi]

63. Diosmin [mart.]

64. Diosmin [usp-rs]

65. Diosmin [who-dd]

66. Mls001304032

67. Schembl120870

68. Diosmin [ep Monograph]

69. Chembl231884

70. Dtxsid4045892

71. 3',5-dihydroxy-4'-methoxy-4-oxo-4h-chromen-7-ylrutosid

72. Bdbm153267

73. Hms2233p16

74. Hms3713l08

75. Act05288

76. Zinc4098512

77. Tox21_111392

78. 3',5-dihydroxy-4'-methoxy-4-oxo-4h-chromen-7-ylrutosid [iupac]

79. S2292

80. Akos015969767

81. Tox21_111392_1

82. Bcp9000612

83. Ccg-208570

84. Db08995

85. Nsc 758417

86. Smp1_000183

87. Ncgc00344564-01

88. 4h-1-benzopyran-4-one, 7-((6-o-(6-deoxy-alpha-l-mannopyranosyl)-beta-d-glucopyranosyl)oxy)-5-hydroxy-2-(3-hydroxy-4-methoxyphenyl)-

89. 4h-1-benzopyran-4-one,7-[[6-o-(6-deoxy-a-l-mannopyranosyl)-b-d-glucopyranosyl]oxy]-5-hydroxy-2-(3-hydroxy-4-methoxyphenyl)-

90. 5-hydroxy-2-(3-hydroxy-4-methoxyphenyl)-4-oxo-4h-1-benzopyran-7-yl 6-o-(6-deoxy-alpha-l-mannopyranosyl)-beta-d-glucopyranoside

91. 5-hydroxy-2-(3-hydroxy-4-methoxyphenyl)-7-((6-o-alpha-l-rhamnopyranosyl-beta-d-glycopyranosyl)oxy)-4-chromenon

92. As-13224

93. Bp-12422

94. Smr000718616

95. Bcp0726000067

96. C10039

97. D07858

98. 520d274

99. 3',5,7-trihydroxy-4'-methoxy Flavone-7-rutinoside

100. Q2607865

101. Sr-01000799147-4

102. Sr-01000799147-5

103. Sr-01000799147-6

104. Diosmin, European Pharmacopoeia (ep) Reference Standard

105. Diosmin, United States Pharmacopeia (usp) Reference Standard

106. Diosmin For System Suitability, European Pharmacopoeia (ep) Reference Standard

107. 5-hydroxy-2-(3-hydroxy-4-methoxyphenyl)-7-((2s,3r,4s,5s,6r)-3,4,5-trihydroxy-6-(((2r,3r,4r,5r,6s)-3,4,5-trihydroxy-6-methyltetrahydro-2h-pyran-2-yloxy)methyl)tetrahydro-2h-pyran-2-yloxy)-4h-chromen-4-one

108. 5-hydroxy-2-(3-hydroxy-4-methoxyphenyl)-7-(o6-alpha-l-rhamnopyranosyl-beta-d-glucopyranosyloxy)chromen-4-one

109. 5-hydroxy-2-(3-hydroxy-4-methoxyphenyl)-7-[(2s,3r,4s,5s,6r)-3,4,5-trihydroxy-6-[[(2s,3s,4s,5s,6r)-3,4,5-trihydroxy-6-methyloxan-2-yl]oxymethyl]oxan-2-yl]oxychromen-4-one

110. 7-((6-o-(6-deoxy-ga-l-mannopyranosyl)-.beta.-d-glucopyranosyl)oxy)-5-hydroxy-2-(3-hydroxy-4-methoxyphenyl)-4h-1-benzopyran-4-one

111. 7-((6-o-(6-deoxy-ga-l-mannopyranosyl)-beta-d-glucopyranosyl)oxy)-5-hydroxy-2-(3-hydroxy-4-methoxyphenyl)-4h-1-benzopyran-4-one

2.4 Create Date

2005-06-24

3 Chemical and Physical Properties

Molecular Formula	C₂₈H₃₂O₁₅
Molecular Weight	608.5 g/mol
XLogP3	-0.8
Hydrogen Bond Donor Count	8
Hydrogen Bond Acceptor Count	15
Rotatable Bond Count	7
Exact Mass	608.17412031 g/mol
Monoisotopic Mass	608.17412031 g/mol
Topological Polar Surface Area	234 Å²
Heavy Atom Count	43
Formal Charge	0
Complexity	995
Isotope Atom Count	0
Defined Atom Stereocenter Count	10
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently Bonded Unit Count	1

4 Drug and Medication Information

4.1 Drug Indication

Diosmin is used over-the-counter alone or with ingredients such as [hesperidin] and [diosmetin] to support vein and capillary function.

5 Pharmacology and Biochemistry

5.1 Pharmacology

Diosmin is a venoactive drug supporting circulatory health through various actions on blood vessels; it supports lymphatic drainage and improves microcirculation while increasing venous tone and elasticity. For these reasons, diosmin is frequently taken by individuals with chronic venous disease to support vascular health and has been demonstrated to improve quality of life. In addition to the above effects, diosmin exerts antioxidant activity and scavenges oxygen free radicals, reducing levels of oxidative stress normally detected through biomarkers such as prostaglandins isoprostane precursors. In one clinical study, mean content of TNF alpha, VEGF-C, VEGF-A IL-6, in addition to FGF2 were decreased by after the therapy with diosmin; findings were statistically significant. Additionally, a decrease in edema and mean leg circumference of patients taking diosmin for three months was observed in a clinical study. Diosmin has been demonstrated to enhance the metabolism of glucose in diabetic disorders.

5.2 ATC Code

C - Cardiovascular system

C05 - Vasoprotectives

C05C - Capillary stabilizing agents

C05CA - Bioflavonoids

C05CA03 - Diosmin

5.3 Absorption, Distribution and Excretion

Absorption

Diosmin is rapidly absorbed in the gastrointestinal tract. After a 900 mg single oral dose in a study using liquid chromatography with tandem mass spectrometry (LC-MS/MS) method, Cmax was 4.23.8 ^ngmL-1, Tmax was 18.79.9 hours, and AUC0~96 was 185.4166.2 ^ngmL-1 in healthy volunteers. Another pharmacokinetic study of 5 adults revealed a Cmax of 41794.1 ng/dL.

Route of Elimination

Pharmacokinetic data show absence of urinary elimination for diosmin and its aglycone diosmetin. Minor metabolites are found to be eliminated in the urine as glucuronic acid conjugates.

Volume of Distribution

A pharmacokinetic study of 5 adults revealed a volume of distribution of 62.17.9 L.

5.4 Metabolism/Metabolites

Degradation products of diosmin such as alkyl-phenolic acids confirm a metabolic pattern similar to that of other flavonoids.

5.5 Biological Half-Life

Diosmin half-life ranges from 26 to 43 hours. One study using a liquid chromatography with tandem mass spectrometry (LC-MS/MS) method after a single 900 mg dose of diosmin demonstrated a half-life of 60.285.7 hours in healthy volunteers.

5.6 Mechanism of Action

Diosmin helps to maintain circulatory system structure and function, particularly vein strength and competence. The molecular mechanism of action of diosmin has not been established. Several resources indicate that diosmin binds to the aryl hydrocarbon receptor, however clinical relevance to vascular function is unknown. One study demonstrates that oral diosmin exerts effects on the in vitro metabolism of noradrenaline by varicose veins, potentially benefitting vascular health.

API SUPPLIERS

01

HealthTech BioActives

Spain

USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

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HealthTech BioActives, leading globally in Flavonoids and Vitamin B12 Derivatives.

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Sichuan Elixir Pharmaceuticals

China

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PMC Isochem

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Basic Nutrition

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Chengdu Okay Pharmaceutical Co Ltd

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Diosmin, Micronised, non-micronised

Certificate Number : R1-CEP 2008-274 - Rev 07

Status : Valid

Issue Date : 2020-06-03

Type : Chemical

Substance Number : 1611

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Certificate Number : R1-CEP 2003-153 - Rev 05

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Registrant Name : Sungjin Exim Co., Ltd.

Registration Date : 2021-03-23

Registration Number : 20210323-211-J-904

Manufacturer Name : HealthTech Bio Actives, SLU

Manufacturer Address : Ctra. De Zeneta 143-145 El Raiguero - La Villa 30130 Beniel (Murcia) Spain

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About the Company : HTBA (HealthTech BioActives) is a leading global company highly specialized in flavonoids and vitamin B12 derivatives After 40 years in the pharmaceutical world of ingredients of ...

HTBA (HealthTech BioActives) is a leading global company highly specialized in flavonoids and vitamin B12 derivatives After 40 years in the pharmaceutical world of ingredients of natural origin, HTBA is determined to formulate today the new methods of tomorrow. HTBA covers the entire value chain, from raw materials to merchandise, with global reach in pharmaceuticals, dietary supplements, human and animal nutrition, and in cosmetics. In HTBA we know that our ingredients have a direct impact, not only in our clients activity but also in the well-being of the consumers of their products.

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About the Company : Specializing in natural & oncology APIs, we establish R&D and production platforms for new salt, crystal form & synthetic biology research. We cooperate with clients for IND, NDA, ...

Specializing in natural & oncology APIs, we establish R&D and production platforms for new salt, crystal form & synthetic biology research. We cooperate with clients for IND, NDA, ANDA, 505b(2) and P-IV challenges. Exploring macromolecular APIs, we focus on Glycans & polypeptides. Expertise in XDC drugs drives innovative research & payload production. With a global registration platform & international cGMP system, we offer API CMO/CDMO services worldwide. Our strategy combines FDF and APIs. Our labs meet GMP standards with a stable R&D team, over 10 years of experience, we've delivered 20+ successful projects.

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Basic Nutrition

China

CPHI Middle east

Not Confirmed

Basic Nutrition, your expert for sourcing from China, India and Europe.

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China

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About the Company : As an ISO9001, ISO22000 certificated supplier, Basic Nutrition supply high-quality ingredients for nutraceuticals. We can offer a range of products from small to large quantites: h...

As an ISO9001, ISO22000 certificated supplier, Basic Nutrition supply high-quality ingredients for nutraceuticals. We can offer a range of products from small to large quantites: herbal extract, amino acid, vitamin, etc. Featured products: cranberry extract, rhidiola extract, Q10, hyaluronic acid, cysteine (non-animals), glutathoninr, orgaic products like organic spirulina, organic red yeast rice powder, etc.

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DATE : JUNE 04,2024 RETEST DATE: MAY,2027)","address":"NO 601 UNIT A, ATLANTIS HEIGHTS,SA","city":"VADODARA,GUJARAT","supplier":"QUANZHOU FORTUNE BIOPHARMA CO.,LTD.","supplierCountry":"CHINA","foreign_port":"BEIJING","customer":"CENTURION HEALTHCARE PRIVATE ","customerCountry":"INDIA","quantity":"155.00","actualQuantity":"155","unit":"KGS","unitRateFc":"50","totalValueFC":"7838.9","currency":"USD","unitRateINR":"4227.5","date":"30-Jul-2024","totalValueINR":"655262.5","totalValueInUsd":"7838.9","indian_port":"Bombay Air","hs_no":"29389090","bill_no":"4791564","productDescription":"API","marketType":"REGULATED MARKET","country":"CHINA","selfForZScoreResived":"Pharma Grade","supplierPort":"BEIJING","supplierAddress":"ROOM2603, RONG TAI\\'AN BUILDING, NO.139 JINHUAI STREET, FENGZE ROAD, FENGZE DISTRICT,QUANZHOU CITY,FUJIAN CHINA","customerAddress":"NO 601 UNIT A, ATLANTIS HEIGHTS,SA"},{"dataSource":"API Import","activeIngredients":"","year":"2024","qtr":"Q3","strtotime":1722537000,"product":"MICRONIZED PURIFIED FLAVONOID FRACTION OF RUTACEAE (DIOSMIN:HESPERIDIN)","address":"B-203 GOPALPALACE, NEARNEHRU NAGAR","city":"AHMEDABAD,GUJARAT","supplier":"CHENGDU YAZHONG BIO-PHARMACEUTICAL","supplierCountry":"CHINA","foreign_port":"SHANGHAI","customer":"NOVAGEN HEALTHCARE PRIVATE ","customerCountry":"INDIA","quantity":"2075.00","actualQuantity":"2075","unit":"KGS","unitRateFc":"35.3","totalValueFC":"73877.5","currency":"USD","unitRateINR":"2986.4","date":"02-Aug-2024","totalValueINR":"6196738.5","totalValueInUsd":"73877.5","indian_port":"JNPT","hs_no":"29420090","bill_no":"4836241","productDescription":"API","marketType":"REGULATED MARKET","country":"CHINA","selfForZScoreResived":"Micronized","supplierPort":"SHANGHAI","supplierAddress":"CO., LTDNO.342, LIRONG STR., LICHUNTOWN,PENGZHOU CITY, SICHUAN PROVINCE,CHINA, 611936 CHINA","customerAddress":"B-203 GOPALPALACE, NEARNEHRU NAGAR"},{"dataSource":"API Import","activeIngredients":"","year":"2024","qtr":"Q3","strtotime":1722969000,"product":"DIOSMIN 90%","address":"G 1, NAVYUG NAGAR BLDG. 1,","city":"MAHARASHTRA","supplier":"N\/A","supplierCountry":"CHINA","foreign_port":"SHANGHAI","customer":"SHETH PHARMACHEM","customerCountry":"INDIA","quantity":"500.00","actualQuantity":"500","unit":"KGS","unitRateFc":"35.5","totalValueFC":"18019","currency":"USD","unitRateINR":"3022.8","date":"07-Aug-2024","totalValueINR":"1511410","totalValueInUsd":"18019","indian_port":"JNPT","hs_no":"29389090","bill_no":"4921153","productDescription":"API","marketType":"REGULATED MARKET","country":"CHINA","selfForZScoreResived":"Pharma Grade","supplierPort":"SHANGHAI","supplierAddress":"N\/A","customerAddress":"G 1, NAVYUG NAGAR BLDG. 1,"},{"dataSource":"API Import","activeIngredients":"","year":"2024","qtr":"Q3","strtotime":1723487400,"product":"DIOSMIN (MICRONIZED PURIFIED FLAVONOID FRACTION DIOSMIN 90 PERCENT AND FLAVONOIDS EXPRESSED AS HESPERIDIN 10 PERCENT)","address":"1003-GIDC,","city":"DIST.SURENDRANAGAR\/GUJARAT","supplier":"CHENGDU YAZHONG BIO-PHARMACEUTICAL","supplierCountry":"CHINA","foreign_port":"SHANGHAI","customer":"MEPRO PHARMACEUTICALS PRIVATE ","customerCountry":"INDIA","quantity":"250.00","actualQuantity":"250","unit":"KGS","unitRateFc":"41","totalValueFC":"10338.2","currency":"USD","unitRateINR":"3468.6","date":"13-Aug-2024","totalValueINR":"867150","totalValueInUsd":"10338.2","indian_port":"JNPT","hs_no":"29389090","bill_no":"5034073","productDescription":"API","marketType":"REGULATED MARKET","country":"CHINA","selfForZScoreResived":"Micronized","supplierPort":"SHANGHAI","supplierAddress":"NO.342, LIRONG STR, LICHUN TOWN, PENGZHOU CITY, SICHUAN PROVINCE, CHINA 611936 CHINA","customerAddress":"1003-GIDC,"},{"dataSource":"API Import","activeIngredients":"","year":"2024","qtr":"Q3","strtotime":1723487400,"product":"DIOSMIN BP (NATURAL)","address":"430, DLF TOWERS,","city":"NEW DELHI","supplier":"HUNAN YUANTONG PHARMACEUTICAL","supplierCountry":"CHINA","foreign_port":"NINGBO","customer":"XL LABORATORIES PRIVATE LIMITED","customerCountry":"INDIA","quantity":"772.00","actualQuantity":"772","unit":"KGS","unitRateFc":"43.6","totalValueFC":"33948.7","currency":"USD","unitRateINR":"3688.6","date":"13-Aug-2024","totalValueINR":"2847568.32","totalValueInUsd":"33948.7","indian_port":"Delhi TKD ICD","hs_no":"29389090","bill_no":"5033320","productDescription":"API","marketType":"REGULATED MARKET","country":"CHINA","selfForZScoreResived":"Pharma Grade","supplierPort":"NINGBO","supplierAddress":"NO.747, KANGWAN ROAD, LIUYANGECONOMIC DEVELOPMENT ZONE, CHANGSHACITY, HUNAN PROVINCE, P.R. CHINA","customerAddress":"430, DLF TOWERS,"},{"dataSource":"API Import","activeIngredients":"","year":"2024","qtr":"Q3","strtotime":1723660200,"product":"MICRONISED PURIFIED FLAVONOIDS WITH 90 % DIOSMINE (BULK DRUG)","address":"SERDIA HOUSE ,OFF.DR.S.S.RAO ROAD,","city":"MUMBAI ,MAHARASHTRA","supplier":"SERVIER","supplierCountry":"FRANCE","foreign_port":"PARIS - CHARLES DE G","customer":"SERVIER","customerCountry":"INDIA","quantity":"1800.00","actualQuantity":"1800","unit":"KGS","unitRateFc":"95","totalValueFC":"191328.4","currency":"EUR","unitRateINR":"8915.8","date":"15-Aug-2024","totalValueINR":"16048350","totalValueInUsd":"191328.4","indian_port":"Bombay Air","hs_no":"29389090","bill_no":"5066038","productDescription":"API","marketType":"REGULATED MARKET","country":"FRANCE","selfForZScoreResived":"Micronized","supplierPort":"PARIS - CHARLES DE G","supplierAddress":"50 RUE CARNOTSURESNESCEDEX FR","customerAddress":"SERDIA HOUSE ,OFF.DR.S.S.RAO ROAD,"},{"dataSource":"API Import","activeIngredients":"","year":"2024","qtr":"Q3","strtotime":1726511400,"product":"MICRONISED PURIFIED FLAVONOIDS WITH 90 % DIOSMINE (BULK DRUG)","address":"SERDIA HOUSE ,OFF.DR.S.S.RAO ROAD,","city":"MUMBAI ,MAHARASHTRA","supplier":"LES LABORATOIRES DU SAINT-LAURENT E.H. LTEE","supplierCountry":"FRANCE","foreign_port":"PARIS - CHARLES DE G","customer":"SERVIER","customerCountry":"INDIA","quantity":"600.00","actualQuantity":"600","unit":"KGS","unitRateFc":"95","totalValueFC":"64447.1","currency":"EUR","unitRateINR":"9001.3","date":"17-Sep-2024","totalValueINR":"5400750","totalValueInUsd":"64447.1","indian_port":"Bombay Air","hs_no":"29389090","bill_no":"5651644","productDescription":"API","marketType":"REGULATED MARKET","country":"FRANCE","selfForZScoreResived":"Micronized","supplierPort":"PARIS - CHARLES DE G","supplierAddress":"50 RUE CARNOT SURESNES CEDEX FR","customerAddress":"SERDIA HOUSE ,OFF.DR.S.S.RAO ROAD,"},{"dataSource":"API Import","activeIngredients":"","year":"2024","qtr":"Q3","strtotime":1726770600,"product":"MICRONIZED PURIFIED MICRONIZED PURIFIED FLAVONOID FRACTION DIOSMIN(90%) AND FLAVONOID EXPRESSED AS HESPERIDIN(10%)BN-H02","address":"905 9TH FLOOR THE AVENUE BLDG,OPP","city":"ANDHERI EAST,MAHARASHTRA","supplier":"BENEPURE PHARMACEUTICAL CO. LTD.","supplierCountry":"CHINA","foreign_port":"CHENGDU","customer":"TAJ PHARMA INDIA ","customerCountry":"INDIA","quantity":"229.24","actualQuantity":"229.24","unit":"KGS","unitRateFc":"42","totalValueFC":"9719.9","currency":"USD","unitRateINR":"3553.2","date":"20-Sep-2024","totalValueINR":"814535.57","totalValueInUsd":"9719.9","indian_port":"Delhi Air","hs_no":"29389090","bill_no":"5713341","productDescription":"API","marketType":"REGULATED MARKET","country":"CHINA","selfForZScoreResived":"Micronized","supplierPort":"CHENGDU","supplierAddress":"99#JIRUI 3RD ROAD,HIGH TECHDISTRICT , CHENGDU, SICHUAN PROV. 610095 CHI NA CHINA","customerAddress":"905 9TH FLOOR THE AVENUE BLDG,OPP"},{"dataSource":"API Import","activeIngredients":"","year":"2024","qtr":"Q4","strtotime":1729621800,"product":"DIOSMIN EP (PHARMACEUTICAL RAW MATERIAL) (CAPTIVE CONSUMPTION)","address":"APEEJAY CHAMBERS,WALLACE ST.","city":"MUMBAI ,MAHARASTHRA","supplier":"M & H ","supplierCountry":"CHINA","foreign_port":"CHENGDU","customer":"MARTIN AND HARRIS LABORATORIES LIMITED","customerCountry":"INDIA","quantity":"2000.00","actualQuantity":"2000","unit":"KGS","unitRateFc":"50","totalValueFC":"101099","currency":"USD","unitRateINR":"4247.5","date":"23-Oct-2024","totalValueINR":"8495000","totalValueInUsd":"101099","indian_port":"Delhi Air","hs_no":"29389090","bill_no":"6287710","productDescription":"API","marketType":"REGULATED MARKET","country":"CHINA","selfForZScoreResived":"Pharma Grade","supplierPort":"CHENGDU","supplierAddress":"05-159 ONE JLT PLOT NO DMCC-EZ1-1AB JLT DUBAI, UNITED ARAB EMIRATES","customerAddress":"APEEJAY CHAMBERS,WALLACE ST."}]

Number of Transactions

Total Quantity (KGS)

Total Value (USD)

Quantity (KGS) & Unit rate (USD/KGS) over time

API Imports and Exports

Importing Country	Total Quantity (KGS)	Average Price (USD/KGS)	Number of Transactions

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FDF Dossiers

01

Sanofi

France

CPHI Middle east

Not Confirmed

Sanofi is a pioneer in Diabetes Solutions, Human Vaccines, Innovative Drugs, Consumer Healthcare, and the new Genzyme.

Contact Supplier

Contact Supplier

France

Digital Content

Regulatory Info :

Registration Country : Switzerland

Diosminum; Hesperidinum

Brand Name : Diosmin Hesperidin Zentiva

Dosage Form : Filmtabl

Dosage Strength : 500mg

Packaging :

Approval Date :

Application Number :

Regulatory Info :

Registration Country : Switzerland

Sanofi Company Banner

Portfolio PDF

Product Web Link

Digital Content

02

Sanofi

France

CPHI Middle east

Not Confirmed

Sanofi is a pioneer in Diabetes Solutions, Human Vaccines, Innovative Drugs, Consumer Healthcare, and the new Genzyme.

Contact Supplier

Contact Supplier

France

Digital Content

Regulatory Info :

Registration Country : Switzerland

Diosminum; Hesperidinum

Brand Name : Diosmin Hesperidin Zentiva

Dosage Form : Filmtabl

Dosage Strength : 500mg

Packaging :

Approval Date :

Application Number :

Regulatory Info :

Registration Country : Switzerland

Sanofi Company Banner

Portfolio PDF

Product Web Link

Digital Content

03

Sanofi

France

CPHI Middle east

Not Confirmed

Sanofi is a pioneer in Diabetes Solutions, Human Vaccines, Innovative Drugs, Consumer Healthcare, and the new Genzyme.

Contact Supplier

Contact Supplier

France

Digital Content

Regulatory Info :

Registration Country : Switzerland

Diosminum; Hesperidinum

Brand Name : Diosmin Hesperidin Zentiva

Dosage Form : Filmtabl

Dosage Strength : 500mg

Packaging :

Approval Date :

Application Number :

Regulatory Info :

Registration Country : Switzerland

Sanofi Company Banner

Portfolio PDF

Product Web Link

Digital Content

04

Alfasigma

Italy

CPHI Middle east

Not Confirmed

05

Fitopharm

Ukraine

CPHI Middle east

Not Confirmed

06

Pantson Pharma Pvt. Limited

India

CPHI Middle east

Not Confirmed

07

Servier

France

CPHI Middle east

Not Confirmed

08

Country

CPHI Middle east

Not Confirmed

09

Country

CPHI Middle east

Not Confirmed

10

Country

CPHI Middle east

Not Confirmed

Only 10 entries up to this point, click to access all

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Europe

01

Helvepharm AG

France

Medlab Asia & Asia Health

Not Confirmed

Sanofi is a pioneer in Diabetes Solutions, Human Vaccines, Innovative Drugs, Consumer Healthcare, and the new Genzyme.

Contact Supplier

Contact Supplier

France

Digital Content

Regulatory Info :

Registration Country : Switzerland

Diosminum; Hesperidinum

Brand Name : Diosmin Hesperidin Zentiva

Dosage Form : Filmtabl

Dosage Strength : 500mg

Packaging :

Approval Date :

Application Number :

Regulatory Info :

Registration Country : Switzerland

Sanofi Company Banner

Portfolio PDF

Product Web Link

Digital Content

02

Helvepharm AG

France

Medlab Asia & Asia Health

Not Confirmed

Sanofi is a pioneer in Diabetes Solutions, Human Vaccines, Innovative Drugs, Consumer Healthcare, and the new Genzyme.

Contact Supplier

Contact Supplier

France

Digital Content

Regulatory Info :

Registration Country : Switzerland

Diosminum; Hesperidinum

Brand Name : Diosmin Hesperidin Zentiva

Dosage Form : Filmtabl

Dosage Strength : 500mg

Packaging :

Approval Date :

Application Number :

Regulatory Info :

Registration Country : Switzerland

Sanofi Company Banner

Portfolio PDF

Product Web Link

Digital Content

03

Helvepharm AG

France

Medlab Asia & Asia Health

Not Confirmed

Sanofi is a pioneer in Diabetes Solutions, Human Vaccines, Innovative Drugs, Consumer Healthcare, and the new Genzyme.

Contact Supplier

Contact Supplier

France

Digital Content

Regulatory Info :

Registration Country : Switzerland

Diosminum; Hesperidinum

Brand Name : Diosmin Hesperidin Zentiva

Dosage Form : Filmtabl

Dosage Strength : 500mg

Packaging :

Approval Date :

Application Number :

Regulatory Info :

Registration Country : Switzerland

Sanofi Company Banner

Portfolio PDF

Product Web Link

Digital Content

04

Farmak JSC

Ukraine

Medlab Asia & Asia Health

Not Confirmed

05

Servier (Switzerland) SA

France

Medlab Asia & Asia Health

Not Confirmed

06

World Medicine Ilac San ve tic LTD STl

Turkey

Medlab Asia & Asia Health

Not Confirmed

07

GEYMONAT SpA

Country

Medlab Asia & Asia Health

Not Confirmed

08

MEDIFARM Srl

Country

Medlab Asia & Asia Health

Not Confirmed

09

PROGRAMMI SANIT.INTEGRATI Srl

Country

Medlab Asia & Asia Health

Not Confirmed

10

BB FARMA Srl

Country

Medlab Asia & Asia Health

Not Confirmed

Only 10 entries up to this point, click to access all

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Listed Dossiers

01

Cifarma

Brazil

CPHI Middle east

Not Confirmed

02

Fitopharm

Ukraine

CPHI Middle east

Not Confirmed

03

Laboratório Gross

Brazil

CPHI Middle east

Not Confirmed

04

Pannon

Hungary

CPHI Middle east

Not Confirmed

05

Pantson Pharma Pvt. Limited

India

CPHI Middle east

Not Confirmed

06

Precise Group

India

CPHI Middle east

Not Confirmed

07

Stragen Pharma SA

Switzerland

CPHI Middle east

Not Confirmed

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API Stability Enhancers

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Finished Drug Prices

01

Brand Name : Diosmin Hesperidin Zentiva

France

CPHI Middle east

Not Confirmed

Sanofi is a pioneer in Diabetes Solutions, Human Vaccines, Innovative Drugs, Consumer Healthcare, and the new Genzyme.

Contact Supplier

Contact Supplier

France

Digital Content

RX/OTC/DISCN : Class D

Helvepharm AG

Diosmin; Hesperidin

Dosage Form : Filmtabl

Dosage Strength : 500mg

Price Per Pack (Euro) : 7.76

Published in :

Country : Switzerland

RX/OTC/DISCN : Class D

Sanofi Company Banner

Portfolio PDF

Product Web Link

Digital Content

02

Brand Name : Diosmin Hesperidin Zentiva

France

CPHI Middle east

Not Confirmed

Sanofi is a pioneer in Diabetes Solutions, Human Vaccines, Innovative Drugs, Consumer Healthcare, and the new Genzyme.

Contact Supplier

Contact Supplier

France

Digital Content

RX/OTC/DISCN : Class D

Helvepharm AG

Diosmin; Hesperidin

Dosage Form : Filmtabl

Dosage Strength : 500mg

Price Per Pack (Euro) : 13.66

Published in :

Country : Switzerland

RX/OTC/DISCN : Class D

Sanofi Company Banner

Portfolio PDF

Product Web Link

Digital Content

03

Brand Name : Diosmin Hesperidin Zentiva

France

CPHI Middle east

Not Confirmed

Sanofi is a pioneer in Diabetes Solutions, Human Vaccines, Innovative Drugs, Consumer Healthcare, and the new Genzyme.

Contact Supplier

Contact Supplier

France

Digital Content

RX/OTC/DISCN : Class D

Helvepharm AG

Diosmin; Hesperidin

Dosage Form : Filmtabl

Dosage Strength : 500mg

Price Per Pack (Euro) : 25.45

Published in :

Country : Switzerland

RX/OTC/DISCN : Class D

Sanofi Company Banner

Portfolio PDF

Product Web Link

Digital Content

04

Brand Name : Alvenex

Italy

CPHI Middle east

Not Confirmed

05

Brand Name : Alvenex

Italy

CPHI Middle east

Not Confirmed

06

Brand Name : Daflon

Country

CPHI Middle east

Not Confirmed

07

Brand Name : Daflon

Country

CPHI Middle east

Not Confirmed

08

Brand Name : Daflon

Country

CPHI Middle east

Not Confirmed

09

Brand Name : Diosven

Country

CPHI Middle east

Not Confirmed

10

Brand Name : Doven Strong

Country

CPHI Middle east

Not Confirmed

Only 10 entries up to this point, click to access all

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Market Place

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APIs

EP Grade Diosmin API needed in Turkey [ENA20287]

A group of companies that focuses on manufacturing, development & distribution of various finished formulations is looking for suppliers of EP Grade Diosmin API for development purposes. The suppliers must support this enquiry with CEP, DMF and CoA.

Reply

16 Aug 2024

Diosmin (50 kg) API needed in India [ENA19920]

A contract manufacturing organization that focuses on manufacturing of various nutraceutical & pharmaceutical finished formulations is looking for suppliers of Diosmin (50 kg) API for commercial purposes. The suppliers must support this enquiry with CoA.

Reply

10 Jul 2024

Diosmin (5 kg) API needed in Malaysia [ENA19608]

A company that focuses on providing services including exclusive formulation development, product research and development, regulatory support, and laboratory testing is looking for suppliers of Diosmin (5 kg) API for development purposes. The suppliers must support this enquiry with USDMF or CEP, GMP & CoA.

Reply

30 May 2024

Diosmin (350 kg - 500 kg) API needed in Taiwan [ENA19214]

A contract development and manufacturing organization (CDMO) specializing in the development and production of unique dosage forms and advanced technology platforms is looking for suppliers of Diosmin (350 kg - 500 kg) API for commercial purposes. The suppliers must support this enquiry with ISO, GMP & CoA.

Reply

19 Mar 2024

Diosmin (MOQ) API needed in India [ENA18538]

A pharmaceutical manufacturing company that deals in beta-lactam, non beta-lactam and food supplements for both tablets and capsules is looking for suppliers of Diosmin (MOQ) API for commercial purposes. The suppliers must support this enquiry with CoA.

Reply

03 Nov 2023

Diosmin (3 MT/ annum) API needed in Mexico [ENA15975]

A company based in Denmark that specializes in the marketing and distribution of various pharmaceutical products is looking for suppliers of Diosmin (3 MT/ annum) API for commercial purposes. The suppliers must support this enquiry with GMP & CoA.

Reply

03 Jan 2023

Various APIs needed in India [ENA14448]

A company that focuses in the manufacturing and marketing of pharmaceuticals, nutritionals, cosmeceuticals, ayurceuticals specialities and hospital products for humans and animals is looking for suppliers of Various APIs for development purpose. The suppliers must support this enquiry with CoA. 1. IP Grade Emtricitabine API 2. Tenofovir Alafenamide Hemifumarate API 3. BP Grade Diosmin API

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25 Jul 2022

Various APIs needed in Russia [ENA13135]

A company that specializes in marketing & distribution of various pharmaceutical products is looking for suppliers of Various APIs for dietary supplement. 1. Diosmin (1305 kg) API 2. Hesperidin (105 kg) API 3. Pancreatin (2.2 MT) API 4. Lysozyme HCl (35 kg) API 5. Pyridoxine (18 kg) API

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29 Mar 2022

Various APIs needed in India [ENA13061]

A pharmaceutical manufacturing company that deals in beta-lactam, non beta-lactam and food supplements for both tablets and capsules is looking for suppliers of Various APIs for commercial purpose. The suppliers must support this enquiry with CoA. 1. Ramosetron (200 g) API 2. Cilostazol (15 kg) API 3. Diosmin (30 kg) API 4. Hesperidin (5 kg) API

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22 Mar 2022

Diosmin (900 kg) & Hesperidin (100 kg) APIs needed in Syria [ENA12245]

A company that deals distribution of various pharmaceutical products is looking for suppliers of Diosmin (900 kg) & Hesperidin (100 kg) APIs for commercial purpose. The suppliers must support this enquiry with DMF, GMP & CoA.

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28 Dec 2021

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