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1. Barosmin
2. Buchu Resin
3. Daflon
4. Resin, Buchu
5. Venosmine
1. 520-27-4
2. Barosmin
3. Diosimin
4. Venosmine
5. Diosmil
6. Diosmine
7. Flebosten
8. Daflon
9. Tovene
10. Ven-detrex
11. Diovenor
12. Buchu Resin
13. Litosmil
14. Veno-v
15. Flebosmil
16. Diosminum
17. Rioven
18. Diosmetin 7-o-rutinoside
19. Diosven
20. Flebaven
21. Flebavena
22. Hemerven
23. Insuven
24. Varinon
25. Dioven
26. Diosmetin-7-o-rutinoside
27. Diosmin [inn]
28. Diosmetin 7-rutinoside
29. 5-hydroxy-2-(3-hydroxy-4-methoxyphenyl)-7-[(2s,3r,4s,5s,6r)-3,4,5-trihydroxy-6-[[(2r,3r,4r,5r,6s)-3,4,5-trihydroxy-6-methyloxan-2-yl]oxymethyl]oxan-2-yl]oxychromen-4-one
30. 7qm776wj5n
31. Chebi:4631
32. 3',5,7-trihydroxy-4'-methoxyflavone 7-rutinoside
33. 3',5,7-trihydroxy-4'-methoxyflavone-7-rutinoside
34. Diosmin (inn)
35. Nsc-758417
36. 5-hydroxy-2-(3-hydroxy-4-methoxyphenyl)-7-(((2s,3r,4s,5s,6r)-3,4,5-trihydroxy-6-((((2r,3r,4r,5r,6s)-3,4,5-trihydroxy-6-methyltetrahydro-2h-pyran-2-yl)oxy)methyl)tetrahydro-2h-pyran-2-yl)oxy)-4h-chromen-4-one
37. Diosmin, Analytical Standard
38. Dsstox_cid_25892
39. Dsstox_rid_81206
40. Dsstox_gsid_45892
41. 3',5,7-trihydroxy-4'-methoxyflavone-7-(6-o-(-deoxy-alpha-l-mannopyraonsyl)-beta-d-glucopyranoside
42. 5-hydroxy-2-(3-hydroxy-4-methoxy-phenyl)-7-[(2s,3r,4s,5s,6r)-3,4,5-trihydroxy-6-[[(2r,3r,4r,5r,6s)-3,4,5-trihydroxy-6-methyl-tetrahydropyran-2-yl]oxymethyl]tetrahydropyran-2-yl]oxy-chromen-4-one
43. 3',5,7-trihydroxy-4'-methoxyflavone 7-rhamnoglucoside
44. Cas-520-27-4
45. Diosmin [inn:ban]
46. Diosmin [inn-spanish]
47. Diosmine [inn-french]
48. Diosminum [inn-latin]
49. Sr-01000799147
50. Unii-7qm776wj5n
51. Ccris 7915
52. Ncgc00095022-01
53. 4h-1-benzopyran-4-one, 7-((6-o-(6-deoxy-.alpha.-l-mannopyranosyl)-.beta.-d-glucopyranosyl)oxy)-5-hydroxy-2-(3-hydroxy-4-methoxyphenyl)-
54. 4h-1-benzopyran-4-one, 7-[[6-o-(6-deoxy-.alpha.-l-mannopyranosyl)-.beta.-d-glucopyranosyl]oxy]-5-hydroxy-2-(3-hydroxy-4-methoxyphenyl)-
55. Einecs 208-289-7
56. Daflon (tn)
57. Mfcd00009772
58. Diosmin (8)
59. Se 4601
60. Diosmine [inci]
61. Diosmin [dsc]
62. Diosmin [mi]
63. Diosmin [mart.]
64. Diosmin [usp-rs]
65. Diosmin [who-dd]
66. Mls001304032
67. Schembl120870
68. Diosmin [ep Monograph]
69. Chembl231884
70. Dtxsid4045892
71. 3',5-dihydroxy-4'-methoxy-4-oxo-4h-chromen-7-ylrutosid
72. Bdbm153267
73. Hms2233p16
74. Hms3713l08
75. Act05288
76. Zinc4098512
77. Tox21_111392
78. 3',5-dihydroxy-4'-methoxy-4-oxo-4h-chromen-7-ylrutosid [iupac]
79. S2292
80. Akos015969767
81. Tox21_111392_1
82. Bcp9000612
83. Ccg-208570
84. Db08995
85. Nsc 758417
86. Smp1_000183
87. Ncgc00344564-01
88. 4h-1-benzopyran-4-one, 7-((6-o-(6-deoxy-alpha-l-mannopyranosyl)-beta-d-glucopyranosyl)oxy)-5-hydroxy-2-(3-hydroxy-4-methoxyphenyl)-
89. 4h-1-benzopyran-4-one,7-[[6-o-(6-deoxy-a-l-mannopyranosyl)-b-d-glucopyranosyl]oxy]-5-hydroxy-2-(3-hydroxy-4-methoxyphenyl)-
90. 5-hydroxy-2-(3-hydroxy-4-methoxyphenyl)-4-oxo-4h-1-benzopyran-7-yl 6-o-(6-deoxy-alpha-l-mannopyranosyl)-beta-d-glucopyranoside
91. 5-hydroxy-2-(3-hydroxy-4-methoxyphenyl)-7-((6-o-alpha-l-rhamnopyranosyl-beta-d-glycopyranosyl)oxy)-4-chromenon
92. As-13224
93. Bp-12422
94. Smr000718616
95. Bcp0726000067
96. C10039
97. D07858
98. 520d274
99. 3',5,7-trihydroxy-4'-methoxy Flavone-7-rutinoside
100. Q2607865
101. Sr-01000799147-4
102. Sr-01000799147-5
103. Sr-01000799147-6
104. Diosmin, European Pharmacopoeia (ep) Reference Standard
105. Diosmin, United States Pharmacopeia (usp) Reference Standard
106. Diosmin For System Suitability, European Pharmacopoeia (ep) Reference Standard
107. 5-hydroxy-2-(3-hydroxy-4-methoxyphenyl)-7-((2s,3r,4s,5s,6r)-3,4,5-trihydroxy-6-(((2r,3r,4r,5r,6s)-3,4,5-trihydroxy-6-methyltetrahydro-2h-pyran-2-yloxy)methyl)tetrahydro-2h-pyran-2-yloxy)-4h-chromen-4-one
108. 5-hydroxy-2-(3-hydroxy-4-methoxyphenyl)-7-(o6-alpha-l-rhamnopyranosyl-beta-d-glucopyranosyloxy)chromen-4-one
109. 5-hydroxy-2-(3-hydroxy-4-methoxyphenyl)-7-[(2s,3r,4s,5s,6r)-3,4,5-trihydroxy-6-[[(2s,3s,4s,5s,6r)-3,4,5-trihydroxy-6-methyloxan-2-yl]oxymethyl]oxan-2-yl]oxychromen-4-one
110. 7-((6-o-(6-deoxy-ga-l-mannopyranosyl)-.beta.-d-glucopyranosyl)oxy)-5-hydroxy-2-(3-hydroxy-4-methoxyphenyl)-4h-1-benzopyran-4-one
111. 7-((6-o-(6-deoxy-ga-l-mannopyranosyl)-beta-d-glucopyranosyl)oxy)-5-hydroxy-2-(3-hydroxy-4-methoxyphenyl)-4h-1-benzopyran-4-one
| Molecular Weight | 608.5 g/mol |
|---|---|
| Molecular Formula | C28H32O15 |
| XLogP3 | -0.8 |
| Hydrogen Bond Donor Count | 8 |
| Hydrogen Bond Acceptor Count | 15 |
| Rotatable Bond Count | 7 |
| Exact Mass | 608.17412031 g/mol |
| Monoisotopic Mass | 608.17412031 g/mol |
| Topological Polar Surface Area | 234 Ų |
| Heavy Atom Count | 43 |
| Formal Charge | 0 |
| Complexity | 995 |
| Isotope Atom Count | 0 |
| Defined Atom Stereocenter Count | 10 |
| Undefined Atom Stereocenter Count | 0 |
| Defined Bond Stereocenter Count | 0 |
| Undefined Bond Stereocenter Count | 0 |
| Covalently Bonded Unit Count | 1 |
Diosmin is used over-the-counter alone or with ingredients such as [hesperidin] and [diosmetin] to support vein and capillary function.
Diosmin is a venoactive drug supporting circulatory health through various actions on blood vessels; it supports lymphatic drainage and improves microcirculation while increasing venous tone and elasticity. For these reasons, diosmin is frequently taken by individuals with chronic venous disease to support vascular health and has been demonstrated to improve quality of life. In addition to the above effects, diosmin exerts antioxidant activity and scavenges oxygen free radicals, reducing levels of oxidative stress normally detected through biomarkers such as prostaglandins isoprostane precursors. In one clinical study, mean content of TNF alpha, VEGF-C, VEGF-A IL-6, in addition to FGF2 were decreased by after the therapy with diosmin; findings were statistically significant. Additionally, a decrease in edema and mean leg circumference of patients taking diosmin for three months was observed in a clinical study. Diosmin has been demonstrated to enhance the metabolism of glucose in diabetic disorders.
C - Cardiovascular system
C05 - Vasoprotectives
C05C - Capillary stabilizing agents
C05CA - Bioflavonoids
C05CA03 - Diosmin
Absorption
Diosmin is rapidly absorbed in the gastrointestinal tract. After a 900 mg single oral dose in a study using liquid chromatography with tandem mass spectrometry (LC-MS/MS) method, Cmax was 4.23.8 ngmL-1, Tmax was 18.79.9 hours, and AUC0~96 was 185.4166.2 ngmL-1 in healthy volunteers. Another pharmacokinetic study of 5 adults revealed a Cmax of 41794.1 ng/dL.
Route of Elimination
Pharmacokinetic data show absence of urinary elimination for diosmin and its aglycone diosmetin. Minor metabolites are found to be eliminated in the urine as glucuronic acid conjugates.
Volume of Distribution
A pharmacokinetic study of 5 adults revealed a volume of distribution of 62.17.9 L.
Degradation products of diosmin such as alkyl-phenolic acids confirm a metabolic pattern similar to that of other flavonoids.
Diosmin half-life ranges from 26 to 43 hours. One study using a liquid chromatography with tandem mass spectrometry (LC-MS/MS) method after a single 900 mg dose of diosmin demonstrated a half-life of 60.285.7 hours in healthy volunteers.
Diosmin helps to maintain circulatory system structure and function, particularly vein strength and competence. The molecular mechanism of action of diosmin has not been established. Several resources indicate that diosmin binds to the aryl hydrocarbon receptor, however clinical relevance to vascular function is unknown. One study demonstrates that oral diosmin exerts effects on the in vitro metabolism of noradrenaline by varicose veins, potentially benefitting vascular health.
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HealthTech BioActives, leading globally in Flavonoids and Vitamin B12 Derivatives.
HealthTech BioActives, leading globally in Flavonoids and Vitamin B12 Derivatives.
Diosmin, Micronised, non-micronised
Certificate Number : R1-CEP 2008-274 - Rev 07
Status : Valid
Issue Date : 2020-06-03
Type : Chemical
Substance Number : 1611
PMC Isochem is your partner for smart CDMOs of Intermediates, APIs, & excipients & a catalog of Intermediates & Generic APIs.
PMC Isochem is your partner for smart CDMOs of Intermediates, APIs, & excipients & a catalog of Intermediates & Generic APIs.
Diosmin, Standard and micronised
Certificate Number : R1-CEP 2003-153 - Rev 05
Status : Valid
Issue Date : 2019-01-25
Type : Chemical
Substance Number : 1611
Certificate Number : R1-CEP 2012-359 - Rev 00
Status : Valid
Issue Date : 2019-10-10
Type : Chemical
Substance Number : 1611
Diosmin, Non-micronised, micronised
Certificate Number : R1-CEP 2012-180 - Rev 02
Status : Valid
Issue Date : 2021-06-07
Type : Chemical
Substance Number : 1611
Certificate Number : R0-CEP 2011-303 - Rev 00
Status : Withdrawn by EDQM Failure to CEP pro...
Issue Date : 2012-10-30
Type : Chemical
Substance Number : 1611
Certificate Number : R1-CEP 2009-306 - Rev 02
Status : Valid
Issue Date : 2018-03-06
Type : Chemical
Substance Number : 1611
Certificate Number : R0-CEP 2016-165 - Rev 00
Status : Expired
Issue Date : 2017-07-07
Type : Chemical
Substance Number : 1611
Certificate Number : R0-CEP 2020-285 - Rev 00
Status : Valid
Issue Date : 2020-12-18
Type : Chemical
Substance Number : 1611
Diosmin, Micronised, non-micronised
Certificate Number : R1-CEP 2011-177 - Rev 01
Status : Valid
Issue Date : 2020-05-07
Type : Chemical
Substance Number : 1611
Certificate Number : R0-CEP 2009-032 - Rev 01
Status : Withdrawn by EDQM Failure to CEP pro...
Issue Date : 2015-03-31
Type : Chemical
Substance Number : 1611
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HealthTech BioActives, leading globally in Flavonoids and Vitamin B12 Derivatives.
Registrant Name : Sungjin Exim Co., Ltd.
Registration Date : 2021-03-23
Registration Number : 20210323-211-J-904
Manufacturer Name : HealthTech Bio Actives, SLU
Manufacturer Address : Ctra. De Zeneta 143-145 El Raiguero - La Villa 30130 Beniel (Murcia) Spain
Registrant Name : Toru Corporation
Registration Date : 2024-07-25
Registration Number : 20231211-211-J-1547(A)
Manufacturer Name : Destilaciones Bordas Chinchu...
Manufacturer Address : C/Acueducto. 4-6 Pol. Ind. Carretera La Isla, 41703 Dos Hermanas (Sevilla), Spain
Registrant Name : Essel Bio Co., Ltd.
Registration Date : 2023-12-11
Registration Number : 20231211-211-J-1547
Manufacturer Name : Destilaciones Bordas Chinchu...
Manufacturer Address : C/Acueducto. 4-6 Pol. Ind. Carretera La Isla, 41703 Dos Hermanas (Sevilla), Spain
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Sanofi is a pioneer in Diabetes Solutions, Human Vaccines, Innovative Drugs, Consumer Healthcare, and the new Genzyme.
Regulatory Info :
Registration Country : Switzerland
Brand Name : Diosmin Hesperidin Zentiva
Dosage Form : Filmtabl
Dosage Strength : 500mg
Packaging :
Approval Date :
Application Number :
Regulatory Info :
Registration Country : Switzerland
Sanofi is a pioneer in Diabetes Solutions, Human Vaccines, Innovative Drugs, Consumer Healthcare, and the new Genzyme.
Regulatory Info :
Registration Country : Switzerland
Brand Name : Diosmin Hesperidin Zentiva
Dosage Form : Filmtabl
Dosage Strength : 500mg
Packaging :
Approval Date :
Application Number :
Regulatory Info :
Registration Country : Switzerland
Sanofi is a pioneer in Diabetes Solutions, Human Vaccines, Innovative Drugs, Consumer Healthcare, and the new Genzyme.
Regulatory Info :
Registration Country : Switzerland
Brand Name : Diosmin Hesperidin Zentiva
Dosage Form : Filmtabl
Dosage Strength : 500mg
Packaging :
Approval Date :
Application Number :
Regulatory Info :
Registration Country : Switzerland
Regulatory Info :
Registration Country : Italy
Brand Name : Alvenex
Dosage Form :
Dosage Strength : 20 Bust Groun Os 450 Mg
Packaging :
Approval Date :
Application Number :
Regulatory Info :
Registration Country : Italy
Regulatory Info :
Registration Country : Italy
Brand Name : Alvenex
Dosage Form :
Dosage Strength : 20 Cpr 450 Mg
Packaging :
Approval Date :
Application Number :
Regulatory Info :
Registration Country : Italy
Regulatory Info :
Registration Country : Switzerland
Brand Name : Daflon 500
Dosage Form : Tabl
Dosage Strength : 500mg
Packaging :
Approval Date :
Application Number :
Regulatory Info :
Registration Country : Switzerland
Regulatory Info :
Registration Country : Italy
Brand Name : Daflon
Dosage Form :
Dosage Strength : 30 Cpr Riv 500 Mg
Packaging :
Approval Date :
Application Number :
Regulatory Info :
Registration Country : Italy
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Regulatory Info :
Registration Country : Italy
Brand Name : Daflon
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Dosage Strength : 30 Cpr Riv 500 Mg
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Registration Country : Italy
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