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HTBA Diosmin

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Sichuan Elixir Pharmaceuticals Diosmin

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ACTIVE PHARMA INGREDIENTS

32 API Suppliers, 5 USDMF, 19 CEP/COS, 1 EU WC, 3 KDMF, 16 Listed Suppliers, $ API Reference Price

32 API Suppliers
5 USDMF
19 CEP/COS
1 EU WC
3 KDMF
16 Listed Suppliers
$ API Reference Price

FINISHED DOSAGE FORMULATIONS

38 FDF Dossiers, 31 Europe, 7 Listed Dossiers

38 FDF Dossiers
31 Europe
7 Listed Dossiers

RELATED EXCIPIENT COMPANIES

1 SPI Pharma, 1 DKSH, 2 Faran Shimi Pharmaceutical, 1 Boai NKY Pharmaceuticals Ltd, 8 Gangwal Healthcare, 4 Anhui Sunhere Pharmaceutical Excipients Co.,Ltd, 11 BASF, 3 DFE Pharma, 5 Gangwal Chemicals, 1 Ideal Cures Pvt Ltd, 1 Ingredion Pharma Solutions, 3 Kerry, 5 Microlex e.U, 1 Novo Excipients, 2 Pharmatrans-Sanaq, 2 Pluviaendo, 2 Prachin Chemical, 12 Roquette, 2 Shanghai Shenmei Pharmaceutical Technology Co., Ltd, 9 Sigachi Industries, 2 Vasa Pharmachem

EXCIPIENTS BY APPLICATIONS

25 Fillers, Diluents & Binders, 19 Direct Compression, 15 Disintegrants & Superdisintegrants, 13 Granulation, 12 Thickeners and Stabilizers, 9 Co-Processed Excipients, 7 Controlled & Modified Release, 7 Coating Systems & Additives, 6 Lubricants & Glidants, 6 Film Formers & Plasticizers, 6 Solubilizers, 2 Rheology Modifiers, 2 Emulsifying Agents, 2 Chewable & Orodispersible Aids, 2 Parenteral, 2 Taste Masking, 1 Topical, 1 API Stability Enhancers

excipientsByApplications
25 Fillers, Diluents & Binders
19 Direct Compression
15 Disintegrants & Superdisintegrants
13 Granulation
12 Thickeners and Stabilizers
9 Co-Processed Excipients
7 Controlled & Modified Release
7 Coating Systems & Additives
6 Lubricants & Glidants
6 Film Formers & Plasticizers
6 Solubilizers
2 Rheology Modifiers
2 Emulsifying Agents
2 Chewable & Orodispersible Aids
2 Parenteral
2 Taste Masking
1 Topical
1 API Stability Enhancers

DIGITAL CONTENT

2 NEWS #PharmaBuzz

media
2 NEWS #PharmaBuzz

GLOBAL SALES INFORMATION

28 Finished Drug Prices

globalSalesInformation
28 Finished Drug Prices

MARKET PLACE

25 APIs, 6 FDF Dossiers

marketPlace
25 APIs
6 FDF Dossiers

REF. STANDARDS & IMPURITIES

2 EDQM , 2 USP , 4 Others

otherSolutions
2 EDQM
2 USP
4 Others

ANALYTICAL

1 BioAnalytical Methods

otherMethods
1 BioAnalytical Methods

HTBA Diosmin

Synopsis

ACTIVE PHARMA INGREDIENTS

32

API Suppliers

5

USDMF

19

CEP/COS

CEP/COS Certifications

0

JDMF

1

EU WC

3

KDMF

0

NDC API

0

VMF

16

Listed Suppliers

API REF. PRICE (USD/KG)

$

$ 172

MARKET PLACE

25

API

6

FDF

0INTERMEDIATES

FINISHED DOSAGE FORMULATIONS

38

FDF Dossiers

0

FDA Orange Book

FDA (Orange Book)

31

Europe

0

Canada

0

Australia

0

South Africa

7

Listed Dossiers

0 DRUGS IN DEVELOPMENT

DRUG PRODUCT COMPOSITIONS

REF. STANDARDS OR IMPURITIES

2

EDQM

2

USP

0

JP

4

Others

PATENTS & EXCLUSIVITIES

0

US Patents

0

US Exclusivities

0

Health Canada Patents

DIGITAL CONTENT

0

Data Compilation #PharmaFlow

0

Stock Recap #PipelineProspector

0

Weekly News Recap #Phispers

2

News #PharmaBuzz

GLOBAL SALES INFORMATION

US Medicaid (USD)

NA

Annual Reports (USD Million)

NA

Finished Drug Prices

78 RELATED EXCIPIENT COMPANIES

137EXCIPIENTS BY APPLICATIONS

Chemistry

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Also known as: 520-27-4, Barosmin, Diosimin, Venosmine, Diosmil, Diosmine

Molecular Formula

C₂₈H₃₂O₁₅

Molecular Weight

608.5 g/mol

InChI Key

GZSOSUNBTXMUFQ-YFAPSIMESA-N

FDA UNII

7QM776WJ5N

Diosmin

A bioflavonoid that strengthens vascular walls.

1 2D Structure

Diosmin

2 Identification

2.1 Computed Descriptors

2.1.1 IUPAC Name

5-hydroxy-2-(3-hydroxy-4-methoxyphenyl)-7-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-[[(2R,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyloxan-2-yl]oxymethyl]oxan-2-yl]oxychromen-4-one

2.1.2 InChI

InChI=1S/C28H32O15/c1-10-21(32)23(34)25(36)27(40-10)39-9-19-22(33)24(35)26(37)28(43-19)41-12-6-14(30)20-15(31)8-17(42-18(20)7-12)11-3-4-16(38-2)13(29)5-11/h3-8,10,19,21-30,32-37H,9H2,1-2H3/t10-,19+,21-,22+,23+,24-,25+,26+,27+,28+/m0/s1

2.1.3 InChI Key

GZSOSUNBTXMUFQ-YFAPSIMESA-N

2.1.4 Canonical SMILES

CC1C(C(C(C(O1)OCC2C(C(C(C(O2)OC3=CC(=C4C(=C3)OC(=CC4=O)C5=CC(=C(C=C5)OC)O)O)O)O)O)O)O)O

2.1.5 Isomeric SMILES

C[C@H]1[C@@H]([C@H]([C@H]([C@@H](O1)OC[C@@H]2[C@H]([C@@H]([C@H]([C@@H](O2)OC3=CC(=C4C(=C3)OC(=CC4=O)C5=CC(=C(C=C5)OC)O)O)O)O)O)O)O)O

2.2 Other Identifiers

2.2.1 UNII

7QM776WJ5N

2.3 Synonyms

2.3.1 MeSH Synonyms

1. Barosmin

2. Buchu Resin

3. Daflon

4. Resin, Buchu

5. Venosmine

2.3.2 Depositor-Supplied Synonyms

1. 520-27-4

2. Barosmin

3. Diosimin

4. Venosmine

5. Diosmil

6. Diosmine

7. Flebosten

8. Daflon

9. Tovene

10. Ven-detrex

11. Diovenor

12. Buchu Resin

13. Litosmil

14. Veno-v

15. Flebosmil

16. Diosminum

17. Rioven

18. Diosmetin 7-o-rutinoside

19. Diosven

20. Flebaven

21. Flebavena

22. Hemerven

23. Insuven

24. Varinon

25. Dioven

26. Diosmetin-7-o-rutinoside

27. Diosmin [inn]

28. Diosmetin 7-rutinoside

29. 5-hydroxy-2-(3-hydroxy-4-methoxyphenyl)-7-[(2s,3r,4s,5s,6r)-3,4,5-trihydroxy-6-[[(2r,3r,4r,5r,6s)-3,4,5-trihydroxy-6-methyloxan-2-yl]oxymethyl]oxan-2-yl]oxychromen-4-one

30. 7qm776wj5n

31. Chebi:4631

32. 3',5,7-trihydroxy-4'-methoxyflavone 7-rutinoside

33. 3',5,7-trihydroxy-4'-methoxyflavone-7-rutinoside

34. Diosmin (inn)

35. Nsc-758417

36. 5-hydroxy-2-(3-hydroxy-4-methoxyphenyl)-7-(((2s,3r,4s,5s,6r)-3,4,5-trihydroxy-6-((((2r,3r,4r,5r,6s)-3,4,5-trihydroxy-6-methyltetrahydro-2h-pyran-2-yl)oxy)methyl)tetrahydro-2h-pyran-2-yl)oxy)-4h-chromen-4-one

37. Diosmin, Analytical Standard

38. Dsstox_cid_25892

39. Dsstox_rid_81206

40. Dsstox_gsid_45892

41. 3',5,7-trihydroxy-4'-methoxyflavone-7-(6-o-(-deoxy-alpha-l-mannopyraonsyl)-beta-d-glucopyranoside

42. 5-hydroxy-2-(3-hydroxy-4-methoxy-phenyl)-7-[(2s,3r,4s,5s,6r)-3,4,5-trihydroxy-6-[[(2r,3r,4r,5r,6s)-3,4,5-trihydroxy-6-methyl-tetrahydropyran-2-yl]oxymethyl]tetrahydropyran-2-yl]oxy-chromen-4-one

43. 3',5,7-trihydroxy-4'-methoxyflavone 7-rhamnoglucoside

44. Cas-520-27-4

45. Diosmin [inn:ban]

46. Diosmin [inn-spanish]

47. Diosmine [inn-french]

48. Diosminum [inn-latin]

49. Sr-01000799147

50. Unii-7qm776wj5n

51. Ccris 7915

52. Ncgc00095022-01

53. 4h-1-benzopyran-4-one, 7-((6-o-(6-deoxy-.alpha.-l-mannopyranosyl)-.beta.-d-glucopyranosyl)oxy)-5-hydroxy-2-(3-hydroxy-4-methoxyphenyl)-

54. 4h-1-benzopyran-4-one, 7-[[6-o-(6-deoxy-.alpha.-l-mannopyranosyl)-.beta.-d-glucopyranosyl]oxy]-5-hydroxy-2-(3-hydroxy-4-methoxyphenyl)-

55. Einecs 208-289-7

56. Daflon (tn)

57. Mfcd00009772

58. Diosmin (8)

59. Se 4601

60. Diosmine [inci]

61. Diosmin [dsc]

62. Diosmin [mi]

63. Diosmin [mart.]

64. Diosmin [usp-rs]

65. Diosmin [who-dd]

66. Mls001304032

67. Schembl120870

68. Diosmin [ep Monograph]

69. Chembl231884

70. Dtxsid4045892

71. 3',5-dihydroxy-4'-methoxy-4-oxo-4h-chromen-7-ylrutosid

72. Bdbm153267

73. Hms2233p16

74. Hms3713l08

75. Act05288

76. Zinc4098512

77. Tox21_111392

78. 3',5-dihydroxy-4'-methoxy-4-oxo-4h-chromen-7-ylrutosid [iupac]

79. S2292

80. Akos015969767

81. Tox21_111392_1

82. Bcp9000612

83. Ccg-208570

84. Db08995

85. Nsc 758417

86. Smp1_000183

87. Ncgc00344564-01

88. 4h-1-benzopyran-4-one, 7-((6-o-(6-deoxy-alpha-l-mannopyranosyl)-beta-d-glucopyranosyl)oxy)-5-hydroxy-2-(3-hydroxy-4-methoxyphenyl)-

89. 4h-1-benzopyran-4-one,7-[[6-o-(6-deoxy-a-l-mannopyranosyl)-b-d-glucopyranosyl]oxy]-5-hydroxy-2-(3-hydroxy-4-methoxyphenyl)-

90. 5-hydroxy-2-(3-hydroxy-4-methoxyphenyl)-4-oxo-4h-1-benzopyran-7-yl 6-o-(6-deoxy-alpha-l-mannopyranosyl)-beta-d-glucopyranoside

91. 5-hydroxy-2-(3-hydroxy-4-methoxyphenyl)-7-((6-o-alpha-l-rhamnopyranosyl-beta-d-glycopyranosyl)oxy)-4-chromenon

92. As-13224

93. Bp-12422

94. Smr000718616

95. Bcp0726000067

96. C10039

97. D07858

98. 520d274

99. 3',5,7-trihydroxy-4'-methoxy Flavone-7-rutinoside

100. Q2607865

101. Sr-01000799147-4

102. Sr-01000799147-5

103. Sr-01000799147-6

104. Diosmin, European Pharmacopoeia (ep) Reference Standard

105. Diosmin, United States Pharmacopeia (usp) Reference Standard

106. Diosmin For System Suitability, European Pharmacopoeia (ep) Reference Standard

107. 5-hydroxy-2-(3-hydroxy-4-methoxyphenyl)-7-((2s,3r,4s,5s,6r)-3,4,5-trihydroxy-6-(((2r,3r,4r,5r,6s)-3,4,5-trihydroxy-6-methyltetrahydro-2h-pyran-2-yloxy)methyl)tetrahydro-2h-pyran-2-yloxy)-4h-chromen-4-one

108. 5-hydroxy-2-(3-hydroxy-4-methoxyphenyl)-7-(o6-alpha-l-rhamnopyranosyl-beta-d-glucopyranosyloxy)chromen-4-one

109. 5-hydroxy-2-(3-hydroxy-4-methoxyphenyl)-7-[(2s,3r,4s,5s,6r)-3,4,5-trihydroxy-6-[[(2s,3s,4s,5s,6r)-3,4,5-trihydroxy-6-methyloxan-2-yl]oxymethyl]oxan-2-yl]oxychromen-4-one

110. 7-((6-o-(6-deoxy-ga-l-mannopyranosyl)-.beta.-d-glucopyranosyl)oxy)-5-hydroxy-2-(3-hydroxy-4-methoxyphenyl)-4h-1-benzopyran-4-one

111. 7-((6-o-(6-deoxy-ga-l-mannopyranosyl)-beta-d-glucopyranosyl)oxy)-5-hydroxy-2-(3-hydroxy-4-methoxyphenyl)-4h-1-benzopyran-4-one

2.4 Create Date

2005-06-24

3 Chemical and Physical Properties

Molecular Formula	C₂₈H₃₂O₁₅
Molecular Weight	608.5 g/mol
XLogP3	-0.8
Hydrogen Bond Donor Count	8
Hydrogen Bond Acceptor Count	15
Rotatable Bond Count	7
Exact Mass	608.17412031 g/mol
Monoisotopic Mass	608.17412031 g/mol
Topological Polar Surface Area	234 Å²
Heavy Atom Count	43
Formal Charge	0
Complexity	995
Isotope Atom Count	0
Defined Atom Stereocenter Count	10
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently Bonded Unit Count	1

4 Drug and Medication Information

4.1 Drug Indication

Diosmin is used over-the-counter alone or with ingredients such as [hesperidin] and [diosmetin] to support vein and capillary function.

5 Pharmacology and Biochemistry

5.1 Pharmacology

Diosmin is a venoactive drug supporting circulatory health through various actions on blood vessels; it supports lymphatic drainage and improves microcirculation while increasing venous tone and elasticity. For these reasons, diosmin is frequently taken by individuals with chronic venous disease to support vascular health and has been demonstrated to improve quality of life. In addition to the above effects, diosmin exerts antioxidant activity and scavenges oxygen free radicals, reducing levels of oxidative stress normally detected through biomarkers such as prostaglandins isoprostane precursors. In one clinical study, mean content of TNF alpha, VEGF-C, VEGF-A IL-6, in addition to FGF2 were decreased by after the therapy with diosmin; findings were statistically significant. Additionally, a decrease in edema and mean leg circumference of patients taking diosmin for three months was observed in a clinical study. Diosmin has been demonstrated to enhance the metabolism of glucose in diabetic disorders.

5.2 ATC Code

C - Cardiovascular system

C05 - Vasoprotectives

C05C - Capillary stabilizing agents

C05CA - Bioflavonoids

C05CA03 - Diosmin

5.3 Absorption, Distribution and Excretion

Absorption

Diosmin is rapidly absorbed in the gastrointestinal tract. After a 900 mg single oral dose in a study using liquid chromatography with tandem mass spectrometry (LC-MS/MS) method, Cmax was 4.23.8 ^ngmL-1, Tmax was 18.79.9 hours, and AUC0~96 was 185.4166.2 ^ngmL-1 in healthy volunteers. Another pharmacokinetic study of 5 adults revealed a Cmax of 41794.1 ng/dL.

Route of Elimination

Pharmacokinetic data show absence of urinary elimination for diosmin and its aglycone diosmetin. Minor metabolites are found to be eliminated in the urine as glucuronic acid conjugates.

Volume of Distribution

A pharmacokinetic study of 5 adults revealed a volume of distribution of 62.17.9 L.

5.4 Metabolism/Metabolites

Degradation products of diosmin such as alkyl-phenolic acids confirm a metabolic pattern similar to that of other flavonoids.

5.5 Biological Half-Life

Diosmin half-life ranges from 26 to 43 hours. One study using a liquid chromatography with tandem mass spectrometry (LC-MS/MS) method after a single 900 mg dose of diosmin demonstrated a half-life of 60.285.7 hours in healthy volunteers.

5.6 Mechanism of Action

Diosmin helps to maintain circulatory system structure and function, particularly vein strength and competence. The molecular mechanism of action of diosmin has not been established. Several resources indicate that diosmin binds to the aryl hydrocarbon receptor, however clinical relevance to vascular function is unknown. One study demonstrates that oral diosmin exerts effects on the in vitro metabolism of noradrenaline by varicose veins, potentially benefitting vascular health.

API SUPPLIERS

01

HealthTech BioActives

Spain

USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

BIO Partnering at JPM

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HealthTech BioActives, leading globally in Flavonoids and Vitamin B12 Derivatives.

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Sichuan Elixir Pharmaceuticals

China

USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

BIO Partnering at JPM

Not Confirmed

Sichuan Elixir Pharmaceutical, a manufacturer of small molecule APIs & a CMO/CDMO service provider for anti-tumor characteristic APIs..

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China

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PMC Isochem

France

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PMC Isochem is your partner for smart CDMOs of Intermediates, APIs, & excipients & a catalog of Intermediates & Generic APIs.

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Basic Nutrition

China

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Basic Nutrition, your expert for sourcing from China, India and Europe.

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Hunan Yuantong Pharmaceutical

China

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06

Shaanxi Huifeng Pharmaceutical Co....

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Sichuan Xieli Pharmaceutical

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Chengdu Yazhong Bio-pharmaceutical

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09

Chengdu Okay Pharmaceutical Co Ltd

China

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API Reference Price

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LTEE","supplierCountry":"FRANCE","foreign_port":"PARIS - CHARLES DE G","customer":"SERVIER","customerCountry":"INDIA","quantity":"1800.00","actualQuantity":"1800","unit":"KGS","unitRateFc":"95","totalValueFC":"193341.4","currency":"EUR","unitRateINR":"9001.3","date":"17-Sep-2024","totalValueINR":"16202250","totalValueInUsd":"193341.4","indian_port":"Bombay Air","hs_no":"29389090","bill_no":"5652404","productDescription":"API","marketType":"REGULATED MARKET","country":"FRANCE","selfForZScoreResived":"Micronized","supplierPort":"PARIS - CHARLES DE G","supplierAddress":"50 RUE CARNOT SURESNES CEDEX FR","customerAddress":"SERDIA HOUSE ,OFF.DR.S.S.RAO ROAD,"},{"dataSource":"API Import","activeIngredients":"","year":"2024","qtr":"Q3","strtotime":1727634600,"product":"DIOSMIN + HESPERIDIN 9:1","address":"SURVEY NO198\/2 & 198\/3,CHANCHARWAD","city":"TALUKA SANAND AHMEDABAD,GUJARAT","supplier":"CHENGDU YAZHONG BIO-PHARMACEUTICAL","supplierCountry":"CHINA","foreign_port":"CHENGDU","customer":"SAGA LIFESCIENCES LIMITED","customerCountry":"INDIA","quantity":"500.00","actualQuantity":"500","unit":"KGS","unitRateFc":"42","totalValueFC":"21200.2","currency":"USD","unitRateINR":"3553.2","date":"30-Sep-2024","totalValueINR":"1776600","totalValueInUsd":"21200.2","indian_port":"Ahmedabad Air","hs_no":"29389090","bill_no":"5888062","productDescription":"API","marketType":"REGULATED MARKET","country":"CHINA","selfForZScoreResived":"Pharma Grade","supplierPort":"CHENGDU","supplierAddress":"NO. 342, LIRONG STR., LICHUN TOWN P ENGZHOU CITY, CHENGDU SICHUAN PROVI NCE 611936 P.R. CHINA Chengdu, , Ch China","customerAddress":"SURVEY NO198\/2 & 198\/3,CHANCHARWAD"},{"dataSource":"API Import","activeIngredients":"","year":"2024","qtr":"Q4","strtotime":1728930600,"product":"MICRONIZED PURIFIED FLAVONOID FRACTION OF RUTACEAE (DIOSMIN:HESPERIDIN)","address":"B-203 GOPALPALACE, NEARNEHRU NAGAR","city":"AHMEDABAD,GUJARAT","supplier":"CHENGDU YAZHONG BIO-PHARMACEUTICAL","supplierCountry":"CHINA","foreign_port":"SHANGHAI","customer":"NOVAGEN HEALTHCARE PRIVATE ","customerCountry":"INDIA","quantity":"1275.00","actualQuantity":"1275","unit":"KGS","unitRateFc":"36.8","totalValueFC":"47379.8","currency":"USD","unitRateINR":"3122.5","date":"15-Oct-2024","totalValueINR":"3981162","totalValueInUsd":"47379.8","indian_port":"JNPT","hs_no":"29420090","bill_no":"6134270","productDescription":"API","marketType":"REGULATED MARKET","country":"CHINA","selfForZScoreResived":"Micronized","supplierPort":"SHANGHAI","supplierAddress":"CO., LTDNO.342, LIRONG STR., LICHUN TOWN,PENGZHOU CITY, SICHUAN PROVIN CE,CHINA, 611936 CHINA","customerAddress":"B-203 GOPALPALACE, NEARNEHRU NAGAR"},{"dataSource":"API Import","activeIngredients":"","year":"2024","qtr":"Q4","strtotime":1731522600,"product":"DIOSMIN PH EUR","address":"ZYDUS TOWER, SARKHEJ-GANDHINAGAR,H","city":"AHMEDABAD,GUJARAT","supplier":"HEALTH TECH BIO ACTIVES S.L.U","supplierCountry":"SPAIN","foreign_port":"BARCELONA","customer":"ZYDUS LIFESCIENCES LIMITED","customerCountry":"INDIA","quantity":"100.00","actualQuantity":"100","unit":"KGS","unitRateFc":"75","totalValueFC":"7572.2","currency":"USD","unitRateINR":"6390","date":"14-Nov-2024","totalValueINR":"639000","totalValueInUsd":"7572.2","indian_port":"Bombay Air","hs_no":"29389090","bill_no":"6677872","productDescription":"API","marketType":"REGULATED MARKET","country":"SPAIN","selfForZScoreResived":"Pharma Grade","supplierPort":"BARCELONA","supplierAddress":"AVDA DIAGONAL 567, PLANTA 4, 08029 BARCELONA Barcelona, , Spain SDNF Spain","customerAddress":"ZYDUS TOWER, SARKHEJ-GANDHINAGAR,H"},{"dataSource":"API Import","activeIngredients":"","year":"2024","qtr":"Q4","strtotime":1731522600,"product":"DIOSMIN PH EUR","address":"ZYDUS TOWER, SARKHEJ-GANDHINAGAR,H","city":"AHMEDABAD,GUJARAT","supplier":"HEALTH TECH BIO ACTIVES S.L.U","supplierCountry":"SPAIN","foreign_port":"BARCELONA","customer":"ZYDUS LIFESCIENCES LIMITED","customerCountry":"INDIA","quantity":"175.00","actualQuantity":"175","unit":"KGS","unitRateFc":"75","totalValueFC":"13251.3","currency":"USD","unitRateINR":"6390","date":"14-Nov-2024","totalValueINR":"1118250","totalValueInUsd":"13251.3","indian_port":"Bombay Air","hs_no":"29389090","bill_no":"6677872","productDescription":"API","marketType":"REGULATED MARKET","country":"SPAIN","selfForZScoreResived":"Pharma Grade","supplierPort":"BARCELONA","supplierAddress":"AVDA DIAGONAL 567, PLANTA 4, 08029 BARCELONA Barcelona, , Spain SDNF Spain","customerAddress":"ZYDUS TOWER, SARKHEJ-GANDHINAGAR,H"},{"dataSource":"API Import","activeIngredients":"","year":"2024","qtr":"Q4","strtotime":1731522600,"product":"DIOSMIN PH EUR","address":"ZYDUS TOWER, SARKHEJ-GANDHINAGAR","city":"AHMEDABAD\/GUJRAT","supplier":"HEALTH TECH BIO ACTIVES S.L.U","supplierCountry":"SPAIN","foreign_port":"BARCELONA","customer":"ZYDUS LIFESCIENCES LIMITED","customerCountry":"INDIA","quantity":"575.00","actualQuantity":"575","unit":"KGS","unitRateFc":"75","totalValueFC":"43539.9","currency":"USD","unitRateINR":"6390","date":"14-Nov-2024","totalValueINR":"3674250","totalValueInUsd":"43539.9","indian_port":"Bombay Air","hs_no":"29389090","bill_no":"6677872","productDescription":"API","marketType":"REGULATED MARKET","country":"SPAIN","selfForZScoreResived":"Pharma Grade","supplierPort":"BARCELONA","supplierAddress":"AVDA DIAGONAL 567, PLANTA 4, 08029 BARCELONA Barcelona, , Spain SDNF Spain","customerAddress":"ZYDUS TOWER, SARKHEJ-GANDHINAGAR"},{"dataSource":"API Import","activeIngredients":"","year":"2024","qtr":"Q4","strtotime":1731954600,"product":"DIOSMIN (MICRONIZED PURIFIED FLAVONOID FRACTION DIOSMIN 90 PERCENT AND FLAVONOIDS EXPRESSED AS HESPERIDIN 10 PERCENT)","address":"1003-GIDC,","city":"DIST.SURENDRANAGAR\/GUJARAT","supplier":"CHENGDU YAZHONG BIO-PHARMACEUTICAL","supplierCountry":"CHINA","foreign_port":"SHANGHAI","customer":"MEPRO PHARMACEUTICALS PRIVATE ","customerCountry":"INDIA","quantity":"101.00","actualQuantity":"101","unit":"KGS","unitRateFc":"41","totalValueFC":"4185.7","currency":"USD","unitRateINR":"3497.3","date":"19-Nov-2024","totalValueINR":"353227.3","totalValueInUsd":"4185.7","indian_port":"JNPT","hs_no":"29389090","bill_no":"6764574","productDescription":"API","marketType":"REGULATED MARKET","country":"CHINA","selfForZScoreResived":"Micronized","supplierPort":"SHANGHAI","supplierAddress":"NO.342, LIRONG STR, LICHUN TOWN, PE NGZHOU CITY, SICHUAN PROVINCE, CHI NA 611936 CHINA","customerAddress":"1003-GIDC,"},{"dataSource":"API Import","activeIngredients":"","year":"2024","qtr":"Q4","strtotime":1731954600,"product":"DIOSMIN (MICRONIZED PURIFIED FLAVONOID FRACTION DIOSMIN 90 PERCENT AND FLAVONOIDS EXPRESSED AS HESPERIDIN 10 PERCENT)","address":"1003-GIDC,","city":"DIST.SURENDRANAGAR\/GUJARAT","supplier":"CHENGDU YAZHONG BIO-PHARMACEUTICAL","supplierCountry":"CHINA","foreign_port":"SHANGHAI","customer":"MEPRO PHARMACEUTICALS PRIVATE ","customerCountry":"INDIA","quantity":"275.00","actualQuantity":"275","unit":"KGS","unitRateFc":"41","totalValueFC":"11396.8","currency":"USD","unitRateINR":"3497.3","date":"19-Nov-2024","totalValueINR":"961757.5","totalValueInUsd":"11396.8","indian_port":"JNPT","hs_no":"29389090","bill_no":"6764574","productDescription":"API","marketType":"REGULATED MARKET","country":"CHINA","selfForZScoreResived":"Micronized","supplierPort":"SHANGHAI","supplierAddress":"NO.342, LIRONG STR, LICHUN TOWN, PE NGZHOU CITY, SICHUAN PROVINCE, CHI NA 611936 CHINA","customerAddress":"1003-GIDC,"}]

Number of Transactions

Total Quantity (KGS)

Total Value (USD)

Quantity (KGS) & Unit rate (USD/KGS) over time

API Imports and Exports

Importing Country	Total Quantity (KGS)	Average Price (USD/KGS)	Number of Transactions

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FDF Dossiers

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Europe

01

Helvepharm AG

France

Pharma, Lab & Chemical Expo

Not Confirmed

Sanofi is a pioneer in Diabetes Solutions, Human Vaccines, Innovative Drugs, Consumer Healthcare, and the new Genzyme.

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France

Digital Content

Regulatory Info :

Registration Country : Switzerland

Diosminum; Hesperidinum

Brand Name : Diosmin Hesperidin Zentiva

Dosage Form : Filmtabl

Dosage Strength : 500mg

Packaging :

Approval Date :

Application Number :

Regulatory Info :

Registration Country : Switzerland

Sanofi Company Banner

Portfolio PDF

Product Web Link

Digital Content

02

Helvepharm AG

France

Pharma, Lab & Chemical Expo

Not Confirmed

Sanofi is a pioneer in Diabetes Solutions, Human Vaccines, Innovative Drugs, Consumer Healthcare, and the new Genzyme.

Contact Supplier

Contact Supplier

France

Digital Content

Regulatory Info :

Registration Country : Switzerland

Diosminum; Hesperidinum

Brand Name : Diosmin Hesperidin Zentiva

Dosage Form : Filmtabl

Dosage Strength : 500mg

Packaging :

Approval Date :

Application Number :

Regulatory Info :

Registration Country : Switzerland

Sanofi Company Banner

Portfolio PDF

Product Web Link

Digital Content

03

Helvepharm AG

France

Pharma, Lab & Chemical Expo

Not Confirmed

Sanofi is a pioneer in Diabetes Solutions, Human Vaccines, Innovative Drugs, Consumer Healthcare, and the new Genzyme.

Contact Supplier

Contact Supplier

France

Digital Content

Regulatory Info :

Registration Country : Switzerland

Diosminum; Hesperidinum

Brand Name : Diosmin Hesperidin Zentiva

Dosage Form : Filmtabl

Dosage Strength : 500mg

Packaging :

Approval Date :

Application Number :

Regulatory Info :

Registration Country : Switzerland

Sanofi Company Banner

Portfolio PDF

Product Web Link

Digital Content

04

Servier (Switzerland) SA

France

Pharma, Lab & Chemical Expo

Not Confirmed

05

World Medicine Ilac San ve tic LTD STl

Turkey

Pharma, Lab & Chemical Expo

Not Confirmed

06

MEDIFARM Srl

Country

Pharma, Lab & Chemical Expo

Not Confirmed

07

FARMA 1000 Srl

Country

Pharma, Lab & Chemical Expo

Not Confirmed

08

PHARMAZENA Srl

Country

Pharma, Lab & Chemical Expo

Not Confirmed

09

BB FARMA Srl

Country

Pharma, Lab & Chemical Expo

Not Confirmed

10

EUROFARMACO Srl

Country

Pharma, Lab & Chemical Expo

Not Confirmed

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Listed Dossiers

01

Cifarma

Brazil

BIO Partnering at JPM

Not Confirmed

02

Fitopharm

Ukraine

BIO Partnering at JPM

Not Confirmed

03

Laboratório Gross

Brazil

BIO Partnering at JPM

Not Confirmed

04

Pannon

Hungary

BIO Partnering at JPM

Not Confirmed

05

Pantson Pharma Pvt. Limited

India

BIO Partnering at JPM

Not Confirmed

06

Precise Group

India

BIO Partnering at JPM

Not Confirmed

07

Stragen Pharma SA

Switzerland

BIO Partnering at JPM

Not Confirmed

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Finished Drug Prices

01

Brand Name : Diosmin Hesperidin Zentiva

France

Pharma, Lab & Chemical Expo

Not Confirmed

Sanofi is a pioneer in Diabetes Solutions, Human Vaccines, Innovative Drugs, Consumer Healthcare, and the new Genzyme.

Contact Supplier

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France

Digital Content

RX/OTC/DISCN : Class D

Helvepharm AG

Diosmin; Hesperidin

Dosage Form : Filmtabl

Dosage Strength : 500mg

Price Per Pack (Euro) : 7.76

Published in :

Country : Switzerland

RX/OTC/DISCN : Class D

Sanofi Company Banner

Portfolio PDF

Product Web Link

Digital Content

02

Brand Name : Diosmin Hesperidin Zentiva

France

Pharma, Lab & Chemical Expo

Not Confirmed

Sanofi is a pioneer in Diabetes Solutions, Human Vaccines, Innovative Drugs, Consumer Healthcare, and the new Genzyme.

Contact Supplier

Contact Supplier

France

Digital Content

RX/OTC/DISCN : Class D

Helvepharm AG

Diosmin; Hesperidin

Dosage Form : Filmtabl

Dosage Strength : 500mg

Price Per Pack (Euro) : 13.66

Published in :

Country : Switzerland

RX/OTC/DISCN : Class D

Sanofi Company Banner

Portfolio PDF

Product Web Link

Digital Content

03

Brand Name : Diosmin Hesperidin Zentiva

France

Pharma, Lab & Chemical Expo

Not Confirmed

Sanofi is a pioneer in Diabetes Solutions, Human Vaccines, Innovative Drugs, Consumer Healthcare, and the new Genzyme.

Contact Supplier

Contact Supplier

France

Digital Content

RX/OTC/DISCN : Class D

Helvepharm AG

Diosmin; Hesperidin

Dosage Form : Filmtabl

Dosage Strength : 500mg

Price Per Pack (Euro) : 25.45

Published in :

Country : Switzerland

RX/OTC/DISCN : Class D

Sanofi Company Banner

Portfolio PDF

Product Web Link

Digital Content

04

Brand Name : Alvenex

Italy

Pharma, Lab & Chemical Expo

Not Confirmed

05

Brand Name : Alvenex

Italy

Pharma, Lab & Chemical Expo

Not Confirmed

06

Brand Name : Daflon

Country

Pharma, Lab & Chemical Expo

Not Confirmed

07

Brand Name : Daflon

Country

Pharma, Lab & Chemical Expo

Not Confirmed

08

Brand Name : Daflon

Country

Pharma, Lab & Chemical Expo

Not Confirmed

09

Brand Name : Diosven

Country

Pharma, Lab & Chemical Expo

Not Confirmed

10

Brand Name : Doven Strong

Country

Pharma, Lab & Chemical Expo

Not Confirmed

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Market Place

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APIs

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FDF DOSSIERS

Various FDFs needed in Russia [ENA19769]

A large pharmaceutical company based in India that devotes itself to R&D, production, marketing and sales of active pharmaceutical ingredients and pharmaceutical intermediates is looking for suppliers of Various Finished Dosage Formulations for commercial purposes. The initial required quantity is MOQ for each. The suppliers must support this enquiry with dossier. 1. Dimenhydrinate (40 mg) + Cinnarizine (20 mg) Tablets 2. Diosmin & Hesperidin (1000 mg) Capsules 3. Vortioxetine Hydrobromide (5 mg, 10 mg & 20 mg) Tablets

Reply

21 Jun 2024

Various Finished Dosage Formulations needed in Romania [ENA17456]

A large pharmaceutical company based in India that devotes itself to R&D, production, marketing and sales of active pharmaceutical ingredients and pharmaceutical intermediates is looking for suppliers of Various Finished Dosage Formulations for commercial purposes. The suppliers must support this enquiry with dossier. 1. Melatonin (1 mg) Spray or Tablets 2. Charcoal (300 mg) + Simethicone (50 mg) Modified Release Tablets 3. Simethicone (40 mg/ 80 mg/ 500 mg) Capsules 4. Amoxicillin (457 mg) + Clavulanic Acid (5 ml) Suspensions 5. Diosimin (900 mg) + Hesperidin (100 mg) Capsules 6. Perindopril (4 mg & 5 mg) + Amlodipine (1.25 mg) + Indapamide (10 mg or 5 mg) Capsules 7. Bisoprolol (2.5 mg/ 5 mg/10 mg) Tablets 8. Dimenhydrinate (40 mg) + Cinnarizine (20 mg) Tablets

Reply

04 Jul 2023

Tender// Various Finished Dosage Formulations needed in Romania [ENA14961]

Spitalul Orasenesc Gaesti is looking for supplies of Various Finished Dosage Formulations for commercial purpose. The deadline is 3-Oct-2022. 1. Folic Acid (5 mg) Capsules. The required quantity is 6,000 units. 2. Diosmin (500 mg) Capsules. The required quantity is 9,360 units. 3. Amoxicillin (500 mg) Capsules. The required quantity is 6,000 units. 4. Ampicillin (1 g) Injections. The required quantity is 10,080 units.

Reply

08 Sep 2022

Various Finished Dosage Formulations needed in Vietnam [ENA12672]

A large pharmaceutical company based in India that deals in various segments such as gynecology, cardiovascular, diabetology, asthma, pediatric, CNS, GI and NSAIDs is looking for suppliers of Various Finished Dosage Formulations for commercial purpose. 1. Cefetamet Pivoxil (250 mg & 500 mg) Tablets 2. Clopidogrel (75 mg) + Aspirin (100 mg) Tablets 3. Diosmin (450 mg) + Hesperidin (250 mg) Tablets 4. Saccharomyces Boulardii (250 mg) Tablets or Sachets 5. Rosuvastatin (5 mg & 10 mg) + Ezetimibe (10 mg) Tablets

Reply

11 Feb 2022

Various Finished Dosage Formulations needed in the UAE [ENA09896]

A company that deals in human medical supplies, veterinary medicines and supplements and medical services & hospitals is looking for suppliers of Various Finished Dosage Formulations for commercial purposes. The required quantity initially is 10,000 units and later 50,000 units - 70,000 units for each. The suppliers must support this enquiry with GMP. 1. Betamethasone Dipropionate (12.56 mg/ 2 ml) + Betamethasone Sodium Phosphate (5.26 mg/ 2 ml) Ampoule 2. Diosmin (450 mg) + Hesperidin (50 mg) Coated Tablets with 500 mg of Micronized Purified Flavonoid Fraction (MPFF) 3. Carbimazole (5 mg) Tablets. The required quantity is 100 units/ pack. 4. Sodium Aescinate (20 mg) Tablets. The required quantity is 40 units/ pack.

Reply

08 Mar 2021

Offer// EU CTD dossier for Diosmin 450 mg + Hesperidin 50 mg available [ENA02721]

A Hungary based pharmaceutical company has developed EU CTD dossier for Diosmin 450 mg + Hesperidin 50 mg and is looking for buyers of the same.

Reply

22 Nov 2018

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ANALYTICAL

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BioAnalytical Methods

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ABOUT THIS PAGE

Diosmin Manufacturers

A Diosmin manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Diosmin, including repackagers and relabelers. The FDA regulates Diosmin manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Diosmin API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

click here to find a list of Diosmin manufacturers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PhamaCompass.

Diosmin Suppliers

A Diosmin supplier is an individual or a company that provides Diosmin active pharmaceutical ingredient (API) or Diosmin finished formulations upon request. The Diosmin suppliers may include Diosmin API manufacturers, exporters, distributors and traders.

click here to find a list of Diosmin suppliers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PharmaCompass.

Diosmin USDMF

A Diosmin DMF (Drug Master File) is a document detailing the whole manufacturing process of Diosmin active pharmaceutical ingredient (API) in detail. Different forms of Diosmin DMFs exist exist since differing nations have different regulations, such as Diosmin USDMF, ASMF (EDMF), JDMF, CDMF, etc.

A Diosmin DMF submitted to regulatory agencies in the US is known as a USDMF. Diosmin USDMF includes data on Diosmin's chemical properties, information on the facilities and procedures used, and details about packaging and storage. The Diosmin USDMF is kept confidential to protect the manufacturer’s intellectual property.

click here to find a list of Diosmin suppliers with USDMF on PharmaCompass.

Diosmin KDMF

In Korea, the Ministry of Food and Drug Safety (MFDS) is in charge of regulating pharmaceutical products and services.

Pharmaceutical companies submit a Diosmin Drug Master File in Korea (Diosmin KDMF) to the MFDS, which includes comprehensive information about the production, processing, facilities, materials, packaging, and testing of Diosmin. The MFDS reviews the Diosmin KDMF as part of the drug registration process and uses the information provided in the Diosmin KDMF to evaluate the safety and efficacy of the drug.

After submitting a Diosmin KDMF to the MFDS, the registered manufacturer can provide importers or distributors with the registration number without revealing confidential information to Korean business partners. Applicants seeking to register their Diosmin API can apply through the Korea Drug Master File (KDMF).

click here to find a list of Diosmin suppliers with KDMF on PharmaCompass.

Diosmin CEP

A Diosmin CEP of the European Pharmacopoeia monograph is often referred to as a Diosmin Certificate of Suitability (COS). The purpose of a Diosmin CEP is to show that the European Pharmacopoeia monograph adequately controls the purity of Diosmin EP produced by a given manufacturer. Suppliers of raw materials can prove the suitability of Diosmin to their clients by showing that a Diosmin CEP has been issued for it. The manufacturer submits a Diosmin CEP (COS) as part of the market authorization procedure, and it takes on the role of a Diosmin CEP holder for the record. Additionally, the data presented in the Diosmin CEP (COS) is managed confidentially and offers a centralized system acknowledged by numerous nations, exactly like the Diosmin DMF.

A Diosmin CEP (COS) is recognised by all 36 nations that make up the European Pharmacopoeia Convention. Diosmin CEPs may be accepted in nations that are not members of the Ph. Eur. at the discretion of the authorities there.

click here to find a list of Diosmin suppliers with CEP (COS) on PharmaCompass.

Diosmin WC

A Diosmin written confirmation (Diosmin WC) is an official document issued by a regulatory agency to a Diosmin manufacturer, verifying that the manufacturing facility of a Diosmin active pharmaceutical ingredient (API) adheres to the Good Manufacturing Practices (GMP) regulations of the importing country. When exporting Diosmin APIs or Diosmin finished pharmaceutical products to another nation, regulatory agencies frequently require a Diosmin WC (written confirmation) as part of the regulatory process.

click here to find a list of Diosmin suppliers with Written Confirmation (WC) on PharmaCompass.

Diosmin GMP

Diosmin Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

PharmaCompass offers a list of Diosmin GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Diosmin GMP manufacturer or Diosmin GMP API supplier for your needs.

Diosmin CoA

A Diosmin CoA (Certificate of Analysis) is a formal document that attests to Diosmin's compliance with Diosmin specifications and serves as a tool for batch-level quality control.

Diosmin CoA mostly includes findings from lab analyses of a specific batch. For each Diosmin CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

Diosmin may be tested according to a variety of international standards, such as European Pharmacopoeia (Diosmin EP), Diosmin JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Diosmin USP).

Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.

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