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    Also known as: Diphenoxylate hcl, 3810-80-8, Diphenoxylate hydrochloride cii, W24od7yw48, Diphenoxylate hydrochloride [usp], R-1132 (antiperistaltic)
    Molecular Formula
    C30H33ClN2O2
    Molecular Weight
    489.0  g/mol
    InChI Key
    SHTAFWKOISOCBI-UHFFFAOYSA-N
    FDA UNII
    W24OD7YW48
    Diphenoxylate Hydrochloride
    A MEPERIDINE congener used as an antidiarrheal, usually in combination with ATROPINE. At high doses, it acts like morphine. Its unesterified metabolite difenoxin has similar properties and is used similarly. It has little or no analgesic activity.
    1 2D Structure

    Diphenoxylate Hydrochloride

    2 Identification
    2.1 Computed Descriptors
    2.1.1 IUPAC Name
    ethyl 1-(3-cyano-3,3-diphenylpropyl)-4-phenylpiperidine-4-carboxylate;hydrochloride
    2.1.2 InChI
    InChI=1S/C30H32N2O2.ClH/c1-2-34-28(33)29(25-12-6-3-7-13-25)18-21-32(22-19-29)23-20-30(24-31,26-14-8-4-9-15-26)27-16-10-5-11-17-27;/h3-17H,2,18-23H2,1H3;1H
    2.1.3 InChI Key
    SHTAFWKOISOCBI-UHFFFAOYSA-N
    2.1.4 Canonical SMILES
    CCOC(=O)C1(CCN(CC1)CCC(C#N)(C2=CC=CC=C2)C3=CC=CC=C3)C4=CC=CC=C4.Cl
    2.2 Other Identifiers
    2.2.1 UNII
    W24OD7YW48
    2.3 Synonyms
    2.3.1 MeSH Synonyms

    1. Diphenoxylate

    2. Diphenoxylate Monohydrochloride

    3. Hydrochloride, Diphenoxylate

    4. Monohydrochloride, Diphenoxylate

    2.3.2 Depositor-Supplied Synonyms

    1. Diphenoxylate Hcl

    2. 3810-80-8

    3. Diphenoxylate Hydrochloride Cii

    4. W24od7yw48

    5. Diphenoxylate Hydrochloride [usp]

    6. R-1132 (antiperistaltic)

    7. Ethyl 1-(3-cyano-3,3-diphenylpropyl)-4-phenylisonipecotate Monohydrochloride

    8. 1-(3-cyano-3,3-diphenylpropyl)-4-phenylisonipecotic Acid Ethyl Ester Hydrochloride

    9. Dsstox_cid_27821

    10. Dsstox_rid_82584

    11. Ethyl 1-(3-cyano-3,3-diphenylpropyl)-4-phenylpiperidine-4-carboxylate;hydrochloride

    12. Dsstox_gsid_47843

    13. 4-piperidinecarboxylic Acid, 1-(3-cyano-3,3-diphenylpropyl)-4-phenyl-, Ethyl Ester, Monohydrochloride

    14. Diphenoxylate Hydrochloride (usp)

    15. Chebi:59784

    16. Cas-3810-80-8

    17. Ethyl 1-(3-cyano-3,3-diphenylpropyl)-4-phenylpiperidine-4-carboxylate Hydrochloride

    18. Ncgc00167963-01

    19. Ncgc00167963-02

    20. R 1132 (antiperistaltic)

    21. Unii-w24od7yw48

    22. Einecs 223-287-6

    23. Diphenoxylati Hydrochloridum

    24. R 1132

    25. Schembl42124

    26. Mls001401383

    27. Chembl1200665

    28. Dtxsid3047843

    29. Diphenoxylate For System Suitability

    30. Tox21_112593

    31. Tox21_112825

    32. Akos027382491

    33. Tox21_112593_1

    34. Ccg-101002

    35. Nc00252

    36. Diphenoxylate Hydrochloride [mi]

    37. Isonipecotic Acid, 1-(3-cyano-3,3-diphenylpropyl)-4-phenyl-, Ethyl Ester, Monohydrochloride

    38. Ncgc00167963-03

    39. Smr000469140

    40. Diphenoxylate Hydrochloride [mart.]

    41. Diphenoxylate Hydrochloride [vandf]

    42. Diphenoxylate Hydrochloride [usp-rs]

    43. Diphenoxylate Hydrochloride [who-dd]

    44. Diphenoxylate Hydrochloride [who-ip]

    45. D03860

    46. Diphenoxylate Hydrochloride [orange Book]

    47. Diphenoxylate Hydrochloride [ep Monograph]

    48. Diphenoxylate Hydrochloride [usp Monograph]

    49. Diphenoxylati Hydrochloridum [who-ip Latin]

    50. Logen Component Diphenoxylate Hydrochloride

    51. Lonox Component Diphenoxylate Hydrochloride

    52. Colonaid Component Diphenoxylate Hydrochloride

    53. Di-atro Component Diphenoxylate Hydrochloride

    54. Lo-trol Component Diphenoxylate Hydrochloride

    55. Lomanate Component Diphenoxylate Hydrochloride

    56. Lomotil Component Diphenoxylate Hydrochloride

    57. Q-201004

    58. Diphenoxylate Hydrochloride Component Of Logen

    59. Diphenoxylate Hydrochloride Component Of Lomotil

    60. Diphenoxylate Hydrochloride Component Of Lonox

    61. Low-quel Component Diphenoxylate Hydrochloride

    62. Q27126896

    63. Diphenoxylate Hydrochloride Component Of Colonaid

    64. Diphenoxylate Hydrochloride Component Of Di-atro

    65. Diphenoxylate Hydrochloride Component Of Lo-trol

    66. Diphenoxylate Hydrochloride Component Of Lomanate

    67. Diphenoxylate Hydrochloride Component Of Low-quel

    68. 4-ethoxycarbonyl-alpha,alpha,4-triphenyl-1-piperidinebutyronitrile, Hydrochloride

    69. Isonipecotic Acid, 1-(3-cyano-3,3-diphenylpropyl)-4-phenyl-, Ethyl Ester, Hydrochloride

    70. Diphenoxylate Hydrochloride Solution, 1.0 Mg/ml In Acetonitrile (as Free Base), Ampule Of 1 Ml, Certified Reference Material

    2.4 Create Date
    2006-04-28
    3 Chemical and Physical Properties
    Molecular Weight 489.0 g/mol
    Molecular Formula C30H33ClN2O2
    Hydrogen Bond Donor Count1
    Hydrogen Bond Acceptor Count4
    Rotatable Bond Count9
    Exact Mass488.2230560 g/mol
    Monoisotopic Mass488.2230560 g/mol
    Topological Polar Surface Area53.3 Ų
    Heavy Atom Count35
    Formal Charge0
    Complexity666
    Isotope Atom Count0
    Defined Atom Stereocenter Count0
    Undefined Atom Stereocenter Count0
    Defined Bond Stereocenter Count0
    Undefined Bond Stereocenter Count0
    Covalently Bonded Unit Count2
    4 Pharmacology and Biochemistry
    4.1 MeSH Pharmacological Classification

    Antidiarrheals

    Miscellaneous agents found useful in the symptomatic treatment of diarrhea. They have no effect on the agent(s) that cause diarrhea, but merely alleviate the condition. (See all compounds classified as Antidiarrheals.)

    Analgesics, Opioid

    Compounds with activity like OPIATE ALKALOIDS, acting at OPIOID RECEPTORS. Properties include induction of ANALGESIA or NARCOSIS. (See all compounds classified as Analgesics, Opioid.)

    API Reference Price

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    29-Apr-2021
    07-Nov-2024
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    ABOUT THIS PAGE

    Diphenoxylate Hydrochloride Manufacturers

    A Diphenoxylate Hydrochloride manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Diphenoxylate Hydrochloride, including repackagers and relabelers. The FDA regulates Diphenoxylate Hydrochloride manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Diphenoxylate Hydrochloride API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

    click here to find a list of Diphenoxylate Hydrochloride manufacturers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PhamaCompass.

    Diphenoxylate Hydrochloride Suppliers

    A Diphenoxylate Hydrochloride supplier is an individual or a company that provides Diphenoxylate Hydrochloride active pharmaceutical ingredient (API) or Diphenoxylate Hydrochloride finished formulations upon request. The Diphenoxylate Hydrochloride suppliers may include Diphenoxylate Hydrochloride API manufacturers, exporters, distributors and traders.

    click here to find a list of Diphenoxylate Hydrochloride suppliers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PharmaCompass.

    Diphenoxylate Hydrochloride USDMF

    A Diphenoxylate Hydrochloride DMF (Drug Master File) is a document detailing the whole manufacturing process of Diphenoxylate Hydrochloride active pharmaceutical ingredient (API) in detail. Different forms of Diphenoxylate Hydrochloride DMFs exist exist since differing nations have different regulations, such as Diphenoxylate Hydrochloride USDMF, ASMF (EDMF), JDMF, CDMF, etc.

    A Diphenoxylate Hydrochloride DMF submitted to regulatory agencies in the US is known as a USDMF. Diphenoxylate Hydrochloride USDMF includes data on Diphenoxylate Hydrochloride's chemical properties, information on the facilities and procedures used, and details about packaging and storage. The Diphenoxylate Hydrochloride USDMF is kept confidential to protect the manufacturer’s intellectual property.

    click here to find a list of Diphenoxylate Hydrochloride suppliers with USDMF on PharmaCompass.

    Diphenoxylate Hydrochloride CEP

    A Diphenoxylate Hydrochloride CEP of the European Pharmacopoeia monograph is often referred to as a Diphenoxylate Hydrochloride Certificate of Suitability (COS). The purpose of a Diphenoxylate Hydrochloride CEP is to show that the European Pharmacopoeia monograph adequately controls the purity of Diphenoxylate Hydrochloride EP produced by a given manufacturer. Suppliers of raw materials can prove the suitability of Diphenoxylate Hydrochloride to their clients by showing that a Diphenoxylate Hydrochloride CEP has been issued for it. The manufacturer submits a Diphenoxylate Hydrochloride CEP (COS) as part of the market authorization procedure, and it takes on the role of a Diphenoxylate Hydrochloride CEP holder for the record. Additionally, the data presented in the Diphenoxylate Hydrochloride CEP (COS) is managed confidentially and offers a centralized system acknowledged by numerous nations, exactly like the Diphenoxylate Hydrochloride DMF.

    A Diphenoxylate Hydrochloride CEP (COS) is recognised by all 36 nations that make up the European Pharmacopoeia Convention. Diphenoxylate Hydrochloride CEPs may be accepted in nations that are not members of the Ph. Eur. at the discretion of the authorities there.

    click here to find a list of Diphenoxylate Hydrochloride suppliers with CEP (COS) on PharmaCompass.

    Diphenoxylate Hydrochloride WC

    A Diphenoxylate Hydrochloride written confirmation (Diphenoxylate Hydrochloride WC) is an official document issued by a regulatory agency to a Diphenoxylate Hydrochloride manufacturer, verifying that the manufacturing facility of a Diphenoxylate Hydrochloride active pharmaceutical ingredient (API) adheres to the Good Manufacturing Practices (GMP) regulations of the importing country. When exporting Diphenoxylate Hydrochloride APIs or Diphenoxylate Hydrochloride finished pharmaceutical products to another nation, regulatory agencies frequently require a Diphenoxylate Hydrochloride WC (written confirmation) as part of the regulatory process.

    click here to find a list of Diphenoxylate Hydrochloride suppliers with Written Confirmation (WC) on PharmaCompass.

    Diphenoxylate Hydrochloride NDC

    National Drug Code is a comprehensive database maintained by the FDA that contains information on all drugs marketed in the US. This directory includes information about finished drug products, unfinished drug products, and compounded drug products, including those containing Diphenoxylate Hydrochloride as an active pharmaceutical ingredient (API).

    Finished drug products

    The FDA updates the NDC directory daily. The NDC numbers for Diphenoxylate Hydrochloride API and other APIs are published in this directory by the FDA.

    Unfinished drugs

    The NDC unfinished drugs database includes product listing information submitted for all unfinished drugs, such as active pharmaceutical ingredients (APIs), drugs intended for further processing and bulk drug substances for compounding.

    Pharmaceutical companies that manufacture Diphenoxylate Hydrochloride as an active pharmaceutical ingredient (API) must furnish the FDA with an updated record of all drugs that they produce, prepare, propagate, compound, or process for commercial distribution in the US at their facilities.

    Compounded drug products

    The NDC directory also contains data on finished compounded human drug products that contain Diphenoxylate Hydrochloride and are produced by outsourcing facilities. While these outsourcing facilities are not mandated to assign a Diphenoxylate Hydrochloride NDC to their finished compounded human drug products, they may choose to do so.

    click here to find a list of Diphenoxylate Hydrochloride suppliers with NDC on PharmaCompass.

    Diphenoxylate Hydrochloride GMP

    Diphenoxylate Hydrochloride Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

    GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

    PharmaCompass offers a list of Diphenoxylate Hydrochloride GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Diphenoxylate Hydrochloride GMP manufacturer or Diphenoxylate Hydrochloride GMP API supplier for your needs.

    Diphenoxylate Hydrochloride CoA

    A Diphenoxylate Hydrochloride CoA (Certificate of Analysis) is a formal document that attests to Diphenoxylate Hydrochloride's compliance with Diphenoxylate Hydrochloride specifications and serves as a tool for batch-level quality control.

    Diphenoxylate Hydrochloride CoA mostly includes findings from lab analyses of a specific batch. For each Diphenoxylate Hydrochloride CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

    Diphenoxylate Hydrochloride may be tested according to a variety of international standards, such as European Pharmacopoeia (Diphenoxylate Hydrochloride EP), Diphenoxylate Hydrochloride JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Diphenoxylate Hydrochloride USP).

    Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
    For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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