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Chemistry

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Also known as: 8v3fgc4j77, Technetium tc-99m medronate anhydrous, Tc-99m-diphosphonate, Technetium diphosphonate, Tc-mdp, Tc-mdp tc-99m
Molecular Formula
CH2O6P2Tc
Molecular Weight
270.88  g/mol
InChI Key
DDVFLVSIVNKSLB-IEOVAKBOSA-J
FDA UNII
8V3FGC4J77

Diphosphonate, Technetium Methylene
Technetium Tc-99m Medronate is a radiopharmaceutical containing methylene diphosphonate (medronate; MDP) complexed with the gamma-emitting radionuclide technetium Tc 99m with radioisotopic activity and hydroxyapatite affinity. Upon intravenous administration, skeletal uptake of technetium Tc 99m methylene diphosphonate occurs as a function of skeletal blood flow and osteogenic activity. The MDP moiety of this agent has affinity for hydroxyapatite crystals in bone with abnormal accumulation at sites with increased osteoid mineralization; labeling of MDP with Tc 99m allows scintigraphic imaging of areas of abnormal osteogenesis associated with malignant bone lesions.
1 2D Structure

Diphosphonate, Technetium Methylene

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
dioxido-oxo-(phosphonatomethyl)-5-phosphane;technetium-99(4+)
2.1.2 InChI
InChI=1S/CH6O6P2.Tc/c2-8(3,4)1-9(5,6)7;/h1H2,(H2,2,3,4)(H2,5,6,7);/q;+4/p-4/i;1+1
2.1.3 InChI Key
DDVFLVSIVNKSLB-IEOVAKBOSA-J
2.1.4 Canonical SMILES
C(P(=O)([O-])[O-])P(=O)([O-])[O-].[Tc+4]
2.1.5 Isomeric SMILES
C(P(=O)([O-])[O-])P(=O)([O-])[O-].[99Tc+4]
2.2 Other Identifiers
2.2.1 UNII
8V3FGC4J77
2.3 Synonyms
2.3.1 MeSH Synonyms

1. Tc-99m-diphosphonate

2. Technetium Diphosphonate

3. Technetium Tc 99m Diphosphonate

2.3.2 Depositor-Supplied Synonyms

1. 8v3fgc4j77

2. Technetium Tc-99m Medronate Anhydrous

3. Tc-99m-diphosphonate

4. Technetium Diphosphonate

5. Tc-mdp

6. Tc-mdp Tc-99m

7. Technetium Tc 99m Diphosphonate

8. Technetium Tc-99m Diphosphonate

9. Diphosphonic Acid, Technetium-99tc Salt

10. Q27271059

11. Dioxido-oxo-(phosphonatomethyl)-lambda5-phosphane;technetium-99(4+)

12. Phosphonic Acid, Methylenebis-, Technetium(4+) Salt (1:1)

13. Phosphonic Acid, Methylenebis-, Technetium(4+)-99tc Salt (1:1)

2.4 Create Date
2006-10-25
3 Chemical and Physical Properties
Molecular Weight 270.88 g/mol
Molecular Formula CH2O6P2Tc
Hydrogen Bond Donor Count0
Hydrogen Bond Acceptor Count6
Rotatable Bond Count0
Exact Mass270.838911 g/mol
Monoisotopic Mass270.838911 g/mol
Topological Polar Surface Area126 Ų
Heavy Atom Count10
Formal Charge0
Complexity129
Isotope Atom Count1
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count2
4 Pharmacology and Biochemistry
4.1 MeSH Pharmacological Classification

Radiopharmaceuticals

Compounds that are used in medicine as sources of radiation for radiotherapy and for diagnostic purposes. They have numerous uses in research and industry. (Martindale, The Extra Pharmacopoeia, 30th ed, p1161) (See all compounds classified as Radiopharmaceuticals.)


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Looking for 101488-09-9 / Diphosphonate, Technetium Methylene API manufacturers, exporters & distributors?

Diphosphonate, Technetium Methylene manufacturers, exporters & distributors 1

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PharmaCompass offers a list of Diphosphonate, Technetium Methylene API manufacturers, exporters & distributors, which can be sorted by GMP, USDMF, JDMF, KDMF, CEP (COS), WC, Price,and more, enabling you to easily find the right Diphosphonate, Technetium Methylene manufacturer or Diphosphonate, Technetium Methylene supplier for your needs.

Send us enquiries for free, and we will assist you in establishing a direct connection with your preferred Diphosphonate, Technetium Methylene manufacturer or Diphosphonate, Technetium Methylene supplier.

PharmaCompass also assists you with knowing the Diphosphonate, Technetium Methylene API Price utilized in the formulation of products. Diphosphonate, Technetium Methylene API Price is not always fixed or binding as the Diphosphonate, Technetium Methylene Price is obtained through a variety of data sources. The Diphosphonate, Technetium Methylene Price can also vary due to multiple factors, including market conditions, regulatory modifications, or negotiated pricing deals.

API | Excipient name

Diphosphonate, Technetium Methylene

Synonyms

8v3fgc4j77, Technetium tc-99m medronate anhydrous, Tc-99m-diphosphonate, Technetium diphosphonate, Tc-mdp, Tc-mdp tc-99m

Cas Number

101488-09-9

Unique Ingredient Identifier (UNII)

8V3FGC4J77

About Diphosphonate, Technetium Methylene

Technetium Tc-99m Medronate is a radiopharmaceutical containing methylene diphosphonate (medronate; MDP) complexed with the gamma-emitting radionuclide technetium Tc 99m with radioisotopic activity and hydroxyapatite affinity. Upon intravenous administration, skeletal uptake of technetium Tc 99m methylene diphosphonate occurs as a function of skeletal blood flow and osteogenic activity. The MDP moiety of this agent has affinity for hydroxyapatite crystals in bone with abnormal accumulation at sites with increased osteoid mineralization; labeling of MDP with Tc 99m allows scintigraphic imaging of areas of abnormal osteogenesis associated with malignant bone lesions.

Diphosphonate, Technetium Methylene Manufacturers

A Diphosphonate, Technetium Methylene manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Diphosphonate, Technetium Methylene, including repackagers and relabelers. The FDA regulates Diphosphonate, Technetium Methylene manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Diphosphonate, Technetium Methylene API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

Diphosphonate, Technetium Methylene Suppliers

A Diphosphonate, Technetium Methylene supplier is an individual or a company that provides Diphosphonate, Technetium Methylene active pharmaceutical ingredient (API) or Diphosphonate, Technetium Methylene finished formulations upon request. The Diphosphonate, Technetium Methylene suppliers may include Diphosphonate, Technetium Methylene API manufacturers, exporters, distributors and traders.

Diphosphonate, Technetium Methylene GMP

Diphosphonate, Technetium Methylene Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

PharmaCompass offers a list of Diphosphonate, Technetium Methylene GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Diphosphonate, Technetium Methylene GMP manufacturer or Diphosphonate, Technetium Methylene GMP API supplier for your needs.

Diphosphonate, Technetium Methylene CoA

A Diphosphonate, Technetium Methylene CoA (Certificate of Analysis) is a formal document that attests to Diphosphonate, Technetium Methylene's compliance with Diphosphonate, Technetium Methylene specifications and serves as a tool for batch-level quality control.

Diphosphonate, Technetium Methylene CoA mostly includes findings from lab analyses of a specific batch. For each Diphosphonate, Technetium Methylene CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

Diphosphonate, Technetium Methylene may be tested according to a variety of international standards, such as European Pharmacopoeia (Diphosphonate, Technetium Methylene EP), Diphosphonate, Technetium Methylene JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Diphosphonate, Technetium Methylene USP).

Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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