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Chemistry

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Also known as: 872363-17-2, Adx48621, Dipraglurant [inn], Adx-48621, Cv8jzr21a1, Chembl2346738
Molecular Formula
C16H12FN3
Molecular Weight
265.28  g/mol
InChI Key
LZXMUJCJAWVHPZ-UHFFFAOYSA-N
FDA UNII
CV8JZR21A1

Dipraglurant
Dipraglurant has been used in trials studying the treatment of Parkinson's Disease. It is a metabotropic glutamate receptor 5 (mGluR5) negative allosteric modulator (NAM).
1 2D Structure

Dipraglurant

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
6-fluoro-2-(4-pyridin-2-ylbut-3-ynyl)imidazo[1,2-a]pyridine
2.1.2 InChI
InChI=1S/C16H12FN3/c17-13-8-9-16-19-15(12-20(16)11-13)7-2-1-5-14-6-3-4-10-18-14/h3-4,6,8-12H,2,7H2
2.1.3 InChI Key
LZXMUJCJAWVHPZ-UHFFFAOYSA-N
2.1.4 Canonical SMILES
C1=CC=NC(=C1)C#CCCC2=CN3C=C(C=CC3=N2)F
2.2 Other Identifiers
2.2.1 UNII
CV8JZR21A1
2.3 Synonyms
2.3.1 MeSH Synonyms

1. 6-fluoro-2-(4-(pyridin-2-yl)but-3-yn-1-yl)imidazo(1,2-a)pyridine

2.3.2 Depositor-Supplied Synonyms

1. 872363-17-2

2. Adx48621

3. Dipraglurant [inn]

4. Adx-48621

5. Cv8jzr21a1

6. Chembl2346738

7. 6-fluoro-2-[4-(pyridin-2-yl)-3-butynyl]imidazo[1,2-a]pyridine

8. 6-fluoro-2-(4-(pyridin-2-yl)but-3-yn-1-yl)imidazo(1,2-a)pyridine

9. 6-fluoro-2-(4-pyridin-2-ylbut-3-ynyl)imidazo[1,2-a]pyridine

10. 6-fluoro-2-[4-(2-pyridinyl)-3-butyn-1-yl]imidazo[1,2-a]pyridine

11. Unii-cv8jzr21a1

12. 6-fluoro-2-(4-(pyridin-2-yl)but-3-yn-1-yl)imidazo[1,2-a]pyridine

13. Schembl103033

14. Gtpl6452

15. Dtxsid90236230

16. Bcp23706

17. 6-fluoro-2-[4-(2-pyridinyl)-3-butyn-1-yl]-imidazo[1,2-a]pyridine

18. Bdbm50431705

19. Zinc72266314

20. Cs-0690

21. Db12733

22. Sb16993

23. Ncgc00351745-02

24. Hy-14859

25. Db-076892

26. Ft-0705373

27. J3.560.334d

28. A916694

29. Adx 48621;adx48621;adx-48621

30. Q19596938

31. 2-(4-{6-fluoroimidazo[1,2-a]pyridin-2-yl}but-1-yn-1-yl)pyridine

2.4 Create Date
2010-01-25
3 Chemical and Physical Properties
Molecular Weight 265.28 g/mol
Molecular Formula C16H12FN3
XLogP33.5
Hydrogen Bond Donor Count0
Hydrogen Bond Acceptor Count3
Rotatable Bond Count3
Exact Mass265.10152556 g/mol
Monoisotopic Mass265.10152556 g/mol
Topological Polar Surface Area30.2 Ų
Heavy Atom Count20
Formal Charge0
Complexity386
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count1

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ABOUT THIS PAGE

Dipraglurant Manufacturers

A Dipraglurant manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Dipraglurant, including repackagers and relabelers. The FDA regulates Dipraglurant manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Dipraglurant API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

Dipraglurant Suppliers

A Dipraglurant supplier is an individual or a company that provides Dipraglurant active pharmaceutical ingredient (API) or Dipraglurant finished formulations upon request. The Dipraglurant suppliers may include Dipraglurant API manufacturers, exporters, distributors and traders.

Dipraglurant GMP

Dipraglurant Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

PharmaCompass offers a list of Dipraglurant GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Dipraglurant GMP manufacturer or Dipraglurant GMP API supplier for your needs.

Dipraglurant CoA

A Dipraglurant CoA (Certificate of Analysis) is a formal document that attests to Dipraglurant's compliance with Dipraglurant specifications and serves as a tool for batch-level quality control.

Dipraglurant CoA mostly includes findings from lab analyses of a specific batch. For each Dipraglurant CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

Dipraglurant may be tested according to a variety of international standards, such as European Pharmacopoeia (Dipraglurant EP), Dipraglurant JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Dipraglurant USP).

Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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