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Chemistry

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Also known as: 10040-45-6, Picosulfate sodium, Laxoberal, Laxoberon, Sodium picosulphate, Evacuol
Molecular Formula
C18H13NNa2O8S2
Molecular Weight
481.4  g/mol
InChI Key
GOZDTZWAMGHLDY-UHFFFAOYSA-L
FDA UNII
VW106606Y8

Sodium Picosulfate
1 2D Structure

Sodium Picosulfate

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
disodium;[4-[pyridin-2-yl-(4-sulfonatooxyphenyl)methyl]phenyl] sulfate
2.1.2 InChI
InChI=1S/C18H15NO8S2.2Na/c20-28(21,22)26-15-8-4-13(5-9-15)18(17-3-1-2-12-19-17)14-6-10-16(11-7-14)27-29(23,24)25;;/h1-12,18H,(H,20,21,22)(H,23,24,25);;/q;2*+1/p-2
2.1.3 InChI Key
GOZDTZWAMGHLDY-UHFFFAOYSA-L
2.1.4 Canonical SMILES
C1=CC=NC(=C1)C(C2=CC=C(C=C2)OS(=O)(=O)[O-])C3=CC=C(C=C3)OS(=O)(=O)[O-].[Na+].[Na+]
2.2 Other Identifiers
2.2.1 UNII
VW106606Y8
2.3 Synonyms
2.3.1 MeSH Synonyms

1. 4,4'-(2-picolylidene)bisphenylsulfuric Acid

2. 4,4'-(picoliliden)-bis-phenylsulphate

3. Laxoberal

4. Picolax

5. Picoprep

6. Picosulfate Sodium

7. Picosulfol

2.3.2 Depositor-Supplied Synonyms

1. 10040-45-6

2. Picosulfate Sodium

3. Laxoberal

4. Laxoberon

5. Sodium Picosulphate

6. Evacuol

7. Picolax

8. Neopax

9. Guttalax-fher

10. Pico-salax

11. Da-1773

12. 4,4'-(2-picolylidene)bis(phenylsulfuric Acid) Disodium Salt

13. La 391

14. Picosulfate Sodium Anhydrous

15. Sodium Picosulfate Anhydrous

16. Anhydrous Sodium Picosulfate

17. Da 1773

18. Sodium Picosulphate Anhydrous

19. Picosulfol

20. Guttalax

21. Rapilax

22. Chebi:32147

23. 4,4'-(2-pyridylmethylene)diphenol Bis(hydrogen Sulfate) Disodium Salt

24. Vw106606y8

25. Laxidogol

26. Evanol

27. Disodium;[4-[pyridin-2-yl-(4-sulfonatooxyphenyl)methyl]phenyl] Sulfate

28. Sodium Picosulfate 100 Microg/ml In Acetonitrile

29. Picosulfate Sodium Hydrate

30. Picoprep

31. Natrii Picosulfas

32. Sodium Picosulphate Monohydrate

33. Picosulfato Sodico

34. Disodium 4,4'-(2-pyridylmethylene)-di(phenyl Sulphate);disodium 4,4'-(2-pyridylmethylene)-di(phenyl Sulphate);sodium Picosulfate

35. Natrii Picosulfas [inn-latin]

36. Picosulfate De Sodium

37. La-391

38. Picosulfato Sodico [inn-spanish]

39. Ncgc00182711-01

40. Picosulfate De Sodium [inn-french]

41. Sodium Picosulfate [inn:ban:jan]

42. Einecs 233-120-9

43. 2-picolylidenebis(p-phenyl Sodium Sulfate)

44. Natriumpicosulfat

45. Unii-vw106606y8

46. Guttalax;laxoberon

47. Disodium 4,4'-disulfoxydiphenyl-(2-pyridyl)methane

48. Bisacodyl Impurity D

49. 4-methyl-2-pentenoicacid

50. 4,4'-(2-pyridylmethylene)diphenolbis(hydrogen Sulfate) (ester) Disodium Salt

51. 4,4'-(2-pyridinylmethylene)bisphenol Bis(hydrogen Sulfate) (ester) Disodium Salt

52. Dsstox_cid_28589

53. Dsstox_rid_82860

54. Dsstox_gsid_48663

55. Schembl346436

56. Picosulfate Sodium [mi]

57. Chembl1697768

58. Dtxsid7048663

59. Sodium Picosulfate [inn]

60. Picosulfate For System Suitability

61. Hms3652k17

62. Bcp11522

63. Tox21_113026

64. Mfcd00867640

65. S4020

66. 4,4'-(2-pyridinylmethylene)bisphenol 1,1'-bis(hydrogen Sulfate) Sodium Salt

67. Phenol, 4,4'-(2-pyridylmethylene)bis-, Bis(hydrogen Sulfate), Disodium Salt

68. Ccg-269559

69. Ac-31735

70. As-15785

71. Cas-10040-45-6

72. Ft-0673898

73. S0936

74. Sw219183-1

75. C71029

76. Q410265

77. Sodium (pyridin-2-ylmethylene)bis(4,1-phenylene) Bis(sulfate)

78. Sodium 4,4'-(pyridin-2-ylmethylene)bis(4,1-phenylene) Disulfate

79. 4,4'-(2-pyridylmethylene)diphenol Bis(hydrogen Sulphate) Disodium Salt

2.4 Create Date
2005-06-24
3 Chemical and Physical Properties
Molecular Weight 481.4 g/mol
Molecular Formula C18H13NNa2O8S2
Hydrogen Bond Donor Count0
Hydrogen Bond Acceptor Count9
Rotatable Bond Count5
Exact Mass480.98779728 g/mol
Monoisotopic Mass480.98779728 g/mol
Topological Polar Surface Area163 Ų
Heavy Atom Count31
Formal Charge0
Complexity633
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count3
4 Pharmacology and Biochemistry
4.1 MeSH Pharmacological Classification

Cathartics

Agents that are used to stimulate evacuation of the bowels. (See all compounds classified as Cathartics.)


4.2 ATC Code

A - Alimentary tract and metabolism

A06 - Drugs for constipation

A06A - Drugs for constipation

A06AB - Contact laxatives

A06AB08 - Sodium picosulfate


API SUPPLIERS

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LGM Pharma

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Nuray Chemicals Private Limited

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Jai Radhe Sales

India

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Kreative Organics

India

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Kreative Organics

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Cambrex Corporation

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Cambrex Corporation

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Dishman Carbogen Amcis

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Dishman Carbogen Amcis

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IWAKI SEIYAKU

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IWAKI SEIYAKU

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Bidachem

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Bidachem

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CARBOGEN AMCIS AG

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CARBOGEN AMCIS AG

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APEX HEALTHCARE LIMITED

India

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APEX HEALTHCARE LIMITED

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Listed Suppliers

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LGM Pharma

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Sodium Picosulfate

About the Company : LGM Pharma is a global leader in sourcing hard-to-find APIs and intermediates for the pharmaceutical and biotech industries. LGM is also a full service CDMO providing formulation, ...

LGM Pharma is a global leader in sourcing hard-to-find APIs and intermediates for the pharmaceutical and biotech industries. LGM is also a full service CDMO providing formulation, analytical method development and testing, and commercial manufacturing. LGM Pharma offers custom API synthesis, analytical development, and regulatory services. With a network of over 300 accredited CGMP manufacturing partners, LGM provides unparalleled supply chain security. And, with over 100,000 square feet of FDA-inspected cGMP manufacturing and warehouse capacity, LGM Pharma provides a one-stop solution for solid dose, powder, semi-solid and liquid drugs.
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02

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Virtual BoothNuray is an expert in the synthesis of Niche novel APIs, the first to launch Generics, NCEs, Advanced Intermediates // USFDA certified.

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Sodium Picosulfate

About the Company : Established in 2012, Nuray Chemicals Pvt Ltd is an API manufacturer for highly regulated markets. Its manufacturing facility with state-of-the-art R&D is located near Chennai in th...

Established in 2012, Nuray Chemicals Pvt Ltd is an API manufacturer for highly regulated markets. Its manufacturing facility with state-of-the-art R&D is located near Chennai in the Indian state of Tamil Nadu. Nuray’s expertise and experience lie in developing the chemistry requirements of the pharmaceutical industry, including the synthesis of NCEs, impurities, metabolites, method development, advanced intermediates and APIs for commercial launch. With its focus on maintaining the highest levels of quality, reliability and transparency, Nuray has emerged as a trusted partner in the global generic market.
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Virtual BoothJai Radhe Sales is your partner for all your sourcing needs.

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Sodium Picosulfate

About the Company : Jai Radhe Sales was founded in 1999 as an out-of-the-box distribution firm specializing in the global supply of high-quality pharmaceutical ingredients. The firm provides complete ...

Jai Radhe Sales was founded in 1999 as an out-of-the-box distribution firm specializing in the global supply of high-quality pharmaceutical ingredients. The firm provides complete sourcing solutions for pharmaceutical products from India, including technical and regulatory assistance. It believes in providing its customers with high-quality products at reasonable prices. It has always endeavored to achieve global standards in the field of pharmaceuticals and has carved out a niche for itself through new methods based on current market needs. Today, it has established itself as a truly global company, with exports to almost every continent.
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Sodium Picosulfate

About the Company : We have been supporting the pharmaceutical and biopharmaceutical industries with drug development for over 30 years, assisting our clients in developing and bringing new drugs to m...

We have been supporting the pharmaceutical and biopharmaceutical industries with drug development for over 30 years, assisting our clients in developing and bringing new drugs to market while improving the lives of their patients across the world. Our objective is to help our customers create a better world as the partner of choice to develop and manufacture complex and challenging substances, highly potent active ingredients, and breaking new ground with innovative vitamin, healthcare, and industrial products.
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Sodium Picosulfate

About the Company : Guangzhou Tosun Pharmaceutical was founded in 1999, which mainly focuses on importation & exportation of Active Pharmaceutical Ingrediants, Chemical Raw Materials, Intermediate, Ex...

Guangzhou Tosun Pharmaceutical was founded in 1999, which mainly focuses on importation & exportation of Active Pharmaceutical Ingrediants, Chemical Raw Materials, Intermediate, Excipients, Herbal extracts, Formulation of Chinese & Western Medicine. With abundant economic strength, the group has successfully developed to a pharmaceutical group enterprise wich intergrets operation of medicine & related products, processing & manufacturing, and importation & exportation together.
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JPN Pharma

India
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JPN Pharma

India
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Sodium Picosulfate

About the Company : We are a renowned pharma player having a wide range of quality products and specialise in manufacturing Active Pharmaceutical Ingredients (API) and Drug Intermediates (DI’s). The...

We are a renowned pharma player having a wide range of quality products and specialise in manufacturing Active Pharmaceutical Ingredients (API) and Drug Intermediates (DI’s). The company commenced its business in 1988 in Mumbai (India) Benchmarked to international standards and conscious about commitment, reliable quality and dependability, our facilities are approved by international regulatory such as WHO-GMP
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Picosulfate Sodium

About the Company : Indian Pharmaceutical Company, Precise Group is emerging as a global player in several verticals in healthcare. The Mumbai based drug manufacturing company’s strength lies in a s...

Indian Pharmaceutical Company, Precise Group is emerging as a global player in several verticals in healthcare. The Mumbai based drug manufacturing company’s strength lies in a strong network of industry professionals who care capable of handling the development of APIs, several Ready-to-fill Pellets and other intermediates, and chemicals. The company’s influence has a universal reach coordinating with multi-levels of global healthcare service providers for generic drugs. It holds a valued equity in niche pharma sectors in USA, Europe and Africa. Precise Group’s business encompasses the protection of the interest of their shareholders, is complaint with international regulatory bodies and meets the protocol favored in any region as a pharma suppler spanning developed and new markets. The technologically advanced manufacturing hub near Mumbai conducts manufacturing programs to sustain quality drugs at cost effect prices.
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Sodium Picosulfate

About the Company : Rakshit is an integrated API manufacturing company. Established in 2000. Today Rakshit has emerged a dependable and strong manufacturer of key APIs & intermediates for global marke...

Rakshit is an integrated API manufacturing company. Established in 2000. Today Rakshit has emerged a dependable and strong manufacturer of key APIs & intermediates for global markets. Focusing on its activities in R&D as well as building up newer facilities/ capacities to catch up with increasing demand year after year. Rakshit group has 4 cGMP compliance Manufacturing Facilities spread over Andhra Pradesh & Telangana states of India. Supplying its products to all over the globe from US, Europe, Japan, Asia & to Latin America. Rakshit facilities are approved by the regulatory authorities like, USFDA, Japan PMDA, Korea-MFDS, CDSCO-India.
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Sodium Picosulfate

About the Company : Shreepati Pharmaceuticals is an ISO-9001 : 2015 and GMP certified company. We are a leading manufacturer and exporter of raw materials for the pharmaceutical industry. Our range i...

Shreepati Pharmaceuticals is an ISO-9001 : 2015 and GMP certified company. We are a leading manufacturer and exporter of raw materials for the pharmaceutical industry. Our range includes Bisacodyl BP, Chlorzoxazone USP, Dicyclomine Hydrochloride IP/BP, Orinidazole, Sodium Picosulphate BP, 4[(3-Methyl Phenyl) amino] 3-Pyridine Sulfonamide (Torsamide Intermediate). Catering to the pharmaceutical industry, quality has been our prime concern ever since our inception. Maintaining international quality standards, we have developed a range of products that are highly efficient and cost-effective.
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Picosulfate Sodium

About the Company : Adapting quickly to the ever-evolving demands, we have emerged as one of the fastest growing organization in the pharmaceutical industry across the globe. With our headquarters loc...

Adapting quickly to the ever-evolving demands, we have emerged as one of the fastest growing organization in the pharmaceutical industry across the globe. With our headquarters located amidst the economic hub of India, Mumbai, we have established our offices in Kenya, Turkey & Vietnam. Further widening our reach overseas, we have made a joint venture with D.R. Congo based company.
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API Reference Price

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06-Jan-2021
28-Oct-2024
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DOSAGE - FOR SOLUTION;ORAL - 12GM/PACKET;3.5G...DOSAGE - FOR SOLUTION;ORAL - 12GM/PACKET;3.5GM/PACKET;10MG/PACKET **Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons**

USFDA APPLICATION NUMBER - 202535

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DOSAGE - SOLUTION;ORAL - 12GM/BOT;3.5GM/BOT;1...DOSAGE - SOLUTION;ORAL - 12GM/BOT;3.5GM/BOT;10MG/BOT

USFDA APPLICATION NUMBER - 209589

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