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CHEMISTRY
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ACTIVE PHARMA INGREDIENTS

23 API Suppliers, 3 USDMF, 3 CEP/COS, 4 JDMF, 4 EU WC, 4 NDC API, 19 Listed Suppliers, $ API Reference Price

23 API Suppliers
3 USDMF
3 CEP/COS
4 JDMF
4 EU WC
4 NDC API
19 Listed Suppliers
$ API Reference Price

DEVELOPMENTS

1 Drugs in Development

1 Drugs in Development

FINISHED DOSAGE FORMULATIONS

24 FDF Dossiers, 4 FDA Orange Book, 12 Europe, 3 Canada, 1 South Africa, 4 Listed Dossiers

24 FDF Dossiers
4 FDA Orange Book
12 Europe
3 Canada
1 South Africa
4 Listed Dossiers

DRUG PRODUCT COMPOSITIONS

FOR SOLUTION;ORAL - 12GM/PACKET;3.5GM/PACKET;10MG/PACKET **Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons**, SOLUTION;ORAL - 12GM/BOT;3.5GM/BOT;10MG/BOT

drugProductComposition
FOR SOLUTION;ORAL - 12GM/PACKET;3.5GM/PACKET;10MG/PACKET **Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons**
SOLUTION;ORAL - 12GM/BOT;3.5GM/BOT;10MG/BOT

RELATED EXCIPIENT COMPANIES

3 Rochem International Inc, 1 DKSH, 1 Pharm-RX Chemical, 2 Gangwal Healthcare, 1 Nanjing Well Pharmaceutical, 1 Actylis, 1 Bioplus Life Sciences, 1 Pluviaendo

relatedExcipients
3 Rochem International Inc
1 DKSH
1 Pharm-RX Chemical
2 Gangwal Healthcare
1 Nanjing Well Pharmaceutical
1 Actylis
1 Bioplus Life Sciences
1 Pluviaendo

EXCIPIENTS BY APPLICATIONS

6 Taste Masking, 1 Parenteral

excipientsByApplications
6 Taste Masking
1 Parenteral

DIGITAL CONTENT

7 NEWS #PharmaBuzz

media
7 NEWS #PharmaBuzz

GLOBAL SALES INFORMATION

4 Finished Drug Prices, 1 Annual Reports

globalSalesInformation
4 Finished Drug Prices
1 Annual Reports

MARKET PLACE

14 APIs

marketPlace
14 APIs

PATENTS & EXCLUSIVITIES

5 US Patents

patents
5 US Patents

REF. STANDARDS & IMPURITIES

2 EDQM , 2 USP , 2 Others

otherSolutions
2 EDQM
2 USP
2 Others

Synopsis

ACTIVE PHARMA INGREDIENTS

API Suppliers

USDMF

CEP/COS

JDMF

EU WC

KDMF

NDC API

Listed Suppliers

API REF. PRICE (USD/KG)

$ 407

MARKET PLACE

API

FDF

0INTERMEDIATES

FINISHED DOSAGE FORMULATIONS

FDF Dossiers

FDA Orange Book

Europe

Canada

Australia

South Africa

Listed Dossiers

1DRUGS IN DEVELOPMENT

DRUG PRODUCT COMPOSITIONS

REF. STANDARDS OR IMPURITIES

EDQM

USP

Others

PATENTS & EXCLUSIVITIES

US Patents

US Exclusivities

Health Canada Patents

DIGITAL CONTENT

Data Compilation #PharmaFlow

Stock Recap #PipelineProspector

Weekly News Recap #Phispers

News #PharmaBuzz

GLOBAL SALES INFORMATION

US Medicaid (USD)

Annual Reports (USD Million)

251

Finished Drug Prices

11 RELATED EXCIPIENT COMPANIES

7EXCIPIENTS BY APPLICATIONS

Chemistry

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Also known as: 10040-45-6, Picosulfate sodium, Laxoberal, Laxoberon, Sodium picosulphate, Evacuol

Molecular Formula

C₁₈H₁₃NNa₂O₈S₂

Molecular Weight

481.4 g/mol

InChI Key

GOZDTZWAMGHLDY-UHFFFAOYSA-L

FDA UNII

VW106606Y8

1 2D Structure

Sodium Picosulfate

2 Identification

2.1 Computed Descriptors

2.1.1 IUPAC Name

disodium;[4-[pyridin-2-yl-(4-sulfonatooxyphenyl)methyl]phenyl] sulfate

2.1.2 InChI

InChI=1S/C18H15NO8S2.2Na/c20-28(21,22)26-15-8-4-13(5-9-15)18(17-3-1-2-12-19-17)14-6-10-16(11-7-14)27-29(23,24)25;;/h1-12,18H,(H,20,21,22)(H,23,24,25);;/q;2*+1/p-2

2.1.3 InChI Key

GOZDTZWAMGHLDY-UHFFFAOYSA-L

2.1.4 Canonical SMILES

C1=CC=NC(=C1)C(C2=CC=C(C=C2)OS(=O)(=O)[O-])C3=CC=C(C=C3)OS(=O)(=O)[O-].[Na+].[Na+]

2.2 Other Identifiers

2.2.1 UNII

VW106606Y8

2.3 Synonyms

2.3.1 MeSH Synonyms

1. 4,4'-(2-picolylidene)bisphenylsulfuric Acid

2. 4,4'-(picoliliden)-bis-phenylsulphate

3. Laxoberal

4. Picolax

5. Picoprep

6. Picosulfate Sodium

7. Picosulfol

2.3.2 Depositor-Supplied Synonyms

1. 10040-45-6

2. Picosulfate Sodium

3. Laxoberal

4. Laxoberon

5. Sodium Picosulphate

6. Evacuol

7. Picolax

8. Neopax

9. Guttalax-fher

10. Pico-salax

11. Da-1773

12. 4,4'-(2-picolylidene)bis(phenylsulfuric Acid) Disodium Salt

13. La 391

14. Picosulfate Sodium Anhydrous

15. Sodium Picosulfate Anhydrous

16. Anhydrous Sodium Picosulfate

17. Da 1773

18. Sodium Picosulphate Anhydrous

19. Picosulfol

20. Guttalax

21. Rapilax

22. Chebi:32147

23. 4,4'-(2-pyridylmethylene)diphenol Bis(hydrogen Sulfate) Disodium Salt

24. Vw106606y8

25. Laxidogol

26. Evanol

27. Disodium;[4-[pyridin-2-yl-(4-sulfonatooxyphenyl)methyl]phenyl] Sulfate

28. Sodium Picosulfate 100 Microg/ml In Acetonitrile

29. Picosulfate Sodium Hydrate

30. Picoprep

31. Natrii Picosulfas

32. Sodium Picosulphate Monohydrate

33. Picosulfato Sodico

34. Disodium 4,4'-(2-pyridylmethylene)-di(phenyl Sulphate);disodium 4,4'-(2-pyridylmethylene)-di(phenyl Sulphate);sodium Picosulfate

35. Natrii Picosulfas [inn-latin]

36. Picosulfate De Sodium

37. La-391

38. Picosulfato Sodico [inn-spanish]

39. Ncgc00182711-01

40. Picosulfate De Sodium [inn-french]

41. Sodium Picosulfate [inn:ban:jan]

42. Einecs 233-120-9

43. 2-picolylidenebis(p-phenyl Sodium Sulfate)

44. Natriumpicosulfat

45. Unii-vw106606y8

46. Guttalax;laxoberon

47. Disodium 4,4'-disulfoxydiphenyl-(2-pyridyl)methane

48. Bisacodyl Impurity D

49. 4-methyl-2-pentenoicacid

50. 4,4'-(2-pyridylmethylene)diphenolbis(hydrogen Sulfate) (ester) Disodium Salt

51. 4,4'-(2-pyridinylmethylene)bisphenol Bis(hydrogen Sulfate) (ester) Disodium Salt

52. Dsstox_cid_28589

53. Dsstox_rid_82860

54. Dsstox_gsid_48663

55. Schembl346436

56. Picosulfate Sodium [mi]

57. Chembl1697768

58. Dtxsid7048663

59. Sodium Picosulfate [inn]

60. Picosulfate For System Suitability

61. Hms3652k17

62. Bcp11522

63. Tox21_113026

64. Mfcd00867640

65. S4020

66. 4,4'-(2-pyridinylmethylene)bisphenol 1,1'-bis(hydrogen Sulfate) Sodium Salt

67. Phenol, 4,4'-(2-pyridylmethylene)bis-, Bis(hydrogen Sulfate), Disodium Salt

68. Ccg-269559

69. Ac-31735

70. As-15785

71. Cas-10040-45-6

72. Ft-0673898

73. S0936

74. Sw219183-1

75. C71029

76. Q410265

77. Sodium (pyridin-2-ylmethylene)bis(4,1-phenylene) Bis(sulfate)

78. Sodium 4,4'-(pyridin-2-ylmethylene)bis(4,1-phenylene) Disulfate

79. 4,4'-(2-pyridylmethylene)diphenol Bis(hydrogen Sulphate) Disodium Salt

2.4 Create Date

2005-06-24

3 Chemical and Physical Properties

Molecular Formula	C₁₈H₁₃NNa₂O₈S₂
Molecular Weight	481.4 g/mol
Hydrogen Bond Donor Count	0
Hydrogen Bond Acceptor Count	9
Rotatable Bond Count	5
Exact Mass	480.98779728 g/mol
Monoisotopic Mass	480.98779728 g/mol
Topological Polar Surface Area	163 Å²
Heavy Atom Count	31
Formal Charge	0
Complexity	633
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently Bonded Unit Count	3

4 Pharmacology and Biochemistry

4.1 MeSH Pharmacological Classification

Cathartics

Agents that are used to stimulate evacuation of the bowels. (See all compounds classified as Cathartics.)

4.2 ATC Code

A - Alimentary tract and metabolism

A06 - Drugs for constipation

A06A - Drugs for constipation

A06AB - Contact laxatives

A06AB08 - Sodium picosulfate

API SUPPLIERS

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USDMF

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CEP/COS

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JDMF

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EU WC

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NDC API

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Listed Suppliers

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API Reference Price

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Total Value (USD)

Quantity (KGS) & Unit rate (USD/KGS) over time

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Importing Country	Total Quantity (KGS)	Average Price (USD/KGS)	Number of Transactions

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DOSAGE - FOR SOLUTION;ORAL - 12GM/PACKET;3.5G...DOSAGE - FOR SOLUTION;ORAL - 12GM/PACKET;3.5GM/PACKET;10MG/PACKET **Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons**

USFDA APPLICATION NUMBER - 202535

DOSAGE - SOLUTION;ORAL - 12GM/BOT;3.5GM/BOT;1...DOSAGE - SOLUTION;ORAL - 12GM/BOT;3.5GM/BOT;10MG/BOT

USFDA APPLICATION NUMBER - 209589

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Disodium;[4-[pyridin-2-yl-(4-sulfonatooxyphenyl)methyl]phenyl] Sulfate

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4 Listed Dossiers

DRUG PRODUCT COMPOSITIONS

FOR SOLUTION;ORAL - 12GM/PACKET;3.5GM/PACKET;10MG/PACKET **Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons**

SOLUTION;ORAL - 12GM/BOT;3.5GM/BOT;10MG/BOT

RELATED EXCIPIENT COMPANIES

3 Rochem International Inc

1 DKSH

1 Pharm-RX Chemical

2 Gangwal Healthcare

1 Nanjing Well Pharmaceutical

1 Actylis

1 Bioplus Life Sciences

1 Pluviaendo

EXCIPIENTS BY APPLICATIONS

6 Taste Masking

1 Parenteral

DIGITAL CONTENT

7 NEWS #PharmaBuzz

GLOBAL SALES INFORMATION

4 Finished Drug Prices

1 Annual Reports

MARKET PLACE

14 APIs

PATENTS & EXCLUSIVITIES

5 US Patents

REF. STANDARDS & IMPURITIES

2 EDQM

2 USP

2 Others

ACTIVE PHARMA INGREDIENTS

API REF. PRICE (USD/KG)

$ 407

MARKET PLACE

0INTERMEDIATES

FINISHED DOSAGE FORMULATIONS

1DRUGS IN DEVELOPMENT

DRUG PRODUCT COMPOSITIONS

REF. STANDARDS OR IMPURITIES

PATENTS & EXCLUSIVITIES

DIGITAL CONTENT

GLOBAL SALES INFORMATION

11 RELATED EXCIPIENT COMPANIES

7EXCIPIENTS BY APPLICATIONS

Average Price (USD/KGS)

Number of Transactions

Total Quantity (KGS)

Total Value (USD)

Quantity (KGS) & Unit rate (USD/KGS) over time

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FOR SOLUTION;ORAL - 12GM/PACKET;3.5GM/PACKET;10MG/PACKET Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons