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Disodium Pamidronate

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ACTIVE PHARMA INGREDIENTS

19 API Suppliers, 9 USDMF, 2 CEP/COS, 1 JDMF, 1 EU WC, 4 NDC API, 11 Listed Suppliers

19 API Suppliers
9 USDMF
2 CEP/COS
1 JDMF
1 EU WC
4 NDC API
11 Listed Suppliers

FINISHED DOSAGE FORMULATIONS

101 FDF Dossiers, 37 FDA Orange Book, 22 Europe, 10 Canada, 11 Australia, 1 South Africa, 20 Listed Dossiers

101 FDF Dossiers
37 FDA Orange Book
22 Europe
10 Canada
11 Australia
1 South Africa
20 Listed Dossiers

RELATED EXCIPIENT COMPANIES

1 Rochem International Inc, 12 SPI Pharma, 1 Faran Shimi Pharmaceutical, 1 Pfanstiehl, 1 BASF, 2 Gangwal Chemicals, 1 Ingredion Pharma Solutions, 2 Kerry, 2 Microlex e.U, 1 Pluviaendo, 3 Roquette, 1 Shanghai Shenmei Pharmaceutical Technology Co., Ltd, 1 Shijiazhuang Huaxu Pharmaceutical, 1 Sigachi Industries

relatedExcipients
1 Rochem International Inc
12 SPI Pharma
1 Faran Shimi Pharmaceutical
1 Pfanstiehl
1 BASF
2 Gangwal Chemicals
1 Ingredion Pharma Solutions
2 Kerry
2 Microlex e.U
1 Pluviaendo
3 Roquette
1 Shanghai Shenmei Pharmaceutical Technology Co., Ltd
1 Shijiazhuang Huaxu Pharmaceutical
1 Sigachi Industries

EXCIPIENTS BY APPLICATIONS

17 Fillers, Diluents & Binders, 10 Chewable & Orodispersible Aids, 9 Taste Masking, 9 Direct Compression, 4 Co-Processed Excipients, 4 Parenteral, 3 Granulation, 3 Disintegrants & Superdisintegrants, 1 API Stability Enhancers, 1 Thickeners and Stabilizers

excipientsByApplications
17 Fillers, Diluents & Binders
10 Chewable & Orodispersible Aids
9 Taste Masking
9 Direct Compression
4 Co-Processed Excipients
4 Parenteral
3 Granulation
3 Disintegrants & Superdisintegrants
1 API Stability Enhancers
1 Thickeners and Stabilizers

DIGITAL CONTENT

1 DATA COMPILATION #PharmaFlow, 1 NEWS #PharmaBuzz

media
1 DATA COMPILATION #PharmaFlow
1 NEWS #PharmaBuzz

GLOBAL SALES INFORMATION

1 US Medicaid Prescriptions, 17 Finished Drug Prices

globalSalesInformation
1 US Medicaid Prescriptions
17 Finished Drug Prices

MARKET PLACE

3 APIs, 1 FDF Dossiers

marketPlace
3 APIs
1 FDF Dossiers

PATENTS & EXCLUSIVITIES

3 Health Canada Patents

patents
3 Health Canada Patents

REF. STANDARDS & IMPURITIES

1 EDQM , 1 USP , 1 Others

otherSolutions
1 EDQM
1 USP
1 Others

Pamidronate

Synopsis

ACTIVE PHARMA INGREDIENTS

API Suppliers

USDMF

CEP/COS

JDMF

EU WC

KDMF

NDC API

VMF

Listed Suppliers

API REF. PRICE (USD/KG)

$ 105,599

MARKET PLACE

API

FDF

0INTERMEDIATES

FINISHED DOSAGE FORMULATIONS

101

FDF Dossiers

FDA Orange Book

Europe

Canada

Australia

South Africa

Listed Dossiers

0 DRUGS IN DEVELOPMENT

DRUG PRODUCT COMPOSITIONS

REF. STANDARDS OR IMPURITIES

EDQM

USP

Others

PATENTS & EXCLUSIVITIES

US Patents

US Exclusivities

Health Canada Patents

DIGITAL CONTENT

Data Compilation #PharmaFlow

Stock Recap #PipelineProspector

Weekly News Recap #Phispers

News #PharmaBuzz

GLOBAL SALES INFORMATION

US Medicaid (USD)

30,879

Annual Reports (USD Million)

Finished Drug Prices

30 RELATED EXCIPIENT COMPANIES

61EXCIPIENTS BY APPLICATIONS

Chemistry

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Also known as: 57248-88-1, Aredia, Aminomux, Disodium pamidronate, Pamidronate disodium salt, Pamidronic acid disodium salt

Molecular Formula

C₃H₉NNa₂O₇P₂

Molecular Weight

279.03 g/mol

InChI Key

CEYUIFJWVHOCPP-UHFFFAOYSA-L

FDA UNII

C7S8VWP5DH

An aminobisphosphonate that inhibits BONE RESORPTION and is used for the treatment of osteolytic lesions, bone pain, and severe HYPERCALCEMIA associated with malignancies.

1 2D Structure

Disodium Pamidronate Pentahydrate

2 Identification

2.1 Computed Descriptors

2.1.1 IUPAC Name

disodium;[3-amino-1-hydroxy-1-[hydroxy(oxido)phosphoryl]propyl]-hydroxyphosphinate

2.1.2 InChI

InChI=1S/C3H11NO7P2.2Na/c4-2-1-3(5,12(6,7)8)13(9,10)11;;/h5H,1-2,4H2,(H2,6,7,8)(H2,9,10,11);;/q;2*+1/p-2

2.1.3 InChI Key

CEYUIFJWVHOCPP-UHFFFAOYSA-L

2.1.4 Canonical SMILES

C(CN)C(O)(P(=O)(O)[O-])P(=O)(O)[O-].[Na+].[Na+]

2.2 Other Identifiers

2.2.1 UNII

C7S8VWP5DH

2.3 Synonyms

2.3.1 MeSH Synonyms

1. (3-amino-1-hydroxypropylidene)-1,1-biphosphonate

2. 1 Hydroxy 3 Aminopropane 1,1 Diphosphonic Acid

3. 1-hydroxy-3-aminopropane-1,1-diphosphonic Acid

4. Ahprbp

5. Amidronate

6. Amino 1 Hydroxypropane 1,1 Diphosphonate

7. Amino-1-hydroxypropane-1,1-diphosphonate

8. Aminohydroxypropylidene Diphosphonate

9. Aminopropanehydroxydiphosphonate

10. Aredia

11. Pamidronate

12. Pamidronate Calcium

13. Pamidronate Monosodium

14. Pamidronic Acid

2.3.2 Depositor-Supplied Synonyms

1. 57248-88-1

2. Aredia

3. Aminomux

4. Disodium Pamidronate

5. Pamidronate Disodium Salt

6. Pamidronic Acid Disodium Salt

7. Cgp 23339a

8. Pamidronate Disodium Anhydrous

9. Pamidronate Disodium Monohydrate

10. Pamidronate (disodium)

11. C7s8vwp5dh

12. Disodium 3-amino-1-hydroxypropane-1,1-diphosphonate

13. Cgp-23339ae

14. Disodium Pamidronate Hydrate

15. Phosphonic Acid, (3-amino-1-hydroxypropylidene)bis-, Disodium Salt

16. Pamidronate (disodium Pentahydrate)

17. Pamedronate Disodium Salt

18. Pamidronatedisodium

19. Pamidronic Acid Sodium Salt

20. Pamindronate Disodium

21. Nsc-722600

22. Cgp 23339 A

23. Einecs 260-647-1

24. Unii-c7s8vwp5dh

25. Sodium 3-amino-1-hydroxypropane-1,1-diylbis(hydrogenphosphonate)

26. Pamidronate Sodium

27. Ahprbp

28. Aminohydroxypropylidene Diphosphonate Disodium Salt

29. (3-amino-1-hydroxypropylidene)diphosphonic Acid Disodium Salt

30. Disodium Dihydrogen (3-amino-1-hydroxypropylidene)bisphosphonate

31. Pamidronate (sodium Salt)

32. Chembl676

33. Schembl18751

34. Dtxsid5042667

35. Pamidronate Disodium Salt Hydrate

36. 3-amino-1-hydroxypropane-1,1-diphosphonic Acid Disodium Salt

37. Cgp-23339a

38. Gcp-23339a

39. Bcp22745

40. Anhydrous Pamidronate Disodium

41. Mfcd00867072

42. S1311

43. Akos015905512

44. Akos025401590

45. Ccg-267232

46. Ig-7913

47. Nsc 722600

48. Cgp 23339a Pound>>gcp23339a

49. Ac-22572

50. Ac-22753

51. Bp164229

52. Pamidronic Acid Disodium Salt [mi]

53. Db-053025

54. Pamidronic Acid Sodium Salt Hydrate- Bio-x

55. D3921

56. Ft-0630698

57. H11402

58. W-105479

59. Q27275302

60. (3-amino-1-hydroxypropylidene)bisphosphonic Acid Disodium

61. Disodium (3-amino-1-hydroxypropane-1,1-diyl)bis[hydrogen (phosphonate)]

62. Disodium Dihydrogen (3-amino-1-hydroxypropylidene)diphosphonate

63. Disodium;[3-amino-1-hydroxy-1-[hydroxy(oxido)phosphoryl]propyl]-hydroxyphosphinate

2.4 Create Date

2005-08-08

3 Chemical and Physical Properties

Molecular Formula	C₃H₉NNa₂O₇P₂
Molecular Weight	279.03 g/mol
Hydrogen Bond Donor Count	4
Hydrogen Bond Acceptor Count	8
Rotatable Bond Count	4
Exact Mass	278.96496419 g/mol
Monoisotopic Mass	278.96496419 g/mol
Topological Polar Surface Area	167 Å²
Heavy Atom Count	15
Formal Charge	0
Complexity	238
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently Bonded Unit Count	3

4 Drug and Medication Information

4.1 Drug Information

1 of 4
Drug Name	Aredia
Active Ingredient	Pamidronate disodium
Dosage Form	Injectable
Route	injection; Injection
Strength	30mg/vial; 60mg/vial; 90mg/vial
Market Status	Prescription
Company	Novartis

2 of 4
Drug Name	Pamidronate disodium
PubMed Health	Pamidronate (Injection)
Drug Classes	Calcium Regulator
Drug Label	Pamidronate Disodium is a sterile bone-resorption inhibitor available in 30 mg and 90 mg vials for intravenous administration. The pamidronate disodium obtained by combining pamidronic acid and sodium hydroxide is provided in a sterile, ready to use...
Active Ingredient	Pamidronate disodium
Dosage Form	Injectable
Route	Injection
Strength	90mg/vial; 30mg/10ml (3mg/ml); 60mg/10ml (6mg/ml); 30mg/vial; 60mg/vial; 90mg/10ml (9mg/ml)
Market Status	Prescription
Company	Pliva Lachema; Areva Pharms; Hospira; Teva Pharms Usa; Sun Pharma Global; Fresenius Kabi Usa; Luitpold; Mustafa Nevzat; Eurohlth Intl; Agila Speclts

3 of 4
Drug Name	Aredia
Active Ingredient	Pamidronate disodium
Dosage Form	Injectable
Route	injection; Injection
Strength	30mg/vial; 60mg/vial; 90mg/vial
Market Status	Prescription
Company	Novartis

4 of 4
Drug Name	Pamidronate disodium
PubMed Health	Pamidronate (Injection)
Drug Classes	Calcium Regulator
Drug Label	Pamidronate Disodium is a sterile bone-resorption inhibitor available in 30 mg and 90 mg vials for intravenous administration. The pamidronate disodium obtained by combining pamidronic acid and sodium hydroxide is provided in a sterile, ready to use...
Active Ingredient	Pamidronate disodium
Dosage Form	Injectable
Route	Injection
Strength	90mg/vial; 30mg/10ml (3mg/ml); 60mg/10ml (6mg/ml); 30mg/vial; 60mg/vial; 90mg/10ml (9mg/ml)
Market Status	Prescription
Company	Pliva Lachema; Areva Pharms; Hospira; Teva Pharms Usa; Sun Pharma Global; Fresenius Kabi Usa; Luitpold; Mustafa Nevzat; Eurohlth Intl; Agila Speclts

5 Pharmacology and Biochemistry

5.1 MeSH Pharmacological Classification

Bone Density Conservation Agents

Agents that inhibit BONE RESORPTION and/or favor BONE MINERALIZATION and BONE REGENERATION. They are used to heal BONE FRACTURES and to treat METABOLIC BONE DISEASES such as OSTEOPOROSIS. (See all compounds classified as Bone Density Conservation Agents.)

5.2 FDA Pharmacological Classification

5.2.1 Pharmacological Classes

Diphosphonates [CS]; Bisphosphonate [EPC]

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