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Chemistry

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Also known as: 57248-88-1, Aredia, Aminomux, Disodium pamidronate, Pamidronate disodium salt, Pamidronic acid disodium salt
Molecular Formula
C3H9NNa2O7P2
Molecular Weight
279.03  g/mol
InChI Key
CEYUIFJWVHOCPP-UHFFFAOYSA-L
FDA UNII
C7S8VWP5DH

Disodium Pamidronate Pentahydrate
An aminobisphosphonate that inhibits BONE RESORPTION and is used for the treatment of osteolytic lesions, bone pain, and severe HYPERCALCEMIA associated with malignancies.
1 2D Structure

Disodium Pamidronate Pentahydrate

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
disodium;[3-amino-1-hydroxy-1-[hydroxy(oxido)phosphoryl]propyl]-hydroxyphosphinate
2.1.2 InChI
InChI=1S/C3H11NO7P2.2Na/c4-2-1-3(5,12(6,7)8)13(9,10)11;;/h5H,1-2,4H2,(H2,6,7,8)(H2,9,10,11);;/q;2*+1/p-2
2.1.3 InChI Key
CEYUIFJWVHOCPP-UHFFFAOYSA-L
2.1.4 Canonical SMILES
C(CN)C(O)(P(=O)(O)[O-])P(=O)(O)[O-].[Na+].[Na+]
2.2 Other Identifiers
2.2.1 UNII
C7S8VWP5DH
2.3 Synonyms
2.3.1 MeSH Synonyms

1. (3-amino-1-hydroxypropylidene)-1,1-biphosphonate

2. 1 Hydroxy 3 Aminopropane 1,1 Diphosphonic Acid

3. 1-hydroxy-3-aminopropane-1,1-diphosphonic Acid

4. Ahprbp

5. Amidronate

6. Amino 1 Hydroxypropane 1,1 Diphosphonate

7. Amino-1-hydroxypropane-1,1-diphosphonate

8. Aminohydroxypropylidene Diphosphonate

9. Aminopropanehydroxydiphosphonate

10. Aredia

11. Pamidronate

12. Pamidronate Calcium

13. Pamidronate Monosodium

14. Pamidronic Acid

2.3.2 Depositor-Supplied Synonyms

1. 57248-88-1

2. Aredia

3. Aminomux

4. Disodium Pamidronate

5. Pamidronate Disodium Salt

6. Pamidronic Acid Disodium Salt

7. Cgp 23339a

8. Pamidronate Disodium Anhydrous

9. Pamidronate Disodium Monohydrate

10. Pamidronate (disodium)

11. C7s8vwp5dh

12. Disodium 3-amino-1-hydroxypropane-1,1-diphosphonate

13. Cgp-23339ae

14. Disodium Pamidronate Hydrate

15. Phosphonic Acid, (3-amino-1-hydroxypropylidene)bis-, Disodium Salt

16. Pamidronate (disodium Pentahydrate)

17. Pamedronate Disodium Salt

18. Pamidronatedisodium

19. Pamidronic Acid Sodium Salt

20. Pamindronate Disodium

21. Nsc-722600

22. Cgp 23339 A

23. Einecs 260-647-1

24. Unii-c7s8vwp5dh

25. Sodium 3-amino-1-hydroxypropane-1,1-diylbis(hydrogenphosphonate)

26. Pamidronate Sodium

27. Ahprbp

28. Aminohydroxypropylidene Diphosphonate Disodium Salt

29. (3-amino-1-hydroxypropylidene)diphosphonic Acid Disodium Salt

30. Disodium Dihydrogen (3-amino-1-hydroxypropylidene)bisphosphonate

31. Pamidronate (sodium Salt)

32. Chembl676

33. Schembl18751

34. Dtxsid5042667

35. Pamidronate Disodium Salt Hydrate

36. 3-amino-1-hydroxypropane-1,1-diphosphonic Acid Disodium Salt

37. Cgp-23339a

38. Gcp-23339a

39. Bcp22745

40. Anhydrous Pamidronate Disodium

41. Mfcd00867072

42. S1311

43. Akos015905512

44. Akos025401590

45. Ccg-267232

46. Ig-7913

47. Nsc 722600

48. Cgp 23339a Pound>>gcp23339a

49. Ac-22572

50. Ac-22753

51. Bp164229

52. Pamidronic Acid Disodium Salt [mi]

53. Db-053025

54. Pamidronic Acid Sodium Salt Hydrate- Bio-x

55. D3921

56. Ft-0630698

57. H11402

58. W-105479

59. Q27275302

60. (3-amino-1-hydroxypropylidene)bisphosphonic Acid Disodium

61. Disodium (3-amino-1-hydroxypropane-1,1-diyl)bis[hydrogen (phosphonate)]

62. Disodium Dihydrogen (3-amino-1-hydroxypropylidene)diphosphonate

63. Disodium;[3-amino-1-hydroxy-1-[hydroxy(oxido)phosphoryl]propyl]-hydroxyphosphinate

2.4 Create Date
2005-08-08
3 Chemical and Physical Properties
Molecular Weight 279.03 g/mol
Molecular Formula C3H9NNa2O7P2
Hydrogen Bond Donor Count4
Hydrogen Bond Acceptor Count8
Rotatable Bond Count4
Exact Mass278.96496419 g/mol
Monoisotopic Mass278.96496419 g/mol
Topological Polar Surface Area167 Ų
Heavy Atom Count15
Formal Charge0
Complexity238
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count3
4 Drug and Medication Information
4.1 Drug Information
1 of 4  
Drug NameAredia
Active IngredientPamidronate disodium
Dosage FormInjectable
Routeinjection; Injection
Strength30mg/vial; 60mg/vial; 90mg/vial
Market StatusPrescription
CompanyNovartis

2 of 4  
Drug NamePamidronate disodium
PubMed HealthPamidronate (Injection)
Drug ClassesCalcium Regulator
Drug LabelPamidronate Disodium is a sterile bone-resorption inhibitor available in 30 mg and 90 mg vials for intravenous administration. The pamidronate disodium obtained by combining pamidronic acid and sodium hydroxide is provided in a sterile, ready to use...
Active IngredientPamidronate disodium
Dosage FormInjectable
RouteInjection
Strength90mg/vial; 30mg/10ml (3mg/ml); 60mg/10ml (6mg/ml); 30mg/vial; 60mg/vial; 90mg/10ml (9mg/ml)
Market StatusPrescription
CompanyPliva Lachema; Areva Pharms; Hospira; Teva Pharms Usa; Sun Pharma Global; Fresenius Kabi Usa; Luitpold; Mustafa Nevzat; Eurohlth Intl; Agila Speclts

3 of 4  
Drug NameAredia
Active IngredientPamidronate disodium
Dosage FormInjectable
Routeinjection; Injection
Strength30mg/vial; 60mg/vial; 90mg/vial
Market StatusPrescription
CompanyNovartis

4 of 4  
Drug NamePamidronate disodium
PubMed HealthPamidronate (Injection)
Drug ClassesCalcium Regulator
Drug LabelPamidronate Disodium is a sterile bone-resorption inhibitor available in 30 mg and 90 mg vials for intravenous administration. The pamidronate disodium obtained by combining pamidronic acid and sodium hydroxide is provided in a sterile, ready to use...
Active IngredientPamidronate disodium
Dosage FormInjectable
RouteInjection
Strength90mg/vial; 30mg/10ml (3mg/ml); 60mg/10ml (6mg/ml); 30mg/vial; 60mg/vial; 90mg/10ml (9mg/ml)
Market StatusPrescription
CompanyPliva Lachema; Areva Pharms; Hospira; Teva Pharms Usa; Sun Pharma Global; Fresenius Kabi Usa; Luitpold; Mustafa Nevzat; Eurohlth Intl; Agila Speclts

5 Pharmacology and Biochemistry
5.1 MeSH Pharmacological Classification

Bone Density Conservation Agents

Agents that inhibit BONE RESORPTION and/or favor BONE MINERALIZATION and BONE REGENERATION. They are used to heal BONE FRACTURES and to treat METABOLIC BONE DISEASES such as OSTEOPOROSIS. (See all compounds classified as Bone Density Conservation Agents.)


5.2 FDA Pharmacological Classification
5.2.1 Pharmacological Classes
Diphosphonates [CS]; Bisphosphonate [EPC]

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DMF Review : Complete

Rev. Date : 2012-12-24

Pay. Date : 2012-11-19

DMF Number : 12803

Submission : 1997-12-22

Status : Active

Type : II

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DMF Review : N/A

Rev. Date :

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DMF Number : 13946

Submission : 1999-01-18

Status : Inactive

Type : II

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Apotex Pharmachem Inc

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Cipla Ltd

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Cipla Ltd

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DMF Review : N/A

Rev. Date :

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DMF Number : 17842

Submission : 2004-11-22

Status : Inactive

Type : II

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Cipla Ltd

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Cipla Ltd

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DMF Review : N/A

Rev. Date :

Pay. Date :

DMF Number : 14686

Submission : 2000-01-26

Status : Inactive

Type : II

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GDUFA

DMF Review : N/A

Rev. Date :

Pay. Date :

DMF Number : 18532

Submission : 2005-07-20

Status : Inactive

Type : II

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Gador Sa

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Gador Sa

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DMF Review : N/A

Rev. Date :

Pay. Date :

DMF Number : 14504

Submission : 1999-10-22

Status : Active

Type : II

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Hospira Inc

U.S.A

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Hospira Inc

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GDUFA

DMF Review : N/A

Rev. Date :

Pay. Date :

DMF Number : 19573

Submission : 2006-07-03

Status : Inactive

Type : II

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API Reference Price

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[{"dataSource":"API Export","activeIngredients":"","year":"2021","qtr":"Q3","strtotime":1628533800,"product":"DISODIUM PAMIDRONATE BP - BULK DRUG","address":"ACME PLAZA, ANDHERI KURLA ROAD,ANDHERI EAST","city":"MUMBAI, MAHARASHTRA.","supplier":"SUN PHARMACEUTICAL INDUSTRIES LIMITED","supplierCountry":"INDIA","foreign_port":"GUARULHOS","customer":"EUROFARMA LABORATORIOS S.A","customerCountry":"BRAZIL","quantity":"2.64","actualQuantity":"2.641","unit":"KGS","unitRateFc":"25200","totalValueFC":"65864.5","currency":"USD","unitRateINR":1849678.1522150701,"date":"10-Aug-2021","totalValueINR":"4885000","totalValueInUsd":"65864.5","indian_port":"BOMBAY AIR","hs_no":"29339990","bill_no":"3749796","productDescription":"API","marketType":"LESS REGULATED MARKET","country":"BRAZIL","selfForZScoreResived":"Pharma Grade","supplierPort":"BOMBAY AIR","supplierAddress":"ACME PLAZA, ANDHERI KURLA ROAD,ANDHERI EAST, MUMBAI, MAHARASHTRA.","customerAddress":""},{"dataSource":"API Import","activeIngredients":"","year":"2023","qtr":"Q3","strtotime":1692383400,"product":"HISY-PMDA-I005-N PAMIDRONIC ACID API","address":"NA","city":"NA","supplier":"CHEMWERTH INC","supplierCountry":"UNITED STATES","foreign_port":"NA","customer":"STERISCIENCE SPECIALTIES PRIVATE ","customerCountry":"INDIA","quantity":"3.50","actualQuantity":"3.5","unit":"KGS","unitRateFc":"110000","totalValueFC":"390404.5","currency":"USD","unitRateINR":"9147506.3","date":"19-Aug-2023","totalValueINR":"32339668.63","totalValueInUsd":"390404.5","indian_port":"BANGALORE AIR","hs_no":"29349990","bill_no":"0","productDescription":"API","marketType":"REGULATED MARKET","country":"UNITED STATES","selfForZScoreResived":"Pharma Grade","supplierPort":"NA","supplierAddress":"","customerAddress":"NA"},{"dataSource":"API Import","activeIngredients":"","year":"2024","qtr":"Q3","strtotime":1726597800,"product":"HISY-PMDA-I005-N PAMIDRONIC ACID","address":"PLOT No.30, GALAXY ,","city":"BENGALURU","supplier":"CHEMWERTH INC","supplierCountry":"UNITED STATES","foreign_port":"NEW YORK - JOHN F. K","customer":"STERISCIENCE SPECIALTIES PRIVATE ","customerCountry":"INDIA","quantity":"2.95","actualQuantity":"2.953","unit":"KGS","unitRateFc":"110000","totalValueFC":"329696.9","currency":"USD","unitRateINR":"9356250.3","date":"18-Sep-2024","totalValueINR":"27629007","totalValueInUsd":"329696.9","indian_port":"Bangalore Air","hs_no":"29349990","bill_no":"5664332","productDescription":"API","marketType":"REGULATED MARKET","country":"UNITED STATES","selfForZScoreResived":"Pharma Grade","supplierPort":"NEW YORK - JOHN F. K","supplierAddress":"1764 LITCHFIELD TURNPIKE SUITE 202 WOODBRIDGE SDNF US","customerAddress":"PLOT No.30, GALAXY ,"}]
10-Aug-2021
18-Sep-2024
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Europe

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Pamidronate

Brand Name : Pamidronate

Dosage Form : Pamidronic Acid 90Mg 10Ml 1 Units Parenteral Use

Dosage Strength : EV 1 bottle groun 90 mg + 1 bottle solv 10 ml

Packaging :

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Regulatory Info :

Registration Country : Italy

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pamidronate disodium, anhydrous

Brand Name : pamidronate disodium Hospira

Dosage Form : CONCENTRATE FOR SOLUTION FOR INFUSION

Dosage Strength : 3 MG / ML

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Regulatory Info :

Registration Country : Sweden

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Pamidronate

Brand Name : Disodium Pamidronate

Dosage Form : Pamidronic Acid 15Mg 5Ml 5 Units Parenteral Use

Dosage Strength : 5 EV vials 15 mg

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Approval Date :

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Regulatory Info :

Registration Country : Italy

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Pamidronate

Brand Name : Disodium Pamidronate

Dosage Form : Pamidronic Acid 60Mg 10Ml 1 Units Parenteral Use

Dosage Strength : 1 ampoule EV 60 mg 10 ml

Packaging :

Approval Date :

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Regulatory Info :

Registration Country : Italy

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Pamidronate

Brand Name : Disodium Pamidronate

Dosage Form : Pamidronic Acid 90Mg 10Ml 1 Units Parenteral Use

Dosage Strength : 1 ampoule EV 90 mg 10 ml

Packaging :

Approval Date :

Application Number :

Regulatory Info :

Registration Country : Italy

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Pamidronate

Brand Name : Pamidronatdinatrium Hospira

Dosage Form : Concentrate to the infusion fluid

Dosage Strength : 3 mg/ml

Packaging : Hood glass

Approval Date :

Application Number :

Regulatory Info :

Registration Country : Norway

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Pamidronate

Brand Name : Pamidronatdinatrium Hospira

Dosage Form : Concentrate to the infusion fluid

Dosage Strength : 6 mg/ml

Packaging : Hood glass

Approval Date :

Application Number :

Regulatory Info :

Registration Country : Norway

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Pamidronate

Brand Name : Pamidronatdinatrium Hospira

Dosage Form : Concentrate to the infusion fluid

Dosage Strength : 9 mg/ml

Packaging : Hood glass

Approval Date :

Application Number :

Regulatory Info :

Registration Country : Norway

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Pamidronate

Brand Name : Texpami

Dosage Form : Pamidronic Acid 60Mg 10Ml 1 Units Parenteral Use

Dosage Strength : 1 bottle EV 60 mg/10 ml

Packaging :

Approval Date :

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Regulatory Info :

Registration Country : Italy

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Pamidronate

Brand Name : Texpami

Dosage Form : Pamidronic Acid 90Mg 10Ml 1 Units Parenteral Use

Dosage Strength : 1 bottle EV 90 mg/10 ml

Packaging :

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Registration Country : Italy

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Australia

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pamidronate disodium

Brand Name : Pamisol

Dosage Form : injection

Dosage Strength : 15 mg/5 mL

Packaging : 1

Approval Date :

Application Number :

Regulatory Info :

Registration Country : Australia

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pamidronate disodium

Brand Name : Pamisol

Dosage Form : injection

Dosage Strength : 30 mg/10 mL

Packaging : 1

Approval Date :

Application Number :

Regulatory Info :

Registration Country : Australia

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pamidronate disodium

Brand Name : Pamisol

Dosage Form : injection

Dosage Strength : 60 mg/10 mL

Packaging : 1

Approval Date :

Application Number :

Regulatory Info :

Registration Country : Australia

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pamidronate disodium

Brand Name : Pamisol

Dosage Form : injection

Dosage Strength : 90 mg/10 mL

Packaging : 1

Approval Date :

Application Number :

Regulatory Info :

Registration Country : Australia

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pamidronate disodium

Brand Name : Pamisol

Dosage Form : injection

Dosage Strength : 15 mg/5 mL

Packaging : 1

Approval Date :

Application Number :

Regulatory Info :

Registration Country : Australia

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pamidronate disodium

Brand Name : Pamisol

Dosage Form : injection

Dosage Strength : 30 mg/10 mL

Packaging : 1

Approval Date :

Application Number :

Regulatory Info :

Registration Country : Australia

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pamidronate disodium

Brand Name : Pamisol

Dosage Form : injection

Dosage Strength : 60 mg/10 mL

Packaging : 1

Approval Date :

Application Number :

Regulatory Info :

Registration Country : Australia

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pamidronate disodium

Brand Name : Pamisol

Dosage Form : injection

Dosage Strength : 90 mg/10 mL

Packaging : 1

Approval Date :

Application Number :

Regulatory Info :

Registration Country : Australia

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pamidronate disodium

Brand Name : Pamisol

Dosage Form : injection

Dosage Strength : 15 mg/5 mL

Packaging : 1

Approval Date :

Application Number :

Regulatory Info :

Registration Country : Australia

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pamidronate disodium

Brand Name : Pamisol

Dosage Form : injection

Dosage Strength : 30 mg/10 mL

Packaging : 1

Approval Date :

Application Number :

Regulatory Info :

Registration Country : Australia

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South Africa

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Novartis South Africa (Pty) Ltd

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Pamidronic Acid

Brand Name : Aredia

Dosage Form : INJ

Dosage Strength : 15mg

Packaging : 5X1mg

Approval Date :

Application Number :

Regulatory Info : Originator

Registration Country : South Africa

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Brand Name : Pamidronatdinatrium Hospira

U.S.A
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Brand Name : Pamidronatdinatrium Hospira

U.S.A
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Disodium Pamidronate Pentahydrate

Dosage Form : Concentrate to the infusion flui...

Dosage Strength : 3 mg/ml

Price Per Pack (Euro) : 88.638

Published in :

Country : Norway

RX/OTC/DISCN :

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Brand Name : Pamidronatdinatrium Hospira

U.S.A
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Antibody Engineering
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Brand Name : Pamidronatdinatrium Hospira

U.S.A
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Antibody Engineering
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Disodium Pamidronate Pentahydrate

Dosage Form : Concentrate to the infusion flui...

Dosage Strength : 3 mg/ml

Price Per Pack (Euro) : 216.03

Published in :

Country : Norway

RX/OTC/DISCN :

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03

Brand Name : Pamidronatdinatrium Hospira

U.S.A
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Antibody Engineering
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Brand Name : Pamidronatdinatrium Hospira

U.S.A
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Disodium Pamidronate Pentahydrate

Dosage Form : Concentrate to the infusion flui...

Dosage Strength : 6 mg/ml

Price Per Pack (Euro) : 208.56

Published in :

Country : Norway

RX/OTC/DISCN :

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Brand Name : Pamidronatdinatrium Hospira

U.S.A
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Brand Name : Pamidronatdinatrium Hospira

U.S.A
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Disodium Pamidronate Pentahydrate

Dosage Form : Concentrate to the infusion flui...

Dosage Strength : 9 mg/ml

Price Per Pack (Euro) : 263.57

Published in :

Country : Norway

RX/OTC/DISCN :

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Brand Name : Disodium Pamidronate

United Kingdom
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Brand Name : Disodium Pamidronate

United Kingdom
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Disodium Pamidronate Pentahydrate

Dosage Form : Pamidronic Acid 15Mg 5Ml 4 Units...

Dosage Strength : 4 bottles 5 ml 15 mg/5 ml

Price Per Pack (Euro) : 185.1

Published in :

Country : Italy

RX/OTC/DISCN : Class H

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06

Brand Name : Texpami

Italy
arrow
Antibody Engineering
Not Confirmed

Brand Name : Texpami

Italy
arrow
Antibody Engineering
Not Confirmed

Disodium Pamidronate Pentahydrate

Dosage Form : Pamidronic Acid 15Mg 5Ml 4 Units...

Dosage Strength : 4 bottles EV 15 mg/5 ml

Price Per Pack (Euro) : 101.08

Published in :

Country : Italy

RX/OTC/DISCN : Class H

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07

Brand Name : Disodium Pamidronate

U.S.A
arrow
Antibody Engineering
Not Confirmed

Brand Name : Disodium Pamidronate

U.S.A
arrow
Antibody Engineering
Not Confirmed

Disodium Pamidronate Pentahydrate

Dosage Form : Pamidronic Acid 15Mg 5Ml 5 Units...

Dosage Strength : 5 EV vials 15 mg

Price Per Pack (Euro) : 173.57

Published in :

Country : Italy

RX/OTC/DISCN : Class H

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08

Brand Name : Disodium Pamidronate

U.S.A
arrow
Antibody Engineering
Not Confirmed

Brand Name : Disodium Pamidronate

U.S.A
arrow
Antibody Engineering
Not Confirmed

Disodium Pamidronate Pentahydrate

Dosage Form : Pamidronic Acid 30Mg 10Ml 1 Unit...

Dosage Strength : 1 ampoule EV 30 mg 10 ml

Price Per Pack (Euro) : 68.96

Published in :

Country : Italy

RX/OTC/DISCN : Class H

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09

Brand Name : Disodium Pamidronate

United Kingdom
arrow
Antibody Engineering
Not Confirmed

Brand Name : Disodium Pamidronate

United Kingdom
arrow
Antibody Engineering
Not Confirmed

Disodium Pamidronate Pentahydrate

Dosage Form : Pamidronic Acid 30Mg 10Ml 2 Unit...

Dosage Strength : 2 bottles 10 ml 30 mg/10 ml

Price Per Pack (Euro) : 183.85

Published in :

Country : Italy

RX/OTC/DISCN : Class H

blank

10

Brand Name : Texpami

Italy
arrow
Antibody Engineering
Not Confirmed

Brand Name : Texpami

Italy
arrow
Antibody Engineering
Not Confirmed

Disodium Pamidronate Pentahydrate

Dosage Form : Pamidronic Acid 30Mg 10Ml 2 Unit...

Dosage Strength : 2 bottles EV 30 mg/10 ml

Price Per Pack (Euro) : 102.89

Published in :

Country : Italy

RX/OTC/DISCN : Class H

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