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Distamycin A

Polfa Tarchomin is a leading Polish pharmaceutical company with 200 year tradition in manufacture and sale of pharmaceutical products.

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ACTIVE PHARMA INGREDIENTS

2 API Suppliers, 1 USDMF, 1 Listed Suppliers

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1 USDMF
1 Listed Suppliers

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Synopsis

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Chemistry

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Also known as: Distamycin a, Distamycin, 636-47-5, Herperetin, Stallimycin [inn], Dst-a

Molecular Formula

C₂₂H₂₇N₉O₄

Molecular Weight

481.5 g/mol

InChI Key

UPBAOYRENQEPJO-UHFFFAOYSA-N

FDA UNII

80O63P88IS

Stallimycin is an oligopeptide antineoplastic antibiotic isolated from the bacterium Streptomyces distallicus. Distamycin preferentially binds to adenine-thymine (A-T) rich sequences in the minor groove of DNA, thereby inhibiting DNA replication and RNA transcription. In addition to antitumor effects, distamycin also possesses antiviral and antiprotozoal activities and is used as a chromosome dye. (NCI04)

1 2D Structure

Distamycin A

2 Identification

2.1 Computed Descriptors

2.1.1 IUPAC Name

N-[5-[[5-[(3-amino-3-iminopropyl)carbamoyl]-1-methylpyrrol-3-yl]carbamoyl]-1-methylpyrrol-3-yl]-4-formamido-1-methylpyrrole-2-carboxamide

2.1.2 InChI

InChI=1S/C22H27N9O4/c1-29-9-13(26-12-32)6-17(29)21(34)28-15-8-18(31(3)11-15)22(35)27-14-7-16(30(2)10-14)20(33)25-5-4-19(23)24/h6-12H,4-5H2,1-3H3,(H3,23,24)(H,25,33)(H,26,32)(H,27,35)(H,28,34)

2.1.3 InChI Key

UPBAOYRENQEPJO-UHFFFAOYSA-N

2.1.4 Canonical SMILES

CN1C=C(C=C1C(=O)NC2=CN(C(=C2)C(=O)NC3=CN(C(=C3)C(=O)NCCC(=N)N)C)C)NC=O

2.2 Other Identifiers

2.2.1 UNII

80O63P88IS

2.3 Synonyms

2.3.1 MeSH Synonyms

1. Distamycin

2. Distamycin A

3. Stallimycin Hydrochloride

4. Stallimycin Monohydrochloride

2.3.2 Depositor-Supplied Synonyms

1. Distamycin A

2. Distamycin

3. 636-47-5

4. Herperetin

5. Stallimycin [inn]

6. Dst-a

7. Nsc82150

8. Nsc-82150

9. Fi 6426

10. Chembl11252

11. 80o63p88is

12. N-[5-[[5-[(3-amino-3-iminopropyl)carbamoyl]-1-methylpyrrol-3-yl]carbamoyl]-1-methylpyrrol-3-yl]-4-formamido-1-methylpyrrole-2-carboxamide

13. Ncgc00018292-04

14. Distamycin 3

15. Nsc 150528

16. Estalimicina

17. Stallimicina

18. Stallimycine

19. Stallimycinum

20. Distamicina A

21. Distamycin Hydrochloride

22. 1h-pyrrole-2-carboxamide, N-(5-(((3-amino-3-iminopropyl)amino)carbonyl)-1-methyl-1h-pyrrol-3-yl)-4-(((4-(formylamino)-1-methyl-1h-pyrrol-2-yl)carbonyl)amino)-1-methyl-

23. 1h-pyrrole-2-carboxamide, N-[5-[[(3-amino-3-iminopropyl)amino]carbonyl]-1-methyl-1h-pyrrol-3-yl]-4-[[[4-(formylamino)-1-methyl-1h-pyrrol-2-yl]carbonyl]amino]-1-methyl-

24. Nsc150528

25. Stallimicina [dcit]

26. Distamicina A [italian]

27. Stallimycine [inn-french]

28. Stallimycinum [inn-latin]

29. Estalimicina [inn-spanish]

30. Unii-80o63p88is

31. Nsc 82150

32. Brn 0468437

33. Dst-3

34. Distamycin A [mi]

35. Dsstox_cid_25637

36. Dsstox_rid_81018

37. Dsstox_gsid_45637

38. Distamycin; Stallimycin

39. Schembl108585

40. Dtxsid9045637

41. Cid_6602691

42. Zinc3872327

43. Tox21_110857

44. Bdbm50055659

45. Ccg-36393

46. N''-(2-amidinoethyl)-4-formamido-1,1',1''-trimethyl-n-4':n'-4''-ter-(2-pyrrolcarboxamid)

47. Ncgc00018292-01

48. Ncgc00018292-02

49. Ncgc00018292-03

50. Ncgc00018292-05

51. Ncgc00024382-03

52. Cas-636-47-5

53. Nci60_041805

54. Sr-01000000269

55. Sr-01000000269-3

56. Q27269162

57. N,4''-ter[pyrrole-2-carboxamide], N''-(2-amidinoethyl)-4-formamido-1,1',1''-trimethyl-

58. (n,4':n',4''-terpyrrole)-2-carboxamide, N''-(2-amidinoethyl)-4-formamido-1,1',1''-trimethyl-

59. 2n-(3,3-aminoiminopropyl)-4-[4-(4-formamido-1-methyl-1h-2-pyrrolylcarboxamido)-1-methyl-1h-2-pyrrolylcarboxamido]-1-methyl-1h-2-pyrrolecarboxamide

60. 2n-[5-(3-amino-3-iminopropylcarbamoyl)-1-methyl-1h-3-pyrrolyl]-4-(4-formamido-1-methyl-1h-2-pyrrolylcarboxamido)-1-methyl-1h-2-pyrrolecarboxamide

61. 2n-[5-(3-amino-3-iminopropylcarbamoyl)-1-methyl-1h-3-pyrrolyl]-4-(4-formamido-1-methyl-1h-2-pyrrolylcarboxamido)-1-methyl-1h-2-pyrrolecarboxamide(distamycin A)

62. 2n-[5-(3-amino-3-iminopropylcarbamoyl)-1-methyl-1h-3-pyrrolyl]-4-(4-formamido-1-methyl-1h-2-pyrrolylcarboxamido)-1-methyl-1h-2-pyrrolecarboxamide(distamycin)

63. 39389-47-4

64. 4n-[5-(3-amino-3-iminopropylcarbamoyl)-1-methyl-1h-2-pyrrolyl]-2-(4-formamido-1-methyl-1h-2-pyrrolylcarboxamido)-1-methyl-1h-4-pyrrolecarboxamide

65. 5n-[5-(3-amino-3-iminopropylcarbamoyl)-1-methyl-2,3-dihydro-1h-3-pyrrolyl]-3-(4-formamido-1-methyl-1h-2-pyrrolylcarboxamido)-1-methyl-2,3-dihydro-1h-5-pyrrolecarboxamide

66. N''-(2-amidinoethyl)-4-formamido-1,1',1''-trimethyl-n,4':n',4''-ter(pyrrole-2-carboxamide)

67. N-(3-amino-3-iminopropyl)-4-(4-(4-formamido-1-methyl-1h-pyrrole-2-carboxamido)-1-methyl-1h-pyrrole-2-carboxamido)-1-methyl-1h-pyrrole-2-carboxamide

68. N-[5-({5-[(3-amino-3-iminopropyl)carbamoyl]-1-methyl-1h-pyrrol-3-yl}carbamoyl)-1-methyl-1h-pyrrol-3-yl]-4-(formylamino)-1-methyl-1h-pyrrole-2-carboxamide

69. N-[5-[[(3-amino-3-iminopropyl)amino]carbonyl]-1-methyl-1h-pyrrol-3-yl]-4-[[[4-(formylamino)-methyl-1h-pyrrol-2-yl]carbonyl]amino]-1h-pyrrole-2-carboxamide

70. N-[5-[[(amino-3-iminopropyl)amino]carbonyl]-1-methyl-1h-pyrrol-3-yl-4-[[(4-(formylamino)-1-methyl-1h-pyrrol-2yl]carbonyl]amino]-1h-pyrrole-2-carboxamide

71. N-[5-[[5-[(3-amino-3-imino-propyl)carbamoyl]-1-methyl-pyrrol-3-yl]carbamoyl]-1-methyl-pyrrol-3-yl]-4-formamido-1-methyl-pyrrole-2-carboxamide

2.4 Create Date

2005-03-25

3 Chemical and Physical Properties

Molecular Formula	C₂₂H₂₇N₉O₄
Molecular Weight	481.5 g/mol
XLogP3	-1.8
Hydrogen Bond Donor Count	6
Hydrogen Bond Acceptor Count	5
Rotatable Bond Count	9
Exact Mass	481.21860038 g/mol
Monoisotopic Mass	481.21860038 g/mol
Topological Polar Surface Area	181 Å²
Heavy Atom Count	35
Formal Charge	0
Complexity	825
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently Bonded Unit Count	1

4 Pharmacology and Biochemistry

4.1 MeSH Pharmacological Classification

Antiviral Agents

Agents used in the prophylaxis or therapy of VIRUS DISEASES. Some of the ways they may act include preventing viral replication by inhibiting viral DNA polymerase; binding to specific cell-surface receptors and inhibiting viral penetration or uncoating; inhibiting viral protein synthesis; or blocking late stages of virus assembly. (See all compounds classified as Antiviral Agents.)

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ABOUT THIS PAGE

Distamycin A Manufacturers

A Distamycin A manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Distamycin A, including repackagers and relabelers. The FDA regulates Distamycin A manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Distamycin A API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

click here to find a list of Distamycin A manufacturers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PhamaCompass.

Distamycin A Suppliers

A Distamycin A supplier is an individual or a company that provides Distamycin A active pharmaceutical ingredient (API) or Distamycin A finished formulations upon request. The Distamycin A suppliers may include Distamycin A API manufacturers, exporters, distributors and traders.

click here to find a list of Distamycin A suppliers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PharmaCompass.

Distamycin A USDMF

A Distamycin A DMF (Drug Master File) is a document detailing the whole manufacturing process of Distamycin A active pharmaceutical ingredient (API) in detail. Different forms of Distamycin A DMFs exist exist since differing nations have different regulations, such as Distamycin A USDMF, ASMF (EDMF), JDMF, CDMF, etc.

A Distamycin A DMF submitted to regulatory agencies in the US is known as a USDMF. Distamycin A USDMF includes data on Distamycin A's chemical properties, information on the facilities and procedures used, and details about packaging and storage. The Distamycin A USDMF is kept confidential to protect the manufacturer’s intellectual property.

click here to find a list of Distamycin A suppliers with USDMF on PharmaCompass.

Distamycin A GMP

Distamycin A Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

PharmaCompass offers a list of Distamycin A GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Distamycin A GMP manufacturer or Distamycin A GMP API supplier for your needs.

Distamycin A CoA

A Distamycin A CoA (Certificate of Analysis) is a formal document that attests to Distamycin A's compliance with Distamycin A specifications and serves as a tool for batch-level quality control.

Distamycin A CoA mostly includes findings from lab analyses of a specific batch. For each Distamycin A CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

Distamycin A may be tested according to a variety of international standards, such as European Pharmacopoeia (Distamycin A EP), Distamycin A JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Distamycin A USP).

Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.