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1. Cleland Reagent
2. Cleland's Reagent
3. Clelands Reagent
4. Dithiothreitol
5. Reagent, Cleland
6. Reagent, Cleland's
7. Sputolysin
1. Dithiothreitol
2. Dl-1,4-dithiothreitol
3. 3483-12-3
4. Dl-dithiothreitol
5. 1,4-dithiothreitol
6. D-dithiothreitol
7. D-1,4-dithiothreitol
8. 27565-41-9
9. D-dtt
10. (2s,3s)-1,4-bis(sulfanyl)butane-2,3-diol
11. (2s,3s)-1,4-disulfanylbutane-2,3-diol
12. Dtt
13. Mfcd00004877
14. D-threo-1,4-dimercapto-2,3-butanediol
15. Threo-1,4-dimercapto-2,3-butanediol
16. Chebi:42170
17. Cis-2,3-dihydroxy-1,4-butanedithiol
18. 35454-97-8
19. Sputolysin
20. Rac-dithiothreitol
21. Dtv
22. 1,4-dithiothreithol
23. Dithio Threitol
24. Wr 34678
25. Reagents, Cleland's
26. 2,3-butanediol, 1,4-dimercapto-, (r*,r*)-
27. (+/-)-dithiothreitol
28. Dl-dithiothreitol, 99%
29. Dl-dithiothreitol, Powder
30. Dtt (threitol Derivative)
31. Dtt, 1,4-dithiothreitol
32. D,l-dithiothreitol (dtt)
33. Schembl10601
34. Threitol, 1,4-dithio-, L-
35. Chembl1232392
36. Dl-dithiothreitol, >=99.0%
37. Dtxsid5041017
38. Dithiothreitol, Biochemical Grade
39. 1,4-dimercapto-butane-2,3-diol
40. Zinc3852211
41. Einecs 240-263-0
42. Ethyl4-nitro-l-phenylalanine
43. Akos005259570
44. Akos015855399
45. Ccg-207964
46. Db02184
47. Dl-dithiothreitol, >=99.0% (rt)
48. Threitol, 1,4-dithio- (7ci,8ci)
49. Brn 2036371
50. Threo-2,3-dihydroxy-1,4-butanedithiol
51. Dl-1,4-dimercapto-2,3-dihydroxybutane
52. Dtt, Dithiothreitol (cleland's Reagenz)
53. (+/-)-1,4-dimercapto-2,3-butanediol
54. As-57473
55. Bp-22785
56. Dl-dithiothreitol Solution, 1 M In H2o
57. B7294
58. D97824
59. Dl-dithiothreitol, Bioultra, >=99.0% (rt)
60. Dl-dithiothreitol, For Electrophoresis, >=99%
61. M02712
62. M02716
63. (r-(r*,r*))-1,4-dimercaptobutane-2,3-diol
64. Dl-dithiothreitol, Saj Special Grade, >=98.0%
65. Dl-dithiothreitol, Vetec(tm) Reagent Grade, 98%
66. Q414783
67. (+/-) Dithiothreitol Molecular Biology Grade >99%
68. 2,3-butanediol, 1,4-dimercapto-, L-threo-
69. Dl-dithiothreitol, Bioxtra, >=99.0% (titration)
70. 2,3-butanediol, 1,4-dimercapto-, (r-(r*,r*))-
71. 2,3-butanediol, 1,4-dimercapto-, (2r,3r)-rel- (9ci)
72. Dl-dithiothreitol, >=98% (hplc), >=99.0% (titration)
73. Dl-dithiothreitol; Cleland Inverted Exclamation Mark S Reagent
74. Dl-dithiothreitol, Bioultra, For Molecular Biology, >=99.5% (rt)
75. Dl-dithiothreitol Solution, Bioultra, For Molecular Biology, ~1 M In H2o
76. Dl-dithiothreitol, For Molecular Biology, >=98% (hplc), >=99% (titration)
| Molecular Weight | 154.3 g/mol |
|---|---|
| Molecular Formula | C4H10O2S2 |
| XLogP3 | -0.4 |
| Hydrogen Bond Donor Count | 4 |
| Hydrogen Bond Acceptor Count | 4 |
| Rotatable Bond Count | 3 |
| Exact Mass | 154.01222190 g/mol |
| Monoisotopic Mass | 154.01222190 g/mol |
| Topological Polar Surface Area | 42.5 Ų |
| Heavy Atom Count | 8 |
| Formal Charge | 0 |
| Complexity | 52 |
| Isotope Atom Count | 0 |
| Defined Atom Stereocenter Count | 2 |
| Undefined Atom Stereocenter Count | 0 |
| Defined Bond Stereocenter Count | 0 |
| Undefined Bond Stereocenter Count | 0 |
| Covalently Bonded Unit Count | 1 |
Two male patients with late stage (uremic) infantile nephropathic cystinosis (INC) were treated by mouth with the reducing agent dithiothreitol (DTT), at doses not exceeding 25 mg/kg body weight three times per day. Three sequential periods of observation were obtained in both patients: on thiol (8.5 months); off thiol (8-9 months); on thiol again (7 months or longer)... Whereas chemical methods are not reliable for detecting and measuring DTT in biologic fluids, preliminary evidence indicates that a silylated derivative of oxidized DTT can be detected in the urine of patients receiving DTT by mouth. This finding suggests that the thiol is absorbed and excreted.
PMID:840501 Depape-Brigger D et al; Pediatr Res 11 (2): 124-31 (1977)
Two male patients with late stage (uremic) infantile nephropathic cystinosis (INC) were treated by mouth with the reducing agent dithiothreitol (DTT), at doses not exceeding 25 mg/kg body weight three times per day. Three sequential periods of observation were obtained in both patients: on thiol (8.5 months); off thiol (8-9 months); on thiol again (7 months or longer)... Whereas chemical methods are not reliable for detecting and measuring DTT in biologic fluids, preliminary evidence indicates that a silylated derivative of oxidized DTT can be detected in the urine of patients receiving DTT by mouth. This finding suggests that the thiol is absorbed and excreted.
PMID:840501 Depape-Brigger D et al; Pediatr Res 11 (2): 124-31 (1977)
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A Dithiothreitol manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Dithiothreitol, including repackagers and relabelers. The FDA regulates Dithiothreitol manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Dithiothreitol API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.
A Dithiothreitol supplier is an individual or a company that provides Dithiothreitol active pharmaceutical ingredient (API) or Dithiothreitol finished formulations upon request. The Dithiothreitol suppliers may include Dithiothreitol API manufacturers, exporters, distributors and traders.
Dithiothreitol Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.
GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).
PharmaCompass offers a list of Dithiothreitol GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Dithiothreitol GMP manufacturer or Dithiothreitol GMP API supplier for your needs.
A Dithiothreitol CoA (Certificate of Analysis) is a formal document that attests to Dithiothreitol's compliance with Dithiothreitol specifications and serves as a tool for batch-level quality control.
Dithiothreitol CoA mostly includes findings from lab analyses of a specific batch. For each Dithiothreitol CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.
Dithiothreitol may be tested according to a variety of international standards, such as European Pharmacopoeia (Dithiothreitol EP), Dithiothreitol JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Dithiothreitol USP).
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