Find Dolastatin 15 manufacturers, exporters & distributors on PharmaCompass

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Synopsis

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Chemistry

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Also known as: 123884-00-4, Dolostatin 15, J9zks885h5, Nsc 617668, (s)-1-((s)-2-benzyl-3-methoxy-5-oxo-2,5-dihydro-1h-pyrrol-1-yl)-3-methyl-1-oxobutan-2-yl n-dimethyl-l-valyl-l-valyl-n-methyl-l-valyl-l-prolyl-l-prolinate, L-proline, n,n-dimethyl-l-valyl-l-valyl-n-methyl-l-valyl-l-prolyl-, (1s)-1-[[(2s)-2,5-dihydro-3-methoxy-5-oxo-2-(phenylmethyl)-1h-pyrrol-1-yl]carbonyl]-2-methylpropyl ester
Molecular Formula
C45H68N6O9
Molecular Weight
837.1  g/mol
InChI Key
LQKSHSFQQRCAFW-CCVNJFHASA-N
FDA UNII
J9ZKS885H5

Dolastatin 15
Dolastatin 15 is a depsipeptide originally isolated from the marine mollusk Dolabella auricularia with potential antineoplastic activity. Less potent than the structurally-related compound dolastatin 10, dolastatin 15 binds weakly to tubulin and blocks microtubule assembly, thereby inhibiting mitosis. Dolastatin 15 also induces tumor cell apoptosis through a mechanism involving bcl-2, an oncoprotein that is overexpressed in some cancers. (NCI04)
1 2D Structure

Dolastatin 15

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
[(2S)-1-[(2S)-2-benzyl-3-methoxy-5-oxo-2H-pyrrol-1-yl]-3-methyl-1-oxobutan-2-yl] (2S)-1-[(2S)-1-[(2S)-2-[[(2S)-2-[[(2S)-2-(dimethylamino)-3-methylbutanoyl]amino]-3-methylbutanoyl]-methylamino]-3-methylbutanoyl]pyrrolidine-2-carbonyl]pyrrolidine-2-carboxylate
2.1.2 InChI
InChI=1S/C45H68N6O9/c1-26(2)36(46-40(53)37(27(3)4)47(9)10)42(55)48(11)38(28(5)6)43(56)49-22-16-20-31(49)41(54)50-23-17-21-32(50)45(58)60-39(29(7)8)44(57)51-33(34(59-12)25-35(51)52)24-30-18-14-13-15-19-30/h13-15,18-19,25-29,31-33,36-39H,16-17,20-24H2,1-12H3,(H,46,53)/t31-,32-,33-,36-,37-,38-,39-/m0/s1
2.1.3 InChI Key
LQKSHSFQQRCAFW-CCVNJFHASA-N
2.1.4 Canonical SMILES
CC(C)C(C(=O)N(C)C(C(C)C)C(=O)N1CCCC1C(=O)N2CCCC2C(=O)OC(C(C)C)C(=O)N3C(C(=CC3=O)OC)CC4=CC=CC=C4)NC(=O)C(C(C)C)N(C)C
2.1.5 Isomeric SMILES
CC(C)[C@@H](C(=O)N(C)[C@@H](C(C)C)C(=O)N1CCC[C@H]1C(=O)N2CCC[C@H]2C(=O)O[C@@H](C(C)C)C(=O)N3[C@H](C(=CC3=O)OC)CC4=CC=CC=C4)NC(=O)[C@H](C(C)C)N(C)C
2.2 Other Identifiers
2.2.1 UNII
J9ZKS885H5
2.3 Synonyms
2.3.1 MeSH Synonyms

1. Nsc 617668

2.3.2 Depositor-Supplied Synonyms

1. 123884-00-4

2. Dolostatin 15

3. J9zks885h5

4. Nsc 617668

5. (s)-1-((s)-2-benzyl-3-methoxy-5-oxo-2,5-dihydro-1h-pyrrol-1-yl)-3-methyl-1-oxobutan-2-yl N-dimethyl-l-valyl-l-valyl-n-methyl-l-valyl-l-prolyl-l-prolinate

6. L-proline, N,n-dimethyl-l-valyl-l-valyl-n-methyl-l-valyl-l-prolyl-, (1s)-1-[[(2s)-2,5-dihydro-3-methoxy-5-oxo-2-(phenylmethyl)-1h-pyrrol-1-yl]carbonyl]-2-methylpropyl Ester

7. Nsc-617668

8. L-proline, N,n-dimethyl-l-valyl-l-valyl-n-methyl-l-valyl-l-prolyl-, (1s)-1-(((2s)-2,5-dihydro-3-methoxy-5-oxo-2-(phenylmethyl)-1h-pyrrol-1-yl)carbonyl)-2-methylpropyl Ester

9. Mfcd00236968

10. Unii-j9zks885h5

11. Dolastatin 15, >=95%

12. Chembl35769

13. Schembl187502

14. Dls-15

15. Dtxsid30924629

16. Hy-p1126

17. Bdbm50472220

18. Zinc95611960

19. Cs-0027988

20. J-004993

21. [(2s)-1-[(2s)-2-benzyl-3-methoxy-5-oxo-2h-pyrrol-1-yl]-3-methyl-1-oxobutan-2-yl] (2s)-1-[(2s)-1-[(2s)-2-[[(2s)-2-[[(2s)-2-(dimethylamino)-3-methylbutanoyl]amino]-3-methylbutanoyl]-methylamino]-3-methylbutanoyl]pyrrolidine-2-carbonyl]pyrrolidine-2-carboxylate

22. L-proline, 1-(1-(n-(n-(n,n-dimethyl-l-valyl)-l-valyl)-n-methyl-l-valyl)-l-prolyl)-, 1-((2,5-dihydro-3-methoxy-5-oxo-2-(phenylmethyl)-1h-pyrrol-1-yl)carbonyl)-2-methylpropyl Ester, (s-(r*,r*))-

23. L-proline, 1-(1-(n-(n-(n,n-dimethyl-l-valyl)-l-valyl)-n-methyl-l-valyl)-l-propyl)-, 1-((2,5-dihydro-3-methoxy-5-oxo-2-(phenylmethyl)-1h-pyrrol-1-yl)carbonyl)-2-methylpropyl Ester, (s-(r*,r*))-

2.4 Create Date
2006-10-25
3 Chemical and Physical Properties
Molecular Weight 837.1 g/mol
Molecular Formula C45H68N6O9
XLogP35.7
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count10
Rotatable Bond Count18
Exact Mass836.50477777 g/mol
Monoisotopic Mass836.50477777 g/mol
Topological Polar Surface Area166 Ų
Heavy Atom Count60
Formal Charge0
Complexity1600
Isotope Atom Count0
Defined Atom Stereocenter Count7
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count1

API SUPPLIERS

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ABOUT THIS PAGE

Dolastatin 15 Manufacturers

A Dolastatin 15 manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Dolastatin 15, including repackagers and relabelers. The FDA regulates Dolastatin 15 manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Dolastatin 15 API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

click here to find a list of Dolastatin 15 manufacturers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PhamaCompass.

Dolastatin 15 Suppliers

A Dolastatin 15 supplier is an individual or a company that provides Dolastatin 15 active pharmaceutical ingredient (API) or Dolastatin 15 finished formulations upon request. The Dolastatin 15 suppliers may include Dolastatin 15 API manufacturers, exporters, distributors and traders.

click here to find a list of Dolastatin 15 suppliers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PharmaCompass.

Dolastatin 15 GMP

Dolastatin 15 Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

PharmaCompass offers a list of Dolastatin 15 GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Dolastatin 15 GMP manufacturer or Dolastatin 15 GMP API supplier for your needs.

Dolastatin 15 CoA

A Dolastatin 15 CoA (Certificate of Analysis) is a formal document that attests to Dolastatin 15's compliance with Dolastatin 15 specifications and serves as a tool for batch-level quality control.

Dolastatin 15 CoA mostly includes findings from lab analyses of a specific batch. For each Dolastatin 15 CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

Dolastatin 15 may be tested according to a variety of international standards, such as European Pharmacopoeia (Dolastatin 15 EP), Dolastatin 15 JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Dolastatin 15 USP).

Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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