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    Also known as: 83898-65-1, 99497-03-7, 899u5wf46a, 5-chloro-1-[1-[3-(2,3-dihydro-2-oxo-1h-benzimidazol-1-yl)propyl]piperidin-4-yl]-1,3-dihydro-2h-benzimidazol-2-one maleate, (z)-but-2-enedioic acid;6-chloro-3-[1-[3-(2-oxo-3h-benzimidazol-1-yl)propyl]piperidin-4-yl]-1h-benzimidazol-2-one, Prestwick-06g02
    Molecular Formula
    C26H28ClN5O6
    Molecular Weight
    542.0  g/mol
    InChI Key
    OAUUYDZHCOULIO-BTJKTKAUSA-N
    FDA UNII
    899U5WF46A
    Domperidone Maleate
    A specific blocker of dopamine receptors. It speeds gastrointestinal peristalsis, causes prolactin release, and is used as antiemetic and tool in the study of dopaminergic mechanisms.
    1 2D Structure

    Domperidone Maleate

    2 Identification
    2.1 Computed Descriptors
    2.1.1 IUPAC Name
    (Z)-but-2-enedioic acid;6-chloro-3-[1-[3-(2-oxo-3H-benzimidazol-1-yl)propyl]piperidin-4-yl]-1H-benzimidazol-2-one
    2.1.2 InChI
    InChI=1S/C22H24ClN5O2.C4H4O4/c23-15-6-7-20-18(14-15)25-22(30)28(20)16-8-12-26(13-9-16)10-3-11-27-19-5-2-1-4-17(19)24-21(27)29;5-3(6)1-2-4(7)8/h1-2,4-7,14,16H,3,8-13H2,(H,24,29)(H,25,30);1-2H,(H,5,6)(H,7,8)/b;2-1-
    2.1.3 InChI Key
    OAUUYDZHCOULIO-BTJKTKAUSA-N
    2.1.4 Canonical SMILES
    C1CN(CCC1N2C3=C(C=C(C=C3)Cl)NC2=O)CCCN4C5=CC=CC=C5NC4=O.C(=CC(=O)O)C(=O)O
    2.1.5 Isomeric SMILES
    C1CN(CCC1N2C3=C(C=C(C=C3)Cl)NC2=O)CCCN4C5=CC=CC=C5NC4=O.C(=C\C(=O)O)\C(=O)O
    2.2 Other Identifiers
    2.2.1 UNII
    899U5WF46A
    2.3 Synonyms
    2.3.1 MeSH Synonyms

    1. Apo Domperidone

    2. Apo-domperidone

    3. Domidon

    4. Domperidon

    5. Domperidon Al

    6. Domperidon Hexal

    7. Domperidon Stada

    8. Domperidon Teva

    9. Domperidon-teva

    10. Domperidona Gamir

    11. Domperidone

    12. Domperidone Maleate (1:1)

    13. Domperidone Monohydrochloride

    14. Gamir, Domperidona

    15. Gastrocure

    16. Hexal, Domperidon

    17. Maleate, Domperidone

    18. Monohydrochloride, Domperidone

    19. Motilium

    20. Nauzelin

    21. Novo Domperidone

    22. Novo-domperidone

    23. Nu Domperidone

    24. Nu-domperidone

    25. Pridys

    26. Pms Domperidone

    27. Pms-domperidone

    28. R-33,812

    29. R-33812

    30. R33,812

    31. R33812

    32. Ratio Domperidone

    33. Ratio-domperidone

    34. Stada, Domperidon

    2.3.2 Depositor-Supplied Synonyms

    1. 83898-65-1

    2. 99497-03-7

    3. 899u5wf46a

    4. 5-chloro-1-[1-[3-(2,3-dihydro-2-oxo-1h-benzimidazol-1-yl)propyl]piperidin-4-yl]-1,3-dihydro-2h-benzimidazol-2-one Maleate

    5. (z)-but-2-enedioic Acid;6-chloro-3-[1-[3-(2-oxo-3h-benzimidazol-1-yl)propyl]piperidin-4-yl]-1h-benzimidazol-2-one

    6. Prestwick-06g02

    7. Chebi:59812

    8. 2h-benzimidazol-2-one,5-chloro-1-[1-[3-(2,3-dihydro-2-oxo-1h-benzimidazol-1-yl)propyl]-4-piperidinyl]-1,3-dihydro-, (2z)-2-butenedioate

    9. 5-chloro-1-(1-(3-(2,3-dihydro-2-oxo-1h-benzimidazol-1-yl)propyl)piperidin-4-yl)-1,3-dihydro-2h-benzimidazol-2-one Maleate

    10. Unii-899u5wf46a

    11. Domperidone (tn)

    12. Einecs 281-277-7

    13. Schembl447643

    14. Chembl3436365

    15. Domperidone (as Maleate)

    16. Hy-b0411a

    17. Dtxsid901019221

    18. Domperidone Maleate [mart.]

    19. Zda49703

    20. Domperidone Maleate [who-dd]

    21. Mfcd07370074

    22. Akos025312518

    23. Ncgc00017157-01

    24. 5-chloro-1-(1-(3-(2-oxo-2,3-dihydro-1h-benzo[d]imidazol-1-yl)propyl)piperidin-4-yl)-1h-benzo[d]imidazol-2(3h)-one Maleate

    25. Domperidone Maleate [ep Monograph]

    26. Cs-0013583

    27. D07868

    28. 497d037

    29. Q27126907

    30. 5-chloro-1-(1-(3-(2-oxobenzimidazolin-1-yl)propyl)-4-piperidyl)benzimidazolin-2-one Maleate

    2.4 Create Date
    2006-05-30
    3 Chemical and Physical Properties
    Molecular Weight 542.0 g/mol
    Molecular Formula C26H28ClN5O6
    Hydrogen Bond Donor Count4
    Hydrogen Bond Acceptor Count7
    Rotatable Bond Count7
    Exact Mass541.1728113 g/mol
    Monoisotopic Mass541.1728113 g/mol
    Topological Polar Surface Area143 Ų
    Heavy Atom Count38
    Formal Charge0
    Complexity774
    Isotope Atom Count0
    Defined Atom Stereocenter Count0
    Undefined Atom Stereocenter Count0
    Defined Bond Stereocenter Count1
    Undefined Bond Stereocenter Count0
    Covalently Bonded Unit Count2
    4 Pharmacology and Biochemistry
    4.1 MeSH Pharmacological Classification

    Antiemetics

    Drugs used to prevent NAUSEA or VOMITING. (See all compounds classified as Antiemetics.)

    Dopamine Antagonists

    Drugs that bind to but do not activate DOPAMINE RECEPTORS, thereby blocking the actions of dopamine or exogenous agonists. Many drugs used in the treatment of psychotic disorders (ANTIPSYCHOTIC AGENTS) are dopamine antagonists, although their therapeutic effects may be due to long-term adjustments of the brain rather than to the acute effects of blocking dopamine receptors. Dopamine antagonists have been used for several other clinical purposes including as ANTIEMETICS, in the treatment of Tourette syndrome, and for hiccup. Dopamine receptor blockade is associated with NEUROLEPTIC MALIGNANT SYNDROME. (See all compounds classified as Dopamine Antagonists.)

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    05-Jan-2021
    26-Oct-2024
    KGS
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