List of Related Excipient Companies and Suppliers of Donepezil by Ingredion Pharma Solutions on PharmaCompass.com

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ACTIVE PHARMA INGREDIENTS

74 API Suppliers, 32 USDMF, 11 CEP/COS, 16 JDMF, 23 EU WC, 70 KDMF, 22 NDC API, 37 Listed Suppliers, $ API Reference Price

74 API Suppliers
32 USDMF
11 CEP/COS
16 JDMF
23 EU WC
70 KDMF
22 NDC API
37 Listed Suppliers
$ API Reference Price

DEVELOPMENTS

12 Drugs in Development

12 Drugs in Development

INTERMEDIATES

30 Intermediates Suppliers

30 Intermediates Suppliers

FINISHED DOSAGE FORMULATIONS

582 FDF Dossiers, 99 FDA Orange Book, 302 Europe, 44 Canada, 32 Australia, 30 South Africa, 75 Listed Dossiers

582 FDF Dossiers
99 FDA Orange Book
302 Europe
44 Canada
32 Australia
30 South Africa
75 Listed Dossiers

DRUG PRODUCT COMPOSITIONS

TABLET;ORAL - 10MG, TABLET;ORAL - 5MG, TABLET, ORALLY DISINTEGRATING;ORAL - 10MG, TABLET, ORALLY DISINTEGRATING;ORAL - 5MG, TABLET;ORAL - 23MG

drugProductComposition
TABLET;ORAL - 10MG
TABLET;ORAL - 5MG
TABLET, ORALLY DISINTEGRATING;ORAL - 10MG
TABLET, ORALLY DISINTEGRATING;ORAL - 5MG
TABLET;ORAL - 23MG

RELATED EXCIPIENT COMPANIES

1 Minakem, 2 Evonik, 5 Rochem International Inc, 18 SPI Pharma, 2 Seqens, 20 DKSH, 3 Jai Radhe Sales, 2 Pharm-RX Chemical, 8 Boai NKY Pharmaceuticals Ltd, 1 Chynops Pharma, 15 Gangwal Healthcare, 10 Nanjing Well Pharmaceutical, 2 Pfanstiehl, 4 ACG Worldwide, 8 Actylis, 1 Aeon Procare, 3 Alcedo Pharmachem, 12 Anhui Sunhere Pharmaceutical Excipients Co.,Ltd, 1 Avesta Pharma, 35 BASF, 1 Bioplus Life Sciences, 2 Clariant, 15 Corel Pharma Chem, 6 DFE Pharma, 2 Finar, 13 Gangwal Chemicals, 16 Ideal Cures Pvt Ltd, 5 Ingredion Pharma Solutions, 33 Kerry, 4 Kima Chemical, 6 Lonza Capsugel, 14 Microlex e.U, 1 Nanjing Bold Chemical, 1 NEWEDGE Overseas, 2 Nomisma Healthcare, 4 Novo Excipients, 5 Pharmatrans-Sanaq, 8 Pluviaendo, 5 Prachin Chemical, 1 Qianhao Chemical (Hebei) Co., Ltd, 2 Qualicaps, 21 Roquette, 14 Seppic, 7 Shanghai Shenmei Pharmaceutical Technology Co., Ltd, 1 Shanghai Welltone Material Technology Co., Ltd, 1 Shijiazhuang Huaxu Pharmaceutical, 12 Sigachi Industries, 3 The Dow Chemical Company, 3 Ulanqab Kema New Material, 2 Valens Pharmachem, 4 Vasa Pharmachem, 1 Vertellus

relatedExcipients
1 Minakem
2 Evonik
5 Rochem International Inc
18 SPI Pharma
2 Seqens
20 DKSH
3 Jai Radhe Sales
2 Pharm-RX Chemical
8 Boai NKY Pharmaceuticals Ltd
1 Chynops Pharma
15 Gangwal Healthcare
10 Nanjing Well Pharmaceutical
2 Pfanstiehl
4 ACG Worldwide
8 Actylis
1 Aeon Procare
3 Alcedo Pharmachem
12 Anhui Sunhere Pharmaceutical Excipients Co.,Ltd
1 Avesta Pharma
35 BASF
1 Bioplus Life Sciences
2 Clariant
15 Corel Pharma Chem
6 DFE Pharma
2 Finar
13 Gangwal Chemicals
16 Ideal Cures Pvt Ltd
5 Ingredion Pharma Solutions
33 Kerry
4 Kima Chemical
6 Lonza Capsugel
14 Microlex e.U
1 Nanjing Bold Chemical
1 NEWEDGE Overseas
2 Nomisma Healthcare
4 Novo Excipients
5 Pharmatrans-Sanaq
8 Pluviaendo
5 Prachin Chemical
1 Qianhao Chemical (Hebei) Co., Ltd
2 Qualicaps
21 Roquette
14 Seppic
7 Shanghai Shenmei Pharmaceutical Technology Co., Ltd
1 Shanghai Welltone Material Technology Co., Ltd
1 Shijiazhuang Huaxu Pharmaceutical
12 Sigachi Industries
3 The Dow Chemical Company
3 Ulanqab Kema New Material
2 Valens Pharmachem
4 Vasa Pharmachem
1 Vertellus

EXCIPIENTS BY APPLICATIONS

102 Fillers, Diluents & Binders, 76 Coating Systems & Additives, 47 Direct Compression, 47 Controlled & Modified Release, 46 Disintegrants & Superdisintegrants, 41 Thickeners and Stabilizers, 38 Solubilizers, 31 Granulation, 26 Taste Masking, 26 Lubricants & Glidants, 25 Parenteral, 24 Topical, 21 Film Formers & Plasticizers, 20 Co-Processed Excipients, 20 Chewable & Orodispersible Aids, 12 Emulsifying Agents, 10 Rheology Modifiers, 9 Empty Capsules, 9 API Stability Enhancers, 6 Surfactant & Foaming Agents, 5 Coloring Agents, 4 Vegetarian Capsules, 1 Soft Gelatin

DIGITAL CONTENT

3 DATA COMPILATION #PharmaFlow, 65 NEWS #PharmaBuzz

media
3 DATA COMPILATION #PharmaFlow
65 NEWS #PharmaBuzz

GLOBAL SALES INFORMATION

4 US Medicaid Prescriptions, 268 Finished Drug Prices, 8 Annual Reports

globalSalesInformation
4 US Medicaid Prescriptions
268 Finished Drug Prices
8 Annual Reports

MARKET PLACE

13 APIs, 3 FDF Dossiers

marketPlace
13 APIs
3 FDF Dossiers

PATENTS & EXCLUSIVITIES

77 US Patents, 2 US Exclusivities, 8 Health Canada Patents

patents
77 US Patents
2 US Exclusivities
8 Health Canada Patents

REF. STANDARDS & IMPURITIES

4 USP , 7 JP , 12 Others

otherSolutions
4 USP
7 JP
12 Others

ANALYTICAL

3 BioAnalytical Methods, 9 Analytical Methods

otherMethods
3 BioAnalytical Methods
9 Analytical Methods

Synopsis

ACTIVE PHARMA INGREDIENTS

API Suppliers

USDMF

CEP/COS

JDMF

EU WC

KDMF

NDC API

VMF

Listed Suppliers

API REF. PRICE (USD/KG)

$ 1,855

MARKET PLACE

API

FDF

30INTERMEDIATES

FINISHED DOSAGE FORMULATIONS

582

FDF Dossiers

FDA Orange Book

302

Europe

Canada

Australia

South Africa

Listed Dossiers

12DRUGS IN DEVELOPMENT

DRUG PRODUCT COMPOSITIONS

REF. STANDARDS OR IMPURITIES

EDQM

USP

Others

PATENTS & EXCLUSIVITIES

US Patents

US Exclusivities

Health Canada Patents

DIGITAL CONTENT

Data Compilation #PharmaFlow

Stock Recap #PipelineProspector

Weekly News Recap #Phispers

News #PharmaBuzz

GLOBAL SALES INFORMATION

US Medicaid (USD)

249,752,925

Annual Reports (USD Million)

2,014

Finished Drug Prices

368 RELATED EXCIPIENT COMPANIES

646EXCIPIENTS BY APPLICATIONS

Chemistry

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Also known as: 120011-70-3, Donepezil hcl, Aricept, Bnag, 110119-84-1, 2-((1-benzylpiperidin-4-yl)methyl)-5,6-dimethoxy-2,3-dihydro-1h-inden-1-one hydrochloride

Molecular Formula

C₂₄H₃₀ClNO₃

Molecular Weight

416.0 g/mol

InChI Key

XWAIAVWHZJNZQQ-UHFFFAOYSA-N

FDA UNII

3O2T2PJ89D

An indan and piperidine derivative that acts as a selective and reversible inhibitor of ACETYLCHOLINESTERASE. Donepezil is highly selective for the central nervous system and is used in the management of mild to moderate DEMENTIA in ALZHEIMER DISEASE.

1 2D Structure

Donepezil

2 Identification

2.1 Computed Descriptors

2.1.1 IUPAC Name

2-[(1-benzylpiperidin-4-yl)methyl]-5,6-dimethoxy-2,3-dihydroinden-1-one;hydrochloride

2.1.2 InChI

InChI=1S/C24H29NO3.ClH/c1-27-22-14-19-13-20(24(26)21(19)15-23(22)28-2)12-17-8-10-25(11-9-17)16-18-6-4-3-5-7-18;/h3-7,14-15,17,20H,8-13,16H2,1-2H3;1H

2.1.3 InChI Key

XWAIAVWHZJNZQQ-UHFFFAOYSA-N

2.1.4 Canonical SMILES

COC1=C(C=C2C(=C1)CC(C2=O)CC3CCN(CC3)CC4=CC=CC=C4)OC.Cl

2.2 Other Identifiers

2.2.1 UNII

3O2T2PJ89D

2.3 Synonyms

2.3.1 MeSH Synonyms

1. 1-benzyl-4-((5,6-dimethoxy-1-indanon)-2-yl)methylpiperidine Hydrochloride

2. Aricept

3. Donepezil

4. Donepezilium Oxalate Trihydrate

5. E 2020

6. E-2020

7. E2020

8. Eranz

2.3.2 Depositor-Supplied Synonyms

1. 120011-70-3

2. Donepezil Hcl

3. Aricept

4. Bnag

5. 110119-84-1

6. 2-((1-benzylpiperidin-4-yl)methyl)-5,6-dimethoxy-2,3-dihydro-1h-inden-1-one Hydrochloride

7. E2020

8. Donepezilhcl

9. E-2020

10. Aricept Odt

11. E 2020

12. Donepezil (hydrochloride)

13. Donepezil, Hcl

14. 2,3-dihydro-5,6-dimethoxy-2-[[1-(phenylmethyl)-4-piperidinyl]methyl]-1h-inden-1-one Hydrochloride

15. Nsc-737535

16. Nsc-758882

17. Chembl1678

18. 3o2t2pj89d

19. 2-[(1-benzylpiperidin-4-yl)methyl]-5,6-dimethoxy-2,3-dihydroinden-1-one;hydrochloride

20. 2-(1-benzyl-4-piperidylmethyl)-5,6-dimethoxy-1-indanone Hydrochloride

21. 120011-70-3 (hcl)

22. E2020;e-2020

23. Dsstox_cid_26698

24. Dsstox_rid_81832

25. Dsstox_gsid_46698

26. 1h-inden-1-one, 2,3-dihydro-5,6-dimethoxy-2-[[1-(phenylmethyl)-4-piperidinyl]methyl]-, Hydrochloride (1:1)

27. Eranz

28. 2-(1-benzyl-piperidin-4-ylmethyl)-5,6-dimethoxy-indan-1-one Hydrochloride

29. E 2020 (pharmaceutical)

30. Smr000449292

31. Cas-120011-70-3

32. Donepezil Hydrochloride [usan]

33. Nsc 737535

34. Nsc 758882

35. Ncgc00167537-01

36. Unii-3o2t2pj89d

37. Memorit

38. Memac

39. Aricept Evess

40. Donepezil,hcl

41. Aricept D

42. (+/-)-2-((1-benzyl-4-piperidyl)methyl)-5,6-dimethoxy-1-indanone Hydrochloride

43. (+/-)-2-[(1-benzyl-4-piperidyl)methyl]-5,6-dimethoxy-1-indanone Hydrochloride

44. Aricept (tn)

45. Donepezil Hydrochloride [usan:usp]

46. Adlarity

47. Donepezil, Hydrochloride

48. 1-benzyl-4-((5,6-dimethoxy-1-indanon)-2-yl)methylpiperidine Hcl

49. Donepezil Hcl (aricept)

50. Donepezil Hcl - Bio-x

51. Schembl1815

52. Donepezil Hydrochloride,(s)

53. Mls000758276

54. Mls001401387

55. Chebi:4696

56. Dtxsid0046698

57. Pharmakon1600-01504403

58. Act02683

59. Amy40527

60. Bcp02205

61. Bcp24884

62. Hy-b0034

63. Donepezil Hydrochloride [mi]

64. Tox21_112534

65. Ac-913

66. Donepezil Hydrochloride (jp17/usp)

67. Donepezil Hydrochloride [jan]

68. Mfcd00881312

69. Nsc737535

70. Nsc758882

71. S2462

72. Akos000277343

73. Akos016340656

74. Tox21_112534_1

75. Ccg-101043

76. Ccg-213309

77. Cs-0863

78. Donepezil Hydrochloride [mart.]

79. Donepezil Hydrochloride [vandf]

80. Ks-1051

81. Nc00293

82. (+-)-2-((1-benzyl-4-piperidyl)methyl)-5,6-dimethoxy-1-indanone Hydrochloride

83. Donepezil Hydrochloride [usp-rs]

84. Donepezil Hydrochloride [who-dd]

85. Ncgc00167537-02

86. 1h-inden-1-one, 2,3-dihydro-5,6-dimethoxy-2-((1-(phenylmethyl)-4-piperidinyl)methyl)-, Hydrochloride

87. Bd164380

88. D4099

89. Donepezil Hydrochloride [orange Book]

90. Ft-0602354

91. Ft-0625589

92. Donepezil Hydrochloride [ep Monograph]

93. D00670

94. Donepezil Hydrochloride [usp Monograph]

95. E-2022

96. Namzaric Component Donepezil Hydrochloride

97. 119d841

98. A804411

99. Donepezil Hydrochloride Component Of Namzaric

100. Donepezil Hydrochloride Monohydrate, >=98% (hplc)

101. Q-100096

102. Q-201040

103. Q27106438

104. Donepezil Hydrochloride 1.0 Mg/ml In Methanol (as Free Base)

105. 2,3-dihydro-5,6-dimethoxy-2-((1-(phenylmethyl)-4-piperidinyl)methyl)-1h-inden-1-one Hcl

106. 2,3-dihydro-5,6-dimethoxy-2-[[1-(phenylmethyl)-4-piperidinyl]-1h-inden-1-one

107. (+-)-2,6-dimethoxy-2-[[1-(phenylmethyl)-4-piperidinyl]methyl]-1h-inden-1-one Hydrochloride

108. 2-((1-benzylpiperidin-4-yl)methyl)-5,6-dimethoxy-2,3-dihydro-1h-inden-1-one Hydrochloride 120014-06-

2.4 Create Date

2005-06-24

3 Chemical and Physical Properties

Molecular Formula	C₂₄H₃₀ClNO₃
Molecular Weight	416.0 g/mol
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	4
Rotatable Bond Count	6
Exact Mass	415.1914215 g/mol
Monoisotopic Mass	415.1914215 g/mol
Topological Polar Surface Area	38.8 Å²
Heavy Atom Count	29
Formal Charge	0
Complexity	510
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	1
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently Bonded Unit Count	2

4 Drug and Medication Information

4.1 Drug Information

1 of 4
Drug Name	Aricept
PubMed Health	Donepezil (By mouth)
Drug Classes	Central Nervous System Agent
Drug Label	ARICEPT (donepezil hydrochloride) is a reversible inhibitor of the enzyme acetylcholinesterase, known chemically as ()-2,3-dihydro-5,6-dimethoxy-2-[[1-(phenylmethyl)-4-piperidinyl]methyl]-1H-inden-1-one hydrochloride. Donepezil hydrochloride is c...
Active Ingredient	Donepezil hydrochloride
Dosage Form	Tablet
Route	Oral
Strength	5mg; 23mg; 10mg
Market Status	Prescription
Company	Eisai

2 of 4
Drug Name	Donepezil hydrochloride
Drug Label	Donepezil hydrochloride is a reversible inhibitor of the enzyme acetylcholinesterase, known chemically as ()-2,3-dihydro-5,6-dimethoxy-2-[[1-(phenylmethyl)-4-piperidinyl]methyl]-1H-inden-1-one hydrochloride. Donepezil hydrochloride is commonly refe...
Active Ingredient	Donepezil hydrochloride
Dosage Form	Tablet, orally disintegrating; Tablet
Route	oral; Oral
Strength	5mg; 23mg; 10mg
Market Status	Tentative Approval; Prescription
Company	Wockhardt; Mylan Pharms; Ranbaxy; Macleods Pharms; Jubilant Generics; Vivimed Labs; Teva; Apotex; Aurobindo; Indicus Pharma; Alembic Pharms; Cspc Ouyi Pharm; Sun Pharm Inds; Pliva Hrvatska Doo; Torrent Pharms; Zydus Pharms Usa; Dr Reddys Labs; Sandoz; Pri

3 of 4
Drug Name	Aricept
PubMed Health	Donepezil (By mouth)
Drug Classes	Central Nervous System Agent
Drug Label	ARICEPT (donepezil hydrochloride) is a reversible inhibitor of the enzyme acetylcholinesterase, known chemically as ()-2,3-dihydro-5,6-dimethoxy-2-[[1-(phenylmethyl)-4-piperidinyl]methyl]-1H-inden-1-one hydrochloride. Donepezil hydrochloride is c...
Active Ingredient	Donepezil hydrochloride
Dosage Form	Tablet
Route	Oral
Strength	5mg; 23mg; 10mg
Market Status	Prescription
Company	Eisai

4 of 4
Drug Name	Donepezil hydrochloride
Drug Label	Donepezil hydrochloride is a reversible inhibitor of the enzyme acetylcholinesterase, known chemically as ()-2,3-dihydro-5,6-dimethoxy-2-[[1-(phenylmethyl)-4-piperidinyl]methyl]-1H-inden-1-one hydrochloride. Donepezil hydrochloride is commonly refe...
Active Ingredient	Donepezil hydrochloride
Dosage Form	Tablet, orally disintegrating; Tablet
Route	oral; Oral
Strength	5mg; 23mg; 10mg
Market Status	Tentative Approval; Prescription
Company	Wockhardt; Mylan Pharms; Ranbaxy; Macleods Pharms; Jubilant Generics; Vivimed Labs; Teva; Apotex; Aurobindo; Indicus Pharma; Alembic Pharms; Cspc Ouyi Pharm; Sun Pharm Inds; Pliva Hrvatska Doo; Torrent Pharms; Zydus Pharms Usa; Dr Reddys Labs; Sandoz; Pri

5 Pharmacology and Biochemistry

5.1 MeSH Pharmacological Classification

Cholinesterase Inhibitors

Drugs that inhibit cholinesterases. The neurotransmitter ACETYLCHOLINE is rapidly hydrolyzed, and thereby inactivated, by cholinesterases. When cholinesterases are inhibited, the action of endogenously released acetylcholine at cholinergic synapses is potentiated. Cholinesterase inhibitors are widely used clinically for their potentiation of cholinergic inputs to the gastrointestinal tract and urinary bladder, the eye, and skeletal muscles; they are also used for their effects on the heart and the central nervous system. (See all compounds classified as Cholinesterase Inhibitors.)

Nootropic Agents

Drugs used to specifically facilitate learning or memory, particularly to prevent the cognitive deficits associated with dementias. These drugs act by a variety of mechanisms. (See all compounds classified as Nootropic Agents.)

5.2 FDA Pharmacological Classification

5.2.1 Pharmacological Classes

Cholinesterase Inhibitors [MoA]; Cholinesterase Inhibitor [EPC]

API SUPPLIERS

01

Gonane Pharma

India

USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

CPhI Worldwide, Milan

Attending

Gonane has API manufacturing expertise in new-age Corticosteroids, Hormones and other pharma raw materials.

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India

Virtual Booth

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USDMF CEP/COS JDMF EU-WC NDC KDMF VMF Others AUDIT

02

LGM Pharma

U.S.A

USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

CPhI Worldwide, Milan

Attending

LGM Pharma accelerates & optimizes the new product pathway from early development through commercialization.

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U.S.A

Virtual Booth

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USDMF CEP/COS JDMF EU-WC NDC KDMF VMF Others AUDIT

03

Metrochem API Private Limited

India

USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

CPhI Worldwide, Milan

Booth #3A33

Metrochem has been delivering customized volume & quality products to customers across the world, taking utmost care of their needs.

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India

Virtual Booth

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USDMF CEP/COS JDMF EU-WC NDC KDMF VMF Others AUDIT

04

Dr. Reddy\'s Laboratories

India

USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

CPhI Worldwide, Milan

Booth #24A41

DRL offers a portfolio of products & services, including APIs, CMO services, generics, biosimilars & differentiated formulations.

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India

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USDMF

CEP/COS JDMF EU-WC NDC

KDMF

VMF Others AUDIT

05

Egis Pharmaceuticals PLC

Hungary

USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

CPhI Worldwide, Milan

Booth #22F114

Egis is a Hungarian generic pharma company with 110 years history. Our activities incorporate all areas of the pharma value chain.

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Hungary

Virtual Booth

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USDMF CEP/COS JDMF EU-WC NDC KDMF VMF Others AUDIT

06

Jai Radhe Sales

India

USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

CPhI Worldwide, Milan

Attending

Jai Radhe Sales is your partner for all your sourcing needs.

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India

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07

Shandong Chenghui Shuangda Pharmac...

China

USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

CPhI Worldwide, Milan

Booth #1A124

Shuangda Pharmaceutical has a world-class first-class production line, having GMP, FDA and other regulatory certifications.

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China

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Shandong Chenghui Shuangda Pharmaceutical

08

HRV Global Life Sciences

India

USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

CPhI Worldwide, Milan

Booth #3A25

HRV Global Life Sciences - Market Expansion Leader in Pharmaceuticals.

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India

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AUDIT

09

Megafine Pharma (P) Limited

India

USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

CPhI Worldwide, Milan

Attending

Megafine Pharma is engaged in the production of APIs, and advanced intermediates, and offers contract manufacturing services.

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India

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EU-WC

NDC KDMF VMF CA, AU, ...

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10

Neuland Laboratories

India

USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

CPhI Worldwide, Milan

Booth #1A18

Neuland Laboratories- A dedicated 100% API provider.

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India

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USDMF

CEP/COS

JDMF EU-WC

NDC

KDMF

VMF Others AUDIT

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API Reference Price

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Number of Transactions

Total Quantity (KGS)

Total Value (USD)

Quantity (KGS) & Unit rate (USD/KGS) over time

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Importing Country	Total Quantity (KGS)	Average Price (USD/KGS)	Number of Transactions

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DOSAGE - TABLET;ORAL - 10MG

USFDA APPLICATION NUMBER - 20690

DOSAGE - TABLET;ORAL - 5MG

USFDA APPLICATION NUMBER - 20690

DOSAGE - TABLET, ORALLY DISINTEGRATING;ORAL -...DOSAGE - TABLET, ORALLY DISINTEGRATING;ORAL - 10MG

USFDA APPLICATION NUMBER - 21720

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USFDA APPLICATION NUMBER - 21720

DOSAGE - TABLET;ORAL - 23MG

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