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Chemistry

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Also known as: 62-31-7, 3-hydroxytyramine hydrochloride, Dopamine hcl, Intropin, 4-(2-aminoethyl)benzene-1,2-diol hydrochloride, Cardiosteril
Molecular Formula
C8H12ClNO2
Molecular Weight
189.64  g/mol
InChI Key
CTENFNNZBMHDDG-UHFFFAOYSA-N
FDA UNII
7L3E358N9L

Dopamine
One of the catecholamine NEUROTRANSMITTERS in the brain. It is derived from TYROSINE and is the precursor to NOREPINEPHRINE and EPINEPHRINE. Dopamine is a major transmitter in the extrapyramidal system of the brain, and important in regulating movement. A family of receptors (RECEPTORS, DOPAMINE) mediate its action.
1 2D Structure

Dopamine

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
4-(2-aminoethyl)benzene-1,2-diol;hydrochloride
2.1.2 InChI
InChI=1S/C8H11NO2.ClH/c9-4-3-6-1-2-7(10)8(11)5-6;/h1-2,5,10-11H,3-4,9H2;1H
2.1.3 InChI Key
CTENFNNZBMHDDG-UHFFFAOYSA-N
2.1.4 Canonical SMILES
C1=CC(=C(C=C1CCN)O)O.Cl
2.2 Other Identifiers
2.2.1 UNII
7L3E358N9L
2.3 Synonyms
2.3.1 MeSH Synonyms

1. 3,4 Dihydroxyphenethylamine

2. 3,4-dihydroxyphenethylamine

3. 4-(2-aminoethyl)-1,2-benzenediol

4. Dopamine

5. Hydrochloride, Dopamine

6. Hydroxytyramine

7. Intropin

2.3.2 Depositor-Supplied Synonyms

1. 62-31-7

2. 3-hydroxytyramine Hydrochloride

3. Dopamine Hcl

4. Intropin

5. 4-(2-aminoethyl)benzene-1,2-diol Hydrochloride

6. Cardiosteril

7. Dopastat

8. Revivan

9. Inotropin

10. Tensamin

11. Dopamine.hcl

12. 3,4-dihydroxyphenethylamine Hydrochloride

13. Dynatra

14. 1,2-benzenediol, 4-(2-aminoethyl)-, Hydrochloride

15. 4-(2-aminoethyl)pyrocatechol Hydrochloride

16. (dopamine Hcl)

17. 2-(3,4-dihydroxyphenyl)ethylamine Hydrochloride

18. M-hydroxytyramine Hydrochloride

19. Dopamine (hydrochloride)

20. 3-hydroxytyramine, Hydrochloride

21. Asl-279

22. P 498

23. 4-(2-aminoethyl)benzene-1,2-diol;hydrochloride

24. Nsc-169105

25. Mls000069419

26. 7l3e358n9l

27. Smr000059081

28. Dopamine Chloride

29. Dopamine Fresenius

30. 62-31-7 (hcl); 51-61-6 (free Base)

31. 1200398-97-5

32. 1,2-benzenediol, 4-(2-aminoethyl)-, Hydrochloride (1:1)

33. 3-hydroxytyraminium Chloride

34. Abbodop

35. Rascordin

36. Pyrocatechol, 4-(2-aminoethyl)-, Hydrochloride

37. 1,2-benzenediol, 4-(2-aminoethyl)-, Hydrochloride (1:1), Homopolymer

38. Nsc169105

39. Einecs 200-527-8

40. Nsc 169105

41. Unii-7l3e358n9l

42. Sr-01000075366

43. .beta.-(3,4-dihydroxyphenyl)ethylamine Hydrochloride

44. Actopamin (tn)

45. Dopamine Hcl Salt

46. Intropin (tn)

47. Beta-(3,4-dihydroxyphenyl)ethylamine Hydrochloride

48. Dopamine Hydrochloride In Dextrose 5%

49. Dopamine Hydrochloride And Dextrose 5%

50. Dopamini Hydrochloridum

51. 3-hydroxytyramine Hcl

52. Dopamine Hydrochloride [usan:usp:jan]

53. 3-hydroxytyramine, Hcl

54. Opera_id_218

55. 3,4-dihydroxyphenyl-ethylamine Hydrochloride

56. Dopamine Hydrogen Chloride

57. Dsstox_cid_550

58. Intropin [as Hydrochloride]

59. Dopamini Hydrochloridum,(s)

60. Chembl1557

61. Dsstox_rid_75655

62. Dsstox_gsid_20550

63. Schembl40951

64. 335081-04-4

65. Mls001074180

66. Spectrum1500263

67. Asl279

68. Chebi:4698

69. Sgcut00110

70. Dtxsid7020550

71. Hy-b0451a

72. Dopamine Hydrochloride And Dextrose 5% In Plastic Container

73. Dopamine Hydrochloride In Dextrose 5% In Plastic Container

74. Dopamine Hydrochloride (inotropin)

75. Hms1920i18

76. Kuc104380c

77. Pharmakon1600-01500263

78. Dopamine Hydrochloride [mi]

79. Bcp06611

80. To_000060

81. Dopamine Hydrochloride (jp17/usp)

82. Dopamine Hydrochloride [jan]

83. Tox21_201018

84. Tox21_500586

85. Ccg-40211

86. Dopamine Hydrochloride [usan]

87. Nsc756749

88. S2529

89. Dopamine Hydrochloride [vandf]

90. Akos008056421

91. Dopamine Hydrochloride [mart.]

92. 1, 4-(2-aminoethyl)-, Hydrochloride

93. Dopamine Hydrochloride [usp-rs]

94. Dopamine Hydrochloride [who-dd]

95. Dopamine Hydrochloride [who-ip]

96. Ks-5304

97. Ksc-10-159

98. Lp00586

99. Nc00545

100. Nsc-756749

101. 3,4-dihydoxyphenethylamine Hydrochloride

102. Cas-62-31-7

103. Ncgc00093965-01

104. Ncgc00093965-02

105. Ncgc00093965-03

106. Ncgc00093965-04

107. Ncgc00258571-01

108. Ncgc00261271-01

109. 3,4-dihydroxyphenylethylaminehydrochloride

110. Ac-12190

111. Bd166234

112. Db-023081

113. Dopamine Hydrochloride [orange Book]

114. A0305

115. Am20080715

116. Dopamine Hydrochloride [ep Monograph]

117. Eu-0100586

118. Ft-0603260

119. Ft-0667775

120. Ft-0695562

121. Sw199608-2

122. Dopamine Hydrochloride [usp Monograph]

123. Dopamini Hydrochloridum [who-ip Latin]

124. D00633

125. F10519

126. H 8502

127. 2-(3,4-dihydroxyphenyl)ethyl-1-13c-amine Hcl

128. 2-(3,4-dihydroxyphenyl)-ethylamine Hydrochloride

129. A937196

130. Dopamine Hydrochloride, Puriss., >=98.5% (at)

131. Sr-01000075366-1

132. Sr-01000075366-8

133. Q27268491

134. F0001-1648

135. Z262221794

136. 963ad780-3e96-47b5-9044-7e59f6c84d67

137. Dopamine Hydrochloride, Certified Reference Material, Tracecert(r)

138. Dopamine Hydrochloride, British Pharmacopoeia (bp) Reference Standard

139. Dopamine Hydrochloride, European Pharmacopoeia (ep) Reference Standard

140. Dopamine Hydrochloride, United States Pharmacopeia (usp) Reference Standard

141. Dopamine Hydrochloride, Pharmaceutical Secondary Standard; Certified Reference Material

142. Dopamine Hydrochloride Solution, 1.0 Mg/ml In Methanol With 5% 1 M Hcl (as Free Base), Ampule Of 1 Ml, Certified Reference Material

2.4 Create Date
2005-06-24
3 Chemical and Physical Properties
Molecular Weight 189.64 g/mol
Molecular Formula C8H12ClNO2
Hydrogen Bond Donor Count4
Hydrogen Bond Acceptor Count3
Rotatable Bond Count2
Exact Mass189.0556563 g/mol
Monoisotopic Mass189.0556563 g/mol
Topological Polar Surface Area66.5 Ų
Heavy Atom Count12
Formal Charge0
Complexity119
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count2
4 Drug and Medication Information
4.1 Drug Information
1 of 2  
Drug NameDopamine hydrochloride
Drug LabelDopamine Hydrochloride in 5% Dextrose Injection, USP is a sterile, nonpyrogenic, prediluted solution of dopamine hydrochloride in 5% dextrose injection. It is administered by intravenous infusion.Each 100 mL contains dopamine hydrochloride 80 mg (0.8...
Active IngredientDopamine hydrochloride
Dosage FormInjectable
RouteInjection
Strength80mg/ml; 160mg/100ml; 40mg/ml; 160mg/ml; 80mg/100ml
Market StatusPrescription
CompanyHospira; Luitpold

2 of 2  
Drug NameDopamine hydrochloride
Drug LabelDopamine Hydrochloride in 5% Dextrose Injection, USP is a sterile, nonpyrogenic, prediluted solution of dopamine hydrochloride in 5% dextrose injection. It is administered by intravenous infusion.Each 100 mL contains dopamine hydrochloride 80 mg (0.8...
Active IngredientDopamine hydrochloride
Dosage FormInjectable
RouteInjection
Strength80mg/ml; 160mg/100ml; 40mg/ml; 160mg/ml; 80mg/100ml
Market StatusPrescription
CompanyHospira; Luitpold

5 Pharmacology and Biochemistry
5.1 MeSH Pharmacological Classification

Sympathomimetics

Drugs that mimic the effects of stimulating postganglionic adrenergic sympathetic nerves. Included here are drugs that directly stimulate adrenergic receptors and drugs that act indirectly by provoking the release of adrenergic transmitters. (See all compounds classified as Sympathomimetics.)


Dopamine Agents

Any drugs that are used for their effects on dopamine receptors, on the life cycle of dopamine, or on the survival of dopaminergic neurons. (See all compounds classified as Dopamine Agents.)


Cardiotonic Agents

Agents that have a strengthening effect on the heart or that can increase cardiac output. They may be CARDIAC GLYCOSIDES; SYMPATHOMIMETICS; or other drugs. They are used after MYOCARDIAL INFARCT; CARDIAC SURGICAL PROCEDURES; in SHOCK; or in congestive heart failure (HEART FAILURE). (See all compounds classified as Cardiotonic Agents.)


5.2 FDA Pharmacological Classification
5.2.1 Pharmacological Classes
Catecholamines [CS]; Catecholamine [EPC]

API SUPPLIERS

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USDMF

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Hoechst Celanese Corp

U.S.A

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GDUFA

DMF Review : N/A

Rev. Date :

Pay. Date :

DMF Number : 4415

Submission : 1982-01-20

Status : Inactive

Type : II

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02

Medlab Asia & Asia Health
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GDUFA

DMF Review : N/A

Rev. Date :

Pay. Date :

DMF Number : 2453

Submission : 1975-05-23

Status : Inactive

Type : II

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04

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04

Medlab Asia & Asia Health
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GDUFA

DMF Review : Complete

Rev. Date : 2015-03-30

Pay. Date : 2014-05-30

DMF Number : 5134

Submission : 1983-06-10

Status : Active

Type : II

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Zambon Spa

Switzerland

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Zambon Spa

Switzerland
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GDUFA

DMF Review : N/A

Rev. Date :

Pay. Date :

DMF Number : 5788

Submission : 1985-03-29

Status : Inactive

Type : II

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Syntha

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Syntha

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GDUFA

DMF Review : N/A

Rev. Date :

Pay. Date :

DMF Number : 3165

Submission : 1978-02-22

Status : Inactive

Type : II

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CEP/COS

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Certificate Number : R0-CEP 2020-355 - Rev 00

Status : Valid

Issue Date : 2023-04-05

Type : Chemical

Substance Number : 664

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Certificate Number : R1-CEP 2007-049 - Rev 01

Status : Valid

Issue Date : 2015-12-15

Type : Chemical

Substance Number : 664

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JDMF

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JP Dopamine Hydrochloride (for manufacturing only)

Registration Number : 218MF10917

Registrant's Address : 326 Yokamachi, Toyama City, Toyama Prefecture

Initial Date of Registration : 2006-11-21

Latest Date of Registration : 2006-11-21

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Dopamine hydrochloride

Registration Number : 218MF10897

Registrant's Address : 4-15-19 Hibarigaoka, Zama City, Kanagawa Prefecture

Initial Date of Registration : 2006-11-10

Latest Date of Registration : 2006-11-10

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Japanese Pharmacopoeia Dopamine Hydrochloride (for manufacturing only)

Registration Number : 222MF10235

Registrant's Address : 530 Chokeiji, Takaoka City, Toyama Prefecture

Initial Date of Registration : 2010-09-30

Latest Date of Registration : 2016-12-05

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Dopamine hydrochloride

Registration Number : 304MF10111

Registrant's Address : VIA M. Civitali, 1-20148 MILANO, ITALY

Initial Date of Registration : 2022-08-03

Latest Date of Registration : 2022-08-03

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Dopamine hydrochloride

Registration Number : 218MF10519

Registrant's Address : Karlstrasse 15, 32423, Minden, Federal Republic of Germany

Initial Date of Registration : 2006-05-18

Latest Date of Registration : 2006-05-18

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KDMF

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Dopamine hydrochloride

Registrant Name : Sangjin Corporation

Registration Date : 2021-07-22

Registration Number : 20210722-210-J-1077

Manufacturer Name : Recordati Industria Chimica ...

Manufacturer Address : Via Mediana Cisterna, 4- 04011 Aprilia (LT) - Italy

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NDC API

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DOPAMINE HYDROCHLORIDE

NDC Package Code : 65724-4500

Start Marketing Date : 2009-06-11

End Marketing Date : 2024-12-31

Dosage Form (Strength) : POWDER (1kg/kg)

Marketing Category : BULK INGREDIENT

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Listed Suppliers

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  • WHO-GMP

Virtual BoothJai Radhe Sales is your partner for all your sourcing needs.

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Dopamine

About the Company : Jai Radhe Sales was founded in 1999 as an out-of-the-box distribution firm specializing in the global supply of high-quality pharmaceutical ingredients. The firm provides complete ...

Jai Radhe Sales was founded in 1999 as an out-of-the-box distribution firm specializing in the global supply of high-quality pharmaceutical ingredients. The firm provides complete sourcing solutions for pharmaceutical products from India, including technical and regulatory assistance. It believes in providing its customers with high-quality products at reasonable prices. It has always endeavored to achieve global standards in the field of pharmaceuticals and has carved out a niche for itself through new methods based on current market needs. Today, it has established itself as a truly global company, with exports to almost every continent.
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Dopamine

About the Company : Beijing Fukangren Biopharmaceutical Technology Co., Ltd. started its drug R&D service in 1999 and is the CRO company with the longest continuous service time in China. Fukangren no...

Beijing Fukangren Biopharmaceutical Technology Co., Ltd. started its drug R&D service in 1999 and is the CRO company with the longest continuous service time in China. Fukangren now has 3 pharmaceutical R&D centers, 1 clinical R&D center, 4 API production bases and 1 preparation production base, forming an end-to-end CDMO service system that can provide customers with drug R&D and production. The development of high-end formulations is a major advantage of Fukangren. Among them, multiple platform projects such as sustained and controlled release formulations.
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Dopamine Hydrochloride

About the Company : With 33 years of CONSISTENCY, CREDIBILITY & CONTINUITY, D K Pharma has established its presence in the Global Market for Manufacturing Bulk Drugs, Speciality Fine Chemicals and Adv...

With 33 years of CONSISTENCY, CREDIBILITY & CONTINUITY, D K Pharma has established its presence in the Global Market for Manufacturing Bulk Drugs, Speciality Fine Chemicals and Advance Intermediates. D K Pharma is a well-integrated Private Limited Company, located in the state-owned M.I.D.C. Industrial area at Badlapur, Maharashtra. D K Pharma is an ISO 9001 : 2008 certified company having a State-of-the-Art facility with ICH, cGMP & WHO compliance. The company has multi-units with Multi-Purpose facilities to produce Multi-Step Advance Intermediates and a dedicated API Facility.
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KIVIPharm

China
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Dopamine

About the Company : Kivipharm was established in 1973. After 40 years development, this company become one of the leading manufacturer of aseptic pharmaceutical products in china. Our products was exp...

Kivipharm was established in 1973. After 40 years development, this company become one of the leading manufacturer of aseptic pharmaceutical products in china. Our products was exported to more than 30 countries from Africa、Middle East、Russia and former CIS countries、South America and South East Asia. Our newly expanded facilities can support our increasing both by markets and by products.
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Recordati

Italy
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Dopamine

About the Company : Recordati, established in 1926, is an international pharmaceutical group, listed on the Italian Stock Exchange (Reuters RECI.MI, Bloomberg REC IM, ISIN IT 0003828271), with a total...

Recordati, established in 1926, is an international pharmaceutical group, listed on the Italian Stock Exchange (Reuters RECI.MI, Bloomberg REC IM, ISIN IT 0003828271), with a total staff of around 4,000, dedicated to the research, development, manufacturing and marketing of pharmaceuticals. Headquartered in Milan, Italy, Recordati has operations in the main European countries, in Russia, in other Central and Eastern European countries, in Turkey, in North Africa and in the United States of America.
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Siegfried AG

Switzerland
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Siegfried AG

Switzerland
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Dopamine

About the Company : As an internationally renowned outsourcing partner, we offer products and tailor-made service packages that are seamlessly embedded in the value chain of our customers. Our pharmac...

As an internationally renowned outsourcing partner, we offer products and tailor-made service packages that are seamlessly embedded in the value chain of our customers. Our pharmaceutical industry partners benefit from a wide range of offers - from the development of active ingredients to development services for ready-made drugs, their approval and production to packaging and logistics. As a former fully integrated pharmaceutical company, Siegfried is now one of the few suppliers who can develop both active ingredients and ready-made drugs under one roof. This combination of experience and know-how is unique in the CDMO market.
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Dopamine

About the Company : Synthetic Molecules Pvt. Ltd (SMPL) is glad to introduce ourselves as established pharmaceutical manufacture & reputed trading house catering the ranges of Intermediates, Active Ph...

Synthetic Molecules Pvt. Ltd (SMPL) is glad to introduce ourselves as established pharmaceutical manufacture & reputed trading house catering the ranges of Intermediates, Active Pharma Ingredients, Vitamins & Speciality Chemicals to Domestic as well as international market. We have entered the business in year 2003. Our indulgence in pharma market under the leadership of Mr. Kishor Thakur, having a vast experience in this field for more than 23 years, has allowed us to create close relations with the various world wide pharma industries.
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API Reference Price

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PRIVATE ","customerCountry":"INDIA","quantity":"10.00","actualQuantity":"10","unit":"KGS","unitRateFc":"1500","totalValueFC":"18294.3","currency":"EUR","unitRateINR":"135684.5","date":"10-Aug-2021","totalValueINR":"1356844.69","totalValueInUsd":"18294.3","indian_port":"BANGALORE AIR","hs_no":"29222990","bill_no":"5002163","productDescription":"API","marketType":"REGULATED MARKET","country":"GERMANY","selfForZScoreResived":"Pharma Grade","supplierPort":"FRANKFURT\/MAIN INT\\'L","supplierAddress":"","customerAddress":"IBC KNOWLEDGE PARK, PHASE-2, D BLOCK, 9TH FLOOR, 4\/1, BANNERGHATTA"},{"dataSource":"API Import","activeIngredients":"","year":"2021","qtr":"Q4","strtotime":1639074600,"product":"DOPAMINE HYDROCHLORIDE","address":"GF-1,GROUND FLOOR,COMMERCE HOUSE 1 ,,OPP.RAJVANSH APPT,JUDGES","city":"BUNGALOW RD BODAKDEV AHMEDABAD,GUJA","supplier":"RECORDATI","supplierCountry":"ITALY","foreign_port":"N\/A","customer":"TROIKAA PHARMACEUTICALS 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LABORATORIES","customerCountry":"INDIA","quantity":"73.70","actualQuantity":"73.7","unit":"KGS","unitRateFc":"320","totalValueFC":"23866.6","currency":"USD","unitRateINR":"25264","date":"24-Jun-2022","totalValueINR":"1861956.8","totalValueInUsd":"23866.6","indian_port":"HYDERABAD AIR","hs_no":"29222990","bill_no":"9261287","productDescription":"API","marketType":"REGULATED MARKET","country":"ITALY","selfForZScoreResived":"Pharma Grade","supplierPort":"NA","supplierAddress":"","customerAddress":"SANALI INFO PARK, 8-2-120\/113,ROAD NO.2, BANJARA HILLS"},{"dataSource":"API Import","activeIngredients":"","year":"2022","qtr":"Q2","strtotime":1656268200,"product":"DOPAMINE HCL USP (REIMPORT FOR PROCESS VIDE S\/B NO. 8977050DT. 16.03.2022","address":"PLOT NO.F-32,W-5,W-6,&W-7,M.I.D.C. ,,BADLAPUR","city":"BADLAPUR,MAHARASHTRA","supplier":"JEBSEN & JESSEN","supplierCountry":"INDIA","foreign_port":"NA","customer":"D K PHARMA ","customerCountry":"INDIA","quantity":"5.00","actualQuantity":"5","unit":"KGS","unitRateFc":"350","totalValueFC":"1868.6","currency":"USD","unitRateINR":"29156.5","date":"27-Jun-2022","totalValueINR":"145782.5","totalValueInUsd":"1868.6","indian_port":"BOMBAY AIR","hs_no":"29072990","bill_no":"9306627","productDescription":"Re-Import","marketType":"REGULATED MARKET","country":"INDIA","selfForZScoreResived":"Pharma Grade","supplierPort":"NA","supplierAddress":"","customerAddress":"PLOT NO.F-32,W-5,W-6,&W-7,M.I.D.C. ,,BADLAPUR"},{"dataSource":"API Import","activeIngredients":"","year":"2023","qtr":"Q3","strtotime":1693247400,"product":"DOPAMINE HCL 5KG, 704241, BATCH 22432022","address":"IBC KNOWLEDGE PARK, PHASE-2, D ,BLOCK, 9TH FLOOR, 4\/1, BANNERGHATTA,RD,OPP:FIRE STATION, , KAR","city":"BANGALORE","supplier":"SIEGFRIED AG","supplierCountry":"GERMANY","foreign_port":"NA","customer":"GLOBAL PHARMATECH PRIVATE 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19-Apr-2021
05-Sep-2024
KGS
overview
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Average Price (USD/KGS)

Number of Transactions

Total Quantity (KGS)

Total Value (USD)

Quantity (KGS) & Unit rate (USD/KGS) over time

API Imports and Exports

Importing Country Total Quantity
(KGS)
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(USD/KGS)
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INTERMEDIATES SUPPLIERS

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01

Medlab Asia & Asia Health
Not Confirmed
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Medlab Asia & Asia Health
Not Confirmed
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CAS Number : 120-20-7

End Use API : Dopamine

About The Company : Aragen is a trusted R&D and manufacturing partner to the global life sciences industry. From concept to commercial, we transform your ideas into solutions for b...

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02

Recordati

Italy
Medlab Asia & Asia Health
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Recordati

Italy
Medlab Asia & Asia Health
Not Confirmed
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CAS Number : 120-20-7

End Use API : Dopamine

About The Company : Recordati, established in 1926, is an international pharmaceutical group, listed on the Italian Stock Exchange (Reuters RECI.MI, Bloomberg REC IM, ISIN IT 00038...

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DOSAGE - INJECTABLE;INJECTION - 160MG/100ML

USFDA APPLICATION NUMBER - 18132

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DOSAGE - INJECTABLE;INJECTION - 40MG/ML

USFDA APPLICATION NUMBER - 18132

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DOSAGE - INJECTABLE;INJECTION - 80MG/100ML

USFDA APPLICATION NUMBER - 18132

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