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ACTIVE PHARMA INGREDIENTS

13 API Suppliers, 8 USDMF, 1 KDMF, 4 NDC API, 8 Listed Suppliers, $ API Reference Price

13 API Suppliers
8 USDMF
1 KDMF
4 NDC API
8 Listed Suppliers
$ API Reference Price

INTERMEDIATES

3 Intermediates Suppliers

3 Intermediates Suppliers

FINISHED DOSAGE FORMULATIONS

77 FDF Dossiers, 20 FDA Orange Book, 32 Europe, 1 Canada, 23 South Africa, 1 Listed Dossiers

77 FDF Dossiers
20 FDA Orange Book
32 Europe
1 Canada
23 South Africa
1 Listed Dossiers

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1 DATA COMPILATION #PharmaFlow, 9 NEWS #PharmaBuzz

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29 Finished Drug Prices

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29 Finished Drug Prices

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3 APIs

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3 APIs

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1 Others

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1 Others

Synopsis

ACTIVE PHARMA INGREDIENTS

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Data Compilation #PharmaFlow

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Chemistry

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Also known as: Magnescope, Meglumine gadoterate (jan), Gadoterate meglumine (usan), Gadoterate meglumine [usan], Meglumine gadoterate [jan], Magnescope (tn)

Molecular Formula

C₂₃H₄₂GdN₅O₁₃

Molecular Weight

753.9 g/mol

InChI Key

RYHQMKVRYNEBNJ-BMWGJIJESA-K

FDA UNII

L0ND3981AG

1 2D Structure

Gadoterate Meglumine

2 Identification

2.1 Computed Descriptors

2.1.1 IUPAC Name

2-[4,7-bis(carboxylatomethyl)-10-(carboxymethyl)-1,4,7,10-tetrazacyclododec-1-yl]acetate;gadolinium(3+);(2R,3R,4R,5S)-6-(methylamino)hexane-1,2,3,4,5-pentol

2.1.2 InChI

InChI=1S/C16H28N4O8.C7H17NO5.Gd/c21-13(22)9-17-1-2-18(10-14(23)24)5-6-20(12-16(27)28)8-7-19(4-3-17)11-15(25)26;1-8-2-4(10)6(12)7(13)5(11)3-9;/h1-12H2,(H,21,22)(H,23,24)(H,25,26)(H,27,28);4-13H,2-3H2,1H3;/q;;+3/p-3/t;4-,5+,6+,7+;/m.0./s1

2.1.3 InChI Key

RYHQMKVRYNEBNJ-BMWGJIJESA-K

2.1.4 Canonical SMILES

CNCC(C(C(C(CO)O)O)O)O.C1CN(CCN(CCN(CCN1CC(=O)O)CC(=O)[O-])CC(=O)[O-])CC(=O)[O-].[Gd+3]

2.1.5 Isomeric SMILES

CNC[C@@H]([C@H]([C@@H]([C@@H](CO)O)O)O)O.C1CN(CCN(CCN(CCN1CC(=O)O)CC(=O)[O-])CC(=O)[O-])CC(=O)[O-].[Gd+3]

2.2 Other Identifiers

2.2.1 UNII

L0ND3981AG

2.3 Synonyms

2.3.1 MeSH Synonyms

1. Gadoterate Meglumine

2.3.2 Depositor-Supplied Synonyms

1. Magnescope

2. Meglumine Gadoterate (jan)

3. Gadoterate Meglumine (usan)

4. Gadoterate Meglumine [usan]

5. Meglumine Gadoterate [jan]

6. Magnescope (tn)

7. Dotarem (tn)

8. Schembl20420633

9. Gadoterate Meglumine [vandf]

10. Gadoterate Meglumine [usp-rs]

11. Meglumine Gadoterate [who-dd]

12. Ek-5504

13. Gadoterate Meglumine [orange Book]

14. P449

15. P-449

16. D03355

17. Q27144071

18. 2-[4,7-bis(carboxylatomethyl)-10-(carboxymethyl)-1,4,7,10-tetrazacyclododec-1-yl]acetate;gadolinium(3+);(2r,3r,4r,5s)-6-(methylamino)hexane-1,2,3,4,5-pentol

19. D-glucitol, 1-deoxy-1-(methylamino)-, (1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetato(4-)-.kappa.n1,.kappa.n4,.kappa.n7,.kappa.n10,.kappa.o1,.kappa.o4,.kappa.o7,.kappa.o10)gadolinate(1-) (1:1)

2.4 Create Date

2006-07-28

3 Chemical and Physical Properties

Molecular Formula	C₂₃H₄₂GdN₅O₁₃
Molecular Weight	753.9 g/mol
Hydrogen Bond Donor Count	7
Hydrogen Bond Acceptor Count	18
Rotatable Bond Count	11
Exact Mass	754.20202 g/mol
Monoisotopic Mass	754.20202 g/mol
Topological Polar Surface Area	284 Å²
Heavy Atom Count	42
Formal Charge	0
Complexity	644
Isotope Atom Count	0
Defined Atom Stereocenter Count	4
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently Bonded Unit Count	3

4 Drug and Medication Information

4.1 Drug Information

1 of 2
Drug Name	Dotarem
PubMed Health	Gadoterate (Injection)
Drug Classes	Diagnostic Agent, Radiopharmaceutical Imaging
Drug Label	DOTAREM (gadoterate meglumine) is a paramagnetic macrocyclic ionic contrast agent administered for magnetic resonance imaging. The chemical name for gadoterate meglumine is D-glucitol, 1-deoxy-1-(methylamino)-,[1,4,7,10-tetraazacyclododecane-1,4,7,10...
Active Ingredient	Gadoterate meglumine
Dosage Form	Solution
Route	Intravenous
Strength	5.6535gm/15ml (376.9mg/ml); 3.769gm/10ml (376.9mg/ml); 37.69gm/100ml (376.9mg/ml); 7.538gm/20ml (376.9mg/ml)
Market Status	Prescription
Company	Guerbet

2 of 2
Drug Name	Dotarem
PubMed Health	Gadoterate (Injection)
Drug Classes	Diagnostic Agent, Radiopharmaceutical Imaging
Drug Label	DOTAREM (gadoterate meglumine) is a paramagnetic macrocyclic ionic contrast agent administered for magnetic resonance imaging. The chemical name for gadoterate meglumine is D-glucitol, 1-deoxy-1-(methylamino)-,[1,4,7,10-tetraazacyclododecane-1,4,7,10...
Active Ingredient	Gadoterate meglumine
Dosage Form	Solution
Route	Intravenous
Strength	5.6535gm/15ml (376.9mg/ml); 3.769gm/10ml (376.9mg/ml); 37.69gm/100ml (376.9mg/ml); 7.538gm/20ml (376.9mg/ml)
Market Status	Prescription
Company	Guerbet

5 Pharmacology and Biochemistry

5.1 MeSH Pharmacological Classification

Contrast Media

Substances used to allow enhanced visualization of tissues. (See all compounds classified as Contrast Media.)

API SUPPLIERS

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USDMF

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KDMF

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NDC API

01

Formosa Laboratories, Inc.

Taiwan

PackExpo

Not Confirmed

02

Hainan Poly Pharm. Co., Ltd.

China

PackExpo

Not Confirmed

03

Jiangsu Hengrui Pharmaceuticals Co....

China

PackExpo

Not Confirmed

04

SIONC PHARMACEUTICALS PVT LTD

India

PackExpo

Not Confirmed

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Listed Suppliers

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API Reference Price

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