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Dothiepin Hydrochloride

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ACTIVE PHARMA INGREDIENTS

10 API Suppliers, 1 USDMF, 2 CEP/COS, 1 JDMF, 3 EU WC, 1 NDC API, 6 Listed Suppliers, $ API Reference Price

10 API Suppliers
1 USDMF
2 CEP/COS
1 JDMF
3 EU WC
1 NDC API
6 Listed Suppliers
$ API Reference Price

FINISHED DOSAGE FORMULATIONS

23 FDF Dossiers, 5 Europe, 4 Australia, 5 South Africa, 9 Listed Dossiers

23 FDF Dossiers
5 Europe
4 Australia
5 South Africa
9 Listed Dossiers

GLOBAL SALES INFORMATION

5 Finished Drug Prices

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5 Finished Drug Prices

MARKET PLACE

6 APIs

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6 APIs

REF. STANDARDS & IMPURITIES

2 EDQM

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2 EDQM

Synopsis

ACTIVE PHARMA INGREDIENTS

API Suppliers

USDMF

CEP/COS

JDMF

EU WC

KDMF

NDC API

VMF

Listed Suppliers

API REF. PRICE (USD/KG)

$ 233

MARKET PLACE

API

FDF

0INTERMEDIATES

FINISHED DOSAGE FORMULATIONS

FDF Dossiers

FDA Orange Book

Europe

Canada

Australia

South Africa

Listed Dossiers

0 DRUGS IN DEVELOPMENT

DRUG PRODUCT COMPOSITIONS

REF. STANDARDS OR IMPURITIES

EDQM

USP

Others

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Finished Drug Prices

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Chemistry

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Also known as: Dothiepin hcl, Depresym, Dosulepin hydrochloride, 897-15-4, Dopress, Dosulepine

Molecular Formula

C₁₉H₂₂ClNS

Molecular Weight

331.9 g/mol

InChI Key

XUPZAARQDNSRJB-SJDTYFKWSA-N

FDA UNII

3H0042311V

A tricyclic antidepressant with some tranquilizing action.

1 2D Structure

Dosulepin HCl

2 Identification

2.1 Computed Descriptors

2.1.1 IUPAC Name

(3E)-3-(6H-benzo[c][1]benzothiepin-11-ylidene)-N,N-dimethylpropan-1-amine;hydrochloride

2.1.2 InChI

InChI=1S/C19H21NS.ClH/c1-20(2)13-7-11-17-16-9-4-3-8-15(16)14-21-19-12-6-5-10-18(17)19;/h3-6,8-12H,7,13-14H2,1-2H3;1H/b17-11+;

2.1.3 InChI Key

XUPZAARQDNSRJB-SJDTYFKWSA-N

2.1.4 Canonical SMILES

CN(C)CCC=C1C2=CC=CC=C2CSC3=CC=CC=C31.Cl

2.1.5 Isomeric SMILES

CN(C)CC/C=C/1\C2=CC=CC=C2CSC3=CC=CC=C31.Cl

2.2 Other Identifiers

2.2.1 UNII

3H0042311V

2.3 Synonyms

2.3.1 MeSH Synonyms

1. Dosulepin

2. Dothiepin

3. Hydrochloride, Dothiepin

4. Prothiaden

2.3.2 Depositor-Supplied Synonyms

1. Dothiepin Hcl

2. Depresym

3. Dosulepin Hydrochloride

4. 897-15-4

5. Dopress

6. Dosulepine

7. Prothiadene

8. Dothep

9. Dothiepin Hydrochloride [usan]

10. Prothiaden

11. Nsc-172130

12. Dosulepin Chloride

13. Prothiadiene

14. 3h0042311v

15. 1-propanamine, 3-dibenzo(b,e)thiepin-11(6h)-ylidene-n,n-dimethyl-, Hydrochloride

16. Prothiaden Hydrochloride

17. Prothiadene Hydrochloride

18. Xerenal

19. Trans-dothiepin Hydrochloride

20. Idom

21. Chebi:36805

22. Trans-11-(3-dimethylaminopropylidene)-6,11-dihydrodibenzo(b,e)thiepin Hydrochloride

23. Thaden

24. Dosulepin Hydrochloride [jan]

25. (3e)-3-(6h-benzo[c][1]benzothiepin-11-ylidene)-n,n-dimethylpropan-1-amine;hydrochloride

26. Unii-3h0042311v

27. Einecs 212-978-8

28. Dothiepinhcl

29. Nsc 172130

30. Nsc172130

31. Schembl35428

32. Mls002153839

33. Dothiepin Hydrochloride- Bio-x

34. Chembl1711280

35. Dtxsid60873550

36. Amy40796

37. Dothiepin Hydrochloride [mi]

38. Ccg-220488

39. Dosulepin Hydrochloride [mart.]

40. 11-(3-dimethylaminopropylidene)-6,11-dihydrodibenzo(b,e)thiepine Hydrochloride

41. Dibenzo(b,e)thiepin-delta(sup 11(6h),gamma)-propylamine, N,n-dimethyl-, Hydrochloride, (e)-

42. Dosulepin Hydrochloride [who-dd]

43. N,n-dimethyldibenzo(b,e)thiepin-delta(sup 11(6h),gamma)-propylamine Hydrochloride

44. Bd164382

45. Smr001233202

46. Dosulepin Hydrochloride [ep Monograph]

47. Wln: T C676 Is&t&j B3n1&1 &gh

48. Sr-01000838836

49. Sr-01000838836-2

50. Q27116969

51. 11-[3-(dimethylamino)propylidene]-6,e]thiepin Hydrochloride

52. 11-[3-(dimethylamino)propylidene]-6,e]thiepine Hydrochloride

53. Dibenzo[b,.gamma.-propylamine, N,n-dimethyl-, Hydrochloride

54. N,e]thiepin-.delta.11(6h),.gamma.-propylamine, Hydrochloride

55. 1-propanamine,e]thiepin-11(6h)-ylidene-n,n-dimethyl-, Hydrochloride

56. Dibenzo(b,e)thiepin-delta(sup 11(6h),gamma)-propylamine, N,n-dimethyl-, Hydrochloride

57. Dibenzo(b,e)thiepin-delta11(6h),gamma-propylamine, N,n-dimethyl-, Hydrochloride

58. Dothiepin Hydrochloride (dosulepin Hydrochloride) 1.0 Mg/ml In Methanol (as Free Base)

59. (3e)-3-(dibenzo[b,e]thiepin-11(6h)-ylidene)-n,n-dimethylpropan-1-amine, Hydrogen Chloride (1:1)

60. Dothiepin (cis/trans) Hydrochloride Solution, 1.0 Mg/ml In Methanol (as Free Base), Ampule Of 1 Ml, Certified Reference Material

2.3.3 Other Synonyms

1. Dosulepin Chloride

2. Dothiepin Hcl

3. Idom

4. Prothiaden

5. Prothiadene

6. Xerenal

7. Dosulepin Hydrochloride

8. Dosulepine

9. Dosulepin

10. Dothiepin

2.4 Create Date

2006-10-25

3 Chemical and Physical Properties

Molecular Formula	C₁₉H₂₂ClNS
Molecular Weight	331.9 g/mol
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	2
Rotatable Bond Count	3
Exact Mass	331.1161486 g/mol
Monoisotopic Mass	331.1161486 g/mol
Topological Polar Surface Area	28.5 Å²
Heavy Atom Count	22
Formal Charge	0
Complexity	363
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	1
Undefined Bond Stereocenter Count	0
Covalently Bonded Unit Count	2

4 Pharmacology and Biochemistry

4.1 MeSH Pharmacological Classification

Adrenergic Uptake Inhibitors

Drugs that block the transport of adrenergic transmitters into axon terminals or into storage vesicles within terminals. The tricyclic antidepressants (ANTIDEPRESSIVE AGENTS, TRICYCLIC) and amphetamines are among the therapeutically important drugs that may act via inhibition of adrenergic transport. Many of these drugs also block transport of serotonin. (See all compounds classified as Adrenergic Uptake Inhibitors.)

Antidepressive Agents, Tricyclic

Substances that contain a fused three-ring moiety and are used in the treatment of depression. These drugs block the uptake of norepinephrine and serotonin into axon terminals and may block some subtypes of serotonin, adrenergic, and histamine receptors. However, the mechanism of their antidepressant effects is not clear because the therapeutic effects usually take weeks to develop and may reflect compensatory changes in the central nervous system. (See all compounds classified as Antidepressive Agents, Tricyclic.)

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API Reference Price

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