EUROAPI, the leading small molecules API player, provides both API sales & CDMO services.

ACCESS ALL DATA
Browse all information
CHEMISTRY
Discover Molecule Insights

ACTIVE PHARMA INGREDIENTS

8 API Suppliers, 1 JDMF, 7 Listed Suppliers

8 API Suppliers
1 JDMF
7 Listed Suppliers

DEVELOPMENTS

5 Drugs in Development

5 Drugs in Development

INTERMEDIATES

7 Intermediates Suppliers

7 Intermediates Suppliers

FINISHED DOSAGE FORMULATIONS

6 FDF Dossiers, 6 Listed Dossiers

6 FDF Dossiers
6 Listed Dossiers

DIGITAL CONTENT

4 NEWS #PharmaBuzz

media
4 NEWS #PharmaBuzz

MARKET PLACE

5 APIs

marketPlace
5 APIs

Synopsis

ACTIVE PHARMA INGREDIENTS

API Suppliers

USDMF

CEP/COS

JDMF

EU WC

KDMF

NDC API

VMF

Listed Suppliers

API REF. PRICE (USD/KG)

$ 0

MARKET PLACE

API

FDF

FINISHED DOSAGE FORMULATIONS

FDF Dossiers

FDA Orange Book

Europe

Canada

Australia

South Africa

Listed Dossiers

DRUG PRODUCT COMPOSITIONS

REF. STANDARDS OR IMPURITIES

EDQM

USP

Others

PATENTS & EXCLUSIVITIES

US Patents

US Exclusivities

Health Canada Patents

DIGITAL CONTENT

Data Compilation #PharmaFlow

Stock Recap #PipelineProspector

Weekly News Recap #Phispers

News #PharmaBuzz

GLOBAL SALES INFORMATION

US Medicaid (USD)

Annual Reports (USD Million)

Finished Drug Prices

0RELATED EXCIPIENT COMPANIES

0EXCIPIENTS BY APPLICATIONS

Chemistry

Click the arrow to open the dropdown

Click the button for full data set

Also known as: 1285572-51-1, Fyu-981, Dotinurad [inn], (3,5-dichloro-4-hydroxyphenyl)(1,1-dioxidobenzo[d]thiazol-3(2h)-yl)methanone, 305eb53128, (3,5-dichloro-4-hydroxyphenyl)-(1,1-dioxo-2h-1,3-benzothiazol-3-yl)methanone

Molecular Formula

C₁₄H₉Cl₂NO₄S

Molecular Weight

358.2 g/mol

InChI Key

VOFLAIHEELWYGO-UHFFFAOYSA-N

FDA UNII

305EB53128

Dotinurad is under investigation in clinical trial NCT03372200 (Febuxostat-controlled, Double-blind, Comparative Study of FYU-981 in Hyperuricemia With or Without Gout).

1 2D Structure

Dotinurad

2 Identification

2.1 Computed Descriptors

2.1.1 IUPAC Name

(3,5-dichloro-4-hydroxyphenyl)-(1,1-dioxo-2H-1,3-benzothiazol-3-yl)methanone

2.1.2 InChI

InChI=1S/C14H9Cl2NO4S/c15-9-5-8(6-10(16)13(9)18)14(19)17-7-22(20,21)12-4-2-1-3-11(12)17/h1-6,18H,7H2

2.1.3 InChI Key

VOFLAIHEELWYGO-UHFFFAOYSA-N

2.1.4 Canonical SMILES

C1N(C2=CC=CC=C2S1(=O)=O)C(=O)C3=CC(=C(C(=C3)Cl)O)Cl

2.2 Other Identifiers

2.2.1 UNII

305EB53128

2.3 Synonyms

2.3.1 MeSH Synonyms

1. (3,5-dichloro-4-hydroxyphenyl)-(1,1-dioxo-2h-1,3-benzothiazol-3-yl)methanone

2. Fyu-981

2.3.2 Depositor-Supplied Synonyms

1. 1285572-51-1

2. Fyu-981

3. Dotinurad [inn]

4. (3,5-dichloro-4-hydroxyphenyl)(1,1-dioxidobenzo[d]thiazol-3(2h)-yl)methanone

5. 305eb53128

6. (3,5-dichloro-4-hydroxyphenyl)-(1,1-dioxo-2h-1,3-benzothiazol-3-yl)methanone

7. Urece

8. Methanone, (3,5-dichloro-4-hydroxyphenyl)(1,1-dioxido-3(2h)-benzothiazolyl)-

9. Urece (tn)

10. Dotinurad (jan/inn)

11. Dotinurad [jan]

12. Dotinurad [who-dd]

13. Fyu981

14. Chembl4594446

15. Schembl10322525

16. Gtpl11389

17. Unii-305eb53128

18. Ex-a5737

19. Bdbm50561689

20. Hy-109031

21. Cs-0030545

22. D11071

23. 3-(3,5-dichloro-4-hydroxybenzoyl)-1,1-dioxo-2,3-dihydro-1,3-benzothiazole

2.4 Create Date

2011-05-09

3 Chemical and Physical Properties

Molecular Formula	C₁₄H₉Cl₂NO₄S
Molecular Weight	358.2 g/mol
XLogP3	2.9
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	4
Rotatable Bond Count	1
Exact Mass	356.9629343 g/mol
Monoisotopic Mass	356.9629343 g/mol
Topological Polar Surface Area	83.1 Å²
Heavy Atom Count	22
Formal Charge	0
Complexity	538
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently Bonded Unit Count	1

4 Pharmacology and Biochemistry

4.1 MeSH Pharmacological Classification

Uricosuric Agents

Gout suppressants that act directly on the renal tubule to increase the excretion of uric acid, thus reducing its concentrations in plasma. (See all compounds classified as Uricosuric Agents.)

API SUPPLIERS