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Chemistry

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Also known as: Bw a938u dichloride, Doxacurium (chloride), Bw-a938u, 106819-53-8, Meso doxacurium chloride, Doxacurium chloride [mi]
Molecular Formula
C56H78Cl2N2O16
Molecular Weight
1106.1  g/mol
InChI Key
APADFLLAXHIMFU-UHFFFAOYSA-L

Doxacurium
1 2D Structure

Doxacurium

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
bis[3-[6,7,8-trimethoxy-2-methyl-1-[(3,4,5-trimethoxyphenyl)methyl]-3,4-dihydro-1H-isoquinolin-2-ium-2-yl]propyl] butanedioate;dichloride
2.1.2 InChI
InChI=1S/C56H78N2O16.2ClH/c1-57(23-19-37-33-45(65-7)53(69-11)55(71-13)49(37)39(57)27-35-29-41(61-3)51(67-9)42(30-35)62-4)21-15-25-73-47(59)17-18-48(60)74-26-16-22-58(2)24-20-38-34-46(66-8)54(70-12)56(72-14)50(38)40(58)28-36-31-43(63-5)52(68-10)44(32-36)64-6;;/h29-34,39-40H,15-28H2,1-14H3;2*1H/q+2;;/p-2
2.1.3 InChI Key
APADFLLAXHIMFU-UHFFFAOYSA-L
2.1.4 Canonical SMILES
C[N+]1(CCC2=CC(=C(C(=C2C1CC3=CC(=C(C(=C3)OC)OC)OC)OC)OC)OC)CCCOC(=O)CCC(=O)OCCC[N+]4(CCC5=CC(=C(C(=C5C4CC6=CC(=C(C(=C6)OC)OC)OC)OC)OC)OC)C.[Cl-].[Cl-]
2.2 Synonyms
2.2.1 MeSH Synonyms

1. 2,2'-((1,4-dioxobutane-1,4-diyl)bis(oxypropane-3,1-diyl))bis(6,7,8-trimethoxy-2-methyl-1-(3,4,5-trimethoxybenzyl)-1,2,3,4-tetrahydroisoquinolinium) Dichloride

2. Bw A938u

3. Bw-a 938u

4. Bw-a-938u

5. Bw-a938u

6. Doxacurium

7. Nuromax

2.2.2 Depositor-Supplied Synonyms

1. Bw A938u Dichloride

2. Doxacurium (chloride)

3. Bw-a938u

4. 106819-53-8

5. Meso Doxacurium Chloride

6. Doxacurium Chloride [mi]

7. Doxacurium Chloride, Meso-

8. Unii-m78tvm3g5z

9. Nuromax (tn)

10. Bw-938u Dichloride

11. Doxacurium Chloride [inn]

12. Doxacurium Chloride [usan]

13. M78tvm3g5z

14. Doxacurium Chloride [vandf]

15. Doxacurium Chloride [mart.]

16. Doxacurium Chloride [who-dd]

17. Schembl1649198

18. Chembl1237099

19. Doxacurium Chloride (usan/inn)

20. Doxacurium Chloride [usan:inn]

21. Hy-a0215

22. Doxacurium Chloride [orange Book]

23. Cs-0017562

24. D00760

25. Q5303681

26. 2,2'-((1,4-dioxobutane-1,4-diyl)bis(oxypropane-3,1-diyl))bis(6,7,8-trimethoxy-2-methyl-1-(3,4,5-trimethoxybenzyl)-1,2,3,4-tetrahydroisoquinolinium) Dichloride

27. 83348-52-1

28. Bis[3-[6,7,8-trimethoxy-2-methyl-1-[(3,4,5-trimethoxyphenyl)methyl]-3,4-dihydro-1h-isoquinolin-2-ium-2-yl]propyl] Butanedioate;dichloride

29. Isoquinolinium, 2,2'-((1,4-dioxo-1,4-butanediyl)bis(oxy-3,1-propanediyl))bis(1,2,3,4-tetrahydro-6,7,8-trimethoxy-2-methyl-1-((3,4,5-trimethoxyphenyl)methyl)-, Dichloride

2.3 Create Date
2005-06-24
3 Chemical and Physical Properties
Molecular Weight 1106.1 g/mol
Molecular Formula C56H78Cl2N2O16
Hydrogen Bond Donor Count0
Hydrogen Bond Acceptor Count18
Rotatable Bond Count29
Exact Mass1104.4728398 g/mol
Monoisotopic Mass1104.4728398 g/mol
Topological Polar Surface Area163 Ų
Heavy Atom Count76
Formal Charge0
Complexity1540
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count4
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count3
4 Pharmacology and Biochemistry
4.1 MeSH Pharmacological Classification

Neuromuscular Nondepolarizing Agents

Drugs that interrupt transmission at the skeletal neuromuscular junction without causing depolarization of the motor end plate. They prevent acetylcholine from triggering muscle contraction and are used as muscle relaxants during electroshock treatments, in convulsive states, and as anesthesia adjuvants. (See all compounds classified as Neuromuscular Nondepolarizing Agents.)


4.2 ATC Code

M - Musculo-skeletal system

M03 - Muscle relaxants

M03A - Muscle relaxants, peripherally acting agents

M03AC - Other quaternary ammonium compounds

M03AC07 - Doxacurium chloride


ABOUT THIS PAGE

Looking for 106819-53-8 / Doxacurium API manufacturers, exporters & distributors?

Doxacurium manufacturers, exporters & distributors 1

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PharmaCompass offers a list of Doxacurium API manufacturers, exporters & distributors, which can be sorted by GMP, USDMF, JDMF, KDMF, CEP (COS), WC, Price,and more, enabling you to easily find the right Doxacurium manufacturer or Doxacurium supplier for your needs.

Send us enquiries for free, and we will assist you in establishing a direct connection with your preferred Doxacurium manufacturer or Doxacurium supplier.

PharmaCompass also assists you with knowing the Doxacurium API Price utilized in the formulation of products. Doxacurium API Price is not always fixed or binding as the Doxacurium Price is obtained through a variety of data sources. The Doxacurium Price can also vary due to multiple factors, including market conditions, regulatory modifications, or negotiated pricing deals.

API | Excipient name

Doxacurium

Synonyms

Bw a938u dichloride, Doxacurium (chloride), Bw-a938u, 106819-53-8, Meso doxacurium chloride, Doxacurium chloride [mi]

Cas Number

106819-53-8

Doxacurium Manufacturers

A Doxacurium manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Doxacurium, including repackagers and relabelers. The FDA regulates Doxacurium manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Doxacurium API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

Doxacurium Suppliers

A Doxacurium supplier is an individual or a company that provides Doxacurium active pharmaceutical ingredient (API) or Doxacurium finished formulations upon request. The Doxacurium suppliers may include Doxacurium API manufacturers, exporters, distributors and traders.

Doxacurium GMP

Doxacurium Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

PharmaCompass offers a list of Doxacurium GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Doxacurium GMP manufacturer or Doxacurium GMP API supplier for your needs.

Doxacurium CoA

A Doxacurium CoA (Certificate of Analysis) is a formal document that attests to Doxacurium's compliance with Doxacurium specifications and serves as a tool for batch-level quality control.

Doxacurium CoA mostly includes findings from lab analyses of a specific batch. For each Doxacurium CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

Doxacurium may be tested according to a variety of international standards, such as European Pharmacopoeia (Doxacurium EP), Doxacurium JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Doxacurium USP).

Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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