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Doxapram Hydrochloride

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ACTIVE PHARMA INGREDIENTS

13 API Suppliers, 5 USDMF, 1 CEP/COS, 1 JDMF, 1 EU WC, 1 NDC API, 8 Listed Suppliers, $ API Reference Price

13 API Suppliers
5 USDMF
1 CEP/COS
1 JDMF
1 EU WC
1 NDC API
8 Listed Suppliers
$ API Reference Price

INTERMEDIATES

1 Intermediates Suppliers

1 Intermediates Suppliers

FINISHED DOSAGE FORMULATIONS

7 FDF Dossiers, 3 FDA Orange Book, 1 South Africa, 3 Listed Dossiers

7 FDF Dossiers
3 FDA Orange Book
1 South Africa
3 Listed Dossiers

RELATED EXCIPIENT COMPANIES

1 Nanjing Well Pharmaceutical, 1 Actylis, 1 Finar

relatedExcipients
1 Nanjing Well Pharmaceutical
1 Actylis
1 Finar

EXCIPIENTS BY APPLICATIONS

2 Topical, 1 Parenteral, 1 Solubilizers

excipientsByApplications
2 Topical
1 Parenteral
1 Solubilizers

DIGITAL CONTENT

1 NEWS #PharmaBuzz

media
1 NEWS #PharmaBuzz

REF. STANDARDS & IMPURITIES

1 EDQM , 2 USP , 2 Others

otherSolutions
1 EDQM
2 USP
2 Others

Midas Pharma Doxapram Hydrochloride

Synopsis

ACTIVE PHARMA INGREDIENTS

API Suppliers

USDMF

CEP/COS

JDMF

EU WC

KDMF

NDC API

VMF

Listed Suppliers

API REF. PRICE (USD/KG)

MARKET PLACE

API

FDF

FINISHED DOSAGE FORMULATIONS

FDF Dossiers

FDA Orange Book

Europe

Canada

Australia

South Africa

Listed Dossiers

0 DRUGS IN DEVELOPMENT

DRUG PRODUCT COMPOSITIONS

REF. STANDARDS OR IMPURITIES

EDQM

USP

Others

PATENTS & EXCLUSIVITIES

US Patents

US Exclusivities

Health Canada Patents

DIGITAL CONTENT

Data Compilation #PharmaFlow

Stock Recap #PipelineProspector

Weekly News Recap #Phispers

News #PharmaBuzz

GLOBAL SALES INFORMATION

US Medicaid (USD)

Annual Reports (USD Million)

Finished Drug Prices

4EXCIPIENTS BY APPLICATIONS

Chemistry

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Also known as: 113-07-5, Stimulexin, Dopram, 1-ethyl-4-(2-morpholinoethyl)-3,3-diphenylpyrrolidin-2-one monohydrochloride, Doxapram hydrochloride anhydrous, Doxapram (hydrochloride)

Molecular Formula

C₂₄H₃₁ClN₂O₂

Molecular Weight

415.0 g/mol

InChI Key

MBGXILHMHYLZJT-UHFFFAOYSA-N

FDA UNII

FB8713U6DM

A central respiratory stimulant with a brief duration of action. (From Martindale, The Extra Pharmocopoeia, 30th ed, p1225)

1 2D Structure

Doxapram Hydrochloride

2 Identification

2.1 Computed Descriptors

2.1.1 IUPAC Name

1-ethyl-4-(2-morpholin-4-ylethyl)-3,3-diphenylpyrrolidin-2-one;hydrochloride

2.1.2 InChI

InChI=1S/C24H30N2O2.ClH/c1-2-26-19-22(13-14-25-15-17-28-18-16-25)24(23(26)27,20-9-5-3-6-10-20)21-11-7-4-8-12-21;/h3-12,22H,2,13-19H2,1H3;1H

2.1.3 InChI Key

MBGXILHMHYLZJT-UHFFFAOYSA-N

2.1.4 Canonical SMILES

CCN1CC(C(C1=O)(C2=CC=CC=C2)C3=CC=CC=C3)CCN4CCOCC4.Cl

2.2 Other Identifiers

2.2.1 UNII

FB8713U6DM

2.3 Synonyms

2.3.1 MeSH Synonyms

1. Docatone

2. Dopram

3. Doxapram

4. Hydrochloride, Doxapram

2.3.2 Depositor-Supplied Synonyms

1. 113-07-5

2. Stimulexin

3. Dopram

4. 1-ethyl-4-(2-morpholinoethyl)-3,3-diphenylpyrrolidin-2-one Monohydrochloride

5. Doxapram Hydrochloride Anhydrous

6. Doxapram (hydrochloride)

7. Fb8713u6dm

8. 1-ethyl-4-(2-morpholin-4-ylethyl)-3,3-diphenylpyrrolidin-2-one;hydrochloride

9. 1-ethyl-4-(2-morpholinoethyl)-3,3-diphenylpyrrolidin-2-onemonohydrochloride

10. Dsstox_cid_27815

11. Dsstox_rid_82579

12. Dsstox_gsid_47837

13. Doxapramhydrochloride

14. Chebi:59837

15. Ahr-619

16. Cas-113-07-5

17. 3,3-diphenyl-1-ethyl-4-(2-morpholinoethyl)-2-pyrrolidinone Hydrochloride

18. 1-ethyl-4-(2-morpholinoethyl)-3,3-diphenyl-2-pyrrolidinone Hydrochloride Hydrate

19. 2-pyrrolidinone, 1-ethyl-4-(2-morpholinoethyl)-3,3-diphenyl-, Monohydrochloride, Monohydrate

20. Ncgc00167459-01

21. Unii-fb8713u6dm

22. Einecs 204-022-3

23. 2-pyrrolidinone, 1-ethyl-4-(2-morpholinoethyl)-3,3-diphenyl-, Monohydrochloride

24. Schembl40645

25. Mls001424142

26. Chembl1200876

27. Dtxsid9047837

28. Tox21_112463

29. Mfcd00072148

30. Nsc170958

31. Akos015906444

32. Tox21_112463_1

33. Ac-4694

34. Ccg-101076

35. Ccg-221205

36. Nc00326

37. Nsc 170958

38. Sb18933

39. 2-pyrrolidinone, 1-ethyl-4-(2-(4-morpholinyl)ethyl)-3,3-diphenyl-, Monohydrochloride

40. Ncgc00167459-02

41. As-13336

42. Smr000469229

43. 2-pyrrolidinone,3-diphenyl-, Monohydrochloride

44. 081d530

45. 113d075

46. J-002892

47. Q27126918

48. 1-ethyl-4-(2-morpholinoethyl)-3,3-diphenylpyrrolidin-2-one Hydrochloride

49. (+/-)-1-ethyl-4-(2-morpholinoethyl)-3,3-diphenyl-2-pyrrolidinone Monohydrochloride

50. 2-pyrrolidinone, 1-ethyl-4-(2-(4-morpholinyl)ethyl)-3,3-diphenyl-, Hydrochloride, Hydrate (1:1:1)

51. 2-pyrrolidinone, 1-ethyl-4-(2-(4-morpholinyl)ethyl)-3,3-diphenyl-, Monohydrochloride, (+/-)-

2.4 Create Date

2005-08-08

3 Chemical and Physical Properties

Molecular Formula	C₂₄H₃₁ClN₂O₂
Molecular Weight	415.0 g/mol
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	3
Rotatable Bond Count	6
Exact Mass	414.2074059 g/mol
Monoisotopic Mass	414.2074059 g/mol
Topological Polar Surface Area	32.8 Å²
Heavy Atom Count	29
Formal Charge	0
Complexity	487
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	1
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently Bonded Unit Count	2

4 Drug and Medication Information

4.1 Drug Information

1 of 2
Drug Name	Doxapram hydrochloride
Drug Label	DOPRAM Injection (doxapram hydrochloride injection, USP) is a clear, colorless, sterile, non-pyrogenic, aqueous solution with pH 3.5 to 5, for intravenous administration.Each 1 mL contains:Doxapram Hydrochloride, USP ....................................
Active Ingredient	Doxapram hydrochloride
Dosage Form	Injectable
Route	Injection
Strength	20mg/ml
Market Status	Prescription
Company	Bedford

2 of 2
Drug Name	Doxapram hydrochloride
Drug Label	DOPRAM Injection (doxapram hydrochloride injection, USP) is a clear, colorless, sterile, non-pyrogenic, aqueous solution with pH 3.5 to 5, for intravenous administration.Each 1 mL contains:Doxapram Hydrochloride, USP ....................................
Active Ingredient	Doxapram hydrochloride
Dosage Form	Injectable
Route	Injection
Strength	20mg/ml
Market Status	Prescription
Company	Bedford

5 Pharmacology and Biochemistry

5.1 MeSH Pharmacological Classification

Central Nervous System Stimulants

A loosely defined group of drugs that tend to increase behavioral alertness, agitation, or excitation. They work by a variety of mechanisms, but usually not by direct excitation of neurons. The many drugs that have such actions as side effects to their main therapeutic use are not included here. (See all compounds classified as Central Nervous System Stimulants.)

Respiratory System Agents

Drugs used for their effects on the respiratory system. (See all compounds classified as Respiratory System Agents.)

5.2 FDA Pharmacological Classification

5.2.1 Pharmacological Classes

Respiratory Stimulant [EPC]; Increased Medullary Respiratory Drive [PE]

API SUPPLIERS

01

Midas Pharma

Germany

USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

Medlab Asia & Asia Health

Not Confirmed

Midas Pharma provides expertise in developing and supplying APIs, finished products, and intermediates.

Contact Supplier

Germany

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USDMF

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CEP/COS

JDMF EU-WC NDC KDMF VMF Others AUDIT

02

Jai Radhe Sales

India

USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

Medlab Asia & Asia Health

Not Confirmed

Jai Radhe Sales is your partner for all your sourcing needs.

Contact Supplier

India

Virtual Booth

Digital Content

USDMF CEP/COS JDMF EU-WC NDC KDMF VMF Others AUDIT

03

ALP Pharm

China

USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

Medlab Asia & Asia Health

Not Confirmed

04

Boehringer Ingelheim GmbH

Germany

USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

Medlab Asia & Asia Health

Not Confirmed

05

Catalytica

India

USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

Medlab Asia & Asia Health

Not Confirmed

06

DMFs Not Supported

Country

Germany

USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

Medlab Asia & Asia Health

Not Confirmed

Only 10 entries up to this point, click to access all

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USDMF

01

Midas Pharma Gmbh

Germany

Medlab Asia & Asia Health

Not Confirmed

Midas Pharma provides expertise in developing and supplying APIs, finished products, and intermediates.

Contact Supplier

Germany

Virtual Booth

Digital Content

Doxapram Hydrochloride

GDUFA

DMF Review : Complete

Rev. Date : 2018-06-11

Pay. Date : 2018-01-26

DMF Number : 32049

Submission : 2018-01-26

Status : Active

Type : II

02

Alp Pharm Beijing Co Ltd

China

Medlab Asia & Asia Health

Not Confirmed

03

Boehringer Ingelheim Chemicals Inc

Germany

Medlab Asia & Asia Health

Not Confirmed

04

Wyckoff Chemical Co Inc

India

Medlab Asia & Asia Health

Not Confirmed

05

Sb Penick And Co

Country

Medlab Asia & Asia Health

Not Confirmed

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CEP/COS

01

MIDAS PHARMA GMBH Ingelheim am Rhei...

Germany

CPHI Middle east

Not Confirmed

Midas Pharma provides expertise in developing and supplying APIs, finished products, and intermediates.

Contact Supplier

Germany

Virtual Booth

Digital Content

Doxapram Hydrochloride

Certificate Number : R1-CEP 2017-084 - Rev 00

Status : Valid

Issue Date : 2023-07-17

Type : Chemical

Substance Number : 1201

Portfolio PDF

Product Web Link

Virtual Booth

Germany

CPHI Middle east

Not Confirmed

Midas Pharma provides expertise in developing and supplying APIs, finished products, and intermediates.

Contact Supplier

Germany

Virtual Booth

Digital Content

Doxapram Hydrochloride

About the Company : Midas Pharma is a pharmaceutical company that excels in providing extensive expertise while fostering connections between companies, individuals, and knowledge. The core competence...

Midas Pharma is a pharmaceutical company that excels in providing extensive expertise while fostering connections between companies, individuals, and knowledge. The core competence of Midas Pharma lies in project management related to pharmaceutical supply chains. The company is actively involved in sourcing, supplying, and developing Active Pharmaceutical Ingredients (API) and Finished Dosage Forms (FDF) manufactured by its contract manufacturing partners. For each project or product, Midas Pharma selects the most suitable match from its network of manufacturing partners.

02

Jai Radhe Sales

India

CPHI Middle east

Not Confirmed

Jai Radhe Sales is your partner for all your sourcing needs.

Contact Supplier

India

Virtual Booth

Digital Content

Doxapram

About the Company : Jai Radhe Sales was founded in 1999 as an out-of-the-box distribution firm specializing in the global supply of high-quality pharmaceutical ingredients. The firm provides complete ...

Jai Radhe Sales was founded in 1999 as an out-of-the-box distribution firm specializing in the global supply of high-quality pharmaceutical ingredients. The firm provides complete sourcing solutions for pharmaceutical products from India, including technical and regulatory assistance. It believes in providing its customers with high-quality products at reasonable prices. It has always endeavored to achieve global standards in the field of pharmaceuticals and has carved out a niche for itself through new methods based on current market needs. Today, it has established itself as a truly global company, with exports to almost every continent.

03

Arevipharma

CPHI Middle east

Not Confirmed

08

Xian Libang Pharmaceutical Co.,Ltd

China

CPHI Middle east

Not Confirmed

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API Reference Price

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