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Doxapram Hydrochloride

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ACTIVE PHARMA INGREDIENTS

13 API Suppliers, 5 USDMF, 1 CEP/COS, 1 JDMF, 1 EU WC, 1 NDC API, 8 Listed Suppliers, $ API Reference Price

13 API Suppliers
5 USDMF
1 CEP/COS
1 JDMF
1 EU WC
1 NDC API
8 Listed Suppliers
$ API Reference Price

INTERMEDIATES

1 Intermediates Suppliers

1 Intermediates Suppliers

FINISHED DOSAGE FORMULATIONS

7 FDF Dossiers, 3 FDA Orange Book, 1 South Africa, 3 Listed Dossiers

7 FDF Dossiers
3 FDA Orange Book
1 South Africa
3 Listed Dossiers

RELATED EXCIPIENT COMPANIES

1 Nanjing Well Pharmaceutical, 1 Actylis, 1 Finar

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1 Nanjing Well Pharmaceutical
1 Actylis
1 Finar

EXCIPIENTS BY APPLICATIONS

2 Topical, 1 Parenteral, 1 Solubilizers

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2 Topical
1 Parenteral
1 Solubilizers

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1 NEWS #PharmaBuzz

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1 NEWS #PharmaBuzz

REF. STANDARDS & IMPURITIES

1 EDQM , 2 USP , 2 Others

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1 EDQM
2 USP
2 Others

Midas Pharma Doxapram Hydrochloride

Synopsis

ACTIVE PHARMA INGREDIENTS

API Suppliers

USDMF

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JDMF

EU WC

KDMF

NDC API

VMF

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API REF. PRICE (USD/KG)

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FDF

FINISHED DOSAGE FORMULATIONS

FDF Dossiers

FDA Orange Book

Europe

Canada

Australia

South Africa

Listed Dossiers

0 DRUGS IN DEVELOPMENT

DRUG PRODUCT COMPOSITIONS

REF. STANDARDS OR IMPURITIES

EDQM

USP

Others

PATENTS & EXCLUSIVITIES

US Patents

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Health Canada Patents

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Data Compilation #PharmaFlow

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Annual Reports (USD Million)

Finished Drug Prices

4EXCIPIENTS BY APPLICATIONS

Chemistry

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Also known as: 113-07-5, Stimulexin, Dopram, 1-ethyl-4-(2-morpholinoethyl)-3,3-diphenylpyrrolidin-2-one monohydrochloride, Doxapram hydrochloride anhydrous, Doxapram (hydrochloride)

Molecular Formula

C₂₄H₃₁ClN₂O₂

Molecular Weight

415.0 g/mol

InChI Key

MBGXILHMHYLZJT-UHFFFAOYSA-N

FDA UNII

FB8713U6DM

A central respiratory stimulant with a brief duration of action. (From Martindale, The Extra Pharmocopoeia, 30th ed, p1225)

1 2D Structure

Doxapram Hydrochloride

2 Identification

2.1 Computed Descriptors

2.1.1 IUPAC Name

1-ethyl-4-(2-morpholin-4-ylethyl)-3,3-diphenylpyrrolidin-2-one;hydrochloride

2.1.2 InChI

InChI=1S/C24H30N2O2.ClH/c1-2-26-19-22(13-14-25-15-17-28-18-16-25)24(23(26)27,20-9-5-3-6-10-20)21-11-7-4-8-12-21;/h3-12,22H,2,13-19H2,1H3;1H

2.1.3 InChI Key

MBGXILHMHYLZJT-UHFFFAOYSA-N

2.1.4 Canonical SMILES

CCN1CC(C(C1=O)(C2=CC=CC=C2)C3=CC=CC=C3)CCN4CCOCC4.Cl

2.2 Other Identifiers

2.2.1 UNII

FB8713U6DM

2.3 Synonyms

2.3.1 MeSH Synonyms

1. Docatone

2. Dopram

3. Doxapram

4. Hydrochloride, Doxapram

2.3.2 Depositor-Supplied Synonyms

1. 113-07-5

2. Stimulexin

3. Dopram

4. 1-ethyl-4-(2-morpholinoethyl)-3,3-diphenylpyrrolidin-2-one Monohydrochloride

5. Doxapram Hydrochloride Anhydrous

6. Doxapram (hydrochloride)

7. Fb8713u6dm

8. 1-ethyl-4-(2-morpholin-4-ylethyl)-3,3-diphenylpyrrolidin-2-one;hydrochloride

9. 1-ethyl-4-(2-morpholinoethyl)-3,3-diphenylpyrrolidin-2-onemonohydrochloride

10. Dsstox_cid_27815

11. Dsstox_rid_82579

12. Dsstox_gsid_47837

13. Doxapramhydrochloride

14. Chebi:59837

15. Ahr-619

16. Cas-113-07-5

17. 3,3-diphenyl-1-ethyl-4-(2-morpholinoethyl)-2-pyrrolidinone Hydrochloride

18. 1-ethyl-4-(2-morpholinoethyl)-3,3-diphenyl-2-pyrrolidinone Hydrochloride Hydrate

19. 2-pyrrolidinone, 1-ethyl-4-(2-morpholinoethyl)-3,3-diphenyl-, Monohydrochloride, Monohydrate

20. Ncgc00167459-01

21. Unii-fb8713u6dm

22. Einecs 204-022-3

23. 2-pyrrolidinone, 1-ethyl-4-(2-morpholinoethyl)-3,3-diphenyl-, Monohydrochloride

24. Schembl40645

25. Mls001424142

26. Chembl1200876

27. Dtxsid9047837

28. Tox21_112463

29. Mfcd00072148

30. Nsc170958

31. Akos015906444

32. Tox21_112463_1

33. Ac-4694

34. Ccg-101076

35. Ccg-221205

36. Nc00326

37. Nsc 170958

38. Sb18933

39. 2-pyrrolidinone, 1-ethyl-4-(2-(4-morpholinyl)ethyl)-3,3-diphenyl-, Monohydrochloride

40. Ncgc00167459-02

41. As-13336

42. Smr000469229

43. 2-pyrrolidinone,3-diphenyl-, Monohydrochloride

44. 081d530

45. 113d075

46. J-002892

47. Q27126918

48. 1-ethyl-4-(2-morpholinoethyl)-3,3-diphenylpyrrolidin-2-one Hydrochloride

49. (+/-)-1-ethyl-4-(2-morpholinoethyl)-3,3-diphenyl-2-pyrrolidinone Monohydrochloride

50. 2-pyrrolidinone, 1-ethyl-4-(2-(4-morpholinyl)ethyl)-3,3-diphenyl-, Hydrochloride, Hydrate (1:1:1)

51. 2-pyrrolidinone, 1-ethyl-4-(2-(4-morpholinyl)ethyl)-3,3-diphenyl-, Monohydrochloride, (+/-)-

2.4 Create Date

2005-08-08

3 Chemical and Physical Properties

Molecular Formula	C₂₄H₃₁ClN₂O₂
Molecular Weight	415.0 g/mol
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	3
Rotatable Bond Count	6
Exact Mass	414.2074059 g/mol
Monoisotopic Mass	414.2074059 g/mol
Topological Polar Surface Area	32.8 Å²
Heavy Atom Count	29
Formal Charge	0
Complexity	487
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	1
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently Bonded Unit Count	2

4 Drug and Medication Information

4.1 Drug Information

1 of 2
Drug Name	Doxapram hydrochloride
Drug Label	DOPRAM Injection (doxapram hydrochloride injection, USP) is a clear, colorless, sterile, non-pyrogenic, aqueous solution with pH 3.5 to 5, for intravenous administration.Each 1 mL contains:Doxapram Hydrochloride, USP ....................................
Active Ingredient	Doxapram hydrochloride
Dosage Form	Injectable
Route	Injection
Strength	20mg/ml
Market Status	Prescription
Company	Bedford

2 of 2
Drug Name	Doxapram hydrochloride
Drug Label	DOPRAM Injection (doxapram hydrochloride injection, USP) is a clear, colorless, sterile, non-pyrogenic, aqueous solution with pH 3.5 to 5, for intravenous administration.Each 1 mL contains:Doxapram Hydrochloride, USP ....................................
Active Ingredient	Doxapram hydrochloride
Dosage Form	Injectable
Route	Injection
Strength	20mg/ml
Market Status	Prescription
Company	Bedford

5 Pharmacology and Biochemistry

5.1 MeSH Pharmacological Classification

Central Nervous System Stimulants

A loosely defined group of drugs that tend to increase behavioral alertness, agitation, or excitation. They work by a variety of mechanisms, but usually not by direct excitation of neurons. The many drugs that have such actions as side effects to their main therapeutic use are not included here. (See all compounds classified as Central Nervous System Stimulants.)

Respiratory System Agents

Drugs used for their effects on the respiratory system. (See all compounds classified as Respiratory System Agents.)

5.2 FDA Pharmacological Classification

5.2.1 Pharmacological Classes

Respiratory Stimulant [EPC]; Increased Medullary Respiratory Drive [PE]

API SUPPLIERS

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USDMF

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JDMF

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EU WC

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NDC API

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Listed Suppliers

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API Reference Price

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