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ACTIVE PHARMA INGREDIENTS

38 API Suppliers, 12 USDMF, 9 CEP/COS, 7 JDMF, 7 EU WC, 6 KDMF, 8 NDC API, 20 Listed Suppliers, $ API Reference Price

38 API Suppliers
12 USDMF
9 CEP/COS
7 JDMF
7 EU WC
6 KDMF
8 NDC API
20 Listed Suppliers
$ API Reference Price

INTERMEDIATES

17 Intermediates Suppliers

17 Intermediates Suppliers

FINISHED DOSAGE FORMULATIONS

349 FDF Dossiers, 82 FDA Orange Book, 219 Europe, 12 Canada, 9 South Africa, 27 Listed Dossiers

349 FDF Dossiers
82 FDA Orange Book
219 Europe
12 Canada
9 South Africa
27 Listed Dossiers

DRUG PRODUCT COMPOSITIONS

TABLET;ORAL - EQ 1MG BASE, TABLET;ORAL - EQ 2MG BASE, TABLET;ORAL - EQ 4MG BASE, TABLET;ORAL - EQ 8MG BASE, TABLET, EXTENDED RELEASE;ORAL - EQ 4MG BASE, TABLET, EXTENDED RELEASE;ORAL - EQ 8MG BASE

drugProductComposition
TABLET;ORAL - EQ 1MG BASE
TABLET;ORAL - EQ 2MG BASE
TABLET;ORAL - EQ 4MG BASE
TABLET;ORAL - EQ 8MG BASE
TABLET, EXTENDED RELEASE;ORAL - EQ 4MG BASE
TABLET, EXTENDED RELEASE;ORAL - EQ 8MG BASE

RELATED EXCIPIENT COMPANIES

4 SPI Pharma, 2 Seqens, 4 DKSH, 5 Faran Shimi Pharmaceutical, 12 Gangwal Healthcare, 1 Nanjing Well Pharmaceutical, 1 ACG Worldwide, 5 Actylis, 8 Anhui Sunhere Pharmaceutical Excipients Co.,Ltd, 15 BASF, 10 Corel Pharma Chem, 7 DFE Pharma, 1 Finar, 6 Gangwal Chemicals, 5 Ideal Cures Pvt Ltd, 4 Ingredion Pharma Solutions, 36 Kerry, 3 Kima Chemical, 6 Lonza Capsugel, 11 Microlex e.U, 2 Nomisma Healthcare, 1 Novo Excipients, 2 Pharmatrans-Sanaq, 5 Pluviaendo, 4 Prachin Chemical, 1 Qianhao Chemical (Hebei) Co., Ltd, 1 Qualicaps, 18 Roquette, 7 Seppic, 5 Shanghai Shenmei Pharmaceutical Technology Co., Ltd, 11 Sigachi Industries, 2 The Dow Chemical Company, 4 Vasa Pharmachem

EXCIPIENTS BY APPLICATIONS

60 Fillers, Diluents & Binders, 45 Coating Systems & Additives, 31 Direct Compression, 28 Disintegrants & Superdisintegrants, 25 Controlled & Modified Release, 21 Granulation, 18 Thickeners and Stabilizers, 15 Co-Processed Excipients, 14 Lubricants & Glidants, 9 Taste Masking, 8 Topical, 7 Film Formers & Plasticizers, 6 Chewable & Orodispersible Aids, 5 Empty Capsules, 5 Coloring Agents, 5 Solubilizers, 5 Parenteral, 4 Vegetarian Capsules, 4 API Stability Enhancers, 4 Emulsifying Agents, 3 Rheology Modifiers, 1 Surfactant & Foaming Agents

DIGITAL CONTENT

1 DATA COMPILATION #PharmaFlow, 11 NEWS #PharmaBuzz

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1 DATA COMPILATION #PharmaFlow
11 NEWS #PharmaBuzz

GLOBAL SALES INFORMATION

2 US Medicaid Prescriptions, 200 Finished Drug Prices, 3 Annual Reports

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2 US Medicaid Prescriptions
200 Finished Drug Prices
3 Annual Reports

MARKET PLACE

7 APIs, 2 FDF Dossiers, 1 Intermediates

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7 APIs
2 FDF Dossiers
1 Intermediates

REF. STANDARDS & IMPURITIES

3 EDQM , 3 USP , 4 JP , 9 Others

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3 EDQM
3 USP
4 JP
9 Others

ANALYTICAL

2 BioAnalytical Methods

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2 BioAnalytical Methods

Midas Doxazosin Mesylate

Synopsis

ACTIVE PHARMA INGREDIENTS

38

API Suppliers

12

USDMF

9

CEP/COS

CEP/COS Certifications

7

JDMF

7

EU WC

6

KDMF

8

NDC API

0

VMF

20

Listed Suppliers

API REF. PRICE (USD/KG)

$

$ 1,073

MARKET PLACE

7

API

2

FDF

17INTERMEDIATES

FINISHED DOSAGE FORMULATIONS

349

FDF Dossiers

82

FDA Orange Book

FDA (Orange Book)

219

Europe

12

Canada

0

Australia

9

South Africa

27

Listed Dossiers

0 DRUGS IN DEVELOPMENT

DRUG PRODUCT COMPOSITIONS

REF. STANDARDS OR IMPURITIES

3

EDQM

3

USP

4

JP

9

Others

PATENTS & EXCLUSIVITIES

0

US Patents

0

US Exclusivities

0

Health Canada Patents

DIGITAL CONTENT

1

Data Compilation #PharmaFlow

0

Stock Recap #PipelineProspector

0

Weekly News Recap #Phispers

11

News #PharmaBuzz

GLOBAL SALES INFORMATION

US Medicaid (USD)

48,915,033

Annual Reports (USD Million)

444

Finished Drug Prices

209 RELATED EXCIPIENT COMPANIES

323EXCIPIENTS BY APPLICATIONS

Chemistry

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Also known as: 77883-43-3, Cardura, Carduran, Alfadil, Cardular, Cardura xl

Molecular Formula

C₂₄H₂₉N₅O₈S

Molecular Weight

547.6 g/mol

InChI Key

VJECBOKJABCYMF-UHFFFAOYSA-N

FDA UNII

86P6PQK0MU

Doxazosin Mesylate

A prazosin-related compound that is a selective alpha-1-adrenergic blocker.

1 2D Structure

Doxazosin Mesylate

2 Identification

2.1 Computed Descriptors

2.1.1 IUPAC Name

[4-(4-amino-6,7-dimethoxyquinazolin-2-yl)piperazin-1-yl]-(2,3-dihydro-1,4-benzodioxin-3-yl)methanone;methanesulfonic acid

2.1.2 InChI

InChI=1S/C23H25N5O5.CH4O3S/c1-30-18-11-14-15(12-19(18)31-2)25-23(26-21(14)24)28-9-7-27(8-10-28)22(29)20-13-32-16-5-3-4-6-17(16)33-20;1-5(2,3)4/h3-6,11-12,20H,7-10,13H2,1-2H3,(H2,24,25,26);1H3,(H,2,3,4)

2.1.3 InChI Key

VJECBOKJABCYMF-UHFFFAOYSA-N

2.1.4 Canonical SMILES

COC1=C(C=C2C(=C1)C(=NC(=N2)N3CCN(CC3)C(=O)C4COC5=CC=CC=C5O4)N)OC.CS(=O)(=O)O

2.2 Other Identifiers

2.2.1 UNII

86P6PQK0MU

2.3 Synonyms

2.3.1 MeSH Synonyms

1. 1 (4-amino-6,7-dimethoxy-2-quinazolinyl)-4-((2,3-dihydro-1,4-benzodioxin-2-yl)carbonyl)piperazine

2. Alfamedin

3. Apo Doxazosin

4. Apo-doxazosin

5. Cardular

6. Cardura

7. Carduran

8. Carduran Neo

9. Ct, Doxazosin Von

10. Diblocin

11. Doxa Puren

12. Doxa-puren

13. Doxacor

14. Doxagamma

15. Doxamax

16. Doxatensa

17. Doxauro

18. Doxazomerck

19. Doxazosin

20. Doxazosin Al

21. Doxazosin Apogepha

22. Doxazosin Azu

23. Doxazosin Beta

24. Doxazosin Findusfit

25. Doxazosin Heumann

26. Doxazosin Klast

27. Doxazosin Monohydrochloride

28. Doxazosin Ratiopharm

29. Doxazosin Stada

30. Doxazosin Von Ct

31. Doxazosin Wolff

32. Doxazosin-ratiopharm

33. Doxazosin-wolff

34. Doxazosina Alter

35. Doxazosina Cinfa

36. Doxazosina Combino Pharm

37. Doxazosina Geminis

38. Doxazosina Normon

39. Doxazosina Pharmagenus

40. Doxazosina Ratiopharm

41. Doxazosina Ur

42. Gen Doxazosin

43. Gen-doxazosin

44. Jutalar

45. Mesylate, Doxazosin

46. Monohydrochloride, Doxazosin

47. Mtw Doxazosin

48. Mtw-doxazosin

49. Neo, Carduran

50. Novo Doxazosin

51. Novo-doxazosin

52. Progandol Neo

53. Ratio Doxazosin

54. Ratio-doxazosin

55. Ratiopharm, Doxazosina

56. Uk 33274

57. Uk-33274

58. Uk33274

59. Uriduct

60. Von Ct, Doxazosin

61. Zoxan

2.3.2 Depositor-Supplied Synonyms

1. 77883-43-3

2. Cardura

3. Carduran

4. Alfadil

5. Cardular

6. Cardura Xl

7. Doxazosin Mesilate

8. Cardenalin

9. Dedralen

10. Progandol

11. Tensiobas

12. Doxazosin (mesylate)

13. Uk 33274 Mesylate

14. Doxazosin (as Mesilate)

15. Doxazosin Methanesulfonate

16. (4-(4-amino-6,7-dimethoxyquinazolin-2-yl)piperazin-1-yl)(2,3-dihydrobenzo[b][1,4]dioxin-2-yl)methanone Methanesulfonate

17. Nsc-759284

18. 86p6pqk0mu

19. Mls000028455

20. Doxazomerck

21. Diblocin

22. Uk-33,274-27

23. Doxazosin Azu

24. Prostadilat

25. Cardoral

26. Cardoxan

27. Doksura

28. Doxaben

29. Doxolbran

30. Kaltensif

31. Normathen

32. Smr000058441

33. Supressin

34. Tonocardin

35. Benur

36. Cardular Uro

37. Diblocin Uro

38. Cardular Pp

39. Diblocin Pp

40. Uk-33274-27

41. Dsstox_cid_25598

42. Dsstox_rid_80991

43. Dsstox_gsid_45598

44. Piperazine, 1-(4-amino-6,7-dimethoxy-2-quinazolinyl)-4-((2,3-dihydro-1,4-benzodioxin-2-yl)carbonyl)-, Monomethanesulfonate

45. Uk 33274

46. Doxazocine

47. Duracin

48. Dosin

49. 1-(4-amino-6,7-dimethoxy-2-quinazolinyl)-4-(1,4-benzodioxan-2-ylcarbonyl)piperazine Monomethanesulfonate

50. Carduran Neo

51. Chebi:4709

52. Doxazosin Mesylate [usan]

53. [4-(4-amino-6,7-dimethoxyquinazolin-2-yl)piperazin-1-yl]-(2,3-dihydro-1,4-benzodioxin-3-yl)methanone;methanesulfonic Acid

54. 2-{4-[(2,3-dihydro-1,4-benzodioxin-2-yl)carbonyl]piperazin-1-yl}-6,7-dimethoxyquinazolin-4-amine; Methanesulfonic Acid

55. Hsdb 7082

56. Sr-01000003045

57. Unii-86p6pqk0mu

58. Doxazosin Mesylate [usan:usp]

59. Uk 33,274-27

60. Ncgc00017136-01

61. Cardura (tn)

62. Cas-77883-43-3

63. Mfcd00216023

64. Prestwick_1026

65. Doxazosin Mesylate Salt

66. Doxazosin Mesylate,(s)

67. Opera_id_1881

68. Doxazosin Mesylate (usp)

69. Doxazosin Mesilate (jp17)

70. Schembl42621

71. 2-[4-(2,3-dihydro-1,4-benzodioxin-2-ylcarbonyl)piperazin-1-yl]-6,7-dimethoxyquinazolin-4-amine; Methanesulfonic Acid

72. Mls000120399

73. Mls001148153

74. Mls002222292

75. Mls006011977

76. Chembl1200561

77. Doxazosin Mesilate [jan]

78. Dtxsid5045598

79. Hy-b0098a

80. Doxazosin Mesylate [hsdb]

81. Doxazosin Mesylate [vandf]

82. Hms1570l17

83. Hms2093j14

84. Hms2097l17

85. Hms2230l18

86. Hms3261o10

87. Hms3372c03

88. Hms3654j15

89. Hms3714l17

90. Hms3884o09

91. Pharmakon1600-01505976

92. Doxazosin Mesilate [mart.]

93. Bcp12163

94. Doxazosin Mesilate [who-dd]

95. Doxazosin Mesylate [usp-rs]

96. Tox21_110796

97. Tox21_500474

98. Nsc759284

99. S1324

100. Akos015895371

101. Piperazin-1-yl)(2,3-dihydrobenzo[b]

102. Tox21_110796_1

103. Ac-6848

104. Ccg-213583

105. Cs-1830

106. Ks-1052

107. Lp00474

108. Nsc 759284

109. Doxazosin Mesylate [orange Book]

110. Doxazosin Mesilate [ep Monograph]

111. Doxazosin Mesylate [usp Impurity]

112. Ncgc00016146-02

113. Ncgc00018158-09

114. Ncgc00093884-01

115. Ncgc00261159-01

116. 1-(4-amino-6,7-dimethoxy-2-quinazolinyl)-4-[4-(1,4-benzodioxan-2-yl)carpiperazin-1-yl)]-6,7-dimethoxyquinazoline Mesylate

117. 2-[4-(2,3-dihydro-1,4-benzodioxine-2-carbonyl)piperazin-1-yl]-6,7-dimethoxyquinazolin-4-amine; Methanesulfonic Acid

118. Bd164387

119. Doxazosin Mesylate [usp Monograph]

120. [1,4]dioxin-2-yl)methanone Methanesulfonate

121. D4126

122. Doxazosin Mesylate, >=97% (hplc), Powder

123. Eu-0100474

124. Ft-0625592

125. Sw197099-3

126. En300-53021

127. 91d858

128. C76492

129. D 9815

130. D00608

131. A839262

132. Sr-01000003045-2

133. Sr-01000003045-4

134. Sr-01000003045-8

135. Q27106443

136. Z1259084903

137. Doxazosin Mesilate, European Pharmacopoeia (ep) Reference Standard

138. Doxazosin Mesylate, United States Pharmacopeia (usp) Reference Standard

139. (4-(4-amino-6,7-dimethoxyquinazolin-2-yl)piperazin-1-yl)(2,3-dihydrobenzo[b][1,4]dioxin-2-yl)methanonemethanesulfonate

140. 1-(4-amino-6,7-dimethoxy-2-quinazolinyl)-4-(1,4-benzodioxan-2-ylcarbonyl)piperazine Methanesulphonate

141. 1-(4-amino-6,7-dimethoxy-2-quinazolinyl)-4-[(1,4-benzodioxan-2-yl)carbonyl]piperazine Methanesulfonate

142. 2,3,4a,8a-tetrahydro-1,4-benzodioxin-3-yl-[4-(4-amino-6,7-dimethoxy-quinazolin-2-yl)piperazin-1-yl]methanone; Methanesulfonate;doxazosin Mesylate

143. 4-amino-2-[4-(1,4-benzodioxan-2-carbonyl)piperazin-1-yl]-6,7-dimethoxyquinazoline Methanesulfonate

144. Methanone, (4-(4-amino-6,7-dimethoxy-2-quinazolinyl)-1-piperazinyl)(2,3-dihydro-1,4-benzodioxin-2-yl)-, Methanesulfonate (1:1)

145. Piperazine, 1-(4-amino-6,7-dimethoxy-2-quinazolinyl)-4-((2,3-dihydro-1,4-benzodioxin-2-yl)carbonyl)-, Monomethanesulphonate

2.4 Create Date

2005-06-24

3 Chemical and Physical Properties

Molecular Formula	C₂₄H₂₉N₅O₈S
Molecular Weight	547.6 g/mol
Hydrogen Bond Donor Count	2
Hydrogen Bond Acceptor Count	12
Rotatable Bond Count	4
Exact Mass	547.17368407 g/mol
Monoisotopic Mass	547.17368407 g/mol
Topological Polar Surface Area	175 Å²
Heavy Atom Count	38
Formal Charge	0
Complexity	770
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	1
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently Bonded Unit Count	2

4 Drug and Medication Information

4.1 Drug Information

1 of 6
Drug Name	Cardura
Drug Label	CARDURA (doxazosin mesylate) is a quinazoline compound that is a selective inhibitor of the alpha1 subtype of alpha-adrenergic receptors. The chemical name of doxazosin mesylate is 1-(4-amino-6,7-dimethoxy-2-quinazolinyl)-4-(1,4-benzodioxan-2-ylcar...
Active Ingredient	Doxazosin mesylate
Dosage Form	Tablet
Route	Oral
Strength	eq 4mg base; eq 2mg base; eq 1mg base; eq 8mg base
Market Status	Prescription
Company	Pfizer

2 of 6
Drug Name	Cardura xl
Drug Label	CARDURA XL contains doxazosin mesylate which is a quinazoline compound with the chemical name 1-(4-amino-6,7-dimethoxy-2-quinazolinyl)-4-(1,4-benzodioxan-2-ylcarbonyl) piperazine methanesulfonate. The empirical formula for doxazosin mesylate is C23H2...
Active Ingredient	Doxazosin mesylate
Dosage Form	Tablet, extended release
Route	Oral
Strength	eq 4mg base; eq 8mg base
Market Status	Prescription
Company	Pfizer

3 of 6
Drug Name	Doxazosin mesylate
PubMed Health	Doxazosin (By mouth)
Drug Classes	Antihypertensive, Benign Prostatic Hypertrophy Agent, Cardiovascular Agent
Drug Label	Doxazosin mesylate is a quinazoline compound that is a selective inhibitor of the alpha1 subtype of alpha adrenergic receptors. The chemical name of doxazosin mesylate is 1-(4-amino-6,7-dimethoxy-2-quinazolinyl)-4-(1,4-benzodioxan-2-ylcarbonyl) piper...
Active Ingredient	Doxazosin mesylate
Dosage Form	Tablet
Route	Oral
Strength	eq 4mg base; eq 2mg base; eq 1mg base; eq 8mg base
Market Status	Prescription
Company	Teva; Apotex; Accord Hlthcare; Pliva; Mylan; Dava Pharms

4 of 6
Drug Name	Cardura
Drug Label	CARDURA (doxazosin mesylate) is a quinazoline compound that is a selective inhibitor of the alpha1 subtype of alpha-adrenergic receptors. The chemical name of doxazosin mesylate is 1-(4-amino-6,7-dimethoxy-2-quinazolinyl)-4-(1,4-benzodioxan-2-ylcar...
Active Ingredient	Doxazosin mesylate
Dosage Form	Tablet
Route	Oral
Strength	eq 4mg base; eq 2mg base; eq 1mg base; eq 8mg base
Market Status	Prescription
Company	Pfizer

5 of 6
Drug Name	Cardura xl
Drug Label	CARDURA XL contains doxazosin mesylate which is a quinazoline compound with the chemical name 1-(4-amino-6,7-dimethoxy-2-quinazolinyl)-4-(1,4-benzodioxan-2-ylcarbonyl) piperazine methanesulfonate. The empirical formula for doxazosin mesylate is C23H2...
Active Ingredient	Doxazosin mesylate
Dosage Form	Tablet, extended release
Route	Oral
Strength	eq 4mg base; eq 8mg base
Market Status	Prescription
Company	Pfizer

6 of 6
Drug Name	Doxazosin mesylate
PubMed Health	Doxazosin (By mouth)
Drug Classes	Antihypertensive, Benign Prostatic Hypertrophy Agent, Cardiovascular Agent
Drug Label	Doxazosin mesylate is a quinazoline compound that is a selective inhibitor of the alpha1 subtype of alpha adrenergic receptors. The chemical name of doxazosin mesylate is 1-(4-amino-6,7-dimethoxy-2-quinazolinyl)-4-(1,4-benzodioxan-2-ylcarbonyl) piper...
Active Ingredient	Doxazosin mesylate
Dosage Form	Tablet
Route	Oral
Strength	eq 4mg base; eq 2mg base; eq 1mg base; eq 8mg base
Market Status	Prescription
Company	Teva; Apotex; Accord Hlthcare; Pliva; Mylan; Dava Pharms

4.2 Therapeutic Uses

Doxazosin is indicated for the treatment of both the urinary outflow obstruction and the obstructive and irritative symptoms associated with benign prostatic hyperplasia (BPH). Obstructive symptoms are hesitation, intermittency, dribbling, weak urinary stream, and incomplete emptying of the bladder; while irritative symptoms include nocturia, daytime frequency, urgency, and burning. Doxaxosin may be used in nomotensive or hypertensive patients. In normotensive patients with BPH, doxazosin does not appear to significantly lower blood pressure. In hypertensive patients with BPH, both conditions are effectively treated with doxazosin. The long term effects of doxazosin on the incidence of acute urinary obstruction or other complications of BPH or on the need for surgery have not yet been determined. /Included in US product labeling/ /Salt not specified/

MICROMEDEX Thomson Health Care. USPDI - Drug Information for the Health Care Professional. 22nd ed. Volume 1. MICROMEDEX Thomson Health Care, Greenwood Village, CO. 2002. Content Reviewed and Approved by the U.S. Pharmacopeial Convention, Inc., p. 1278

Doxazosin is indicated in the treatment of hypertension. /Included in US product labeling/ /Salt not specified/

MICROMEDEX Thomson Health Care. USPDI - Drug Information for the Health Care Professional. 22nd ed. Volume 1. MICROMEDEX Thomson Health Care, Greenwood Village, CO. 2002. Content Reviewed and Approved by the U.S. Pharmacopeial Convention, Inc., p. 1278

Antihypertensive; in treatment of benign prostatic hypertrophy. /Salt not specified/

O'Neil, M.J. (ed.). The Merck Index - An Encyclopedia of Chemicals, Drugs, and Biologicals. 13th Edition, Whitehouse Station, NJ: Merck and Co., Inc., 2001., p. 604

Evaluation of atherosclerosis is important in the treatment of hypertension. To evaluate the preventive effects of a small amount of alpha-blockade, arterial and endothelial dysfunction were measured by noninvasive tests, i.e., pulse wave velocity, acceleration plethysmography and strain-gauge plethysmography, in patients with essential hypertension. Fifteen patients (65+/-3 years old) with essential hypertension (WHO stage I or II) were analyzed in this study. We performed noninvasive evaluations to measure aortic stiffness and endothelial dysfunction, in addition to measuring blood pressure, cholesterol profile, and levels of cells adhesion molecules and nitric oxide before and 6 and 12 months after the start of doxazosin treatment (1.0 mg/day). Blood pressure and heart rate did not significantly change during treatment. The pulse wave velocity index was significantly reduced both at 6 (7.72+/-0.23 m/s; p<0.05) and 12 (7.34+/-0.26 m/s; p<0.05) months after the start of treatment compared to the pretreatment level that at baseline. There was also a significant improvement in b/a after 12 months (-0.46+/-0.04; p<0.05) and in d/a after 6 months (-0.38+/-0.03; p<0.05) and 12 months (-0.39+/-0.03; p=0.05) compared to the pretreatment values. Moreover, reactive hyperemia evaluated by strain-gauge plethysmography after 6 months (1.34+/-0.11; p<0.05) and 12 months (1.49+/-0.16; p<0.05) was significantly improved compared to that before treatment, and NOx was significantly increased after 12 months (89.7+/-15.7 micromol/l; p<0.005). These data suggest that a low dose of doxazosin may play an important role in improving arterial stiffness and endothelial dysfunction without changing cardiac hemodynamics. /Salt not specified/

Komai N et al; Hypertens Res 25(1) : p.5-10 (2002)

For more Therapeutic Uses (Complete) data for DOXAZOSIN MESYLATE (18 total), please visit the HSDB record page.

4.3 Drug Warning

Adverse effects occurring most frequently during doxazosin mesylate therapy for hypertension include dizziness, headache, drowsiness, lack of energy (eg, lethargy, fatigue), nausea, edema, and rhinitis. In patients receiving the drug for benign prostatic hyperplasia (BPH), the most frequent adverse effects are dizziness, headache, fatigue, edema, dyspnea, abdominal pain, and diarrhea. The frequency of adverse effects in controlled clinical trails generally has been lower in patients receiving doxazosin for BPH than in those receiving the drug for hypertension; however, dosages employed for this condition also generally have been lower than those for hypertension. /Salt not specified/

McEvoy, G.K. (ed.). American Hospital Formulary Service- Drug Information 2002. Bethesda, MD: American Society of Health-System Pharmacists, Inc. 2002 (Plus Supplements)., p. 1819

While adverse effects occur frequently in patients receiving the drug, most are mild to moderate in severity, and discontinuance of doxazosin secondary to adverse effects was required in only 7% of patients with hypertension during clinical trials. The principal reasons for discontinuance in patients with hypertension were postural effects in 2% of patients and edema, malaise/fatigue, and heart rate disturbance each in about 0.7% of patients. In controlled clinical trials in patients with hypertension, only dizziness (including postural effects), weight gain, somnolence, and malaise/fatigue occurred at rates significantly greater than those for placebo; postural effects and edema appeared to be dose related. Only dizziness, fatigue, hypotension, edema, and dyspnea occurred significantly more frequently with the drug than placebo in controlled clinical trials for BPH; dizziness and dyspnea appeared to be dose-related. /Salt not specified/

McEvoy, G.K. (ed.). American Hospital Formulary Service- Drug Information 2002. Bethesda, MD: American Society of Health-System Pharmacists, Inc. 2002 (Plus Supplements)., p. 1819

Besides dizziness ..., headache is the most common adverse nervous system effect associated with doxazosin therapy, occurring in about 14 or 10% of patients receiving the drug for hypertension or benign prostatic hyperplasia (BPH), respectively. Somnolence occurs in 5 or 3% of such patients, respectively, and pain in 2% of patients. Nervousness occurs in about 2% of patients receiving doxazosin for hypertension, and insomnia and anxiety occur in 1.2 and 1.1%, respectively, of those receiving the drug for BPH; insomnia occurs in 1% of hypertensive patients. Adverse nervous system effects occurring in 0.5-1% of patients include paresthesia, kinetic disorders, ataxia, hypertonia, hypoesthesia, agitation, depression, and decreased libido. Paresis, tremor, twitching, confusion, migraine, paroniria, amnesia, emotional lability, impaired concentration, abnormal thinking, and depresonalization have been reported in less than 0.5% of patients, but a causal relationship to the drug has not been established. /Salt not specified/

McEvoy, G.K. (ed.). American Hospital Formulary Service- Drug Information 2002. Bethesda, MD: American Society of Health-System Pharmacists, Inc. 2002 (Plus Supplements)., p. 1819

Nausea, diarrhea, and dry mouth are the most common adverse GI effects of doxazosin in hypertensive patients, occurring in 3, 2, and 2% of such patients, respectively, and abdominal pain, diarrhea, dyspepsia, nausea, and dry mouth are the most common in those with benign prostatic hyperplasia (BPH), occurring in 2.4, 2.3, 1.7, 1.5, and 1.4% of such patients, respectively; dyspepsia occurs in 1% of hypertensive patients. Constipation and flatulence occur in 1% of patients receiving the drug for hypertension. Increased appetite, anorexia, fecal incontinence, and gastroenteritis have been reported in less than 0.5% of hypertensive patients but not directly attributed to the drug. Vomiting has been reported during postmarketing experience with doxazosin. /Salt not specified/

McEvoy, G.K. (ed.). American Hospital Formulary Service- Drug Information 2002. Bethesda, MD: American Society of Health-System Pharmacists, Inc. 2002 (Plus Supplements)., p. 1820

For more Drug Warnings (Complete) data for DOXAZOSIN MESYLATE (12 total), please visit the HSDB record page.

5 Pharmacology and Biochemistry

5.1 MeSH Pharmacological Classification

Adrenergic alpha-1 Receptor Antagonists

Drugs that bind to and block the activation of ADRENERGIC ALPHA-1 RECEPTORS. (See all compounds classified as Adrenergic alpha-1 Receptor Antagonists.)

Antihypertensive Agents

Drugs used in the treatment of acute or chronic vascular HYPERTENSION regardless of pharmacological mechanism. Among the antihypertensive agents are DIURETICS; (especially DIURETICS, THIAZIDE); ADRENERGIC BETA-ANTAGONISTS; ADRENERGIC ALPHA-ANTAGONISTS; ANGIOTENSIN-CONVERTING ENZYME INHIBITORS; CALCIUM CHANNEL BLOCKERS; GANGLIONIC BLOCKERS; and VASODILATOR AGENTS. (See all compounds classified as Antihypertensive Agents.)

5.2 FDA Pharmacological Classification

5.2.1 Pharmacological Classes

alpha-Adrenergic Blocker [EPC]; Adrenergic alpha-Antagonists [MoA]

5.3 Absorption, Distribution and Excretion

Most doxazosin metabolites are eliminated in the feces. /Salt not specified/

Hardman, J.G., L.E. Limbird, P.B., A.G. Gilman. Goodman and Gilman's The Pharmacological Basis of Therapeutics. 10th ed. New York, NY: McGraw-Hill, 2001., p. 246

Well absorbed from gastrointestinal tract; bioavailability is about 65%. /Salt not specified/

MICROMEDEX Thomson Health Care. USPDI - Drug Information for the Health Care Professional. 22nd ed. Volume 1. MICROMEDEX Thomson Health Care, Greenwood Village, CO. 2002. Content Reviewed and Approved by the U.S. Pharmacopeial Convention, Inc., p. 1278

Elimination: Fecal: Unchanged drug, about 5%; metabolites, 63 to 65%. Renal: 9%. /Salt not specified/

MICROMEDEX Thomson Health Care. USPDI - Drug Information for the Health Care Professional. 22nd ed. Volume 1. MICROMEDEX Thomson Health Care, Greenwood Village, CO. 2002. Content Reviewed and Approved by the U.S. Pharmacopeial Convention, Inc., p. 1278

5.4 Metabolism/Metabolites

Metabolized extensively in the liver. Although several active and inactive metabolites have been identified (2-piperazinyl, 6' and 7'-hydroxy,6' and 7'-O-desmethyl, and 2-amino), there is no evidence that they are present in substantial amounts. /Salt not specified/

MICROMEDEX Thomson Health Care. USPDI - Drug Information for the Health Care Professional. 22nd ed. Volume 1. MICROMEDEX Thomson Health Care, Greenwood Village, CO. 2002. Content Reviewed and Approved by the U.S. Pharmacopeial Convention, Inc., p. 1278

5.5 Biological Half-Life

The half-life of doxazosin is approximately 20 hours ... /Salt not specified/

Hardman, J.G., L.E. Limbird, P.B., A.G. Gilman. Goodman and Gilman's The Pharmacological Basis of Therapeutics. 10th ed. New York, NY: McGraw-Hill, 2001., p. 246

Elimination /half life/: 19 to 22 hours; does not appear to be significantly influenced by age or mild to moderate renal impairment. /Salt not specified/

MICROMEDEX Thomson Health Care. USPDI - Drug Information for the Health Care Professional. 22nd ed. Volume 1. MICROMEDEX Thomson Health Care, Greenwood Village, CO. 2002. Content Reviewed and Approved by the U.S. Pharmacopeial Convention, Inc., p. 1278

5.6 Mechanism of Action

Selective alpha1-adrenergic blocker related to prazosin, q.v. /Salt not specified/

O'Neil, M.J. (ed.). The Merck Index - An Encyclopedia of Chemicals, Drugs, and Biologicals. 13th Edition, Whitehouse Station, NJ: Merck and Co., Inc., 2001., p. 604

Blocks postsynaptic alpha 1 receptors and cause vasodilation /Salt not specified/

Ellenhorn, M.J., S. Schonwald, G. Ordog, J. Wasserberger. Ellenhorn's Medical Toxicology: Diagnosis and Treatment of Human Poisoning. 2nd ed. Baltimore, MD: Williams and Wilkins, 1997., p. 552

Hypertension: Blockade of alpha1-adrenergic receptors by doxazosin results in peripheral vasodilation, which produces a fall in blood pressure because of decreased peripheral vascular resistance. Benign prostatic hyperplasia: Relaxation of smooth muscle in the bladder neck, prostate, and prostate capsule produced by alpha1-adrenergic blockade results in a reduction in urethral resistance and pressure, bladder outlet resistance, and urinary symptoms. /Salt not specified/

MICROMEDEX Thomson Health Care. USPDI - Drug Information for the Health Care Professional. 22nd ed. Volume 1. MICROMEDEX Thomson Health Care, Greenwood Village, CO. 2002. Content Reviewed and Approved by the U.S. Pharmacopeial Convention, Inc., p. 1278

Previous studies have demonstrated that the alpha(1)-adrenergic receptor antagonist doxazosin (Dox) inhibits multiple mitogenic signaling pathways in human vascular smooth muscle cells. This broad antiproliferative activity of Dox occurs through a novel mechanism unrelated to its blocking the alpha(1)-adrenergic receptor. Flow cytometry demonstrated that Dox prevents mitogen-induced G(1)-->S progression of human coronary artery smooth muscle cells (CASMCs) in a dose-dependent manner, with a maximal reduction of S-phase transition by 88+/-10.5% in 20 ng/mL platelet-derived growth factor and 1 micromol/L insulin (P+I)-stimulated cells (P<0.01 for 10 micromol/L Dox versus P+I alone) and 52+/-18.7% for 10% FBS-induced mitogenesis (P<0.05 for 10 micromol/L Dox versus 10% FBS alone). Inhibition of G(1) exit by Dox was accompanied by a significant blockade of retinoblastoma protein (Rb) phospstimulated quiescent CASMCs to progress through G(1) and enter the S phase. E2F-mediated G(1) exit was not affected by Dox, suggesting that it targets events upstream from Rb hyperphosphorylation. Downregulation of the cyclin-dependent kinase inhibitory protein p27 is important for maximal activation of G(1) cyclin/cyclin-dependent kinase holoenzymes to overcome the cell cycle inhibitory activity of Rb. In Western blot analysis, p27 levels decreased after mitogenic stimulation (after P+I, 43+/-1.8% of quiescent cells [P<0.01 versus quiescent cells]; after 10% FBS, 55+/-7.7% of quiescent cells [P<0. 05 versus quiescent cells]), whereas the addition of Dox (10 micromol/L) markedly attenuated its downregulation (after P+I, 90+/-8.3% of quiescent cells [P<0.05 versus P+I alone]; after 10% FBS, 78+/-8.3% of quiescent cells [P<0.05 versus 10% FBS alone]). Furthermore, Dox inhibited cyclin A expression, an E2F regulated gene that is essential for cell cycle progression into the S phase. The present study demonstrates that Dox inhibits CASMC proliferation by blocking cell cycle progression from the G(0)/G(1) phase to the S phase. This G(1)-->S blockade likely results from an inhibition of mitogen-induced Rb hyperphosphorylation through prevention of p27 downregulation. /Salt not specified/

Kintscher U et al; Arterioscler Thromb Vasc Biol 20(5): p.1216-1224 (2002)

For more Mechanism of Action (Complete) data for DOXAZOSIN MESYLATE (6 total), please visit the HSDB record page.

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Zeon Pharma is a manufacturer and supplier of APIs & Intermediates.

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India

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About the Company : Zeon Pharma Industries India Pvt ltd is an ISO & GMP certified manufacturer of Bulk drugs & Intermediate and also supplies our associate manufacturing plant API / Semi finish form...

Zeon Pharma Industries India Pvt ltd is an ISO & GMP certified manufacturer of Bulk drugs & Intermediate and also supplies our associate manufacturing plant API / Semi finish formulations/Excipients, Phytochemicals/Enzymes & Intermediate and also has a GMP certified Manufacturing facility for Phytochemicals/Herbal extract and Enzymes through our associates.

Zeon Pharma Industries India Pvt Ltd

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10

Almelo

India

Pharma, Lab & Chemical Expo

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Number of Transactions

Total Quantity (KGS)

Total Value (USD)

Quantity (KGS) & Unit rate (USD/KGS) over time

API Imports and Exports

Importing Country	Total Quantity (KGS)	Average Price (USD/KGS)	Number of Transactions

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INTERMEDIATES SUPPLIERS

01

Cohance Lifesciences

India

Pharma, Lab & Chemical Expo

Not Confirmed

Cohance Lifesciences, offers full range of CDMO services for small molecule APIs, intermediates, ADCs, Pellets and Formulations.

4-Amino-2-chloro-6,7-dimethoxyquinazoline

CAS Number : 23680-84-4

End Use API : Doxazosin Mesylate

Product Web Link

Digital Content

02

PMC Isochem

France

Pharma, Lab & Chemical Expo

Not Confirmed

PMC Isochem is your partner for smart CDMOs of Intermediates, APIs, & excipients & a catalog of Intermediates & Generic APIs.

4-Amino-2-chloro-6,7-dimethoxyquinazoline

CAS Number : 23680-84-4

End Use API : Doxazosin Mesylate

Product Web Link

Digital Content

03

Zeon Pharma Industries India Pvt Lt...

India

Pharma, Lab & Chemical Expo

Not Confirmed

Zeon Pharma is a manufacturer and supplier of APIs & Intermediates.

1-(2,3-Dihydro-1,4-benzodioxan-2-yl) carbonyl] pip...

CAS Number : 70918-00-2

End Use API : Doxazosin Mesylate

Zeon Pharma Industries India Pvt Ltd

Product Web Link

Digital Content

04

Almelo

India

Pharma, Lab & Chemical Expo

Not Confirmed

05

Almelo

India

Pharma, Lab & Chemical Expo

Not Confirmed

06

Almelo

India

Pharma, Lab & Chemical Expo

Not Confirmed

07

Delta Finochem P Ltd

India

Pharma, Lab & Chemical Expo

Not Confirmed

08

Indian Tex Dyes Industries

India

Pharma, Lab & Chemical Expo

Not Confirmed

09

Indian Tex Dyes Industries

India

Pharma, Lab & Chemical Expo

Not Confirmed

10

Luna Chemicals

China

Pharma, Lab & Chemical Expo

Not Confirmed

Only 10 entries up to this point, click to access all

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FDF Dossiers

01

Sanofi

France

Pharma, Lab & Chemical Expo

Not Confirmed

Sanofi is a pioneer in Diabetes Solutions, Human Vaccines, Innovative Drugs, Consumer Healthcare, and the new Genzyme.

Contact Supplier

Contact Supplier

France

Digital Content

Regulatory Info :

Registration Country : Switzerland

Brand Name : Doxazosin retard Zentiva

Dosage Form : Ret Filmtabl

Dosage Strength : 4mg

Packaging :

Approval Date :

Application Number :

Regulatory Info :

Registration Country : Switzerland

Sanofi Company Banner

Portfolio PDF

Product Web Link

Digital Content

02

Sanofi

France

Pharma, Lab & Chemical Expo

Not Confirmed

Sanofi is a pioneer in Diabetes Solutions, Human Vaccines, Innovative Drugs, Consumer Healthcare, and the new Genzyme.

Contact Supplier

Contact Supplier

France

Digital Content

Regulatory Info :

Registration Country : Switzerland

Brand Name : Doxazosin retard Zentiva

Dosage Form : Ret Filmtabl

Dosage Strength : 4mg

Packaging :

Approval Date :

Application Number :

Regulatory Info :

Registration Country : Switzerland

Sanofi Company Banner

Portfolio PDF

Product Web Link

Digital Content

03

Sanofi

France

Pharma, Lab & Chemical Expo

Not Confirmed

Sanofi is a pioneer in Diabetes Solutions, Human Vaccines, Innovative Drugs, Consumer Healthcare, and the new Genzyme.

Contact Supplier

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France

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DOSAGE - TABLET;ORAL - EQ 1MG BASE

USFDA APPLICATION NUMBER - 19668

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DOSAGE - TABLET, EXTENDED RELEASE;ORAL - EQ 4...DOSAGE - TABLET, EXTENDED RELEASE;ORAL - EQ 4MG BASE

USFDA APPLICATION NUMBER - 21269

DOSAGE - TABLET, EXTENDED RELEASE;ORAL - EQ 8...DOSAGE - TABLET, EXTENDED RELEASE;ORAL - EQ 8MG BASE

USFDA APPLICATION NUMBER - 21269

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ABOUT THIS PAGE

Doxazosin Mesylate Manufacturers

A Doxazosin Mesylate manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Doxazosin Mesylate, including repackagers and relabelers. The FDA regulates Doxazosin Mesylate manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Doxazosin Mesylate API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

click here to find a list of Doxazosin Mesylate manufacturers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PhamaCompass.

Doxazosin Mesylate Suppliers

A Doxazosin Mesylate supplier is an individual or a company that provides Doxazosin Mesylate active pharmaceutical ingredient (API) or Doxazosin Mesylate finished formulations upon request. The Doxazosin Mesylate suppliers may include Doxazosin Mesylate API manufacturers, exporters, distributors and traders.

click here to find a list of Doxazosin Mesylate suppliers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PharmaCompass.

Doxazosin Mesylate USDMF

A Doxazosin Mesylate DMF (Drug Master File) is a document detailing the whole manufacturing process of Doxazosin Mesylate active pharmaceutical ingredient (API) in detail. Different forms of Doxazosin Mesylate DMFs exist exist since differing nations have different regulations, such as Doxazosin Mesylate USDMF, ASMF (EDMF), JDMF, CDMF, etc.

A Doxazosin Mesylate DMF submitted to regulatory agencies in the US is known as a USDMF. Doxazosin Mesylate USDMF includes data on Doxazosin Mesylate's chemical properties, information on the facilities and procedures used, and details about packaging and storage. The Doxazosin Mesylate USDMF is kept confidential to protect the manufacturer’s intellectual property.

click here to find a list of Doxazosin Mesylate suppliers with USDMF on PharmaCompass.

Doxazosin Mesylate JDMF

The Pharmaceuticals and Medical Devices Agency (PMDA) established the Japan Drug Master File (JDMF), also known as the Master File (MF), to permit Japanese and foreign manufacturers of drug substances, intermediates, excipients, raw materials, and packaging materials (‘Products’) to voluntarily register confidential information about the production and management of their products in Japan.

The Doxazosin Mesylate Drug Master File in Japan (Doxazosin Mesylate JDMF) empowers Doxazosin Mesylate API manufacturers to present comprehensive information (e.g., production methods, data, etc.) to the review authority, i.e., PMDA (Pharmaceuticals & Medical Devices Agency).

PMDA reviews the Doxazosin Mesylate JDMF during the approval evaluation for pharmaceutical products. At the time of Doxazosin Mesylate JDMF registration, PMDA checks if the format is accurate, if the necessary items have been included (application), and if data has been attached.

click here to find a list of Doxazosin Mesylate suppliers with JDMF on PharmaCompass.

Doxazosin Mesylate KDMF

In Korea, the Ministry of Food and Drug Safety (MFDS) is in charge of regulating pharmaceutical products and services.

Pharmaceutical companies submit a Doxazosin Mesylate Drug Master File in Korea (Doxazosin Mesylate KDMF) to the MFDS, which includes comprehensive information about the production, processing, facilities, materials, packaging, and testing of Doxazosin Mesylate. The MFDS reviews the Doxazosin Mesylate KDMF as part of the drug registration process and uses the information provided in the Doxazosin Mesylate KDMF to evaluate the safety and efficacy of the drug.

After submitting a Doxazosin Mesylate KDMF to the MFDS, the registered manufacturer can provide importers or distributors with the registration number without revealing confidential information to Korean business partners. Applicants seeking to register their Doxazosin Mesylate API can apply through the Korea Drug Master File (KDMF).

click here to find a list of Doxazosin Mesylate suppliers with KDMF on PharmaCompass.

Doxazosin Mesylate CEP

A Doxazosin Mesylate CEP of the European Pharmacopoeia monograph is often referred to as a Doxazosin Mesylate Certificate of Suitability (COS). The purpose of a Doxazosin Mesylate CEP is to show that the European Pharmacopoeia monograph adequately controls the purity of Doxazosin Mesylate EP produced by a given manufacturer. Suppliers of raw materials can prove the suitability of Doxazosin Mesylate to their clients by showing that a Doxazosin Mesylate CEP has been issued for it. The manufacturer submits a Doxazosin Mesylate CEP (COS) as part of the market authorization procedure, and it takes on the role of a Doxazosin Mesylate CEP holder for the record. Additionally, the data presented in the Doxazosin Mesylate CEP (COS) is managed confidentially and offers a centralized system acknowledged by numerous nations, exactly like the Doxazosin Mesylate DMF.

A Doxazosin Mesylate CEP (COS) is recognised by all 36 nations that make up the European Pharmacopoeia Convention. Doxazosin Mesylate CEPs may be accepted in nations that are not members of the Ph. Eur. at the discretion of the authorities there.

click here to find a list of Doxazosin Mesylate suppliers with CEP (COS) on PharmaCompass.

Doxazosin Mesylate WC

A Doxazosin Mesylate written confirmation (Doxazosin Mesylate WC) is an official document issued by a regulatory agency to a Doxazosin Mesylate manufacturer, verifying that the manufacturing facility of a Doxazosin Mesylate active pharmaceutical ingredient (API) adheres to the Good Manufacturing Practices (GMP) regulations of the importing country. When exporting Doxazosin Mesylate APIs or Doxazosin Mesylate finished pharmaceutical products to another nation, regulatory agencies frequently require a Doxazosin Mesylate WC (written confirmation) as part of the regulatory process.

click here to find a list of Doxazosin Mesylate suppliers with Written Confirmation (WC) on PharmaCompass.

Doxazosin Mesylate NDC

National Drug Code is a comprehensive database maintained by the FDA that contains information on all drugs marketed in the US. This directory includes information about finished drug products, unfinished drug products, and compounded drug products, including those containing Doxazosin Mesylate as an active pharmaceutical ingredient (API).

Finished drug products

The FDA updates the NDC directory daily. The NDC numbers for Doxazosin Mesylate API and other APIs are published in this directory by the FDA.

Unfinished drugs

The NDC unfinished drugs database includes product listing information submitted for all unfinished drugs, such as active pharmaceutical ingredients (APIs), drugs intended for further processing and bulk drug substances for compounding.

Pharmaceutical companies that manufacture Doxazosin Mesylate as an active pharmaceutical ingredient (API) must furnish the FDA with an updated record of all drugs that they produce, prepare, propagate, compound, or process for commercial distribution in the US at their facilities.

Compounded drug products

The NDC directory also contains data on finished compounded human drug products that contain Doxazosin Mesylate and are produced by outsourcing facilities. While these outsourcing facilities are not mandated to assign a Doxazosin Mesylate NDC to their finished compounded human drug products, they may choose to do so.

click here to find a list of Doxazosin Mesylate suppliers with NDC on PharmaCompass.

Doxazosin Mesylate GMP

Doxazosin Mesylate Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

PharmaCompass offers a list of Doxazosin Mesylate GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Doxazosin Mesylate GMP manufacturer or Doxazosin Mesylate GMP API supplier for your needs.

Doxazosin Mesylate CoA

A Doxazosin Mesylate CoA (Certificate of Analysis) is a formal document that attests to Doxazosin Mesylate's compliance with Doxazosin Mesylate specifications and serves as a tool for batch-level quality control.

Doxazosin Mesylate CoA mostly includes findings from lab analyses of a specific batch. For each Doxazosin Mesylate CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

Doxazosin Mesylate may be tested according to a variety of international standards, such as European Pharmacopoeia (Doxazosin Mesylate EP), Doxazosin Mesylate JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Doxazosin Mesylate USP).

Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.

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