Find Doxcercalciferol manufacturers, exporters & distributors on PharmaCompass

Doxercalciferol

DRL offers a portfolio of products & services, including APIs, CMO services, generics, biosimilars & differentiated formulations.

ACCESS ALL DATA
Browse all information
CHEMISTRY
Discover Molecule Insights

ACTIVE PHARMA INGREDIENTS

15 API Suppliers, 10 USDMF, 2 EU WC, 4 NDC API, 8 Listed Suppliers

15 API Suppliers
10 USDMF
2 EU WC
4 NDC API
8 Listed Suppliers

FINISHED DOSAGE FORMULATIONS

35 FDF Dossiers, 33 FDA Orange Book, 2 Listed Dossiers

35 FDF Dossiers
33 FDA Orange Book
2 Listed Dossiers

DRUG PRODUCT COMPOSITIONS

INJECTABLE;INJECTION - 10MCG/5ML (2MCG/ML), INJECTABLE;INJECTION - 4MCG/2ML (2MCG/ML), CAPSULE;ORAL - 0.5MCG, CAPSULE;ORAL - 1MCG, CAPSULE;ORAL - 2.5MCG

drugProductComposition
INJECTABLE;INJECTION - 10MCG/5ML (2MCG/ML)
INJECTABLE;INJECTION - 4MCG/2ML (2MCG/ML)
CAPSULE;ORAL - 0.5MCG
CAPSULE;ORAL - 1MCG
CAPSULE;ORAL - 2.5MCG

RELATED EXCIPIENT COMPANIES

7 DKSH, 2 Nanjing Well Pharmaceutical, 4 ACG Worldwide, 4 Actylis, 3 BASF, 1 Finar, 1 Gangwal Chemicals, 1 Kerry, 3 Lonza Capsugel, 1 Pluviaendo, 1 Qualicaps, 2 Roquette, 3 Seppic, 1 Valens Pharmachem

relatedExcipients
7 DKSH
2 Nanjing Well Pharmaceutical
4 ACG Worldwide
4 Actylis
3 BASF
1 Finar
1 Gangwal Chemicals
1 Kerry
3 Lonza Capsugel
1 Pluviaendo
1 Qualicaps
2 Roquette
3 Seppic
1 Valens Pharmachem

EXCIPIENTS BY APPLICATIONS

8 Parenteral, 8 Empty Capsules, 7 Topical, 7 Coating Systems & Additives, 7 Solubilizers, 6 Thickeners and Stabilizers, 5 Film Formers & Plasticizers, 4 Fillers, Diluents & Binders, 3 Coloring Agents, 2 Emulsifying Agents, 2 Surfactant & Foaming Agents, 1 Controlled & Modified Release, 1 Taste Masking

excipientsByApplications
8 Parenteral
8 Empty Capsules
7 Topical
7 Coating Systems & Additives
7 Solubilizers
6 Thickeners and Stabilizers
5 Film Formers & Plasticizers
4 Fillers, Diluents & Binders
3 Coloring Agents
2 Emulsifying Agents
2 Surfactant & Foaming Agents
1 Controlled & Modified Release
1 Taste Masking

DIGITAL CONTENT

9 NEWS #PharmaBuzz

media
9 NEWS #PharmaBuzz

MARKET PLACE

6 APIs

marketPlace
6 APIs

REF. STANDARDS & IMPURITIES

1 USP , 1 Others

otherSolutions
1 USP
1 Others

Synopsis

ACTIVE PHARMA INGREDIENTS

API Suppliers

USDMF

CEP/COS

JDMF

EU WC

KDMF

NDC API

VMF

Listed Suppliers

API REF. PRICE (USD/KG)

$ 0

MARKET PLACE

API

FDF

0INTERMEDIATES

FINISHED DOSAGE FORMULATIONS

FDF Dossiers

FDA Orange Book

Europe

Canada

Australia

South Africa

Listed Dossiers

0 DRUGS IN DEVELOPMENT

DRUG PRODUCT COMPOSITIONS

REF. STANDARDS OR IMPURITIES

EDQM

USP

Others

PATENTS & EXCLUSIVITIES

US Patents

US Exclusivities

Health Canada Patents

DIGITAL CONTENT

Data Compilation #PharmaFlow

Stock Recap #PipelineProspector

Weekly News Recap #Phispers

News #PharmaBuzz

GLOBAL SALES INFORMATION

US Medicaid (USD)

Annual Reports (USD Million)

Finished Drug Prices

34 RELATED EXCIPIENT COMPANIES

61EXCIPIENTS BY APPLICATIONS

Chemistry

Click the arrow to open the dropdown

Click the button for full data set

Also known as: 54573-75-0, Hectorol, 1-hydroxyergocalciferol, 1alpha-hydroxyergocalciferol, Tsa 840, 1alpha-hydroxyvitamin d2

Molecular Formula

C₂₈H₄₄O₂

Molecular Weight

412.6 g/mol

InChI Key

HKXBNHCUPKIYDM-CGMHZMFXSA-N

FDA UNII

3DIZ9LF5Y9

Doxercalciferol is a synthetic analog of vitamin D with potential antineoplastic activity. In the liver, doxercalciferol is converted to its biologically active vitamin D metabolites, which control the intestinal absorption of dietary calcium, the tubular reabsorption of calcium by the kidney and, in conjunction with parathyroid hormone (PTH), the mobilization of calcium from the skeleton. Through interaction with specific receptor proteins in target tissues, these vitamin D metabolites act directly on osteoblasts to stimulate skeletal growth, and on the parathyroid glands to suppress PTH synthesis and secretion. This agent has also been shown to inhibit the growth of retinoblastomas, and may exhibit some antiproliferative activity against prostate cancer cells.

Doxercalciferol is a Vitamin D2 Analog.

1 2D Structure

Doxcercalciferol

2 Identification

2.1 Computed Descriptors

2.1.1 IUPAC Name

(1R,3S,5Z)-5-[(2E)-2-[(1R,3aS,7aR)-1-[(E,2R,5R)-5,6-dimethylhept-3-en-2-yl]-7a-methyl-2,3,3a,5,6,7-hexahydro-1H-inden-4-ylidene]ethylidene]-4-methylidenecyclohexane-1,3-diol

2.1.2 InChI

InChI=1S/C28H44O2/c1-18(2)19(3)9-10-20(4)25-13-14-26-22(8-7-15-28(25,26)6)11-12-23-16-24(29)17-27(30)21(23)5/h9-12,18-20,24-27,29-30H,5,7-8,13-17H2,1-4,6H3/b10-9+,22-11+,23-12-/t19-,20+,24+,25+,26-,27-,28+/m0/s1

2.1.3 InChI Key

HKXBNHCUPKIYDM-CGMHZMFXSA-N

2.1.4 Canonical SMILES

CC(C)C(C)C=CC(C)C1CCC2C1(CCCC2=CC=C3CC(CC(C3=C)O)O)C

2.1.5 Isomeric SMILES

C[C@H](/C=C/[C@H](C)C(C)C)[C@H]1CC[C@@H]\2[C@@]1(CCC/C2=C\C=C/3\C[C@H](C[C@@H](C3=C)O)O)C

2.2 Other Identifiers

2.2.1 UNII

3DIZ9LF5Y9

2.3 Synonyms

2.3.1 MeSH Synonyms

1. 1 Alpha-hydroxyergocalciferol

2. 1alpha(oh)2d2

3. 1alpha-hydroxyvitamin D2

4. 1alpha-ohd2

5. Doxacalciferol

6. Hectorol

2.3.2 Depositor-Supplied Synonyms

1. 54573-75-0

2. Hectorol

3. 1-hydroxyergocalciferol

4. 1alpha-hydroxyergocalciferol

5. Tsa 840

6. 1alpha-hydroxyvitamin D2

7. 1-alpha-hydroxyvitamin D2

8. 1-alpha-hydroxyergocalciferol

9. 1-hydroxyvitamin D2

10. 1.alpha.-hydroxyvitamin D2

11. 1alpha-oh-d2

12. (1r,3s,5z)-5-[(2e)-2-[(1r,3as,7ar)-1-[(e,2r,5r)-5,6-dimethylhept-3-en-2-yl]-7a-methyl-2,3,3a,5,6,7-hexahydro-1h-inden-4-ylidene]ethylidene]-4-methylidenecyclohexane-1,3-diol

13. 3diz9lf5y9

14. (1s,3r,5z,7e,22e)-9,10-secoergosta-5,7,10,22-tetraene-1,3-diol

15. 1.alpha.-hydroxyergocalciferol

16. Chebi:4712

17. 1-.alpha.-hydroxyergocalciferol

18. Tsa-840

19. Gz427397

20. Doxercalciferol [inn]

21. 1alpha-hydroxyvitamin D2 / 1alpha-hydroxyergocalciferol

22. (5z,7e,22e)-(1s,3r)-9,10-seco-5,7,10(19),22-ergostatetraene-1,3-diol

23. Hectorol (tn)

24. (1r,3s,5z)-5-[(2e)-2-[(1r,3as,7ar)-7a-methyl-1-[(e,1r,4r)-1,4,5-trimethylhex-2-enyl]-2,3,3a,5,6,7-hexahydro-1h-inden-4-ylidene]ethylidene]-4-methylene-cyclohexane-1,3-diol

25. Vitamin D2, 1alpha-hydroxy-

26. Unii-3diz9lf5y9

27. Brn 4716774

28. Doxercalciferol [usan:inn]

29. Doxercalciferolum

30. Ncgc00182058-03

31. 1alphaohd2

32. Mfcd00871065

33. 1a-hydroxyvitamin D2

34. 1alpha-hydroxy Vitamin D2

35. (5z,7e,22e)-9,10-secoergosta-5,7,10(19),22-tetraene-1alpha,3beta-diol

36. Vitamin D2, 1a-hydroxy-

37. 1-alpha-hydroxy-vitamin D2

38. Doxercalciferol [mi]

39. Dsstox_cid_14214

40. Dsstox_rid_79125

41. Doxercalciferol (usan/inn)

42. Dsstox_gsid_34214

43. Doxercalciferol [usan]

44. Schembl322422

45. Doxercalciferol [vandf]

46. Gtpl2790

47. Doxercalciferol [mart.]

48. 1-alpha-hydroxyvitamind2

49. Chembl1200810

50. Doxercalciferol [usp-rs]

51. Doxercalciferol [who-dd]

52. Dtxsid1034214

53. Act06836

54. Ex-a4428

55. Zinc4641374

56. Tox21_112978

57. Doxercalciferol [orange Book]

58. Hsci1_000341

59. Lmst03010028

60. Akos005146517

61. Cs-0395

62. Db06410

63. Doxercalciferol [usp Monograph]

64. 9,10-secoergosta-5,7,10(19),22-tetraene-1,3-diol, (1-alpha,3-beta,5z,7e,22e)-

65. 9,10-secoergosta-5,7,10(19),22-tetraene-1,3-diol, (1.alpha.,3.beta.,5z,7e,22e)-

66. Bs-17040

67. Hy-32348

68. Cas-54573-75-0

69. 1a-hydroxyergocalciferol (ercalcidol)

70. C08211

71. D01009

72. D82103

73. 573d750

74. Q5303688

75. Doxercalciferol, >=98% (hplc), Solubility: >10 Mg/ml In Dmso

76. Doxercalciferol, United States Pharmacopeia (usp) Reference Standard

77. (5z,7e,22e)-9,10-secoergosta-5,7,10(19),22-tetraene-1.alpha.,3.beta.-diol

78. 7,10(19),22-tetraene-1,3-diol,(1-alpha,3-beta,5z,7e,22e)-10-secoergosta-5

79. 9,10-secoergosta-5,7,10(19),22-tetraene-1,3-diol, (1alpha,3beta,5z,7e,22e)-

80. (1r,3s,5z)-4-methylene-5-[(2e)-2-[(1r,3as,7ar)-octahydro-7?-methyl-1-[(1r,2e)-1,4,5-trimethyl-2-hexen-1-yl]-4h-inden-4-ylidene]ethylidene]-1,3-cyclohexanediol

81. (1r,3s,z)-5-((e)-2-((1r,3as,7ar)-1-((2r,5r,e)-5,6-dimethylhept-3-en-2-yl)-7a-methyldihydro-1h-inden-4(2h,5h,6h,7h,7ah)-ylidene)ethylidene)-4-methylenecyclohexane-1,3-diol

82. (1r,3s,z)-5-((e)-2-((1r,3as,7ar)-1-((2r,5r,e)-5,6-dimethylhept-3-en-2-yl)-7a-methylhexahydro-1h-inden-4(2h)-ylidene)ethylidene)-4-methylenecyclohexane-1,3-diol

83. 1,3-cyclohexanediol, 4-methylene-5-((2e)-2-((1r,3as,7ar)-octahydro-7a-methyl-1-((1r,2e)-1,4,5-trimethyl-2-hexen-1-yl)-4h-inden-4-ylidene)ethylidene)-, (1r,3s,5z)-

2.4 Create Date

2005-06-24

3 Chemical and Physical Properties

Molecular Formula	C₂₈H₄₄O₂
Molecular Weight	412.6 g/mol
XLogP3	6.3
Hydrogen Bond Donor Count	2
Hydrogen Bond Acceptor Count	2
Rotatable Bond Count	5
Exact Mass	412.334130642 g/mol
Monoisotopic Mass	412.334130642 g/mol
Topological Polar Surface Area	40.5 Å²
Heavy Atom Count	30
Formal Charge	0
Complexity	712
Isotope Atom Count	0
Defined Atom Stereocenter Count	7
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	3
Undefined Bond Stereocenter Count	0
Covalently Bonded Unit Count	1

4 Drug and Medication Information

4.1 Drug Information

1 of 4
Drug Name	Doxercalciferol
PubMed Health	Doxercalciferol
Drug Classes	Calcium Regulator, Endocrine-Metabolic Agent, Nutriceutical, Nutritive Agent
Drug Label	Doxercalciferol is a synthetic vitamin D2 analog that undergoes metabolic activation in vivo to form 1,25-dihydroxyvitamin D2 (1,25-(OH)2D2), a naturally occurring, biologically active form of vitamin D2. Doxercalciferol injection is supplied in...
Active Ingredient	Doxercalciferol
Dosage Form	Injectable; Capsule
Route	injection; Injection; Oral
Strength	0.5mcg; 4mcg/2ml (2mcg/ml); 2mcg/ml; 1mcg; 2.5mcg
Market Status	Tentative Approval; Prescription
Company	Cobrek Pharma; Sandoz; Hikma Pharms; Roxane

2 of 4
Drug Name	Hectorol
PubMed Health	Doxercalciferol
Drug Classes	Calcium Regulator, Endocrine-Metabolic Agent, Nutriceutical, Nutritive Agent
Drug Label	Doxercalciferol, the active ingredient in Hectorol, is a synthetic vitamin D2 analog that undergoes metabolic activation in vivo to form 1,25-dihydroxyvitamin D2 (1,25-(OH)2D2), a naturally occurring, biologically active form of vitamin D2. H...
Active Ingredient	Doxercalciferol
Dosage Form	Capsule; Injectable
Route	Injection; Oral
Strength	0.5mcg; 1mcg; 2mcg/ml (2mcg/ml); 4mcg/2ml (2mcg/ml); 2.5mcg
Market Status	Prescription
Company	Genzyme

3 of 4
Drug Name	Doxercalciferol
PubMed Health	Doxercalciferol
Drug Classes	Calcium Regulator, Endocrine-Metabolic Agent, Nutriceutical, Nutritive Agent
Drug Label	Doxercalciferol is a synthetic vitamin D2 analog that undergoes metabolic activation in vivo to form 1,25-dihydroxyvitamin D2 (1,25-(OH)2D2), a naturally occurring, biologically active form of vitamin D2. Doxercalciferol injection is supplied in...
Active Ingredient	Doxercalciferol
Dosage Form	Injectable; Capsule
Route	injection; Injection; Oral
Strength	0.5mcg; 4mcg/2ml (2mcg/ml); 2mcg/ml; 1mcg; 2.5mcg
Market Status	Tentative Approval; Prescription
Company	Cobrek Pharma; Sandoz; Hikma Pharms; Roxane

4 of 4
Drug Name	Hectorol
PubMed Health	Doxercalciferol
Drug Classes	Calcium Regulator, Endocrine-Metabolic Agent, Nutriceutical, Nutritive Agent
Drug Label	Doxercalciferol, the active ingredient in Hectorol, is a synthetic vitamin D2 analog that undergoes metabolic activation in vivo to form 1,25-dihydroxyvitamin D2 (1,25-(OH)2D2), a naturally occurring, biologically active form of vitamin D2. H...
Active Ingredient	Doxercalciferol
Dosage Form	Capsule; Injectable
Route	Injection; Oral
Strength	0.5mcg; 1mcg; 2mcg/ml (2mcg/ml); 4mcg/2ml (2mcg/ml); 2.5mcg
Market Status	Prescription
Company	Genzyme

4.2 Drug Indication

Doxercalciferol is indicated for the treatment of secondary hyperparathyroidism in patients with chronic kidney disease on dialysis, as well as for the treatment of secondary hyperparathyroidism in patients with Stage 3 or Stage 4 chronic kidney disease.

FDA Label

5 Pharmacology and Biochemistry

5.1 MeSH Pharmacological Classification

Bone Density Conservation Agents

Agents that inhibit BONE RESORPTION and/or favor BONE MINERALIZATION and BONE REGENERATION. They are used to heal BONE FRACTURES and to treat METABOLIC BONE DISEASES such as OSTEOPOROSIS. (See all compounds classified as Bone Density Conservation Agents.)

Vitamins

Organic substances that are required in small amounts for maintenance and growth, but which cannot be manufactured by the human body. (See all compounds classified as Vitamins.)

5.2 FDA Pharmacological Classification

5.2.1 Active Moiety

DOXERCALCIFEROL

5.2.2 FDA UNII

3DIZ9LF5Y9

5.2.3 Pharmacological Classes

Vitamin D2 Analog [EPC]; Ergocalciferols [CS]

5.3 ATC Code

H - Systemic hormonal preparations, excl. sex hormones and insulins

H05 - Calcium homeostasis

H05B - Anti-parathyroid agents

H05BX - Other anti-parathyroid agents

H05BX03 - Doxercalciferol

5.4 Metabolism/Metabolites

Doxercalciferol is absorbed from the gastrointestinal tract and activated by CYP 27 in the liver to form 1,25-(OH)2D2 (major metabolite) and 1,24-dihydroxyvitamin D2 (minor metabolite). Activation of doxercalciferol does not require the involvement of the kidneys.

5.5 Biological Half-Life

32 to 37 hours.

5.6 Mechanism of Action

Calcitriol (1,25-(OH)2D3) and 1,25-(OH)2D2 regulate blood calcium at levels required for essential body functions. Specifically, the biologically active vitamin D metabolites control the intestinal absorption of dietary calcium, the tubular reabsorption of calcium by the kidney and, in conjunction with parathyroid hormone (PTH), the mobilization of calcium from the skeleton. They act directly on bone cells (osteoblasts) to stimulate skeletal growth, and on the parathyroid glands to suppress PTH (parathyroid hormone) synthesis and secretion. These functions are mediated by the interaction of these biologically active metabolites with specific receptor proteins in the various target tissues. In patients with chronic kidney disease (CKD), deficient production of biologically active vitamin D metabolites (due to lack of or insufficient 25-hydroxyvitamin D-1-alpha-hydroxylase activity) leads to secondary hyperparathyroidism, which contributes to the development of metabolic bone disease.

API SUPPLIERS

FULL SCREEN VIEW Click here to open all results in a new tab [this preview display 10 results]

USDMF

FULL SCREEN VIEW Click here to open all results in a new tab [this preview display 10 results]

EU WC

FULL SCREEN VIEW Click here to open all results in a new tab [this preview display 10 results]

NDC API

FULL SCREEN VIEW Click here to open all results in a new tab [this preview display 10 results]

Listed Suppliers

FULL SCREEN VIEW Click here to open all results in a new tab [this preview display 10 results]

FDF Dossiers

FULL SCREEN VIEW Click here to open all results in a new tab [this preview display 10 results]

FDA Orange Book

FULL SCREEN VIEW Click here to open all results in a new tab [this preview display 10 results]

Listed Dossiers

FULL SCREEN VIEW Click here to open all results in a new tab [this preview display 10 results]

DRUG PRODUCT COMPOSITIONS

Do you need Business Intel? Ask us

DOSAGE - INJECTABLE;INJECTION - 10MCG/5ML (2M...DOSAGE - INJECTABLE;INJECTION - 10MCG/5ML (2MCG/ML)

USFDA APPLICATION NUMBER - 208614

DOSAGE - INJECTABLE;INJECTION - 4MCG/2ML (2MC...DOSAGE - INJECTABLE;INJECTION - 4MCG/2ML (2MCG/ML)

USFDA APPLICATION NUMBER - 208614

DOSAGE - CAPSULE;ORAL - 0.5MCG

USFDA APPLICATION NUMBER - 20862

DOSAGE - CAPSULE;ORAL - 1MCG

USFDA APPLICATION NUMBER - 20862

DOSAGE - CAPSULE;ORAL - 2.5MCG

USFDA APPLICATION NUMBER - 20862

Related Excipient Companies

Upload your portfolio for free, ask us

Excipients by Applications

Click here to find the perfect excipient manufacturers by their capabilities

Parenteral

Empty Capsules

Topical

Coating Systems & Additives

Solubilizers

Thickeners and Stabilizers

Film Formers & Plasticizers

Fillers, Diluents & Binders

Coloring Agents

Emulsifying Agents

Surfactant & Foaming Agents

Controlled & Modified Release

Taste Masking

Digital Content

Create Content with PharmaCompass, ask us

NEWS #PharmaBuzz

Market Place

Do you need sourcing support? Ask us

APIs

FULL SCREEN VIEW Click here to open all results in a new tab [this preview display 10 results]

REF. STANDARDS & IMPURITIES

Upload your portfolio for free, ask us

USP

Others

FULL SCREEN VIEW Click here to open all results in a new tab [this preview display 10 results]

ABOUT THIS PAGE

Market Place

Home

Post Enquiry

Market Place

Find Doxcercalciferol manufacturers, exporters & distributors on PharmaCompass

Doxercalciferol

ACCESS ALL DATA

Browse all information

CHEMISTRY

Discover Molecule Insights

ACTIVE PHARMA INGREDIENTS

15 API Suppliers

10 USDMF

2 EU WC

4 NDC API

8 Listed Suppliers

FINISHED DOSAGE FORMULATIONS

35 FDF Dossiers

33 FDA Orange Book

2 Listed Dossiers

DRUG PRODUCT COMPOSITIONS

INJECTABLE;INJECTION - 10MCG/5ML (2MCG/ML)

INJECTABLE;INJECTION - 4MCG/2ML (2MCG/ML)

CAPSULE;ORAL - 0.5MCG

CAPSULE;ORAL - 1MCG

CAPSULE;ORAL - 2.5MCG

RELATED EXCIPIENT COMPANIES

7 DKSH

2 Nanjing Well Pharmaceutical

4 ACG Worldwide

4 Actylis

3 BASF

1 Finar

1 Gangwal Chemicals

1 Kerry

3 Lonza Capsugel

1 Pluviaendo

1 Qualicaps

2 Roquette

3 Seppic

1 Valens Pharmachem

EXCIPIENTS BY APPLICATIONS

8 Parenteral

8 Empty Capsules

7 Topical

7 Coating Systems & Additives

7 Solubilizers

6 Thickeners and Stabilizers

5 Film Formers & Plasticizers

4 Fillers, Diluents & Binders

3 Coloring Agents

2 Emulsifying Agents

2 Surfactant & Foaming Agents

1 Controlled & Modified Release

1 Taste Masking

DIGITAL CONTENT

9 NEWS #PharmaBuzz

MARKET PLACE

6 APIs

REF. STANDARDS & IMPURITIES

1 USP

1 Others

ACTIVE PHARMA INGREDIENTS

API REF. PRICE (USD/KG)

$ 0

MARKET PLACE

0INTERMEDIATES

FINISHED DOSAGE FORMULATIONS

0 DRUGS IN DEVELOPMENT

DRUG PRODUCT COMPOSITIONS

REF. STANDARDS OR IMPURITIES

PATENTS & EXCLUSIVITIES

DIGITAL CONTENT

GLOBAL SALES INFORMATION

34 RELATED EXCIPIENT COMPANIES

61EXCIPIENTS BY APPLICATIONS

What are you looking for?