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Chemistry

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Also known as: 358970-97-5, Ave-1625, Ave1625, Drinabant [inn], Ave 1625, 61s98rll5i
Molecular Formula
C23H20Cl2F2N2O2S
Molecular Weight
497.4  g/mol
InChI Key
IQQBRKLVEALROM-UHFFFAOYSA-N
FDA UNII
61S98RLL5I

Drinabant
AVE-1625 is an oral selective and potent antagonist of cannabinoid 1 (CB1) receptors having the same mechanism of action as rimonabant. It is currently developed in obesity and its associated comorbidities. AVE-1625 is also being developed for the treatment of Alzheimer disease.
1 2D Structure

Drinabant

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
N-[1-[bis(4-chlorophenyl)methyl]azetidin-3-yl]-N-(3,5-difluorophenyl)methanesulfonamide
2.1.2 InChI
InChI=1S/C23H20Cl2F2N2O2S/c1-32(30,31)29(21-11-19(26)10-20(27)12-21)22-13-28(14-22)23(15-2-6-17(24)7-3-15)16-4-8-18(25)9-5-16/h2-12,22-23H,13-14H2,1H3
2.1.3 InChI Key
IQQBRKLVEALROM-UHFFFAOYSA-N
2.1.4 Canonical SMILES
CS(=O)(=O)N(C1CN(C1)C(C2=CC=C(C=C2)Cl)C3=CC=C(C=C3)Cl)C4=CC(=CC(=C4)F)F
2.2 Other Identifiers
2.2.1 UNII
61S98RLL5I
2.3 Synonyms
2.3.1 MeSH Synonyms

1. Ave1625

2.3.2 Depositor-Supplied Synonyms

1. 358970-97-5

2. Ave-1625

3. Ave1625

4. Drinabant [inn]

5. Ave 1625

6. 61s98rll5i

7. N-[1-[bis(4-chlorophenyl)methyl]azetidin-3-yl]-n-(3,5-difluorophenyl)methanesulfonamide

8. N-(1-(bis(4-chlorophenyl)methyl)azetidin-3-yl)-n-(3,5-difluorophenyl)methanesulfonamide

9. Unii-61s98rll5i

10. Drinabant [who-dd]

11. Schembl684143

12. Chembl3545166

13. Dtxsid50189455

14. Zinc59299699

15. Hy-14788

16. Cs-0003562

17. 970d975

18. Q5307675

19. Methanesulfonamide, N-(1-(bis(4-chlorophenyl)methyl)-3-azetidinyl)-n-(3,5-difluorophenyl)-

20. N-[1-[bis(4-chlorophenyl)methyl]-3-azetidinyl]-n-(3,5-difluorophenyl)methanesulfonamide

2.4 Create Date
2006-10-25
3 Chemical and Physical Properties
Molecular Weight 497.4 g/mol
Molecular Formula C23H20Cl2F2N2O2S
XLogP35.6
Hydrogen Bond Donor Count0
Hydrogen Bond Acceptor Count6
Rotatable Bond Count6
Exact Mass496.0590608 g/mol
Monoisotopic Mass496.0590608 g/mol
Topological Polar Surface Area49 Ų
Heavy Atom Count32
Formal Charge0
Complexity686
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count1
4 Drug and Medication Information
4.1 Drug Indication

Investigated for use/treatment in alzheimer's disease, obesity, and schizophrenia and schizoaffective disorders.


5 Pharmacology and Biochemistry
5.1 Mechanism of Action

AVE-1625 is a selective and potent antagonist of cannabinoid 1 (CB1) receptors having the same mechanism of action as rimonabant.


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ABOUT THIS PAGE

Looking for 358970-97-5 / Drinabant API manufacturers, exporters & distributors?

Drinabant manufacturers, exporters & distributors 1

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PharmaCompass offers a list of Drinabant API manufacturers, exporters & distributors, which can be sorted by GMP, USDMF, JDMF, KDMF, CEP (COS), WC, Price,and more, enabling you to easily find the right Drinabant manufacturer or Drinabant supplier for your needs.

Send us enquiries for free, and we will assist you in establishing a direct connection with your preferred Drinabant manufacturer or Drinabant supplier.

PharmaCompass also assists you with knowing the Drinabant API Price utilized in the formulation of products. Drinabant API Price is not always fixed or binding as the Drinabant Price is obtained through a variety of data sources. The Drinabant Price can also vary due to multiple factors, including market conditions, regulatory modifications, or negotiated pricing deals.

API | Excipient name

Drinabant

Synonyms

358970-97-5, Ave-1625, Ave1625, Drinabant [inn], Ave 1625, 61s98rll5i

Cas Number

358970-97-5

Unique Ingredient Identifier (UNII)

61S98RLL5I

About Drinabant

AVE-1625 is an oral selective and potent antagonist of cannabinoid 1 (CB1) receptors having the same mechanism of action as rimonabant. It is currently developed in obesity and its associated comorbidities. AVE-1625 is also being developed for the treatment of Alzheimer disease.

Drinabant Manufacturers

A Drinabant manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Drinabant, including repackagers and relabelers. The FDA regulates Drinabant manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Drinabant API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

Drinabant Suppliers

A Drinabant supplier is an individual or a company that provides Drinabant active pharmaceutical ingredient (API) or Drinabant finished formulations upon request. The Drinabant suppliers may include Drinabant API manufacturers, exporters, distributors and traders.

Drinabant GMP

Drinabant Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

PharmaCompass offers a list of Drinabant GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Drinabant GMP manufacturer or Drinabant GMP API supplier for your needs.

Drinabant CoA

A Drinabant CoA (Certificate of Analysis) is a formal document that attests to Drinabant's compliance with Drinabant specifications and serves as a tool for batch-level quality control.

Drinabant CoA mostly includes findings from lab analyses of a specific batch. For each Drinabant CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

Drinabant may be tested according to a variety of international standards, such as European Pharmacopoeia (Drinabant EP), Drinabant JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Drinabant USP).

Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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