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Valsynthese, part of the SSE Group, is a CDMO focused on highly energetic and highly hazardous chemistry.

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CHEMISTRY
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ACTIVE PHARMA INGREDIENTS

16 API Suppliers, 2 EU WC, 15 Listed Suppliers, $ API Reference Price

16 API Suppliers
2 EU WC
15 Listed Suppliers
$ API Reference Price

FINISHED DOSAGE FORMULATIONS

19 FDF Dossiers, 19 Listed Dossiers

19 FDF Dossiers
19 Listed Dossiers

MARKET PLACE

10 APIs, 27 FDF Dossiers

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10 APIs
27 FDF Dossiers

ANALYTICAL

2 BioAnalytical Methods

otherMethods
2 BioAnalytical Methods

Synopsis

ACTIVE PHARMA INGREDIENTS

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CEP/COS

JDMF

EU WC

KDMF

NDC API

VMF

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API REF. PRICE (USD/KG)

$ 60

MARKET PLACE

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FDF

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Canada

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South Africa

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USP

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US Patents

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Chemistry

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Also known as: 985-12-6, Drotaverine hcl, Drotin; isodihydroperparine hydrochloride; nosh-bra; no-spa, Dihydroisoperparine; drotaverin; isodihydroperparine; perparine, isodihydro-, 1-[(3,4-diethoxyphenyl)methylidene]-6,7-diethoxy-3,4-dihydro-2h-isoquinoline;hydrochloride, Bcp32864

Molecular Formula

C₂₄H₃₂ClNO₄

Molecular Weight

434.0 g/mol

InChI Key

JBFLYOLJRKJYNV-UHFFFAOYSA-N

1 2D Structure

Drotaverine

2 Identification

2.1 Computed Descriptors

2.1.1 IUPAC Name

1-[(3,4-diethoxyphenyl)methylidene]-6,7-diethoxy-3,4-dihydro-2H-isoquinoline;hydrochloride

2.1.2 InChI

InChI=1S/C24H31NO4.ClH/c1-5-26-21-10-9-17(14-22(21)27-6-2)13-20-19-16-24(29-8-4)23(28-7-3)15-18(19)11-12-25-20;/h9-10,13-16,25H,5-8,11-12H2,1-4H3;1H

2.1.3 InChI Key

JBFLYOLJRKJYNV-UHFFFAOYSA-N

2.1.4 Canonical SMILES

CCOC1=C(C=C(C=C1)C=C2C3=CC(=C(C=C3CCN2)OCC)OCC)OCC.Cl

2.2 Synonyms

2.2.1 MeSH Synonyms

1. Dihydroisoperparine

2. Drotaverin

3. Drotaverine

4. Isodihydroperparine

5. No-shpa

6. No-spa

7. Nospan

8. Nospanum

2.2.2 Depositor-Supplied Synonyms

1. 985-12-6

2. Drotaverine Hcl

3. Drotin; Isodihydroperparine Hydrochloride; Nosh-bra; No-spa

4. Dihydroisoperparine; Drotaverin; Isodihydroperparine; Perparine, Isodihydro-

5. 1-[(3,4-diethoxyphenyl)methylidene]-6,7-diethoxy-3,4-dihydro-2h-isoquinoline;hydrochloride

6. Bcp32864

7. Akos030255224

8. Db-057733

9. Ft-0603535

10. Drotaverine Hcl;tetraspasmin-lefa; Ctk8f9383

11. 1-[(3,4-diethoxy Phenyl)methylene]-6,7-diethoxy-1,2,3,4-tetrahydroisoquinoline Hydrochloride

2.3 Create Date

2005-08-08

3 Chemical and Physical Properties

Molecular Formula	C₂₄H₃₂ClNO₄
Molecular Weight	434.0 g/mol
Hydrogen Bond Donor Count	2
Hydrogen Bond Acceptor Count	5
Rotatable Bond Count	9
Exact Mass	433.2019862 g/mol
Monoisotopic Mass	433.2019862 g/mol
Topological Polar Surface Area	49 Å²
Heavy Atom Count	30
Formal Charge	0
Complexity	511
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	1
Covalently Bonded Unit Count	2

4 Pharmacology and Biochemistry

4.1 MeSH Pharmacological Classification

Analgesics

Compounds capable of relieving pain without the loss of CONSCIOUSNESS. (See all compounds classified as Analgesics.)

Vasodilator Agents

Drugs used to cause dilation of the blood vessels. (See all compounds classified as Vasodilator Agents.)

Parasympatholytics

Agents that inhibit the actions of the parasympathetic nervous system. The major group of drugs used therapeutically for this purpose is the MUSCARINIC ANTAGONISTS. (See all compounds classified as Parasympatholytics.)

API SUPPLIERS

01

EUROAPI

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Cohance Lifesciences

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04

HRV Global Life Sciences

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HRV Global Life Sciences - Market Expansion Leader in Pharmaceuticals.

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India

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Synthokem Labs

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EUROAPI

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EUROAPI, the leading small molecules API player, provides both API sales & CDMO services.

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France

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Drotaverine

About the Company : EUROAPI is the market leader in small molecule APIs with projected sales of about €1 billion in 2022. With around 200 APIs, it has one of the largest portfolios in the market. Th...

EUROAPI is the market leader in small molecule APIs with projected sales of about €1 billion in 2022. With around 200 APIs, it has one of the largest portfolios in the market. Thanks to its excellent R&D skills and six manufacturing facilities across Europe, EUROAPI guarantees API manufacturing of the highest quality to its clients in over 80 countries. Its strong innovation and R&D skills helps it to speed the development of more complex molecule segments through CDMO operations. It also offers experience in supply, regulation and quality. EUROAPI employs 3,350 people and is listed on Euronext.

02

Cohance Lifesciences

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Drotaverine

About the Company : Cohance Lifesciences is a leading CDMO and API platform, offering products and services across all phases of a molecule’s lifecycle from development to commercialzation. With our...

Cohance Lifesciences is a leading CDMO and API platform, offering products and services across all phases of a molecule’s lifecycle from development to commercialzation. With our expertise in complex chemistries, we provide end-to-end CDMO services to global innovators and have delivered numerous projects from concept to commercialization over the years.As a global API player, we serve customers across nearly 60 countries with 80+ molecules backed by robust R&D, regulatory capabilities and manufacturing infrastructure. We are among the top backward integrated exporters of pellets and have strong development and manufacturing capabilities.

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About the Company : Jai Radhe Sales was founded in 1999 as an out-of-the-box distribution firm specializing in the global supply of high-quality pharmaceutical ingredients. The firm provides complete ...

Jai Radhe Sales was founded in 1999 as an out-of-the-box distribution firm specializing in the global supply of high-quality pharmaceutical ingredients. The firm provides complete sourcing solutions for pharmaceutical products from India, including technical and regulatory assistance. It believes in providing its customers with high-quality products at reasonable prices. It has always endeavored to achieve global standards in the field of pharmaceuticals and has carved out a niche for itself through new methods based on current market needs. Today, it has established itself as a truly global company, with exports to almost every continent.

04

HRV Global Life Sciences

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Drotaverine

About the Company : HRV Global is a leading global manufacturer, seller & exporter of a wide range of APIs, advanced intermediates, pellets, food grade chemicals, food additives & food ingredients. It...

HRV Global is a leading global manufacturer, seller & exporter of a wide range of APIs, advanced intermediates, pellets, food grade chemicals, food additives & food ingredients. It offers services such as sourcing, manufacturing & supply, helping partners enter new markets worldwide. Its strong partnerships with major players in the pharma and food additive industries help HRV Global effectively promote projects and products. HRV Global represents over 30 large Indian drugmakers, primarily targeting Europe, the US & the Middle East markets. Headquartered in India, HRV Global has offices in the US, Switzerland, Dubai, Lithuania & Turkey.

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Synthokem Labs

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Drotaverine Hydrochloride

About the Company : Synthokem Labs Pvt Ltd is a privately owned company established in 1978, specializing in the production of Active Pharmaceutical Ingredients and Drug Intermediates. Operating acros...

Synthokem Labs Pvt Ltd is a privately owned company established in 1978, specializing in the production of Active Pharmaceutical Ingredients and Drug Intermediates. Operating across two states, Telangana and Andhra Pradesh, in India, the company has earned global recognition for its expertise in manufacturing and distributing a diverse range of products. With a strong focus on research and development, Synthokem Labs is dedicated to offering accessible and affordable pharmaceutical solutions to those in need.

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API Reference Price

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A.P.","customerAddress":""},{"dataSource":"API Export","activeIngredients":"","year":"2021","qtr":"Q1","strtotime":1611253800,"product":"DROTAVERINE HCL","address":"#.6-3-1239\/2, AMAR HOUSE, 4TH FLOORRAJBHAWAN ROAD, SOMAJIGUDA,","city":"HYDERABAD, A.P.","supplier":"RA CHEM PHARMA ","supplierCountry":"INDIA","foreign_port":"DHAKA","customer":"ADVANCED CHEMICAL INDUSTRIES","customerCountry":"BANGLADESH","quantity":"120.00","actualQuantity":"120","unit":"KGS","unitRateFc":"70.6","totalValueFC":"8575.6","currency":"USD","unitRateINR":5226.5916666666662,"date":"22-Jan-2021","totalValueINR":"627191","totalValueInUsd":"8575.6","indian_port":"HYDERABAD AIR","hs_no":"29334900","bill_no":"8082886","productDescription":"API","marketType":"LESS REGULATED MARKET","country":"BANGLADESH","selfForZScoreResived":"Pharma Grade","supplierPort":"HYDERABAD AIR","supplierAddress":"#.6-3-1239\/2, AMAR HOUSE, 4TH FLOORRAJBHAWAN ROAD, SOMAJIGUDA,, HYDERABAD, A.P.","customerAddress":""},{"dataSource":"API Export","activeIngredients":"","year":"2021","qtr":"Q1","strtotime":1611253800,"product":"DROTAVERINE HCL","address":"#.6-3-1239\/2, AMAR HOUSE, 4TH FLOORRAJBHAWAN ROAD, SOMAJIGUDA,","city":"HYDERABAD, A.P.","supplier":"RA CHEM PHARMA ","supplierCountry":"INDIA","foreign_port":"DHAKA","customer":"ALBION LABORATORIES LIMITED","customerCountry":"BANGLADESH","quantity":"300.00","actualQuantity":"300","unit":"KGS","unitRateFc":"63.1","totalValueFC":"19176.9","currency":"USD","unitRateINR":4675.1333333333332,"date":"22-Jan-2021","totalValueINR":"1402540","totalValueInUsd":"19176.9","indian_port":"HYDERABAD AIR","hs_no":"29334900","bill_no":"8082847","productDescription":"API","marketType":"LESS REGULATED MARKET","country":"BANGLADESH","selfForZScoreResived":"Pharma Grade","supplierPort":"HYDERABAD AIR","supplierAddress":"#.6-3-1239\/2, AMAR HOUSE, 4TH FLOORRAJBHAWAN ROAD, SOMAJIGUDA,, HYDERABAD, A.P.","customerAddress":""},{"dataSource":"API Export","activeIngredients":"","year":"2021","qtr":"Q1","strtotime":1611858600,"product":"DROTAVERINE HCL BATCH NO:DRO\/506\/01\/21","address":"#.6-3-1239\/2, AMAR HOUSE, 4TH FLOORRAJBHAWAN ROAD, SOMAJIGUDA,","city":"HYDERABAD, A.P.","supplier":"RA CHEM PHARMA ","supplierCountry":"INDIA","foreign_port":"KARACHI -","customer":"TABROS PHARMA PVT ","customerCountry":"PAKISTAN","quantity":"75.00","actualQuantity":"75","unit":"KGS","unitRateFc":"66","totalValueFC":"4594.1","currency":"USD","unitRateINR":4480,"date":"29-Jan-2021","totalValueINR":"336000","totalValueInUsd":"4594.1","indian_port":"HYDERABAD AIR","hs_no":"29334900","bill_no":"8238114","productDescription":"API","marketType":"LESS REGULATED MARKET","country":"PAKISTAN","selfForZScoreResived":"Pharma Grade","supplierPort":"HYDERABAD AIR","supplierAddress":"#.6-3-1239\/2, AMAR HOUSE, 4TH FLOORRAJBHAWAN ROAD, SOMAJIGUDA,, HYDERABAD, A.P.","customerAddress":""},{"dataSource":"API Export","activeIngredients":"DROTAVERINE HYDROCHLORIDE","year":"2021","qtr":"Q1","strtotime":1612204200,"product":"DROTAVERINE HYDROCHLORIDE","address":"SCO-417-418,SECTOR -35-C,","city":"CHANDIGARH","supplier":"PUNJAB CHEMICALS AND CROP PROTECTION LIMITED IN 140 501 LALRU","supplierCountry":"INDIA","foreign_port":"DHAKA","customer":"PUBALI BANK LTD.","customerCountry":"BANGLADESH","quantity":"100.00","actualQuantity":"0.1","unit":"MTS","unitRateFc":"61000","totalValueFC":"5658.8","currency":"USD","unitRateINR":4120000,"date":"02-Feb-2021","totalValueINR":"412000","totalValueInUsd":"5658.8","indian_port":"DELHI AIR","hs_no":"29334900","bill_no":"8334324","productDescription":"API","marketType":"LESS REGULATED MARKET","country":"BANGLADESH","selfForZScoreResived":"Pharma Grade","supplierPort":"DELHI AIR","supplierAddress":"SCO-417-418,SECTOR -35-C,, CHANDIGARH","customerAddress":""},{"dataSource":"API Export","activeIngredients":"","year":"2021","qtr":"Q1","strtotime":1612895400,"product":"DROTAVERINE HCL BATCH NO. 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