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Chemistry

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Also known as: 985-12-6, Drotaverine hcl, Drotin; isodihydroperparine hydrochloride; nosh-bra; no-spa, Dihydroisoperparine; drotaverin; isodihydroperparine; perparine, isodihydro-, 1-[(3,4-diethoxyphenyl)methylidene]-6,7-diethoxy-3,4-dihydro-2h-isoquinoline;hydrochloride, Bcp32864
Molecular Formula
C24H32ClNO4
Molecular Weight
434.0  g/mol
InChI Key
JBFLYOLJRKJYNV-UHFFFAOYSA-N

Drotaverine
1 2D Structure

Drotaverine

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
1-[(3,4-diethoxyphenyl)methylidene]-6,7-diethoxy-3,4-dihydro-2H-isoquinoline;hydrochloride
2.1.2 InChI
InChI=1S/C24H31NO4.ClH/c1-5-26-21-10-9-17(14-22(21)27-6-2)13-20-19-16-24(29-8-4)23(28-7-3)15-18(19)11-12-25-20;/h9-10,13-16,25H,5-8,11-12H2,1-4H3;1H
2.1.3 InChI Key
JBFLYOLJRKJYNV-UHFFFAOYSA-N
2.1.4 Canonical SMILES
CCOC1=C(C=C(C=C1)C=C2C3=CC(=C(C=C3CCN2)OCC)OCC)OCC.Cl
2.2 Synonyms
2.2.1 MeSH Synonyms

1. Dihydroisoperparine

2. Drotaverin

3. Drotaverine

4. Isodihydroperparine

5. No-shpa

6. No-spa

7. Nospan

8. Nospanum

2.2.2 Depositor-Supplied Synonyms

1. 985-12-6

2. Drotaverine Hcl

3. Drotin; Isodihydroperparine Hydrochloride; Nosh-bra; No-spa

4. Dihydroisoperparine; Drotaverin; Isodihydroperparine; Perparine, Isodihydro-

5. 1-[(3,4-diethoxyphenyl)methylidene]-6,7-diethoxy-3,4-dihydro-2h-isoquinoline;hydrochloride

6. Bcp32864

7. Akos030255224

8. Db-057733

9. Ft-0603535

10. Drotaverine Hcl;tetraspasmin-lefa; Ctk8f9383

11. 1-[(3,4-diethoxy Phenyl)methylene]-6,7-diethoxy-1,2,3,4-tetrahydroisoquinoline Hydrochloride

2.3 Create Date
2005-08-08
3 Chemical and Physical Properties
Molecular Weight 434.0 g/mol
Molecular Formula C24H32ClNO4
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count5
Rotatable Bond Count9
Exact Mass433.2019862 g/mol
Monoisotopic Mass433.2019862 g/mol
Topological Polar Surface Area49 Ų
Heavy Atom Count30
Formal Charge0
Complexity511
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count1
Covalently Bonded Unit Count2
4 Pharmacology and Biochemistry
4.1 MeSH Pharmacological Classification

Analgesics

Compounds capable of relieving pain without the loss of CONSCIOUSNESS. (See all compounds classified as Analgesics.)


Vasodilator Agents

Drugs used to cause dilation of the blood vessels. (See all compounds classified as Vasodilator Agents.)


Parasympatholytics

Agents that inhibit the actions of the parasympathetic nervous system. The major group of drugs used therapeutically for this purpose is the MUSCARINIC ANTAGONISTS. (See all compounds classified as Parasympatholytics.)


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06-Jan-2021
24-Dec-2024
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Looking for 985-12-6 / Drotaverine API manufacturers, exporters & distributors?

Drotaverine manufacturers, exporters & distributors 1

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PharmaCompass offers a list of Drotaverine API manufacturers, exporters & distributors, which can be sorted by GMP, USDMF, JDMF, KDMF, CEP (COS), WC, Price,and more, enabling you to easily find the right Drotaverine manufacturer or Drotaverine supplier for your needs.

Send us enquiries for free, and we will assist you in establishing a direct connection with your preferred Drotaverine manufacturer or Drotaverine supplier.

PharmaCompass also assists you with knowing the Drotaverine API Price utilized in the formulation of products. Drotaverine API Price is not always fixed or binding as the Drotaverine Price is obtained through a variety of data sources. The Drotaverine Price can also vary due to multiple factors, including market conditions, regulatory modifications, or negotiated pricing deals.

API | Excipient name

Drotaverine

Synonyms

985-12-6, Drotaverine hcl, Drotin; isodihydroperparine hydrochloride; nosh-bra; no-spa, Dihydroisoperparine; drotaverin; isodihydroperparine; perparine, isodihydro-, 1-[(3,4-diethoxyphenyl)methylidene]-6,7-diethoxy-3,4-dihydro-2h-isoquinoline;hydrochloride, Bcp32864

Cas Number

985-12-6

Drotaverine Manufacturers

A Drotaverine manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Drotaverine, including repackagers and relabelers. The FDA regulates Drotaverine manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Drotaverine API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

click here to find a list of Drotaverine manufacturers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PhamaCompass.

Drotaverine Suppliers

A Drotaverine supplier is an individual or a company that provides Drotaverine active pharmaceutical ingredient (API) or Drotaverine finished formulations upon request. The Drotaverine suppliers may include Drotaverine API manufacturers, exporters, distributors and traders.

click here to find a list of Drotaverine suppliers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PharmaCompass.

Drotaverine WC

A Drotaverine written confirmation (Drotaverine WC) is an official document issued by a regulatory agency to a Drotaverine manufacturer, verifying that the manufacturing facility of a Drotaverine active pharmaceutical ingredient (API) adheres to the Good Manufacturing Practices (GMP) regulations of the importing country. When exporting Drotaverine APIs or Drotaverine finished pharmaceutical products to another nation, regulatory agencies frequently require a Drotaverine WC (written confirmation) as part of the regulatory process.

click here to find a list of Drotaverine suppliers with Written Confirmation (WC) on PharmaCompass.

Drotaverine GMP

Drotaverine Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

PharmaCompass offers a list of Drotaverine GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Drotaverine GMP manufacturer or Drotaverine GMP API supplier for your needs.

Drotaverine CoA

A Drotaverine CoA (Certificate of Analysis) is a formal document that attests to Drotaverine's compliance with Drotaverine specifications and serves as a tool for batch-level quality control.

Drotaverine CoA mostly includes findings from lab analyses of a specific batch. For each Drotaverine CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

Drotaverine may be tested according to a variety of international standards, such as European Pharmacopoeia (Drotaverine EP), Drotaverine JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Drotaverine USP).

Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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