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Also known as: 91161-71-6, Lamisil, Lamasil, (e)-n,6,6-trimethyl-n-(naphthalen-1-ylmethyl)hept-2-en-4-yn-1-amine, Sf-86-327, Lamisil at
Molecular Formula
C21H25N
Molecular Weight
291.4  g/mol
InChI Key
DOMXUEMWDBAQBQ-WEVVVXLNSA-N
FDA UNII
G7RIW8S0XP

Terbinafine
A naphthalene derivative that inhibits fungal SQUALENE EPOXIDASE and is used to treat DERMATOMYCOSES of the skin and nails.
Terbinafine is an Allylamine Antifungal.
1 2D Structure

Terbinafine

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
(E)-N,6,6-trimethyl-N-(naphthalen-1-ylmethyl)hept-2-en-4-yn-1-amine
2.1.2 InChI
InChI=1S/C21H25N/c1-21(2,3)15-8-5-9-16-22(4)17-19-13-10-12-18-11-6-7-14-20(18)19/h5-7,9-14H,16-17H2,1-4H3/b9-5+
2.1.3 InChI Key
DOMXUEMWDBAQBQ-WEVVVXLNSA-N
2.1.4 Canonical SMILES
CC(C)(C)C#CC=CCN(C)CC1=CC=CC2=CC=CC=C21
2.1.5 Isomeric SMILES
CC(C)(C)C#C/C=C/CN(C)CC1=CC=CC2=CC=CC=C21
2.2 Other Identifiers
2.2.1 UNII
G7RIW8S0XP
2.3 Synonyms
2.3.1 MeSH Synonyms

1. (e)-n-(6,6-dimethyl-2-heptenynyl)-n-methyl-1-naphthalenementhamin Hydrochloride

2. Da 5505

3. Lamisil

4. Sf 86 327

5. Sf 86-327

6. Sf 86327

7. Sf-86-327

8. Sf86327

9. Tdt 067

10. Tdt-067

11. Tdt067

12. Terbinafine Hydrochloride

13. Terbinafine, (z)-

14. Terbinafine, (z)-isomer

2.3.2 Depositor-Supplied Synonyms

1. 91161-71-6

2. Lamisil

3. Lamasil

4. (e)-n,6,6-trimethyl-n-(naphthalen-1-ylmethyl)hept-2-en-4-yn-1-amine

5. Sf-86-327

6. Lamisil At

7. Sf 86-327

8. Terbinafin

9. Terbinex

10. (e)-n-(6,6-dimethyl-2-hepten-4-ynyl)-n-methyl-1-naphthalenemethylamine

11. Terbinafina

12. (e)-n-(6,6-dimethyl-2-hepten-4-ynyl)-n-methyl-1-naphthalene Methanamine

13. Terbinafine Free Base

14. Tdt-067

15. G7riw8s0xp

16. Chembl822

17. Chebi:9448

18. Lamisil Tablet

19. 91161-71-6 (free Base)

20. Terbinafinum

21. Zabel

22. 1-naphthalenemethanamine, N-(6,6-dimethyl-2-hepten-4-ynyl)-n-methyl-, (e)-

23. Ncgc00159346-02

24. (2e)-n,6,6-trimethyl-n-(1-naphthylmethyl)hept-2-en-4-yn-1-amine

25. (2e)-n,6,6-trimethyl-n-(naphthalen-1-ylmethyl)hept-2-en-4-yn-1-amine

26. Dsstox_cid_3640

27. N-[(2e)-6,6-dimethyl-2-hepten-4-yn-1-yl]-n-methyl-1-naphthalenemethanamine

28. Dsstox_rid_77123

29. Dsstox_gsid_23640

30. Lamasil (tn)

31. Cas-91161-71-6

32. Unii-g7riw8s0xp

33. Terbinafine (usan/inn)

34. Brn 4256376

35. Corbinal

36. Terbinafine [usan:inn:ban]

37. N,6,6-trimethyl-n-(1-naphthylmethyl)hept-2-en-4-yn-1-amine Hydrochloride

38. Erbinafine Hydrochloride

39. Terbinafine [mi]

40. Terbinafine, Sf-86-327, Lamisil, Tbnf

41. Terbinafine [inn]

42. Terbinafine [usan]

43. Ec 618-706-8

44. Terbinafine [vandf]

45. Terbinafine [mart.]

46. Schembl36794

47. Schembl37843

48. Terbinafine [who-dd]

49. Mls006011885

50. Bidd:gt0825

51. Dtxsid2023640

52. Terbinafine (lamisil, Terbinex)

53. Terbinafine [green Book]

54. Chebi:94705

55. Terbinafine [orange Book]

56. Hms2089b20

57. Hms3715l08

58. Albb-027269

59. Bcp22896

60. Osurnia Component Terbinafine

61. Zinc1530981

62. Tox21_111591

63. (e)-n,6,6-trimethyl-n-(1-naphthylmethyl)hept-2-en-4-yn-1-amine

64. Bbl010959

65. Bdbm50018518

66. Hy-17395a

67. Mfcd00242672

68. S1725

69. Stk802069

70. Akos001451917

71. Tox21_111591_1

72. Ac-8561

73. Ccg-221253

74. Cs-1944

75. Db00857

76. Gs-3099

77. Terbinafine Component Of Osurnia

78. (e)-n,6,6-trimethyl-n-(naphthalen-1

79. Ncgc00159346-03

80. Ncgc00159346-04

81. Ncgc00188975-01

82. Terbinafine [ema Epar Veterinary]

83. Sf86-327

84. Smr004703509

85. Sbi-0206829.p001

86. Sw197656-3

87. T3677

88. C08079

89. D02375

90. Ab00698510-07

91. Ab00698510-09

92. Ab00698510-10

93. Ab00698510-11

94. Ab00698510_12

95. Ab00698510_13

96. Ab00698510_14

97. 161t716

98. A843743

99. Q415259

100. Brd-k68132782-003-05-4

101. (6,6-dimethyl-hept-2-en-4-ynyl)-methyl-naphthalen-1-ylmethyl-amine

102. N,6,6-trimethyl-n-(1-naphthylmethyl)-2-heptene-4-yne-1-amine

103. Sf 86-327; Sf-86-327; Sf86-327; Lamasil; Lamisil At

104. ((e)-6,6-dimethyl-hept-2-en-4-ynyl)-methyl-naphthalen-1-ylmethyl-amine

105. 1n,6,6-trimethyl-1n-(1-naphthylmethyl)-(e)-2-hepten-4-yn-1-amine

106. (6,6-dimethyl-hept-2-en-4-ynyl)-methyl-naphthalen-1-ylmethyl-amine(terbinafine)

107. (6,6-dimethylhept-2-en-4-yn-1-yl)methyl(1-naphthylmethyl)amine Hydrochloride

108. [(2e)-6,6-dimethylhept-2-en-4-yn-1-yl](methyl)[(naphthalen-1-yl)methyl]amine

109. [(e)-6,6-dimethyl-hept-2-en-4-ynyl]-methyl-(naphthalen-1-yl-methyl)-amine

110. 1-naphthalenemethanamine, N-[(2e)-6,6-dimethyl-2-hepten-4-yn-1-yl]-n-methyl-

2.4 Create Date
2005-03-25
3 Chemical and Physical Properties
Molecular Weight 291.4 g/mol
Molecular Formula C21H25N
XLogP35.6
Hydrogen Bond Donor Count0
Hydrogen Bond Acceptor Count1
Rotatable Bond Count5
Exact Mass291.198699802 g/mol
Monoisotopic Mass291.198699802 g/mol
Topological Polar Surface Area3.2 Ų
Heavy Atom Count22
Formal Charge0
Complexity428
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count1
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count1
4 Drug and Medication Information
4.1 Drug Information
1 of 4  
Drug NameLamisil
PubMed HealthTerbinafine
Drug ClassesAntifungal
Drug LabelLamisil Tablets contain the synthetic allylamine antifungal compound terbinafine hydrochloride.Chemically, terbinafine hydrochloride is (E)-N-(6,6-dimethyl-2-hepten-4-ynyl)-N-methyl-1-naphthalenemethanamine hydrochloride. The empirical formula C21H26...
Active IngredientTerbinafine hydrochloride
Dosage FormTablet; Cream; Granule
RouteOral; Topical
Strengtheq 187.5mg base/packet; 1%; eq 250mg base; eq 125mg base/packet
Market StatusOver the Counter; Prescription
CompanyNovartis

2 of 4  
Drug NameLamisil at
Active IngredientTerbinafine hydrochloride; Terbinafine
Dosage FormSpray; Gel; Solution
RouteTopical
Strength1%
Market StatusOver the Counter
CompanyNovartis

3 of 4  
Drug NameLamisil
PubMed HealthTerbinafine
Drug ClassesAntifungal
Drug LabelLamisil Tablets contain the synthetic allylamine antifungal compound terbinafine hydrochloride.Chemically, terbinafine hydrochloride is (E)-N-(6,6-dimethyl-2-hepten-4-ynyl)-N-methyl-1-naphthalenemethanamine hydrochloride. The empirical formula C21H26...
Active IngredientTerbinafine hydrochloride
Dosage FormTablet; Cream; Granule
RouteOral; Topical
Strengtheq 187.5mg base/packet; 1%; eq 250mg base; eq 125mg base/packet
Market StatusOver the Counter; Prescription
CompanyNovartis

4 of 4  
Drug NameLamisil at
Active IngredientTerbinafine hydrochloride; Terbinafine
Dosage FormSpray; Gel; Solution
RouteTopical
Strength1%
Market StatusOver the Counter
CompanyNovartis

4.2 Drug Indication

Terbinafine hydrochloride is indicated to treat fungal skin and nail infections caused by _Trichophyton_ species, _Microsporum canis_, _Epidermophyton floccosum_, and _Tinea_ species. Terbinafine hydrochloride also treats yeast infections of the skin caused by _Candida_ species and _Malassezia furfur_.


FDA Label


5 Pharmacology and Biochemistry
5.1 Pharmacology

Terbinafine is an allylamine antifungal that inhibits squalene epoxidase (also known as squalene monooxygenase) to prevent the formation of ergosterol and cause an accumulation of squalene, weakening the cell wall of fungal cells. Terbinafine distributes into tissues and has a long terminal elimination half life, so the duration of action is long. Overdose with terbinafine is rare, even above the therapeutic dose, so the therapeutic index is wide. Patients taking oral terbinafine should have liver function tests performed prior to treatment to reduce the risk of liver injury.


5.2 MeSH Pharmacological Classification

Antifungal Agents

Substances that destroy fungi by suppressing their ability to grow or reproduce. They differ from FUNGICIDES, INDUSTRIAL because they defend against fungi present in human or animal tissues. (See all compounds classified as Antifungal Agents.)


Enzyme Inhibitors

Compounds or agents that combine with an enzyme in such a manner as to prevent the normal substrate-enzyme combination and the catalytic reaction. (See all compounds classified as Enzyme Inhibitors.)


5.3 FDA Pharmacological Classification
5.3.1 Active Moiety
TERBINAFINE
5.3.2 FDA UNII
G7RIW8S0XP
5.3.3 Pharmacological Classes
Allylamine [CS]; Allylamine Antifungal [EPC]
5.4 ATC Code

D - Dermatologicals

D01 - Antifungals for dermatological use

D01A - Antifungals for topical use

D01AE - Other antifungals for topical use

D01AE15 - Terbinafine


D - Dermatologicals

D01 - Antifungals for dermatological use

D01B - Antifungals for systemic use

D01BA - Antifungals for systemic use

D01BA02 - Terbinafine


5.5 Absorption, Distribution and Excretion

Absorption

Oral terbinafine is >70% absorbed but only 40% bioavailable after first pass metabolism, reaching a Cmax of 1g/mL with a Tmax of 2 hours an an AUC of 4.56g\*h/mL. Over the course of a week, 1% topical terbinafine's Cmax increases from 949-1049ng/cm2 and the AUC increases from 9694-13,492ng/cm2/h.


Route of Elimination

Terbinafine is approximately 80% eliminated in urine, while the remainder is eliminated in feces. The unmetabolized parent drug is not present in urine.


Volume of Distribution

A single 250mg oral dose of terbinafine has a volume of distribution at steady state of 947.5L or 16.6L/kg.


Clearance

A single 250mg oral dose of terbinafine has a clearance of 76L/h or 1.11L/h/kg.


5.6 Metabolism/Metabolites

Terbinafine can be deaminated to 1-naphthaldehyde by CYP2C9, 2B6, 2C8, 1A2, 3A4, and 2C19. 1-naphthaldehyde is then oxidized to 1-naphthoic acid or reduced to 1-naphthalenemethanol. Terbinafine can also be hydroxylated by CYP1A2, 2C9, 2C8, 2B6, and 2C19 to hydroxyterbinafine. Hydroxyterbinafine is then oxidized to carboxyterbinafine or N-demethylated by CYP3A4, 2B6, 1A2, 2C9, 2C8, and 2C19 to desmethylhydroxyterbinafine. Terbinafine can be N-demethylated to desmethylterbinafine. Desmethylterbinafine is then dihydroxylated to a desmethyldihydrodiol or hydroxylated to desmethylhydroxyterbinafine. Finally, terbinafine can be dihydroxylated to a dihydrodiol which is then N-demethylated to a desmethyldihydrodiol.


Terbinafine has known human metabolites that include 1-Naphtaldehyde, Hydroxyterbinafine, and N-Desmethylterbinafine.

S73 | METXBIODB | Metabolite Reaction Database from BioTransformer | DOI:10.5281/zenodo.4056560


5.7 Biological Half-Life

Oral terbinafine has an effective half life of approximately 36 hours. However, the terminal half life ranges from 200-400 hours as it distributes into skin and adipose tissue. 1% topical terbinafine's half life increases over the first seven days from approximately 10-40 hours.


5.8 Mechanism of Action

Terbinafine inhibits the enzyme squalene monooxygenase (also called squalene epoxidase), preventing the conversion of squalene to 2,3-oxydosqualene, a step in the synthesis of ergosterol. This inhibition leads to decreased ergosterol, which would normally be incorporated into the cell wall, and accumulation of squalene. Generation of a large number of squalene containing vesicles in the cytoplasm may leach other lipids away from, and further weaken, the cell wall.


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04-Jan-2021
30-Sep-2024
KGS
overview
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Average Price (USD/KGS)

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Total Quantity (KGS)

Total Value (USD)

Quantity (KGS) & Unit rate (USD/KGS) over time

API Imports and Exports

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(KGS)
Average Price
(USD/KGS)
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