Find Dubermatinib manufacturers, exporters & distributors on PharmaCompass

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Chemistry

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Also known as: Dubermatinib, Tp-0903, 1341200-45-0, Tp0903, Tp 0903, Dubermatinib [usan]
Molecular Formula
C24H30ClN7O2S
Molecular Weight
516.1  g/mol
InChI Key
YUAALFPUEOYPNX-UHFFFAOYSA-N
FDA UNII
14D65TV20J

Dubermatinib
Dubermatinib is an orally available and selective inhibitor of the receptor tyrosine kinase AXL (UFO), with potential antineoplastic activity. Upon administration, dubermatinib targets and binds to AXL and prevents its activity. This blocks AXL-mediated signal transduction pathways and inhibits the epithelial-mesenchymal transition (EMT), which, in turn, inhibits tumor cell proliferation and migration. In addition, TP-0903 enhances chemo-sensitivity to certain other chemotherapeutic agents. AXL, a member of the Tyro3, AXL and Mer (TAM) family of receptor tyrosine kinases and overexpressed by many tumor cell types, plays a key role in tumor cell proliferation, survival, invasion and metastasis; its expression is associated with drug resistance and poor prognosis.
1 2D Structure

Dubermatinib

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
2-[[5-chloro-2-[4-[(4-methylpiperazin-1-yl)methyl]anilino]pyrimidin-4-yl]amino]-N,N-dimethylbenzenesulfonamide
2.1.2 InChI
InChI=1S/C24H30ClN7O2S/c1-30(2)35(33,34)22-7-5-4-6-21(22)28-23-20(25)16-26-24(29-23)27-19-10-8-18(9-11-19)17-32-14-12-31(3)13-15-32/h4-11,16H,12-15,17H2,1-3H3,(H2,26,27,28,29)
2.1.3 InChI Key
YUAALFPUEOYPNX-UHFFFAOYSA-N
2.1.4 Canonical SMILES
CN1CCN(CC1)CC2=CC=C(C=C2)NC3=NC=C(C(=N3)NC4=CC=CC=C4S(=O)(=O)N(C)C)Cl
2.2 Other Identifiers
2.2.1 UNII
14D65TV20J
2.3 Synonyms
2.3.1 MeSH Synonyms

1. 2-((5-chloro-2-(4-((4-methylpiperazin-1-yl)methyl)anilino)pyrimidin-4-yl)amino)-n,n-dimethylbenzenesulfonamide

2. Dubermatinib

3. Tp-0903

4. Tp0903

2.3.2 Depositor-Supplied Synonyms

1. Dubermatinib

2. Tp-0903

3. 1341200-45-0

4. Tp0903

5. Tp 0903

6. Dubermatinib [usan]

7. Chembl2022968

8. Hcl-2084

9. Compound 13

10. 14d65tv20j

11. 2-[[5-chloro-2-[4-[(4-methylpiperazin-1-yl)methyl]anilino]pyrimidin-4-yl]amino]-n,n-dimethylbenzenesulfonamide

12. Dubermatinib [inn]

13. Dubermatinib [who-dd]

14. Unii-14d65tv20j

15. Gtpl8863

16. Schembl12813478

17. Ex-a609

18. Amy10826

19. Bcp15884

20. Bdbm50382425

21. Mfcd28502172

22. Nsc798200

23. Who 10925

24. Zinc84617535

25. Akos026750306

26. Ccg-269819

27. Cs-4281

28. Db15187

29. Nsc-798200

30. Sb17174

31. Ncgc00481577-01

32. Ac-30945

33. As-55868

34. Da-45909

35. Hy-12963

36. Ft-0700169

37. S7846

38. A900291

39. J-690134

40. Q27089011

41. 2-{[5-chloro-2-({4-[(4-methylpiperazin-1-yl)methyl]phenyl}amino)pyrimidin-4-yl]amino}-n,n-dimethylbenzene-1-sulfonamide

42. 35-chloro-n,n,74-trimethyl-2,4-diaza-3(4,2)-pyrimidina-7(1)-piperazina-1(1),5(1,4)-dibenzenaheptaphane-12-sulfonamide

43. Benzenesulfonamide, 2-((5-chloro-2-((4-((4-methyl-1-piperazinyl)methyl)phenyl)amino)-4-pyrimidinyl)amino)-n,n-dimethyl-

2.4 Create Date
2012-03-19
3 Chemical and Physical Properties
Molecular Weight 516.1 g/mol
Molecular Formula C24H30ClN7O2S
XLogP33.9
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count9
Rotatable Bond Count8
Exact Mass515.1870221 g/mol
Monoisotopic Mass515.1870221 g/mol
Topological Polar Surface Area102 Ų
Heavy Atom Count35
Formal Charge0
Complexity752
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count1

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ABOUT THIS PAGE

Dubermatinib Manufacturers

A Dubermatinib manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Dubermatinib, including repackagers and relabelers. The FDA regulates Dubermatinib manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Dubermatinib API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

Dubermatinib Suppliers

A Dubermatinib supplier is an individual or a company that provides Dubermatinib active pharmaceutical ingredient (API) or Dubermatinib finished formulations upon request. The Dubermatinib suppliers may include Dubermatinib API manufacturers, exporters, distributors and traders.

Dubermatinib GMP

Dubermatinib Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

PharmaCompass offers a list of Dubermatinib GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Dubermatinib GMP manufacturer or Dubermatinib GMP API supplier for your needs.

Dubermatinib CoA

A Dubermatinib CoA (Certificate of Analysis) is a formal document that attests to Dubermatinib's compliance with Dubermatinib specifications and serves as a tool for batch-level quality control.

Dubermatinib CoA mostly includes findings from lab analyses of a specific batch. For each Dubermatinib CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

Dubermatinib may be tested according to a variety of international standards, such as European Pharmacopoeia (Dubermatinib EP), Dubermatinib JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Dubermatinib USP).

Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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