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Chemistry

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Also known as: 931395-42-5, L-arginyl-l-isoleucyl-l-valyl-l-prolyl-l-alaninamide, Rivpa, Sgx94, Sgx942, Dusquetide (usan/inn)
Molecular Formula
C25H47N9O5
Molecular Weight
553.7  g/mol
InChI Key
ZUJBBVJXXYRPFS-DYKIIFRCSA-N

Dusquetide
Dusquetide is a synthetic, 5-amino acid peptide and Innate Defense Regulator (IDR), with immunomodulating, anti-inflammatory, anti-infective and anti-mucositis activities. Upon intravenous administration, dusquetide binds to the ZZ domain of sequestosome-1, also called p62, and activates regulatory signaling transduction pathways involved in the modulation of the innate immune system, such as those mediated by mitogen-activated protein kinase (MAPK) p38 and CCAAT-enhancer-binding protein. This agent promotes monocyte and macrophage recruitment to, and accelerates healing in damaged and infected tissue; it suppresses inflammation through the regulation of the expression of multiple cytokines. This agent may prevent or decrease chemo- or radiotherapy-induced mucositis as well as other types of infection. p62, an intracellular adaptor protein that functions downstream of certain signaling receptors, plays a key role in the activation of the innate immune system.
1 2D Structure

Dusquetide

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
(2S)-1-[(2S)-2-[[(2S,3S)-2-[[(2S)-2-amino-5-(diaminomethylideneamino)pentanoyl]amino]-3-methylpentanoyl]amino]-3-methylbutanoyl]-N-[(2S)-1-amino-1-oxopropan-2-yl]pyrrolidine-2-carboxamide
2.1.2 InChI
InChI=1S/C25H47N9O5/c1-6-14(4)19(33-21(36)16(26)9-7-11-30-25(28)29)23(38)32-18(13(2)3)24(39)34-12-8-10-17(34)22(37)31-15(5)20(27)35/h13-19H,6-12,26H2,1-5H3,(H2,27,35)(H,31,37)(H,32,38)(H,33,36)(H4,28,29,30)/t14-,15-,16-,17-,18-,19-/m0/s1
2.1.3 InChI Key
ZUJBBVJXXYRPFS-DYKIIFRCSA-N
2.1.4 Canonical SMILES
CCC(C)C(C(=O)NC(C(C)C)C(=O)N1CCCC1C(=O)NC(C)C(=O)N)NC(=O)C(CCCN=C(N)N)N
2.1.5 Isomeric SMILES
CC[C@H](C)[C@@H](C(=O)N[C@@H](C(C)C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)N)NC(=O)[C@H](CCCN=C(N)N)N
2.2 Synonyms
2.2.1 MeSH Synonyms

1. Sgx94 Peptide

2.2.2 Depositor-Supplied Synonyms

1. 931395-42-5

2. L-arginyl-l-isoleucyl-l-valyl-l-prolyl-l-alaninamide

3. Rivpa

4. Sgx94

5. Sgx942

6. Dusquetide (usan/inn)

7. Arg-ile-val-pro-ala-nh2

8. Sgx-94

9. Chembl3545314

10. Schembl16671001

11. Imx-942

12. Sgx-942

13. Hy-p2076

14. Cs-0107857

15. J3.575.671j

16. D11751

17. Q27280772

18. (2s)-1-[(2s)-2-[[(2s,3s)-2-[[(2s)-2-amino-5-(diaminomethylideneamino)pentanoyl]amino]-3-methylpentanoyl]amino]-3-methylbutanoyl]-n-[(2s)-1-amino-1-oxopropan-2-yl]pyrrolidine-2-carboxamide

2.3 Create Date
2013-09-30
3 Chemical and Physical Properties
Molecular Weight 553.7 g/mol
Molecular Formula C25H47N9O5
XLogP3-2.7
Hydrogen Bond Donor Count7
Hydrogen Bond Acceptor Count7
Rotatable Bond Count15
Exact Mass553.37001563 g/mol
Monoisotopic Mass553.37001563 g/mol
Topological Polar Surface Area241 Ų
Heavy Atom Count39
Formal Charge0
Complexity906
Isotope Atom Count0
Defined Atom Stereocenter Count6
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count1
4 Drug and Medication Information
4.1 Drug Indication

Prevention of oral mucositis


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ABOUT THIS PAGE

Dusquetide Manufacturers

A Dusquetide manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Dusquetide, including repackagers and relabelers. The FDA regulates Dusquetide manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Dusquetide API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

Dusquetide Suppliers

A Dusquetide supplier is an individual or a company that provides Dusquetide active pharmaceutical ingredient (API) or Dusquetide finished formulations upon request. The Dusquetide suppliers may include Dusquetide API manufacturers, exporters, distributors and traders.

Dusquetide GMP

Dusquetide Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

PharmaCompass offers a list of Dusquetide GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Dusquetide GMP manufacturer or Dusquetide GMP API supplier for your needs.

Dusquetide CoA

A Dusquetide CoA (Certificate of Analysis) is a formal document that attests to Dusquetide's compliance with Dusquetide specifications and serves as a tool for batch-level quality control.

Dusquetide CoA mostly includes findings from lab analyses of a specific batch. For each Dusquetide CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

Dusquetide may be tested according to a variety of international standards, such as European Pharmacopoeia (Dusquetide EP), Dusquetide JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Dusquetide USP).

Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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