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    Chemistry

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    Also known as: 536-43-6, Dyclonine hcl, Dyclone, Dyclothane, Dyclocaine hydrochloride, Tanaclone
    Molecular Formula
    C18H28ClNO2
    Molecular Weight
    325.9  g/mol
    InChI Key
    KNZADIMHVBBPOA-UHFFFAOYSA-N
    FDA UNII
    ZEC193879Q
    Dyclonine
    Dyclonine Hydrochloride is the hydrochloride salt of Dyclonine, an unclassified compound with local anesthetic effect. Dyclonine reversibly binds to activated sodium channels on the neuronal membrane, thereby decreasing the neuronal membrane's permeability to sodium ions, leading to an increased threshold for excitation. This reversibly stabilizes the membrane and inhibits depolarization, leading to the failure of a propagated action potential and subsequent conduction blockade. This results in a transient and reversible loss of sensation in a localized area of the body.
    1 2D Structure

    Dyclonine

    2 Identification
    2.1 Computed Descriptors
    2.1.1 IUPAC Name
    1-(4-butoxyphenyl)-3-piperidin-1-ylpropan-1-one;hydrochloride
    2.1.2 InChI
    InChI=1S/C18H27NO2.ClH/c1-2-3-15-21-17-9-7-16(8-10-17)18(20)11-14-19-12-5-4-6-13-19;/h7-10H,2-6,11-15H2,1H3;1H
    2.1.3 InChI Key
    KNZADIMHVBBPOA-UHFFFAOYSA-N
    2.1.4 Canonical SMILES
    CCCCOC1=CC=C(C=C1)C(=O)CCN2CCCCC2.Cl
    2.2 Other Identifiers
    2.2.1 UNII
    ZEC193879Q
    2.3 Synonyms
    2.3.1 MeSH Synonyms

    1. Dyclone

    2. Dyclonine

    3. Dyclonine Hcl

    4. Sucrets

    5. Tanac

    2.3.2 Depositor-Supplied Synonyms

    1. 536-43-6

    2. Dyclonine Hcl

    3. Dyclone

    4. Dyclothane

    5. Dyclocaine Hydrochloride

    6. Tanaclone

    7. Dyclonine (hydrochloride)

    8. Diclonina

    9. 4'-butoxy-3-piperidinopropiophenone Hydrochloride

    10. 1-propanone, 1-(4-butoxyphenyl)-3-(1-piperidinyl)-, Hydrochloride

    11. P-267

    12. Nsc-23018

    13. 1-(4-butoxyphenyl)-3-piperidin-1-ylpropan-1-one;hydrochloride

    14. Diclonia

    15. Dyclonine Hydrochloride [usp]

    16. Mls000069532

    17. Zec193879q

    18. Dyclocainum

    19. Mfcd00035386

    20. Smr000038382

    21. Dsstox_cid_25323

    22. Dsstox_rid_80802

    23. Dsstox_gsid_45323

    24. Dyclonine Hydrochloride (usp)

    25. Wln: T6ntj A2vr Do4 &gh

    26. Chebi:4725

    27. Dycloninehydrochloride

    28. Dyclonine, Hydrochloride

    29. Ncgc00016498-01

    30. Cas-536-43-6

    31. Einecs 208-633-6

    32. Nsc 23018

    33. 4-n-butoxy-.beta.-(1-piperidyl)propiophenone Hydrochloride

    34. Unii-zec193879q

    35. Sr-01000000032

    36. S 154

    37. C 5422

    38. Dyclopro (tn)

    39. Prestwick_674

    40. Dyclone (tn)

    41. Piperidine, 1-(2-(4-butoxybenzoyl)ethyl), Hydrochloride

    42. Opera_id_1265

    43. Mls001077359

    44. Mls002222240

    45. Schembl317219

    46. Spectrum1500268

    47. Propiophenone, 4'-butoxy-3-piperidino-, Hydrochloride

    48. Chembl1200478

    49. Dtxsid6045323

    50. Hy-b0364a

    51. Hms1568f10

    52. Hms1920k06

    53. Pharmakon1600-01500268

    54. Bcp28402

    55. Nsc23018

    56. Nsc25588

    57. Dyclonine Hydrochloride [mi]

    58. Tox21_110459

    59. Ccg-40231

    60. Nsc-25588

    61. Nsc756745

    62. S2041

    63. Akos015951364

    64. Tox21_110459_1

    65. Ac-8346

    66. Ds-3341

    67. Dyclonine Hydrochloride [mart.]

    68. Dyclonine Hydrochloride [vandf]

    69. Nsc-756745

    70. Dyclonine Hydrochloride [usp-rs]

    71. Dyclonine Hydrochloride [who-dd]

    72. Ncgc00016498-08

    73. Ncgc00094662-01

    74. Ncgc00094662-02

    75. Ncgc00094662-03

    76. Ncgc00094662-04

    77. Sy066681

    78. D4303

    79. Dyclonine Hydrochloride [orange Book]

    80. Ft-0625635

    81. Sw196829-3

    82. Dyclonine Hcl;dyclone;dyclocaine Hydrochloride

    83. D00735

    84. Dyclonine Hydrochloride [usp Monograph]

    85. N12006

    86. A829700

    87. Sr-01000000032-4

    88. W-105718

    89. Q27106453

    90. 4-butoxy-3-piperidinopropiophenone Hydrochloride

    91. 4-n-butoxy-.beta.-piperidonopropiophenone Hydrochloride

    92. 1-(4-butoxyphenyl)-3-(1-piperidinyl)-1-propanone Hydrochloride

    93. 1-(4-butoxyphenyl)-3-piperidin-1-ylpropan-1-one;hydron;chloride

    94. 1-propanone, 1-(4-butoxyphenyl)-3-(1-piperidinyl)hydrochloride

    95. Dyclonine Hydrochloride, United States Pharmacopeia (usp) Reference Standard

    96. Dyclonine Hydrochloride, Pharmaceutical Secondary Standard; Certified Reference Material

    2.4 Create Date
    2005-06-24
    3 Chemical and Physical Properties
    Molecular Weight 325.9 g/mol
    Molecular Formula C18H28ClNO2
    Hydrogen Bond Donor Count1
    Hydrogen Bond Acceptor Count3
    Rotatable Bond Count8
    Exact Mass325.1808568 g/mol
    Monoisotopic Mass325.1808568 g/mol
    Topological Polar Surface Area29.5 Ų
    Heavy Atom Count22
    Formal Charge0
    Complexity292
    Isotope Atom Count0
    Defined Atom Stereocenter Count0
    Undefined Atom Stereocenter Count0
    Defined Bond Stereocenter Count0
    Undefined Bond Stereocenter Count0
    Covalently Bonded Unit Count2
    4 Pharmacology and Biochemistry
    4.1 MeSH Pharmacological Classification

    Anesthetics, Local

    Drugs that block nerve conduction when applied locally to nerve tissue in appropriate concentrations. They act on any part of the nervous system and on every type of nerve fiber. In contact with a nerve trunk, these anesthetics can cause both sensory and motor paralysis in the innervated area. Their action is completely reversible. (From Gilman AG, et. al., Goodman and Gilman's The Pharmacological Basis of Therapeutics, 8th ed) Nearly all local anesthetics act by reducing the tendency of voltage-dependent sodium channels to activate. (See all compounds classified as Anesthetics, Local.)

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    ABOUT THIS PAGE

    dyclonine hydrochloride Manufacturers

    A dyclonine hydrochloride manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of dyclonine hydrochloride, including repackagers and relabelers. The FDA regulates dyclonine hydrochloride manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. dyclonine hydrochloride API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

    click here to find a list of dyclonine hydrochloride manufacturers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PhamaCompass.

    dyclonine hydrochloride Suppliers

    A dyclonine hydrochloride supplier is an individual or a company that provides dyclonine hydrochloride active pharmaceutical ingredient (API) or dyclonine hydrochloride finished formulations upon request. The dyclonine hydrochloride suppliers may include dyclonine hydrochloride API manufacturers, exporters, distributors and traders.

    click here to find a list of dyclonine hydrochloride suppliers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PharmaCompass.

    dyclonine hydrochloride USDMF

    A dyclonine hydrochloride DMF (Drug Master File) is a document detailing the whole manufacturing process of dyclonine hydrochloride active pharmaceutical ingredient (API) in detail. Different forms of dyclonine hydrochloride DMFs exist exist since differing nations have different regulations, such as dyclonine hydrochloride USDMF, ASMF (EDMF), JDMF, CDMF, etc.

    A dyclonine hydrochloride DMF submitted to regulatory agencies in the US is known as a USDMF. dyclonine hydrochloride USDMF includes data on dyclonine hydrochloride's chemical properties, information on the facilities and procedures used, and details about packaging and storage. The dyclonine hydrochloride USDMF is kept confidential to protect the manufacturer’s intellectual property.

    click here to find a list of dyclonine hydrochloride suppliers with USDMF on PharmaCompass.

    dyclonine hydrochloride NDC

    National Drug Code is a comprehensive database maintained by the FDA that contains information on all drugs marketed in the US. This directory includes information about finished drug products, unfinished drug products, and compounded drug products, including those containing dyclonine hydrochloride as an active pharmaceutical ingredient (API).

    Finished drug products

    The FDA updates the NDC directory daily. The NDC numbers for dyclonine hydrochloride API and other APIs are published in this directory by the FDA.

    Unfinished drugs

    The NDC unfinished drugs database includes product listing information submitted for all unfinished drugs, such as active pharmaceutical ingredients (APIs), drugs intended for further processing and bulk drug substances for compounding.

    Pharmaceutical companies that manufacture dyclonine hydrochloride as an active pharmaceutical ingredient (API) must furnish the FDA with an updated record of all drugs that they produce, prepare, propagate, compound, or process for commercial distribution in the US at their facilities.

    Compounded drug products

    The NDC directory also contains data on finished compounded human drug products that contain dyclonine hydrochloride and are produced by outsourcing facilities. While these outsourcing facilities are not mandated to assign a dyclonine hydrochloride NDC to their finished compounded human drug products, they may choose to do so.

    click here to find a list of dyclonine hydrochloride suppliers with NDC on PharmaCompass.

    dyclonine hydrochloride GMP

    dyclonine hydrochloride Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

    GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

    PharmaCompass offers a list of dyclonine hydrochloride GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right dyclonine hydrochloride GMP manufacturer or dyclonine hydrochloride GMP API supplier for your needs.

    dyclonine hydrochloride CoA

    A dyclonine hydrochloride CoA (Certificate of Analysis) is a formal document that attests to dyclonine hydrochloride's compliance with dyclonine hydrochloride specifications and serves as a tool for batch-level quality control.

    dyclonine hydrochloride CoA mostly includes findings from lab analyses of a specific batch. For each dyclonine hydrochloride CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

    dyclonine hydrochloride may be tested according to a variety of international standards, such as European Pharmacopoeia (dyclonine hydrochloride EP), dyclonine hydrochloride JP (Japanese Pharmacopeia) and the US Pharmacopoeia (dyclonine hydrochloride USP).

    Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
    For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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