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Synopsis

Synopsis

ACTIVE PHARMA INGREDIENTS

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API Suppliers

API Suppliers

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USDMF

US DMFs Filed

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CEP/COS

CEP/COS Certifications

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JDMF

JDMFs Filed

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EU WC

EU WC

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KDMF

KDMF

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NDC API

NDC API

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VMF

NDC API

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Listed Suppliers

Other Suppliers

API REF. PRICE (USD/KG)

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MARKET PLACE

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API

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FDF

0INTERMEDIATES

FINISHED DOSAGE FORMULATIONS

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FDF Dossiers

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FDA Orange Book

FDA (Orange Book)

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Europe

Europe

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Canada

Canada

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Australia

Australia

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South Africa

South Africa

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Listed Dossiers

Listed Dossiers

FDF Dossiers

DRUG PRODUCT COMPOSITIONS

REF. STANDARDS OR IMPURITIES

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EDQM

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USP

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JP

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Others

PATENTS & EXCLUSIVITIES

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Health Canada Patents

DIGITAL CONTENT

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Data Compilation #PharmaFlow

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GLOBAL SALES INFORMATION

US Medicaid

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Chemistry

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Also known as: E6201, E-6201, Unii-czp9gb25ho, Czp9gb25ho, Er-806201, E 6201
Molecular Formula
C21H27NO6
Molecular Weight
389.4  g/mol
InChI Key
MWUFVYLAWAXDHQ-HMNLTAHHSA-N
FDA UNII
CZP9GB25HO

E6201
MEK-1/MEKK-1 Inhibitor E6201 is a synthetic, fungal metabolite analogue inhibitor of mitogen-activated protein kinase kinase 1 (MEK-1) and mitogen-activated protein kinase kinase kinase 1 (MEKK-1) with potential antipsoriatic and antineoplastic activities. MEK-1/MEKK-1 inhibitor E6201 specifically binds to and inhibits the activities of MEK-1 and MEKK-1, which may result in the inhibition of tumor cell proliferation. MEK-1 and MEKK-1 are key components in the RAS/RAF/MEK/MAPK signaling pathway, which regulates cell proliferation and is frequently activated in human cancers.
1 2D Structure

E6201

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
(4S,5R,6Z,9S,10S,12E)-16-(ethylamino)-9,10,18-trihydroxy-4,5-dimethyl-3-oxabicyclo[12.4.0]octadeca-1(14),6,12,15,17-pentaene-2,8-dione
2.1.2 InChI
InChI=1S/C21H27NO6/c1-4-22-15-10-14-6-5-7-16(23)20(26)17(24)9-8-12(2)13(3)28-21(27)19(14)18(25)11-15/h5-6,8-13,16,20,22-23,25-26H,4,7H2,1-3H3/b6-5+,9-8-/t12-,13+,16+,20+/m1/s1
2.1.3 InChI Key
MWUFVYLAWAXDHQ-HMNLTAHHSA-N
2.1.4 Canonical SMILES
CCNC1=CC2=C(C(=C1)O)C(=O)OC(C(C=CC(=O)C(C(CC=C2)O)O)C)C
2.1.5 Isomeric SMILES
CCNC1=CC\2=C(C(=C1)O)C(=O)O[C@H]([C@@H](/C=C\C(=O)[C@H]([C@H](C/C=C2)O)O)C)C
2.2 Other Identifiers
2.2.1 UNII
CZP9GB25HO
2.3 Synonyms
2.3.1 MeSH Synonyms

1. 14-(ethylamino)-8,9,16-trihydroxy-3,4-dimethyl-3,4,9,19-tetrahydro-1h-2-benzoxacyclotetradecine-1,7(8h)-dione

2. E 6201

3. E-6201

4. E6201 Cpd

2.3.2 Depositor-Supplied Synonyms

1. E6201

2. E-6201

3. Unii-czp9gb25ho

4. Czp9gb25ho

5. Er-806201

6. E 6201

7. 603987-35-5

8. (3s,4r,5z,8s,9s,11e)-14-(ethylamino)-8,9,16-trihydroxy-3,4-dimethyl-3,4,9,10-tetrahydro-1h-benzo[c][1]oxacyclotetradecine-1,7(8h)-dione

9. (4~{s},5~{r},6~{z},9~{s},10~{s},12~{e})-16-(ethylamino)-4,5-dimethyl-9,10,18-tris(oxidanyl)-3-oxabicyclo[12.4.0]octadeca-1(14),6,12,15,17-pentaene-2,8-dione

10. Gtpl7836

11. Schembl6983345

12. Chembl1097999

13. Bdbm50515043

14. Zinc34374629

15. Db11687

16. (3s,4r,5z,8s,9s,11e)-14-(ethylamino)-8, 9,16-trihydroxy-3,4-dimethyl-3,4,9,19-tetrahydro-1h-2-benzoxacyclotetradecine-1,7(8h)-dione

17. Hy-15496

18. Cs-0006796

19. J-504641

20. Q27077143

21. (4s,5r,6z,9s,10s,12e)-16-(ethylamino)-9,10,18-trihydroxy-4,5-dimethyl-3-oxabicyclo[12.4.0]octadeca-1(14),6,12,15,17-pentaene-2,8-dione

22. (4s,5r,6z,9s,10s,12e)-16-ethylamino-9,10,18-trihydroxy-4,5-dimethyl-3-oxabicyclo[12.4.0]octadeca-1(14),6,12,15,17-pentaene-2,8-dione

23. 1108193-99-2

24. 1h-2-benzoxacyclotetradecin-1,7(8h)-dione, 14-(ethylamino)-3,4,9,10-tetrahydro-8,9,16-trihydroxy-3,4-dimethyl-, (3s,4r,5z,8s,9s,11e)-

25. 1h-2-benzoxacyclotetradecin-1,7(8h)-dione, 14-(ethylamino)-3,4,9,10-tetrahydro-8,9,16-trihydroxy-3,4-dimethyl-, (3s,4r,5z,8s,9s,11e) -

2.4 Create Date
2006-10-25
3 Chemical and Physical Properties
Molecular Weight 389.4 g/mol
Molecular Formula C21H27NO6
XLogP33.3
Hydrogen Bond Donor Count4
Hydrogen Bond Acceptor Count7
Rotatable Bond Count2
Exact Mass389.18383758 g/mol
Monoisotopic Mass389.18383758 g/mol
Topological Polar Surface Area116 Ų
Heavy Atom Count28
Formal Charge0
Complexity604
Isotope Atom Count0
Defined Atom Stereocenter Count4
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count2
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count1

ABOUT THIS PAGE

Looking for 1108193-99-2 / E6201 API manufacturers, exporters & distributors?

E6201 manufacturers, exporters & distributors 1

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PharmaCompass offers a list of E6201 API manufacturers, exporters & distributors, which can be sorted by GMP, USDMF, JDMF, KDMF, CEP (COS), WC, Price,and more, enabling you to easily find the right E6201 manufacturer or E6201 supplier for your needs.

Send us enquiries for free, and we will assist you in establishing a direct connection with your preferred E6201 manufacturer or E6201 supplier.

PharmaCompass also assists you with knowing the E6201 API Price utilized in the formulation of products. E6201 API Price is not always fixed or binding as the E6201 Price is obtained through a variety of data sources. The E6201 Price can also vary due to multiple factors, including market conditions, regulatory modifications, or negotiated pricing deals.

API | Excipient name

E6201

Synonyms

E-6201, Unii-czp9gb25ho, Czp9gb25ho, Er-806201, E 6201, 603987-35-5

Cas Number

1108193-99-2

Unique Ingredient Identifier (UNII)

CZP9GB25HO

About E6201

MEK-1/MEKK-1 Inhibitor E6201 is a synthetic, fungal metabolite analogue inhibitor of mitogen-activated protein kinase kinase 1 (MEK-1) and mitogen-activated protein kinase kinase kinase 1 (MEKK-1) with potential antipsoriatic and antineoplastic activities. MEK-1/MEKK-1 inhibitor E6201 specifically binds to and inhibits the activities of MEK-1 and MEKK-1, which may result in the inhibition of tumor cell proliferation. MEK-1 and MEKK-1 are key components in the RAS/RAF/MEK/MAPK signaling pathway, which regulates cell proliferation and is frequently activated in human cancers.

E6201 Manufacturers

A E6201 manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of E6201, including repackagers and relabelers. The FDA regulates E6201 manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. E6201 API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

E6201 Suppliers

A E6201 supplier is an individual or a company that provides E6201 active pharmaceutical ingredient (API) or E6201 finished formulations upon request. The E6201 suppliers may include E6201 API manufacturers, exporters, distributors and traders.

E6201 GMP

E6201 Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

PharmaCompass offers a list of E6201 GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right E6201 GMP manufacturer or E6201 GMP API supplier for your needs.

E6201 CoA

A E6201 CoA (Certificate of Analysis) is a formal document that attests to E6201's compliance with E6201 specifications and serves as a tool for batch-level quality control.

E6201 CoA mostly includes findings from lab analyses of a specific batch. For each E6201 CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

E6201 may be tested according to a variety of international standards, such as European Pharmacopoeia (E6201 EP), E6201 JP (Japanese Pharmacopeia) and the US Pharmacopoeia (E6201 USP).

Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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