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1. 4-diphenylmethoxy-1-(3-(4-tert-butylbenzoyl)propyl)piperidine
2. Bactil
3. Busidril
4. Ebastel
5. Evastel
6. Kestin
7. Kestine
8. Las W-090
1. 90729-43-4
2. Kestine
3. Ebastel
4. Ebastin
5. Kestin
6. Bactil
7. Las W-090
8. Rp 64305
9. 4-(4-benzhydryloxypiperidin-1-yl)-1-(4-tert-butylphenyl)butan-1-one
10. Las-w-090
11. 1-(4-tert-butylphenyl)-4-[4-(diphenylmethoxy)piperidin-1-yl]butan-1-one
12. Las-w 090;rp64305
13. Rp-64305
14. Chembl305660
15. Tqd7q784p1
16. 4-(4-(benzhydryloxy)piperidin-1-yl)-1-(4-(tert-butyl)phenyl)butan-1-one
17. Rp64305
18. Ncgc00164603-01
19. Evastel
20. Dsstox_cid_26472
21. Dsstox_rid_81644
22. Dsstox_gsid_46472
23. Ebastinum [latin]
24. Ebastina [spanish]
25. Ebastina
26. Ebastinum
27. Estivan
28. Bastel
29. Cas-90729-43-4
30. Unii-tqd7q784p1
31. Ebastine [usan:inn:ban]
32. 4-(4-(benzhydryloxy)piperidin-1-yl)-1-(4-tert-butylphenyl)butan-1-one
33. 4-[4-(benzhydryloxy)piperidin-1-yl]-1-(4-tert-butylphenyl)butan-1-one
34. 4-diphenylmethoxy-1-(3-(4-tert-butylbenzoyl)propyl)piperidine
35. Las-w 090
36. No-sedat
37. Kestine (tn)
38. Mfcd00865661
39. 4'-tert-butyl-4-(4-(diphenylmethoxy)piperidino)butyrophenone
40. Ebastine [usan]
41. Ebastine [inn]
42. Ebastine [jan]
43. Ebastine [mi]
44. 4-(4-benzhydryloxy-1-piperidyl)-1-(4-tert-butylphenyl)butan-1-one
45. Ebastine [mart.]
46. Ebastine [who-dd]
47. 1-(4-(1,1-dimethylethyl)phenyl)-4-(4-(diphenylmethoxy)-1-piperidinyl)-1-butanone
48. Schembl18467
49. Ebastine [ep Impurity]
50. Ebastine (jp17/usan/inn)
51. Ebastine [ep Monograph]
52. Dtxsid6046472
53. Bdbm22873
54. Chebi:31528
55. Hms3261i03
56. Hms3887c19
57. Bcp08300
58. Hy-b0674
59. Zinc3781952
60. Tox21_112225
61. Tox21_500361
62. Bbl029069
63. Ebastine, >=98% (hplc), Solid
64. S4262
65. Stk624411
66. Akos005557491
67. Tox21_112225_1
68. Ccg-221665
69. Db11742
70. Ks-1349
71. Lp00361
72. Sdccgsbi-0633701.p001
73. 1-butanone, 1-(4-(1,1-dimethylethyl)phenyl)-4-(4-(diphenylmethoxy)-1-piperidinyl)-
74. Ncgc00164603-02
75. Ncgc00164603-04
76. Ncgc00164603-05
77. Ncgc00164603-11
78. Ncgc00261046-01
79. Ac-15213
80. Ac-30629
81. Be164400
82. Db-057220
83. E0925
84. Ft-0630975
85. W-090
86. A14946
87. C77079
88. D01478
89. Ab01325291-02
90. 729e434
91. A843625
92. Sr-01000883997
93. Q-201053
94. Q2327739
95. Sr-01000883997-1
96. 4-diphenylmethoxy-1[3-(4-tert-butylbenzoyl)propyl]-piperidine
97. Ebastine, United States Pharmacopeia (usp) Reference Standard
| Molecular Weight | 469.7 g/mol |
|---|---|
| Molecular Formula | C32H39NO2 |
| XLogP3 | 7.2 |
| Hydrogen Bond Donor Count | 0 |
| Hydrogen Bond Acceptor Count | 3 |
| Rotatable Bond Count | 10 |
| Exact Mass | 469.298079487 g/mol |
| Monoisotopic Mass | 469.298079487 g/mol |
| Topological Polar Surface Area | 29.5 Ų |
| Heavy Atom Count | 35 |
| Formal Charge | 0 |
| Complexity | 594 |
| Isotope Atom Count | 0 |
| Defined Atom Stereocenter Count | 0 |
| Undefined Atom Stereocenter Count | 0 |
| Defined Bond Stereocenter Count | 0 |
| Undefined Bond Stereocenter Count | 0 |
| Covalently Bonded Unit Count | 1 |
Histamine H1 Antagonists
Drugs that selectively bind to but do not activate histamine H1 receptors, thereby blocking the actions of endogenous histamine. Included here are the classical antihistaminics that antagonize or prevent the action of histamine mainly in immediate hypersensitivity. They act in the bronchi, capillaries, and some other smooth muscles, and are used to prevent or allay motion sickness, seasonal rhinitis, and allergic dermatitis and to induce somnolence. The effects of blocking central nervous system H1 receptors are not as well understood. (See all compounds classified as Histamine H1 Antagonists.)
R06AX22
S76 | LUXPHARMA | Pharmaceuticals Marketed in Luxembourg | Pharmaceuticals marketed in Luxembourg, as published by d'Gesondheetskeess (CNS, la caisse nationale de sante, www.cns.lu), mapped by name to structures using CompTox by R. Singh et al. (in prep.). List downloaded from https://cns.public.lu/en/legislations/textes-coordonnes/liste-med-comm.html. Dataset DOI:10.5281/zenodo.4587355
R - Respiratory system
R06 - Antihistamines for systemic use
R06A - Antihistamines for systemic use
R06AX - Other antihistamines for systemic use
R06AX22 - Ebastine
Ebastine has known human metabolites that include 4-(4-tert-butylphenyl)-4-oxobutanal and Deslakylebastine.
S73 | METXBIODB | Metabolite Reaction Database from BioTransformer | DOI:10.5281/zenodo.4056560
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ABOUT THIS PAGE
A Ebastine manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Ebastine, including repackagers and relabelers. The FDA regulates Ebastine manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Ebastine API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.
click here to find a list of Ebastine manufacturers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PhamaCompass.
A Ebastine supplier is an individual or a company that provides Ebastine active pharmaceutical ingredient (API) or Ebastine finished formulations upon request. The Ebastine suppliers may include Ebastine API manufacturers, exporters, distributors and traders.
click here to find a list of Ebastine suppliers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PharmaCompass.
The Pharmaceuticals and Medical Devices Agency (PMDA) established the Japan Drug Master File (JDMF), also known as the Master File (MF), to permit Japanese and foreign manufacturers of drug substances, intermediates, excipients, raw materials, and packaging materials (‘Products’) to voluntarily register confidential information about the production and management of their products in Japan.
The Ebastine Drug Master File in Japan (Ebastine JDMF) empowers Ebastine API manufacturers to present comprehensive information (e.g., production methods, data, etc.) to the review authority, i.e., PMDA (Pharmaceuticals & Medical Devices Agency).
PMDA reviews the Ebastine JDMF during the approval evaluation for pharmaceutical products. At the time of Ebastine JDMF registration, PMDA checks if the format is accurate, if the necessary items have been included (application), and if data has been attached.
click here to find a list of Ebastine suppliers with JDMF on PharmaCompass.
In Korea, the Ministry of Food and Drug Safety (MFDS) is in charge of regulating pharmaceutical products and services.
Pharmaceutical companies submit a Ebastine Drug Master File in Korea (Ebastine KDMF) to the MFDS, which includes comprehensive information about the production, processing, facilities, materials, packaging, and testing of Ebastine. The MFDS reviews the Ebastine KDMF as part of the drug registration process and uses the information provided in the Ebastine KDMF to evaluate the safety and efficacy of the drug.
After submitting a Ebastine KDMF to the MFDS, the registered manufacturer can provide importers or distributors with the registration number without revealing confidential information to Korean business partners. Applicants seeking to register their Ebastine API can apply through the Korea Drug Master File (KDMF).
click here to find a list of Ebastine suppliers with KDMF on PharmaCompass.
A Ebastine CEP of the European Pharmacopoeia monograph is often referred to as a Ebastine Certificate of Suitability (COS). The purpose of a Ebastine CEP is to show that the European Pharmacopoeia monograph adequately controls the purity of Ebastine EP produced by a given manufacturer. Suppliers of raw materials can prove the suitability of Ebastine to their clients by showing that a Ebastine CEP has been issued for it. The manufacturer submits a Ebastine CEP (COS) as part of the market authorization procedure, and it takes on the role of a Ebastine CEP holder for the record. Additionally, the data presented in the Ebastine CEP (COS) is managed confidentially and offers a centralized system acknowledged by numerous nations, exactly like the Ebastine DMF.
A Ebastine CEP (COS) is recognised by all 36 nations that make up the European Pharmacopoeia Convention. Ebastine CEPs may be accepted in nations that are not members of the Ph. Eur. at the discretion of the authorities there.
click here to find a list of Ebastine suppliers with CEP (COS) on PharmaCompass.
A Ebastine written confirmation (Ebastine WC) is an official document issued by a regulatory agency to a Ebastine manufacturer, verifying that the manufacturing facility of a Ebastine active pharmaceutical ingredient (API) adheres to the Good Manufacturing Practices (GMP) regulations of the importing country. When exporting Ebastine APIs or Ebastine finished pharmaceutical products to another nation, regulatory agencies frequently require a Ebastine WC (written confirmation) as part of the regulatory process.
click here to find a list of Ebastine suppliers with Written Confirmation (WC) on PharmaCompass.
Ebastine Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.
GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).
PharmaCompass offers a list of Ebastine GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Ebastine GMP manufacturer or Ebastine GMP API supplier for your needs.
A Ebastine CoA (Certificate of Analysis) is a formal document that attests to Ebastine's compliance with Ebastine specifications and serves as a tool for batch-level quality control.
Ebastine CoA mostly includes findings from lab analyses of a specific batch. For each Ebastine CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.
Ebastine may be tested according to a variety of international standards, such as European Pharmacopoeia (Ebastine EP), Ebastine JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Ebastine USP).
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