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ACTIVE PHARMA INGREDIENTS

7 API Suppliers, 2 USDMF, 6 Listed Suppliers, $ API Reference Price

7 API Suppliers
2 USDMF
6 Listed Suppliers
$ API Reference Price

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1 Drugs in Development

1 Drugs in Development

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4 FDF Dossiers, 4 Listed Dossiers

4 FDF Dossiers
4 Listed Dossiers

MARKET PLACE

5 APIs, 1 Intermediates

marketPlace
5 APIs
1 Intermediates

Synopsis

ACTIVE PHARMA INGREDIENTS

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API REF. PRICE (USD/KG)

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Chemistry

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Also known as: 96702-03-3, L-ectoine, (s)-2-methyl-3,4,5,6-tetrahydropyrimidine-4-carboxylic acid, Thp(b), 7gxz3858ry, (s)-2-methyl-1,4,5,6-tetrahydropyrimidine-4-carboxylic acid

Molecular Formula

C₆H₁₀N₂O₂

Molecular Weight

142.16 g/mol

InChI Key

WQXNXVUDBPYKBA-YFKPBYRVSA-N

FDA UNII

7GXZ3858RY

Ectoine is a metabolite found in or produced by Escherichia coli (strain K12, MG1655).

1 2D Structure

Ectoine

2 Identification

2.1 Computed Descriptors

2.1.1 IUPAC Name

(6S)-2-methyl-1,4,5,6-tetrahydropyrimidine-6-carboxylic acid

2.1.2 InChI

InChI=1S/C6H10N2O2/c1-4-7-3-2-5(8-4)6(9)10/h5H,2-3H2,1H3,(H,7,8)(H,9,10)/t5-/m0/s1

2.1.3 InChI Key

WQXNXVUDBPYKBA-YFKPBYRVSA-N

2.1.4 Canonical SMILES

CC1=NCCC(N1)C(=O)O

2.1.5 Isomeric SMILES

CC1=NCC[C@H](N1)C(=O)O

2.2 Other Identifiers

2.2.1 UNII

7GXZ3858RY

2.3 Synonyms

2.3.1 MeSH Synonyms

1. 1,4,5,6-tetrahydro-2-methyl-4-pyrimidinecarboxylic Acid

2. Ectoin

2.3.2 Depositor-Supplied Synonyms

1. 96702-03-3

2. L-ectoine

3. (s)-2-methyl-3,4,5,6-tetrahydropyrimidine-4-carboxylic Acid

4. Thp(b)

5. 7gxz3858ry

6. (s)-2-methyl-1,4,5,6-tetrahydropyrimidine-4-carboxylic Acid

7. Chebi:27592

8. (4s)-2-methyl-1,4,5,6-tetrahydropyrimidine-4-carboxylic Acid

9. (6s)-2-methyl-1,4,5,6-tetrahydropyrimidine-6-carboxylic Acid

10. (s)-2-methyl- 1,4,5,6-tetrahydropyrimidine-4-carboxylic Acid

11. Ectoin

12. (+)-1,4,5,6-tetrahydro-2-methyl-4-pyrimidinecarboxylic Acid

13. Smr000127407

14. Ectoine, Primary Pharmaceutical Reference Standard

15. Unii-7gxz3858ry

16. Mfcd03419286

17. Nsc-614616

18. (4s)-2-methyl-1,4,5,6-tetrahydropyrimidine-4-carboxylate

19. 4cs

20. Ectoine, Osmoprotectant

21. Ectoin [inci]

22. Ectoine [mi]

23. 4-pyrimidinecarboxylicacid, 3,4,5,6-tetrahydro-2-methyl-, (4s)-

24. Ectoine [who-dd]

25. Schembl93532

26. Us9138393, Ectoine

27. Us9144538, Ectoine

28. Mls001332487

29. Mls001332488

30. Chembl1230264

31. Dtxsid50869280

32. Bdbm181140

33. Ectoine, >=95.0% (hplc)

34. (4s)-3,4,5,6-tetrahydro-2-methyl-4-pyrimidinecarboxylic Acid

35. Ex-a1678

36. Zinc1612568

37. 4-pyrimidinecarboxylic Acid, 1,4,5,6-tetrahydro-2-methyl-, (4s)-

38. S5591

39. Akos006348056

40. Ccg-266161

41. Ds-3343

42. Nsc 614616

43. Ac-33942

44. Hy-107784

45. Cs-0030647

46. E1372

47. C06231

48. I11596

49. Q414414

50. (s)-1,4,5,6-tetrahydro-2-methyl-4-pyrimi-dinecarboxylic Acid

51. (s)-1,4,5,6-tetrahydro-2-methyl-4-pyrimidinecarboxylic Acid

52. (6s)-2-methyl-1,4,5,6-tetrahydropyrimidin-3-ium-6-carboxylate

53. 4-pyrimidinecarboxylic Acid, 1,4,5,6-tetrahydro-2-methyl-, (+)-

54. Ectoine (2-methyl-1,4,5,6-tetrahydropyrimidine-4-carboxylic Acid)

2.4 Create Date

2005-07-19

3 Chemical and Physical Properties

Molecular Formula	C₆H₁₀N₂O₂
Molecular Weight	142.16 g/mol
XLogP3	-0.8
Hydrogen Bond Donor Count	2
Hydrogen Bond Acceptor Count	3
Rotatable Bond Count	1
Exact Mass	142.074227566 g/mol
Monoisotopic Mass	142.074227566 g/mol
Topological Polar Surface Area	61.7 Å²
Heavy Atom Count	10
Formal Charge	0
Complexity	177
Isotope Atom Count	0
Defined Atom Stereocenter Count	1
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently Bonded Unit Count	1

API SUPPLIERS

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USDMF

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Listed Suppliers

01

Bloomage Biotechnology Corp., Ltd

China

CPhI Worldwide, Milan

Booth #1B81

Bloomage is a one-stop source for CEP Sodium Hyaluronate and Hyaluronic Acid// FDA-inspected & GMP-certified.

Contact Supplier

China

Virtual Booth

Digital Content

Ectoine

About the Company : Bloomage Biotechnology Corporation Limited, formerly Bloomage Freda Biopharm, was established by Bloomage International Investment Group. It is a global leader in bioactive materia...

Bloomage Biotechnology Corporation Limited, formerly Bloomage Freda Biopharm, was established by Bloomage International Investment Group. It is a global leader in bioactive materials like mucopolysaccharides, proteins, peptides, amino acids, & natural compounds. In the 1990s, it became the first company in China to develop fermentation-based sodium hyaluronate. With around 200 specifications of hyaluronic acid, it caters to the pharmaceutical, medical devices, cosmetics, & functional food sectors. For pharma raw materials, Bloomage offers innovative solutions in aesthetics, dermatology, ophthalmology, orthopedics, & regenerative medicines.

02

Shanghai Minbiotech

China

CPhI Worldwide, Milan

Attending

Shanghai Minbiotech is the leading producer of biopharmaceuticals and a variety of high-end generic & innovative drugs.

Contact Supplier

China

Virtual Booth

Digital Content

Ectoine

About the Company : Headquartered in Fengxian District, Shanghai Minbiotch Co., Ltd. is a company specializing in the R&D and production of advanced pharmaceutical intermediates and biological APIs...

Headquartered in Fengxian District, Shanghai Minbiotch Co., Ltd. is a company specializing in the R&D and production of advanced pharmaceutical intermediates and biological APIs. There are more than 1000 square meters of R&D centers in Nantong, Jiangsu and Jinan, Shandong, with more than 13,000㎡ of production sites. While supplying products to customers, the company also provides services such as technology development, technology transfer and technology exchange, aiming to provide customers with comprehensive supply and solutions in the biomedical industry.

Corporate PDF

03

Anhui HaiKang Pharmaceutical

China

ASC 2024

Not Confirmed

04

Bitop AG

Germany

ASC 2024

Not Confirmed

05

Jin Dun Medical

China

ASC 2024

Not Confirmed

06

SBS Genetech

China

ASC 2024

Not Confirmed

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API Reference Price

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Import","activeIngredients":"","year":"2023","qtr":"Q1","strtotime":1676485800,"product":"RONACARE ECTOIN 2PCS X 5KG","address":"8TH FLOOR, GODREJ ONE, GODREJ COMPOUND,VIKHROLI EAST Conta","city":"MUMBAI","supplier":"MERCK ELECTRONICS KGAA","supplierCountry":"GERMANY","foreign_port":"NA","customer":"MERCK PERFORMANCE MATERIALS PRIVATE LIMITED","customerCountry":"INDIA","quantity":"10.00","actualQuantity":"10","unit":"KGS","unitRateFc":"67362.4","totalValueFC":"8199.5","currency":"INR","unitRateINR":"67719.9","date":"16-Feb-2023","totalValueINR":"677199.41","totalValueInUsd":"8199.5","indian_port":"BOMBAY AIR","hs_no":"29335990","bill_no":"4667252","productDescription":"API","marketType":"REGULATED MARKET","country":"GERMANY","selfForZScoreResived":"Pharma Grade","supplierPort":"NA","supplierAddress":"","customerAddress":"8TH FLOOR, GODREJ ONE, GODREJ COMPOUND,VIKHROLI EAST Conta"},{"dataSource":"API Import","activeIngredients":"","year":"2023","qtr":"Q1","strtotime":1678991400,"product":"RONACARE ECTOIN 2PCS X 5KG","address":"8TH FLOOR, GODREJ ONE, GODREJ COMPOUND,VIKHROLI EAST Conta","city":"MUMBAI","supplier":"MERCK ELECTRONICS KGAA","supplierCountry":"GERMANY","foreign_port":"NA","customer":"MERCK GROUP","customerCountry":"INDIA","quantity":"10.00","actualQuantity":"10","unit":"KGS","unitRateFc":"66871.7","totalValueFC":"8182.6","currency":"INR","unitRateINR":"67302.3","date":"17-Mar-2023","totalValueINR":"673022.89","totalValueInUsd":"8182.6","indian_port":"BOMBAY AIR","hs_no":"29335990","bill_no":"5087005","productDescription":"API","marketType":"REGULATED MARKET","country":"GERMANY","selfForZScoreResived":"Pharma Grade","supplierPort":"NA","supplierAddress":"","customerAddress":"8TH FLOOR, GODREJ ONE, GODREJ COMPOUND,VIKHROLI EAST Conta"},{"dataSource":"API Import","activeIngredients":"","year":"2023","qtr":"Q2","strtotime":1683829800,"product":"RONACARE ECTOIN 2PCS X 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Number of Transactions

Total Quantity (KGS)

Total Value (USD)

Quantity (KGS) & Unit rate (USD/KGS) over time

API Imports and Exports

Importing Country	Total Quantity (KGS)	Average Price (USD/KGS)	Number of Transactions

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Drugs in Development

01 Bloomage Biotechnology Corp., Ltd

China

CPhI Worldwide, Milan

Booth #1B81

Bloomage is a one-stop source for CEP Sodium Hyaluronate and Hyaluronic Acid// FDA-inspected & GMP-certified.

Lead Product(s) : Ectoine

Therapeutic Area : Immunology

Highest Development Status : Approved

Partner/Sponsor/Collaborator : Not Applicable

Deal Size : Not Applicable

Deal Type : Not Applicable

DEALS_DEV

Bloomecto™ Ectoine -- Nasal Spray New Solution

Details : Bloomecto (ectoine) is an osmoprotectant which form a hydration layer outside the cells, reduce the impact of allergens on cells, ease the development of inflammation.

Brand Name : Bloomecto

Molecule Type : Small molecule

Upfront Cash : Not Applicable

October 30, 2022

Stock Recap
#PipelineProspector

Data Compilation
#PharmaFlow

Virtual Booth

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FDF Dossiers