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Also known as: 89-25-8, 3-methyl-1-phenyl-2-pyrazolin-5-one, Radicut, Norphenazone, Mci-186, Developer z
Molecular Formula
C10H10N2O
Molecular Weight
174.20  g/mol
InChI Key
QELUYTUMUWHWMC-UHFFFAOYSA-N

Edaravone
An antipyrine derivative that functions as a free radical scavenger and neuroprotective agent. It is used in the treatment of AMYOTROPHIC LATERAL SCLEROSIS and STROKE.
1 2D Structure

Edaravone

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
5-methyl-2-phenyl-4H-pyrazol-3-one
2.1.2 InChI
InChI=1S/C10H10N2O/c1-8-7-10(13)12(11-8)9-5-3-2-4-6-9/h2-6H,7H2,1H3
2.1.3 InChI Key
QELUYTUMUWHWMC-UHFFFAOYSA-N
2.1.4 Canonical SMILES
CC1=NN(C(=O)C1)C2=CC=CC=C2
2.2 Synonyms
2.2.1 MeSH Synonyms

1. 1 Phenyl 3 Methyl 5 Pyrazolone

2. 1-phenyl-3-methyl-5-pyrazolone

3. 3 Methyl 1 Phenyl 2 Pyrazolin 5 One

4. 3-methyl-1-phenyl-2-pyrazolin-5-one

5. Edarabone

6. Mci 186

7. Mci-186

8. Mci186

9. Norantipyrine

10. Norphenazone

11. Phenylmethylpyrazolone

12. Radicava

2.2.2 Depositor-Supplied Synonyms

1. 89-25-8

2. 3-methyl-1-phenyl-2-pyrazolin-5-one

3. Radicut

4. Norphenazone

5. Mci-186

6. Developer Z

7. Methylphenylpyrazolone

8. Norantipyrine

9. C.i. Developer 1

10. Phenyl Methyl Pyrazolone

11. Phenylmethylpyrazolone

12. Radicava

13. 3-methyl-1-phenyl-1h-pyrazol-5(4h)-one

14. 5-methyl-2-phenyl-2,4-dihydro-3h-pyrazol-3-one

15. 1-phenyl-3-methyl-5-oxo-2-pyrazoline

16. 5-methyl-2-phenyl-4h-pyrazol-3-one

17. 1-phenyl-3-methylpyrazolone

18. 3h-pyrazol-3-one, 2,4-dihydro-5-methyl-2-phenyl-

19. 1-phenyl-3-methylpyrazolone-5

20. 3-methyl-1-phenylpyrazol-5-one

21. 3-methyl-1-phenyl-2-pyrazoline-5-one

22. Nci-c03952

23. 2-pyrazolin-5-one, 3-methyl-1-phenyl-

24. 5-pyrazolone, 3-methyl-1-phenyl-

25. 2,4-dihydro-5-methyl-2-phenyl-3h-pyrazol-3-one

26. Edaravone (mci-186)

27. 1-fenyl-3-methyl-2-pyrazolin-5-on

28. 3-methyl-1-phenyl-4,5-dihydro-1h-pyrazol-5-one

29. Chebi:31530

30. Nsc-2629

31. Nsc-26139

32. Antipyrine Related Compound A

33. Mls000069602

34. 3-methyl-1-phenyl-2-pyrazolin-5-one (mci-186)

35. Ci Developer 1

36. Ncgc00164015-01

37. Smr000059020

38. Dsstox_cid_1130

39. Dsstox_rid_75961

40. Dsstox_gsid_21130

41. Monopyrazolone

42. Wln: T5nmv Dhj Br& E1

43. Cas-89-25-8

44. Ccris 512

45. Radicut (tn)

46. Hsdb 4102

47. 3h-pyrazol-3-one,4-dihydro-5-methyl-2-phenyl-

48. Sr-01000000135

49. 1-fenyl-3-methyl-2-pyrazolin-5-on [czech]

50. Einecs 201-891-0

51. Mfcd00003138

52. Unii-s798v6yjrp

53. Brn 0609575

54. Ai3-03557

55. Mci186

56. (edaravone)

57. Radicava (tn)

58. (mci-186)

59. Cds1_000986

60. Spectrum_000267

61. Tocris-0786

62. Mci-186; Edaravone

63. Edaravone [usan:inn]

64. Maybridge1_005738

65. Opera_id_1057

66. Spectrum2_001574

67. Spectrum3_000971

68. Spectrum4_001091

69. Spectrum5_001217

70. M0687

71. Ec 201-891-0

72. Schembl4704

73. Bspbio_001235

74. Bspbio_002601

75. Kbiogr_000575

76. Kbiogr_001502

77. Kbioss_000575

78. Kbioss_000747

79. Ae-641/00371017

80. Mls001146878

81. Mls002415675

82. Mls006011753

83. Divk1c_001018

84. Divk1c_002026

85. Spectrum1503635

86. Spbio_001508

87. Chembl290916

88. Edaravone (usan/jp17/inn)

89. Dtxsid9021130

90. Bcbcmap01_000127

91. Gtpl11994

92. Hms503k17

93. Hms557m18

94. Kbio1_001018

95. Kbio2_000575

96. Kbio2_000747

97. Kbio2_003143

98. Kbio2_003315

99. Kbio2_005711

100. Kbio2_005883

101. Kbio3_001029

102. Kbio3_001030

103. Kbio3_001821

104. Nsc2629

105. Ninds_001018

106. Bcpp000246

107. Bio1_000438

108. Bio1_000927

109. Bio1_001416

110. Bio2_000448

111. Bio2_000928

112. Hms1362m17

113. Hms1792m17

114. Hms1990m17

115. Hms2234m19

116. Hms3266f04

117. Hms3403m17

118. Hms3411l05

119. Hms3654l15

120. Hms3675l05

121. Hms3884a11

122. Pharmakon1600-01503635

123. Act07289

124. Bcp26336

125. Hy-b0099

126. Nsc26139

127. Tox21_112077

128. Tox21_201747

129. Tox21_302819

130. Bdbm50200541

131. Ccg-39352

132. Nsc758622

133. S1326

134. Stk201315

135. Zinc18203737

136. 3-methyl-1-phenyl-2-pyrazolin-5one

137. Akos000313817

138. Tox21_112077_1

139. Ac-4745

140. Bcp9000635

141. Cs-1832

142. Db12243

143. Nsc-758622

144. Sb19128

145. Idi1_001018

146. Idi1_002203

147. 1-pehnyl-3-methyl-5-pyrazalone

148. Ncgc00018218-01

149. Ncgc00018218-02

150. Ncgc00018218-03

151. Ncgc00018218-04

152. Ncgc00018218-05

153. Ncgc00018218-06

154. Ncgc00018218-07

155. Ncgc00018218-08

156. Ncgc00018218-10

157. Ncgc00018218-17

158. Ncgc00022665-02

159. Ncgc00022665-04

160. Ncgc00022665-05

161. Ncgc00022665-06

162. Ncgc00256515-01

163. Ncgc00259296-01

164. Sbi-0051836.p002

165. Db-002517

166. Am20060748

167. Ft-0608243

168. Sw148216-2

169. 5-methyl-2-phenyl-2,4-dihydro-3-pyrazolone

170. 3-methyl-1-phenyl-2-pyrazoline-5-one, 99%

171. 4e-901

172. 5-methyl-2-phenyl-2,4-dihydro-pyrazol-3-one

173. D01552

174. D86209

175. 3-?methyl-?1-?phenyl-?2-?pyrazolin-?5-?one

176. Ab00375776_14

177. Ab00375776_15

178. 2 4-dihydro-5-methyl-2-phenyl-3h-pyrazol-3-one

179. 2,4-dihydro-2-phenyl-5-methyl-3h-pyrazol-3-one

180. A843105

181. Q335099

182. Q-200386

183. Sr-01000000135-2

184. Sr-01000000135-3

185. Sr-01000000135-5

186. 5-methyl-2-phenyl-2,4-dihydro-3h-pyrazol-3-one #

187. Brd-k35458079-001-04-2

188. Brd-k35458079-001-12-5

189. Brd-k35458079-001-23-2

190. Z50145861

191. F0391-0021

192. 3-methyl-1-phenyl-2-pyrazoline-5-one, Saj Special Grade

193. 3-methyl-1-phenyl-2-pyrazoline-5-one, Purum, >=98.0% (nt)

194. 5-methyl-2-phenyl-2,4-dihydro-3h-pyrazol-3-one (edaravone)

195. Phenazone Impurity A, European Pharmacopoeia (ep) Reference Standard

196. 5-methyl-2-phenyl-1,2-dihydropyrazol-3-one;3-methyl-1-phenyl-2-pyrazolin-5-one

197. Antipyrine Related Compound A, United States Pharmacopeia (usp) Reference Standard

2.3 Create Date
2005-03-25
3 Chemical and Physical Properties
Molecular Weight 174.20 g/mol
Molecular Formula C10H10N2O
XLogP31.3
Hydrogen Bond Donor Count0
Hydrogen Bond Acceptor Count2
Rotatable Bond Count1
Exact Mass174.079312947 g/mol
Monoisotopic Mass174.079312947 g/mol
Topological Polar Surface Area32.7 Ų
Heavy Atom Count13
Formal Charge0
Complexity241
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count1
4 Drug and Medication Information
4.1 Drug Indication

Indicated for improving neurological symptoms and damage from acute ischemic stroke and delaying disease progression of ALS.


FDA Label


Treatment of amyotrophic lateral sclerosis


Treatment of amyotrophic lateral sclerosis


5 Pharmacology and Biochemistry
5.1 Pharmacology

Edaravone scavenges free hydroxyl radicals and peroxynitrite radicals which are highly associated with neuronal damage/death from many cerebral vascular disorders such as ischemic strokes and degenerative neurological disorders such as ALS. It exerts a neuroprotective and antioxidant effect and delays disease progression by limiting the extent of lipid peroxidation via free radical generation and cell membrane damage from oxidative stress. It reversed the reduction in regional blood flow and cerebral edema in a case of ischemic stroke.


5.2 MeSH Pharmacological Classification

Free Radical Scavengers

Substances that eliminate free radicals. Among other effects, they protect PANCREATIC ISLETS against damage by CYTOKINES and prevent myocardial and pulmonary REPERFUSION INJURY. (See all compounds classified as Free Radical Scavengers.)


Neuroprotective Agents

Drugs intended to prevent damage to the brain or spinal cord from ischemia, stroke, convulsions, or trauma. Some must be administered before the event, but others may be effective for some time after. They act by a variety of mechanisms, but often directly or indirectly minimize the damage produced by endogenous excitatory amino acids. (See all compounds classified as Neuroprotective Agents.)


5.3 ATC Code

N - Nervous system

N07 - Other nervous system drugs

N07X - Other nervous system drugs

N07XX - Other nervous system drugs

N07XX14 - Edaravone


5.4 Absorption, Distribution and Excretion

Absorption

The peak plasma concentration of the parent drug is reached at the end of infusion, without accumulation of the drug with multiple dosing regimen. The mean Cmax value in healthy male adults is 888ng/mL for intravenous infusion. The values of AUC and Cmax are increased in a dose-proportional relationship. The oral bioavailability in mouse studies is 38% of the I.V. delivery.


Route of Elimination

About 0.7-0.9% of the dose is excreted as unchanged drug and 71.0-79.9% of the dose is excreted as metabolites (mostly as glucuronide conjugates) through mainly renal elimination.


Volume of Distribution

The mean Vd value following an intravenous infusion of a single 30mg dose is 18.5L/kg.


Clearance

The mean total plasma drug clearance following an intravenous infusion of a single 30mg dose is 0.1L/min.


5.5 Metabolism/Metabolites

Multiple renal and hepatic uridine diphosphate glucuronosyltransferase (UGT) isoforms catalyze glucuronidation reaction of edaravone to form glucuronide conjugates. Edaravone is also metabolized into sulfate conjugates via sulfotransferase activity, which is the main metabolite form predominantly found circulating in plasma. It is predicted that the sulfate conjugate is hydrolyzed back to edaravone, which is then converted to the glucuronide conjugate in the human kidney before excretion into the urine. These metabolites have no pharmacological activity.


5.6 Biological Half-Life

The mean terminal elimination half-life of edaravone is 4.5 to 6 hours and the half-lives of its metabolites are 2 to 2.8 hours.


5.7 Mechanism of Action

Nootropic and neuroprotective effects are mediated through inhibiting lipid peroxidation and scavenging free radicals. Edaravone acts to increase prostacyclin production, decrease lipoxygenase metabolism of arachidonic acid by trapping hydroxyl radicals, and inhibit alloxan-induced lipid peroxidation and quench active oxygen species. It targets various kinds of cells, including neurons, endothelial cells and myocardial cells. There is also evidence of reduction of neuronal nitric oxide synthase (nNOS) levels and potentiation of SOD1 levels after transient ischemia in rabbits thus preventing spinal cord injury.


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08-Apr-2021
31-Jan-2025
KGS
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US Medicaid Prescriptions

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01

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World ADC London
Not Confirmed
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World ADC London
Not Confirmed

Company :

Edaravone

Drug Cost (USD) : 45,010,772

Year : 2022

Prescribers : 524

Prescriptions : 3778

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02

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World ADC London
Not Confirmed
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World ADC London
Not Confirmed

Company :

Edaravone

Drug Cost (USD) : 64,882,863

Year : 2021

Prescribers : 698

Prescriptions : 5562

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03

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World ADC London
Not Confirmed
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World ADC London
Not Confirmed

Company :

Edaravone

Drug Cost (USD) : 67,589,597

Year : 2019

Prescribers : 749

Prescriptions : 6104

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04

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World ADC London
Not Confirmed
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World ADC London
Not Confirmed

Company :

Edaravone

Drug Cost (USD) : 64,233,760

Year : 2018

Prescribers : 775

Prescriptions : 5837

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Edaravone

Drug Cost (USD) : 8,801,715

Year : 2017

Prescribers : 289

Prescriptions : 882

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Company :

Edaravone

Drug Cost (USD) : 0

Year : 2016

Prescribers :

Prescriptions : 0

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Company :

Edaravone

Drug Cost (USD) : 0

Year : 2015

Prescribers :

Prescriptions : 0

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Annual Reports

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Brand Name : Radicava

Edaravone

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Edaravone

Main Therapeutic Indication : CNS & Anesthesia

Currency : USD

2020 Revenue in Millions : 201

2019 Revenue in Millions : 218

Growth (%) : -8

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Brand Name : Radicava

Edaravone

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Japan
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Edaravone

Main Therapeutic Indication : Neurology

Currency : USD

2021 Revenue in Millions : 210

2020 Revenue in Millions : 198

Growth (%) : 14

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Brand Name : Radicava

Edaravone

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Japan
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Edaravone

Main Therapeutic Indication : Neurology

Currency : USD

2022 Revenue in Millions : 349

2021 Revenue in Millions : 208

Growth (%) : 68

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Brand Name : Radicut

Edaravone

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Japan
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Edaravone

Main Therapeutic Indication : Neurology

Currency : USD

2023 Revenue in Millions : 28

2022 Revenue in Millions : 0

Growth (%) : New Launch

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Edaravone

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Japan
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Edaravone

Main Therapeutic Indication : Neurology

Currency : USD

2023 Revenue in Millions : 483

2022 Revenue in Millions : 349

Growth (%) : 55

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Edaravone

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Edaravone

Main Therapeutic Indication : Neuroscience/Mental Health

Currency : USD

2014 Revenue in Millions : -32%

2013 Revenue in Millions :

Growth (%) :

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Edaravone

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Edaravone

Main Therapeutic Indication : Neurological/Mental Disorders

Currency : USD

2017 Revenue in Millions : 54

2016 Revenue in Millions : 60

Growth (%) : -10

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Edaravone

Main Therapeutic Indication : Neurological/Mental Disorders

Currency : USD

2017 Revenue in Millions : 61

2016 Revenue in Millions : 0

Growth (%) : New Launch

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Brand Name : Radicava

Edaravone

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Japan
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Edaravone

Main Therapeutic Indication : Neurological/Mental Disorders

Currency : USD

2018 Revenue in Millions : 237

2017 Revenue in Millions : 58

Growth (%) : 311%

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Edaravone

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Edaravone

Main Therapeutic Indication : CNS & Anesthesia

Currency : USD

2019 Revenue in Millions : 220

2018 Revenue in Millions : 245

Growth (%) : -10

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Market Place

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Patents & EXCLUSIVITIES

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US Patents

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EDARAVONE

US Patent Number : 11826352

Drug Substance Claim :

Drug Product Claim : Y

Application Number : 215446

Patent Use Code :

Delist Requested :

Patent Use Description :

Patent Expiration Date : 2039-11-01

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EDARAVONE

US Patent Number : 11957660

Drug Substance Claim :

Drug Product Claim : Y

Application Number : 215446

Patent Use Code :

Delist Requested :

Patent Use Description :

Patent Expiration Date : 2039-11-01

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EDARAVONE

US Patent Number : 11241416

Drug Substance Claim :

Drug Product Claim : Y

Application Number : 215446

Patent Use Code :

Delist Requested :

Patent Use Description :

Patent Expiration Date : 2039-11-01

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EDARAVONE

US Patent Number : 10987341

Drug Substance Claim :

Drug Product Claim : Y

Application Number : 215446

Patent Use Code :

Delist Requested :

Patent Use Description :

Patent Expiration Date : 2039-11-01

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EDARAVONE

US Patent Number : 11478450

Drug Substance Claim :

Drug Product Claim :

Application Number : 215446

Patent Use Code : U-3468

Delist Requested :

Patent Use Description :

Patent Expiration Date : 2039-11-01

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EDARAVONE

US Patent Number : 12194025

Drug Substance Claim :

Drug Product Claim :

Application Number : 215446

Patent Use Code : U-4111

Delist Requested :

Patent Use Description :

Patent Expiration Date : 2041-11-12

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REF. STANDARDS & IMPURITIES

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Others

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Edaravone Impurity 6

CAS Number : 1323485-71-7

Quantity Per Vial :

Sale Unit :

Price :

Details : Specific Purity - 97.15%; Mol Wt -296.34

Monograph :

Storage :

Code/Batch No : Catalog # E0063.06

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ABOUT THIS PAGE

Looking for 89-25-8 / Edaravone API manufacturers, exporters & distributors?

Edaravone manufacturers, exporters & distributors 1

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PharmaCompass offers a list of Edaravone API manufacturers, exporters & distributors, which can be sorted by GMP, USDMF, JDMF, KDMF, CEP (COS), WC, Price,and more, enabling you to easily find the right Edaravone manufacturer or Edaravone supplier for your needs.

Send us enquiries for free, and we will assist you in establishing a direct connection with your preferred Edaravone manufacturer or Edaravone supplier.

PharmaCompass also assists you with knowing the Edaravone API Price utilized in the formulation of products. Edaravone API Price is not always fixed or binding as the Edaravone Price is obtained through a variety of data sources. The Edaravone Price can also vary due to multiple factors, including market conditions, regulatory modifications, or negotiated pricing deals.

API | Excipient name

Edaravone

Synonyms

89-25-8, 3-methyl-1-phenyl-2-pyrazolin-5-one, Radicut, Norphenazone, Mci-186, Developer z

Cas Number

89-25-8

About Edaravone

An antipyrine derivative that functions as a free radical scavenger and neuroprotective agent. It is used in the treatment of AMYOTROPHIC LATERAL SCLEROSIS and STROKE.

Edaravone Manufacturers

A Edaravone manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Edaravone, including repackagers and relabelers. The FDA regulates Edaravone manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Edaravone API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

click here to find a list of Edaravone manufacturers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PhamaCompass.

Edaravone Suppliers

A Edaravone supplier is an individual or a company that provides Edaravone active pharmaceutical ingredient (API) or Edaravone finished formulations upon request. The Edaravone suppliers may include Edaravone API manufacturers, exporters, distributors and traders.

click here to find a list of Edaravone suppliers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PharmaCompass.

Edaravone USDMF

A Edaravone DMF (Drug Master File) is a document detailing the whole manufacturing process of Edaravone active pharmaceutical ingredient (API) in detail. Different forms of Edaravone DMFs exist exist since differing nations have different regulations, such as Edaravone USDMF, ASMF (EDMF), JDMF, CDMF, etc.

A Edaravone DMF submitted to regulatory agencies in the US is known as a USDMF. Edaravone USDMF includes data on Edaravone's chemical properties, information on the facilities and procedures used, and details about packaging and storage. The Edaravone USDMF is kept confidential to protect the manufacturer’s intellectual property.

click here to find a list of Edaravone suppliers with USDMF on PharmaCompass.

Edaravone JDMF

The Pharmaceuticals and Medical Devices Agency (PMDA) established the Japan Drug Master File (JDMF), also known as the Master File (MF), to permit Japanese and foreign manufacturers of drug substances, intermediates, excipients, raw materials, and packaging materials (‘Products’) to voluntarily register confidential information about the production and management of their products in Japan.

The Edaravone Drug Master File in Japan (Edaravone JDMF) empowers Edaravone API manufacturers to present comprehensive information (e.g., production methods, data, etc.) to the review authority, i.e., PMDA (Pharmaceuticals & Medical Devices Agency).

PMDA reviews the Edaravone JDMF during the approval evaluation for pharmaceutical products. At the time of Edaravone JDMF registration, PMDA checks if the format is accurate, if the necessary items have been included (application), and if data has been attached.

click here to find a list of Edaravone suppliers with JDMF on PharmaCompass.

Edaravone WC

A Edaravone written confirmation (Edaravone WC) is an official document issued by a regulatory agency to a Edaravone manufacturer, verifying that the manufacturing facility of a Edaravone active pharmaceutical ingredient (API) adheres to the Good Manufacturing Practices (GMP) regulations of the importing country. When exporting Edaravone APIs or Edaravone finished pharmaceutical products to another nation, regulatory agencies frequently require a Edaravone WC (written confirmation) as part of the regulatory process.

click here to find a list of Edaravone suppliers with Written Confirmation (WC) on PharmaCompass.

Edaravone NDC

National Drug Code is a comprehensive database maintained by the FDA that contains information on all drugs marketed in the US. This directory includes information about finished drug products, unfinished drug products, and compounded drug products, including those containing Edaravone as an active pharmaceutical ingredient (API).

Finished drug products

The FDA updates the NDC directory daily. The NDC numbers for Edaravone API and other APIs are published in this directory by the FDA.

Unfinished drugs

The NDC unfinished drugs database includes product listing information submitted for all unfinished drugs, such as active pharmaceutical ingredients (APIs), drugs intended for further processing and bulk drug substances for compounding.

Pharmaceutical companies that manufacture Edaravone as an active pharmaceutical ingredient (API) must furnish the FDA with an updated record of all drugs that they produce, prepare, propagate, compound, or process for commercial distribution in the US at their facilities.

Compounded drug products

The NDC directory also contains data on finished compounded human drug products that contain Edaravone and are produced by outsourcing facilities. While these outsourcing facilities are not mandated to assign a Edaravone NDC to their finished compounded human drug products, they may choose to do so.

click here to find a list of Edaravone suppliers with NDC on PharmaCompass.

Edaravone GMP

Edaravone Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

PharmaCompass offers a list of Edaravone GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Edaravone GMP manufacturer or Edaravone GMP API supplier for your needs.

Edaravone CoA

A Edaravone CoA (Certificate of Analysis) is a formal document that attests to Edaravone's compliance with Edaravone specifications and serves as a tool for batch-level quality control.

Edaravone CoA mostly includes findings from lab analyses of a specific batch. For each Edaravone CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

Edaravone may be tested according to a variety of international standards, such as European Pharmacopoeia (Edaravone EP), Edaravone JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Edaravone USP).

Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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