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Edetate Sodium

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Synopsis

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Chemistry

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Also known as: Sodium edetate, 64-02-8, Edta tetrasodium, Ethylenediaminetetraacetic acid tetrasodium salt, Tetrasodium edta, Edta sodium

Molecular Formula

C₁₀H₁₂N₂Na₄O₈

Molecular Weight

380.17 g/mol

InChI Key

UEUXEKPTXMALOB-UHFFFAOYSA-J

FDA UNII

MP1J8420LU

1 2D Structure

Edetate Sodium

2 Identification

2.1 Computed Descriptors

2.1.1 IUPAC Name

tetrasodium;2-[2-[bis(carboxylatomethyl)amino]ethyl-(carboxylatomethyl)amino]acetate

2.1.2 InChI

InChI=1S/C10H16N2O8.4Na/c13-7(14)3-11(4-8(15)16)1-2-12(5-9(17)18)6-10(19)20;;;;/h1-6H2,(H,13,14)(H,15,16)(H,17,18)(H,19,20);;;;/q;4*+1/p-4

2.1.3 InChI Key

UEUXEKPTXMALOB-UHFFFAOYSA-J

2.1.4 Canonical SMILES

C(CN(CC(=O)[O-])CC(=O)[O-])N(CC(=O)[O-])CC(=O)[O-].[Na+].[Na+].[Na+].[Na+]

2.2 Other Identifiers

2.2.1 UNII

MP1J8420LU

2.3 Synonyms

2.3.1 Depositor-Supplied Synonyms

1. Sodium Edetate

2. 64-02-8

3. Edta Tetrasodium

4. Ethylenediaminetetraacetic Acid Tetrasodium Salt

5. Tetrasodium Edta

6. Edta Sodium

7. Edta Tetrasodium Salt

8. Sodium Edta

9. Complexone

10. Edta, Tetrasodium

11. Calsol

12. Versene 100

13. Endrate Tetrasodium

14. Tetrasodium Edetate

15. Sequestrene

16. Tetrine

17. Syntes 12a

18. Trilon B

19. Tetrasodium Ethylenediaminetetraacetate

20. Versene 220

21. Na4edta

22. Edetate Sodium [usan]

23. Tetrasodium Salt Of Edta

24. Nervanaid

25. Nullapo

26. Sodium Ethylenediaminetetraacetate

27. 67401-50-7

28. Mp1j8420lu

29. Glycine, N,n'-1,2-ethanediylbis(n-(carboxymethyl)-, Sodium Salt (1:4)

30. Edta, Tetrasodium Salt, Ultra Pure

31. Aquamollin

32. Irgalon

33. Komplexon

34. Nullapon

35. Questex

36. Tetracemin

37. Tyclarosol

38. Distol

39. Edetate Sodium (usan)

40. Ergon

41. Kalex

42. Natrii Edetas

43. Versene Beads

44. Versene Flake

45. Versene Powder

46. Sequestrene St

47. Aquamoline Bc

48. Metaquest C

49. Nervanaid B

50. Nullapon B

51. Kutrilon Cs

52. Natrium Aedeticum

53. Syntron B

54. Cheelox Bf

55. Clewat T

56. Conigon Bc

57. Nullapon Bfc

58. Sequestrene 30a

59. Celon E

60. Celon H

61. Ergon B

62. Questex 4

63. Celon Is

64. Sequestrene Na 4

65. Distol 8

66. Nervanaid B Liquid

67. Nervanaid-b Liquid

68. Hamp-ene Na4

69. Warkeelate S-42

70. Nullapon Bfc Xonc

71. Chemcolox 200

72. Versene 67

73. Perma Kleer 100

74. Perma-kleer 100

75. Ethylene Diamine Tetra Acetic Acid Tetra Sodium Salt

76. Nullapon Bf-12

77. Nullapon Bf-78

78. Warkeelate Ps-42

79. Warkeelate Ps-43

80. Warkeelate Ps-47

81. Clewat S 2

82. Edathanil Tetrasodium

83. Buffer Concentrate, Ph 7.00

84. Nullapon Bfc Liquid

85. Cheelox Bf-12

86. Cheelox Bf-13

87. Cheelox Bf-78

88. Cheelox Br-33

89. Chelest 400

90. Kemplex 100

91. Perma-kleer Tetra Cp

92. Sodium (edetate De)

93. Perma Kleer Tetra Cp

94. Chelon 100

95. Hamp-ene 100s

96. Caswell No. 846

97. Glycine, N,n'-1,2-ethanediylbis(n-(carboxymethyl)-, Tetrasodium Salt

98. Hamp-ene 100

99. Hamp-ene 215

100. Hamp-ene 220

101. Tetracemate Tetrasodium

102. Tetrasodium Salt Edta

103. Chemcolox 240 Powder

104. Tetrasodium Ethylenediaminetetraacetate Trihydrate

105. Nullapon Bfc Xonc Beads

106. Perma Kleer 50 Crystals

107. Ethylenediaminetetraaceticacidtetrasodiumsalt

108. Versene Powder Tetra Sodium

109. Edetic Acid Tetrasodium Salt

110. Ccris 6797

111. Glycine, N,n'-1,2-ethanediylbis[n-(carboxymethyl)-, Tetrasodium Salt

112. Hsdb 5003

113. 8013-51-2

114. Einecs 200-573-9

115. Tetrasodium Ethylenediaminetetracetate

116. Sodium Ethylenediaminetetraacetic Acid

117. Epa Pesticide Chemical Code 039107

118. Unii-mp1j8420lu

119. Edta Tetrasodium Salt Hydrate

120. Ethylenediamine Tetraacetic Acid Tetrasodium Salt

121. Tetrasodium (ethylenedinitrilo)tetraacetate

122. Ai3-17182

123. Ethylene Diamine Tetraacetic Acid Sodium Salt

124. Tetranatrium Ethylendiamintetraacetat [czech]

125. Sodium Salt Of Ethylenediaminetetraacetic Acid

126. Tetrasodium Ethylenediaminetetraacetate Hydrate

127. Tetrasodium;2-[2-[bis(carboxylatomethyl)amino]ethyl-(carboxylatomethyl)amino]acetate

128. Edetate Tetrasodium

129. Ethylenebis(iminodiacetic Acid) Tetrasodium Salt

130. Ethylenediaminetetraacetic Acid, Tetrasodium Salt

131. Tetrasodium Salt Of Edta Solution

132. Tetrasodium Salt Of Ethylenediaminetetracetic Acid

133. N,n'-ethylenediaminediacetic Acid Tetrasodium Salt

134. Tetranatrium Ethylendiamintetraacetat

135. (ethylenedinitrilo)tetraacetic Acid Tetrasodium Salt

136. Tetrasodium Ethylenediamine-n,n,n',n'-tetraacetate

137. Tetrasodium(ethylenedinitrilo)tetraacetate

138. Edta 4na

139. Edetate [vandf]

140. 7379-28-4

141. N,n'-1,2-ethanediylbis(n-(carboxymethyl)glycine) Tetrasodium Salt

142. Ec 200-573-9

143. Edetate Sodium [ii]

144. Edetate Sodium [hsdb]

145. Edetate Sodium [vandf]

146. Tetrasodium Edta [inci]

147. Acetic Acid, (ethylenedinitrilo)tetra-, Tetrasodium Salt

148. Chembl2104344

149. Dtxsid3026350

150. Edta Tetrasodium [vandf]

151. Ethylenediaminetetraacetic Acid, Tetrasodium Salt Solution

152. Sodium Edetate [who-dd]

153. Edta Tetrasodium Salt [mi]

154. Sodium Edetate [green Book]

155. Tetrasodium Edetate [mart.]

156. Glycine, N,n'-1,2-ethanediylbis(n-carboxymethyl-, Tetrasodium Salt

157. Mfcd00012460

158. N,n'-1,2-ethanediylbis(n-(carboxymethyl)glycine), Tetrasodium Salt

159. Akos015960370

160. Tetrasodium Edta Tetrahydrate, Powder

161. Db13404

162. Ac-10617

163. E0099

164. E0565

165. Ft-0626315

166. Sodium Salt Of Ethylenediamine Tetracetic Acid

167. D03946

168. E75734

169. Ethylenediaminetetraacetic Acid Tetra Sodium Salt

170. A834617

171. Acetic Acid, (ethylenedinitrilo)tetra-, Sodium Salt

172. J-006165

173. J-521350

174. Q27284152

175. Ethylenediamine Tetraacetic Acid Tetrasodiumsalt, 86-88%

176. Edta, Tetrasodium Tetrahydrate Salt - Cas 13235-36-4

177. Tetrasodium 2,2',2'',2'''-(ethane-1,2-diyldinitrilo)tetraacetate

178. Tetrasodium 2-[2-[bis(carboxylatomethyl)amino]ethyl-(carboxylatomethyl)amino]acetate

179. Tetrasodium 2-[2-[bis(2-oxidanidyl-2-oxidanylidene-ethyl)amino]ethyl-(2-oxidanidyl-2-oxidanylidene-ethyl)amino]ethanoate

2.4 Create Date

2005-08-08

3 Chemical and Physical Properties

Molecular Formula	C₁₀H₁₂N₂Na₄O₈
Molecular Weight	380.17 g/mol
Hydrogen Bond Donor Count	0
Hydrogen Bond Acceptor Count	10
Rotatable Bond Count	7
Exact Mass	380.01844247 g/mol
Monoisotopic Mass	380.01844247 g/mol
Topological Polar Surface Area	167 Å²
Heavy Atom Count	24
Formal Charge	0
Complexity	293
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently Bonded Unit Count	5

4 Drug and Medication Information

4.1 Therapeutic Uses

Tetrasodium edetate used in dust as sequestering agent should not be applied to eye unless first neutralized, because it forms solution sufficiently alkaline to be injurious to eye.

Grant, W.M. Toxicology of the Eye. 3rd ed. Springfield, IL: Charles C. Thomas Publisher, 1986., p. 390

/Investigators/ examined the efficacy of tetrasodium EDTA in eradicating biofilms derived from salivary inocula or pure cultures of Candida albicans on discs of polymethyl methacrylate (PMMA) denture base or on toothbrushes that had been used normally for 4-8 weeks. Its efficiency in virus neutralization was also determined. Overnight (16 hr) treatment with 4% (w/v) tetrasodium EDTA solution reduced salivary and C. albicans biofilm viable counts by > or =99%. Biofilm removal was confirmed using confocal laser scanning microscopy. Presence/absence of sucrose during biofilm formation had no effect on killing efficacy. Prolonged treatment of PMMA with tetrasodium EDTA did not influence subsequent formation of C. albicans biofilms or affect surface roughness of the PMMA, but it reduced subsequent biofilm formation from a salivary inoculum. Infectivities of herpes simplex virus and polio virus suspensions were reduced by >99.99% by treatment for 1 and 2 hr, respectively. Tetrasodium EDTA solution efficiently disinfected toothbrushes and PMMA discs, with the detachment of biofilms, and rapidly neutralized both nonenveloped and enveloped viruses. Dentures and toothbrushes become contaminated by bacterial biofilms and by viruses. There is a need for disinfection methods that are rapidly effective, cost-effective, nontoxic and easily implemented. These studies indicate that tetrasodium EDTA solution has disinfection applications in the oral care field.

PMID:18045435 Devine DA et al; J Appl Microbiol 103 (6): 2516-24 (2007)

Central venous catheter (CVC)-related bloodstream infections (BSIs) are known to increase rates of morbidity and mortality in both inpatients and outpatients, including hematology-oncology patients and those undergoing hemodialysis or home infusion therapy. Biofilm-associated organisms on the lumens of these catheters have reduced susceptibility to antimicrobial chemotherapy. This study tested the efficacy of tetrasodium EDTA as a catheter lock solution on biofilms of several clinically relevant microorganisms. Biofilms of Staphylococcus epidermidis, methicillin-resistant S. aureus, Pseudomonas aeruginosa, Escherichia coli, Klebsiella pneumoniae, and Candida albicans were grown to levels of approximately 1 x 10+5 colony-forming units (CFU) cm(-1) on CVC segments in a model system, then subjected to the tetrasodium EDTA lock treatment. Comparisons of biofilms before and after exposure to the 40-mg mL(-1) tetrasodium EDTA lock for 21 hours showed that the biofilm viable cell counts of all organisms tested were significantly reduced (P < 0.05) after exposure to the treatment. Antimicrobial lock treatment using 40 mg mL(-1) of tetrasodium EDTA for at least 21 hours could significantly reduce or potentially eradicate CVC-associated biofilms of clinically relevant microorganisms.

PMID:16018425 Percival SL et al; Infect Control Hosp Epidemiol 26 (6): 515-9 (2005)

Exptl use: trilon b had significant therapeutic effect when injected iv at 50 mg/kg into rabbits and 150-175 mg/kg ip into mice poisoned with lithium chloride.

Samilov N et al; BYULL EKSP-BIOL MED 74 (8): 46 (1972)

...Tetrasodium edta is effective for treating lime burns of cornea and /as chelating agent/ for treating hypercalcemia patients by removing blood calcium.

Luckey, T.D. and B. Venugopal. Metal Toxicity in Mammals, 1. New York: Plenum Press, 1977., p. 119

5 Pharmacology and Biochemistry

5.1 ATC Code

S - Sensory organs

S01 - Ophthalmologicals

S01X - Other ophthalmologicals

S01XA - Other ophthalmologicals

S01XA05 - Sodium edetate

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