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Edrophonium Chloride

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1 NDC API
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17 FDF Dossiers, 9 FDA Orange Book, 8 Listed Dossiers

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Synopsis

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Chemistry

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Also known as: 116-38-1, N-ethyl-3-hydroxy-n,n-dimethylbenzenaminium chloride, Antirex, Tensilon chloride, Reversol, Enlon

Molecular Formula

C₁₀H₁₆ClNO

Molecular Weight

201.69 g/mol

InChI Key

BXKDSDJJOVIHMX-UHFFFAOYSA-N

FDA UNII

QO611KSM5P

A rapid-onset, short-acting cholinesterase inhibitor used in cardiac arrhythmias and in the diagnosis of myasthenia gravis. It has also been used as an antidote to curare principles.

1 2D Structure

Edrophonium Chloride

2 Identification

2.1 Computed Descriptors

2.1.1 IUPAC Name

ethyl-(3-hydroxyphenyl)-dimethylazanium;chloride

2.1.2 InChI

InChI=1S/C10H15NO.ClH/c1-4-11(2,3)9-6-5-7-10(12)8-9;/h5-8H,4H2,1-3H3;1H

2.1.3 InChI Key

BXKDSDJJOVIHMX-UHFFFAOYSA-N

2.1.4 Canonical SMILES

CC[N+](C)(C)C1=CC(=CC=C1)O.[Cl-]

2.2 Other Identifiers

2.2.1 UNII

QO611KSM5P

2.3 Synonyms

2.3.1 MeSH Synonyms

1. Bromide, Edrophonium

2. Chloride, Edrophonium

3. Edrophonium

4. Edrophonium Bromide

5. Edroponium

6. Tensilon

2.3.2 Depositor-Supplied Synonyms

1. 116-38-1

2. N-ethyl-3-hydroxy-n,n-dimethylbenzenaminium Chloride

3. Antirex

4. Tensilon Chloride

5. Reversol

6. Enlon

7. Edrophonii Chloridum

8. Ethyl(m-hydroxyphenyl)dimethylammonium Chloride

9. Cloruro De Edrofonio

10. Chlorure D'edrophonium

11. Edrophonium (chloride)

12. Benzenaminium, N-ethyl-3-hydroxy-n,n-dimethyl-, Chloride

13. N-ethyl-3-hydroxy-n,n-dimethylanilinium Chloride

14. Nsc-759577

15. Qo611ksm5p

16. Mls000028677

17. Chebi:4759

18. Ethyl-(3-hydroxyphenyl)-dimethylazanium;chloride

19. Edrophone Chloride

20. Smr000058672

21. Dsstox_cid_2978

22. (3-hydroxyphenyl)dimethylethylammonium Chloride

23. Dsstox_rid_76815

24. 3-hydroxy-n,n-dimethyl-n-ethylanilinium Chloride

25. Dsstox_gsid_22978

26. Edrofonio Cloruro

27. Edrofonio Cloruro [dcit]

28. Tensilon Preservative Free

29. Edrophonii Chloridum [inn-latin]

30. Sr-01000000275

31. Ncgc00015409-02

32. Cas-116-38-1

33. Cloruro De Edrofonio [inn-spanish]

34. Einecs 204-138-4

35. Chlorure D'edrophonium [inn-french]

36. Edrophonium Chloride Preservative Free

37. Unii-qo611ksm5p

38. Tensilon (tn)

39. Prestwick_192

40. Ammonium, Dimethylethyl(m-hydroxyphenyl)-, Chloride

41. Enlon (tn)

42. Edrophonium Chloride [usp:inn:ban:jan]

43. Edrophoniumchloride

44. Opera_id_1421

45. Chembl1128

46. Schembl34789

47. Mls001074086

48. Spectrum2300219

49. Dtxsid1022978

50. Hms502i11

51. Ammonium, Ethyl(m-hydroxyphenyl)dimethyl-, Chloride

52. Edrophonium Chloride [mi]

53. Edrophonium Chloride [inn]

54. Edrophonium Chloride [jan]

55. Hms1568a08

56. Hms1922j20

57. Hms2093n16

58. Hms2095a08

59. Hms2233g08

60. Hms3259e12

61. Hms3261h03

62. Hms3369m15

63. Hms3712a08

64. Hms3886d07

65. Pharmakon1600-02300219

66. Benzenaminium, N-ethyl-3-hydroxy-n,n-dimethyl-, Chloride (1:1)

67. Hy-b0882

68. Edrophonium Chloride [vandf]

69. Tox21_110138

70. Tox21_500511

71. Ccg-39644

72. Edrophonium Chloride [mart.]

73. Mfcd00055064

74. Nsc759577

75. Edrophonium Chloride [usp-rs]

76. Edrophonium Chloride [who-dd]

77. Edrophonium Chloride [who-ip]

78. Akos015890417

79. Tox21_110138_1

80. Cs-4337

81. Ds-0552

82. Edrophonium Chloride (jp17/usp/inn)

83. Lp00511

84. Nc00561

85. Nsc 759577

86. Ncgc00015409-11

87. Ncgc00093908-01

88. Ncgc00093908-02

89. Ncgc00093908-03

90. Ncgc00093908-04

91. Ncgc00093908-05

92. Ncgc00261196-01

93. Edrophonium Chloride [orange Book]

94. Edrophonium Chloride [ep Monograph]

95. Edrophonii Chloridum [who-ip Latin]

96. Edrophonium Chloride [usp Monograph]

97. Eu-0100511

98. Ft-0657849

99. D00994

100. E 3256

101. Enlon-plus Component Edrophonium Chloride

102. Ethyl-(3-hydroxyphenyl)-dimethylammonium Chloride

103. A803607

104. Ethyl-(3-hydroxyphenyl)-dimethyl-azanium Chloride

105. Edrophonium Chloride Component Of Enlon-plus

106. J-003433

107. Sr-01000000275-2

108. Sr-01000000275-4

109. Sr-01000000275-6

110. N-ethyl-3-hydroxy-n,n-dimethyl-benzenaminium Chloride

111. Q27068168

112. Edrophonium Chloride, Europepharmacopoeia (ep) Reference Standard

113. Edrophonium Chloride, United States Pharmacopeia (usp) Reference Standard

2.4 Create Date

2005-03-27

3 Chemical and Physical Properties

Molecular Formula	C₁₀H₁₆ClNO
Molecular Weight	201.69 g/mol
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	2
Rotatable Bond Count	2
Exact Mass	201.0920418 g/mol
Monoisotopic Mass	201.0920418 g/mol
Topological Polar Surface Area	20.2 Å²
Heavy Atom Count	13
Formal Charge	0
Complexity	145
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently Bonded Unit Count	2

4 Drug and Medication Information

4.1 Drug Information

1 of 2
Drug Name	Tensilon preservative free
Active Ingredient	Edrophonium chloride
Dosage Form	Injectable
Route	Injection
Strength	10mg/ml
Market Status	Prescription
Company	Valeant Pharms

2 of 2
Drug Name	Tensilon preservative free
Active Ingredient	Edrophonium chloride
Dosage Form	Injectable
Route	Injection
Strength	10mg/ml
Market Status	Prescription
Company	Valeant Pharms

5 Pharmacology and Biochemistry

5.1 MeSH Pharmacological Classification

Cholinesterase Inhibitors

Drugs that inhibit cholinesterases. The neurotransmitter ACETYLCHOLINE is rapidly hydrolyzed, and thereby inactivated, by cholinesterases. When cholinesterases are inhibited, the action of endogenously released acetylcholine at cholinergic synapses is potentiated. Cholinesterase inhibitors are widely used clinically for their potentiation of cholinergic inputs to the gastrointestinal tract and urinary bladder, the eye, and skeletal muscles; they are also used for their effects on the heart and the central nervous system. (See all compounds classified as Cholinesterase Inhibitors.)

Antidotes

Agents counteracting or neutralizing the action of POISONS. (See all compounds classified as Antidotes.)

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