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    Chemistry

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    Also known as: 99300-78-4, Venlafaxine hcl, Effexor, Efexor, Effexor xr, Dobupal
    Molecular Formula
    C17H28ClNO2
    Molecular Weight
    313.9  g/mol
    InChI Key
    QYRYFNHXARDNFZ-UHFFFAOYSA-N
    FDA UNII
    7D7RX5A8MO
    Venlafaxine Hydrochloride
    A cyclohexanol and phenylethylamine derivative that functions as a SEROTONIN AND NORADRENALINE REUPTAKE INHIBITOR (SNRI) and is used as an ANTIDEPRESSIVE AGENT.
    1 2D Structure

    Venlafaxine Hydrochloride

    2 Identification
    2.1 Computed Descriptors
    2.1.1 IUPAC Name
    1-[2-(dimethylamino)-1-(4-methoxyphenyl)ethyl]cyclohexan-1-ol;hydrochloride
    2.1.2 InChI
    InChI=1S/C17H27NO2.ClH/c1-18(2)13-16(17(19)11-5-4-6-12-17)14-7-9-15(20-3)10-8-14;/h7-10,16,19H,4-6,11-13H2,1-3H3;1H
    2.1.3 InChI Key
    QYRYFNHXARDNFZ-UHFFFAOYSA-N
    2.1.4 Canonical SMILES
    CN(C)CC(C1=CC=C(C=C1)OC)C2(CCCCC2)O.Cl
    2.2 Other Identifiers
    2.2.1 UNII
    7D7RX5A8MO
    2.3 Synonyms
    2.3.1 MeSH Synonyms

    1. 1-(2-(dimethylamino)-1-(4-methoxyphenyl)ethyl)cyclohexanol Hcl

    2. Cyclohexanol, 1-(2-(dimethylamino)-1-(4-methoxyphenyl)ethyl)-, Hydrochloride

    3. Dobupal

    4. Efexor

    5. Effexor

    6. Hydrochloride, Venlafaxine

    7. Sila Venlafaxine

    8. Sila-venlafaxine

    9. Trevilor

    10. Vandral

    11. Venlafaxine

    12. Wy 45,030

    13. Wy 45030

    14. Wy-45,030

    15. Wy-45030

    16. Wy45,030

    17. Wy45030

    2.3.2 Depositor-Supplied Synonyms

    1. 99300-78-4

    2. Venlafaxine Hcl

    3. Effexor

    4. Efexor

    5. Effexor Xr

    6. Dobupal

    7. Vandral

    8. Venlafaxinehydrochloride

    9. Wy-45030

    10. Venlafaxine (hydrochloride)

    11. Wy 45030

    12. Wy-45,030

    13. Wy 45030 Hydrochloride

    14. 1-(2-(dimethylamino)-1-(4-methoxyphenyl)ethyl)cyclohexanol Hydrochloride

    15. 1-[2-(dimethylamino)-1-(4-methoxyphenyl)ethyl]cyclohexanol Hydrochloride

    16. Nsc-745751

    17. 7d7rx5a8mo

    18. Venlafaxine (as Hydrochloride)

    19. 1-[2-(dimethylamino)-1-(4-methoxyphenyl)ethyl]cyclohexan-1-ol Hydrochloride

    20. Cyclohexanol, 1-(2-(dimethylamino)-1-(4-methoxyphenyl)ethyl)-, Hydrochloride

    21. 1-(2-(dimethylamino)-1-(4-methoxyphenyl)ethyl)cyclohexan-1-ol Hydrochloride

    22. 1-[2-(dimethylamino)-1-(4-methoxyphenyl)ethyl]cyclohexan-1-ol;hydrochloride

    23. Chebi:9944

    24. Venlafaxine Hydrochloride [usan]

    25. Venlafaxine Hydorchloride

    26. Unii-7d7rx5a8mo

    27. C17h27no2.hcl

    28. Venlift

    29. Vexor

    30. D,l-venlafaxine, Hydrochloride

    31. Venlafaxine Ea

    32. Venlafaxine Xr

    33. Effexor Lp

    34. Effexor Xl

    35. Efexor Xl

    36. Venlafaxine, Hcl

    37. Effexor (tn)

    38. Venlafaxine Hydrochloride [usan:usp]

    39. Venlafaxine Hydro Chloride

    40. Dsstox_cid_27397

    41. Dsstox_rid_82318

    42. Dsstox_gsid_47397

    43. Schembl41936

    44. Mls001401454

    45. Chembl1201066

    46. Dtxsid8047397

    47. Hy-b0196a

    48. Bvf-012

    49. Amy32694

    50. Bcp21401

    51. Dl-venlafaxine Hydrochloride- Bio-x

    52. Tox21_302508

    53. Tox21_500449

    54. Nsc745751

    55. S1441

    56. Venlafaxine Hydrochloride (jan/usp)

    57. Venlafaxine Hydrochloride [mi]

    58. Akos000280874

    59. Akos016340594

    60. Ac-1696

    61. Ccg-100979

    62. Ccg-213270

    63. H13v695

    64. Ks-5049

    65. Lp00449

    66. Nc00229

    67. Nsc 745751

    68. Pw-4112

    69. Venlafaxine Hydrochloride [jan]

    70. Venlafaxine Hydrochloride [hsdb]

    71. Ncgc00256703-01

    72. Ncgc00261134-01

    73. Venlafaxine Hydrochloride [mart.]

    74. Venlafaxine Hydrochloride [vandf]

    75. Bv164514

    76. Smr000469154

    77. Venlafaxine Hydrochloride [usp-rs]

    78. Venlafaxine Hydrochloride [who-dd]

    79. Cas-99300-78-4

    80. Ft-0642395

    81. Sw197609-3

    82. V0110

    83. Pf-00345408

    84. D00821

    85. Venlafaxine Hydrochloride [ep Impurity]

    86. Venlafaxine Hydrochloride [ep Monograph]

    87. Venlafaxine Hydrochloride [orange Book]

    88. Venlafaxine Hydrochloride [usp Monograph]

    89. A845995

    90. Venlafaxine Hydrochloride, >=98% (hplc), Powder

    91. Venlafaxine Hydrochloride 100 Microg/ml In Methanol

    92. Q27108525

    93. Venlafaxine Hydrochloride 100 Microg/ml In Acetonitrile

    94. 1-[2-dimethylamino-1-(4-methoxyphenyl)ethyl]cyclohexanol -hcl

    95. Venlafaxine Hydrochloride 1.0 Mg/ml In Methanol (as Free Base)

    96. 1-[2-(dimethylamino)-1-(4-methoxyph Enyl)ethyl]cyclohexanol Hydrochloride

    97. 1-[2-dimethylamino-1-(4-methoxy-phenyl)-ethyl]-cyclohexanol Hydrochloride

    98. Venlafaxine Hydrochloride, European Pharmacopoeia (ep) Reference Standard

    99. (+/-)-1-(.alpha.-((dimethylamino)methyl)-p-methoxybenzyl)cyclohexanol Hydrochloride

    100. (rs)-1-(2-dimethylamino-1-(4-methoxyphenyl)ethyl)cyclohexanol Hydrochloride

    101. 1-[2-(dimethylamino)-1-(4-methoxyphenyl)ethyl]-1-cyclohexanol Hydrochloride

    102. Cyclohexanol, 1-[2-(dimethylamino)-1-(4-methoxyphenyl)ethyl]-, Hydrochloride (1:1

    103. Venlafaxine For System Suitability, European Pharmacopoeia (ep) Reference Standard

    104. Venlafaxine Hydrochloride, Pharmaceutical Secondary Standard; Certified Reference Material

    105. Venlafaxine Hydrochloride, United States Pharmacopeia (usp) Reference Standard

    106. Venlafaxine Hydrochloride Solution, 1.0 Mg/ml In Methanol (as Free Base), Ampule Of 1 Ml, Certified Reference Material

    2.4 Create Date
    2005-06-24
    3 Chemical and Physical Properties
    Molecular Weight 313.9 g/mol
    Molecular Formula C17H28ClNO2
    Hydrogen Bond Donor Count2
    Hydrogen Bond Acceptor Count3
    Rotatable Bond Count5
    Exact Mass313.1808568 g/mol
    Monoisotopic Mass313.1808568 g/mol
    Topological Polar Surface Area32.7 Ų
    Heavy Atom Count21
    Formal Charge0
    Complexity279
    Isotope Atom Count0
    Defined Atom Stereocenter Count0
    Undefined Atom Stereocenter Count1
    Defined Bond Stereocenter Count0
    Undefined Bond Stereocenter Count0
    Covalently Bonded Unit Count2
    4 Drug and Medication Information
    4.1 Drug Information
    1 of 4  
    Drug NameEffexor xr
    Drug LabelEffexor XR is an extended-release capsule for oral administration that contains venlafaxine hydrochloride, a structurally novel antidepressant. It is designated (R/S)-1-[2-(dimethylamino)-1-(4-methoxyphenyl)ethyl] cyclohexanol hydrochloride or ()-1...
    Active IngredientVenlafaxine hydrochloride
    Dosage FormCapsule, extended release
    RouteOral
    Strengtheq 150mg base; eq 37.5mg base; eq 75mg base
    Market StatusPrescription
    CompanyWyeth Pharms

    2 of 4  
    Drug NameVenlafaxine hydrochloride
    PubMed HealthVenlafaxine (By mouth)
    Drug ClassesAntidepressant
    Drug LabelVenlafaxine hydrochloride extended-release capsules for oral administration contain venlafaxine hydrochloride, a structurally novel antidepressant. It is designated (R/S)-1-[2-(dimethylamino)-1-(4-methoxyphenyl)ethyl] cyclohexanol hydrochloride or (c...
    Active IngredientVenlafaxine hydrochloride
    Dosage FormTablet, extended release; Tablet; Capsule, extended release
    Routeoral; Oral
    Strength37.5mg; eq 100mg base; eq 225mg base; eq 50mg base; 150mg; eq 150mg base; eq 75mg base; 75mg; eq 25mg base; eq 37.5mg base
    Market StatusTentative Approval; Prescription
    CompanyAmneal Pharms; Wockhardt; Anchen Pharms; Teva; Alembic Pharms; Aurobindo Pharma; Sun Pharm Inds; Torrent Pharms; Osmotica Pharm; Sun Pharma Global; Vintage; Valeant Bermuda; Zydus Pharms Usa; Dr Reddys Labs; Orchid Hlthcare; Mylan; Impax Labs; Heritage Ph

    3 of 4  
    Drug NameEffexor xr
    Drug LabelEffexor XR is an extended-release capsule for oral administration that contains venlafaxine hydrochloride, a structurally novel antidepressant. It is designated (R/S)-1-[2-(dimethylamino)-1-(4-methoxyphenyl)ethyl] cyclohexanol hydrochloride or ()-1...
    Active IngredientVenlafaxine hydrochloride
    Dosage FormCapsule, extended release
    RouteOral
    Strengtheq 150mg base; eq 37.5mg base; eq 75mg base
    Market StatusPrescription
    CompanyWyeth Pharms

    4 of 4  
    Drug NameVenlafaxine hydrochloride
    PubMed HealthVenlafaxine (By mouth)
    Drug ClassesAntidepressant
    Drug LabelVenlafaxine hydrochloride extended-release capsules for oral administration contain venlafaxine hydrochloride, a structurally novel antidepressant. It is designated (R/S)-1-[2-(dimethylamino)-1-(4-methoxyphenyl)ethyl] cyclohexanol hydrochloride or (c...
    Active IngredientVenlafaxine hydrochloride
    Dosage FormTablet, extended release; Tablet; Capsule, extended release
    Routeoral; Oral
    Strength37.5mg; eq 100mg base; eq 225mg base; eq 50mg base; 150mg; eq 150mg base; eq 75mg base; 75mg; eq 25mg base; eq 37.5mg base
    Market StatusTentative Approval; Prescription
    CompanyAmneal Pharms; Wockhardt; Anchen Pharms; Teva; Alembic Pharms; Aurobindo Pharma; Sun Pharm Inds; Torrent Pharms; Osmotica Pharm; Sun Pharma Global; Vintage; Valeant Bermuda; Zydus Pharms Usa; Dr Reddys Labs; Orchid Hlthcare; Mylan; Impax Labs; Heritage Ph

    5 Pharmacology and Biochemistry
    5.1 MeSH Pharmacological Classification

    Antidepressive Agents, Second-Generation

    A structurally and mechanistically diverse group of drugs that are not tricyclics or monoamine oxidase inhibitors. The most clinically important appear to act selectively on serotonergic systems, especially by inhibiting serotonin reuptake. (See all compounds classified as Antidepressive Agents, Second-Generation.)

    Serotonin and Noradrenaline Reuptake Inhibitors

    Drugs that selectively block or suppress the plasma membrane transport of SEROTONIN and NORADRENALINE into axon terminals and are used as ANTIDEPRESSIVE AGENTS. (See all compounds classified as Serotonin and Noradrenaline Reuptake Inhibitors.)

    5.2 FDA Pharmacological Classification
    5.2.1 Pharmacological Classes
    Serotonin Uptake Inhibitors [MoA]; Serotonin and Norepinephrine Reuptake Inhibitor [EPC]; Norepinephrine Uptake Inhibitors [MoA]

    API Reference Price

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PHARMALABS","customerCountry":"INDIA","quantity":"445.77","actualQuantity":"445.77","unit":"KGS","unitRateFc":"79","totalValueFC":"35571.2","currency":"USD","unitRateINR":"6663.7","date":"11-Apr-2024","totalValueINR":"2970455.26","totalValueInUsd":"35571.2","indian_port":"Bombay Air","hs_no":"29221990","bill_no":"2977481","productDescription":"Re-Import","marketType":"REGULATED MARKET","country":"INDIA","selfForZScoreResived":"Pharma Grade","supplierPort":"MADRID","supplierAddress":"AVDA. MIRALCAMPO 7-POLIG.IND.DEMIRALCAMPO 19200 AZUQUECA DE HENARES-GUADALAJARA-SPAIN SPAIN","customerAddress":"2ND FLOOR, GODOWN No. 204"}]
    04-Jan-2021
    30-Sep-2024
    KGS
    overview
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    Average Price (USD/KGS)

    Number of Transactions

    Total Quantity (KGS)

    Total Value (USD)

    Quantity (KGS) & Unit rate (USD/KGS) over time

    API Imports and Exports

    Importing Country Total Quantity
    (KGS)    		 Average Price
    (USD/KGS)    		 Number of Transactions

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    DOSAGE - TABLET, EXTENDED RELEASE;ORAL - EQ 1...DOSAGE - TABLET, EXTENDED RELEASE;ORAL - EQ 150MG BASE

    USFDA APPLICATION NUMBER - 22104

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    DOSAGE - TABLET, EXTENDED RELEASE;ORAL - EQ 2...DOSAGE - TABLET, EXTENDED RELEASE;ORAL - EQ 225MG BASE

    USFDA APPLICATION NUMBER - 22104

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    DOSAGE - TABLET, EXTENDED RELEASE;ORAL - EQ 3...DOSAGE - TABLET, EXTENDED RELEASE;ORAL - EQ 37.5MG BASE

    USFDA APPLICATION NUMBER - 22104

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    DOSAGE - TABLET, EXTENDED RELEASE;ORAL - EQ 7...DOSAGE - TABLET, EXTENDED RELEASE;ORAL - EQ 75MG BASE

    USFDA APPLICATION NUMBER - 22104

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