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Polfa Tarchomin is a leading Polish pharmaceutical company with 200 year tradition in manufacture and sale of pharmaceutical products.

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ACTIVE PHARMA INGREDIENTS

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3 APIs

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3 APIs

Synopsis

ACTIVE PHARMA INGREDIENTS

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Chemistry

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Also known as: 111011-53-1, Efonidipine hcl, Efonidipine (hydrochloride), Nz 105, Nz-105 hydrochloride, Nz-105

Molecular Formula

C₃₄H₃₉ClN₃O₇P

Molecular Weight

668.1 g/mol

InChI Key

OXVTXPCIJDYQIS-UHFFFAOYSA-N

FDA UNII

3BR983K69O

1 2D Structure

Efonidipine Hydrochloride

2 Identification

2.1 Computed Descriptors

2.1.1 IUPAC Name

2-(N-benzylanilino)ethyl 5-(5,5-dimethyl-2-oxo-1,3,25-dioxaphosphinan-2-yl)-2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3-carboxylate;hydrochloride

2.1.2 InChI

InChI=1S/C34H38N3O7P.ClH/c1-24-30(33(38)42-19-18-36(28-15-9-6-10-16-28)21-26-12-7-5-8-13-26)31(27-14-11-17-29(20-27)37(39)40)32(25(2)35-24)45(41)43-22-34(3,4)23-44-45;/h5-17,20,31,35H,18-19,21-23H2,1-4H3;1H

2.1.3 InChI Key

OXVTXPCIJDYQIS-UHFFFAOYSA-N

2.1.4 Canonical SMILES

CC1=C(C(C(=C(N1)C)P2(=O)OCC(CO2)(C)C)C3=CC(=CC=C3)[N+](=O)[O-])C(=O)OCCN(CC4=CC=CC=C4)C5=CC=CC=C5.Cl

2.2 Other Identifiers

2.2.1 UNII

3BR983K69O

2.3 Synonyms

2.3.1 MeSH Synonyms

1. 5-(5,5-dimethyl-1,3,2-dioxaphosphorinan-2-yl)-1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3-pyridinecarboxylic Acid, 2-(phenyl(phenylmethyl)amino) Ethyl Ester, P-oxide, Hydrochloride

2. Efonidipine

3. Enfonidipine Hydrochloride

4. Nz 105

5. Nz-105

2.3.2 Depositor-Supplied Synonyms

1. 111011-53-1

2. Efonidipine Hcl

3. Efonidipine (hydrochloride)

4. Nz 105

5. Nz-105 Hydrochloride

6. Nz-105

7. 3br983k69o

8. 3-pyridinecarboxylic Acid, 5-(5,5-dimethyl-1,3,2-dioxaphosphorinan-2-yl)-1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-, 2-(phenyl(phenylmethyl)amino)ethyl Ester, P-oxide, Monohydrochloride

9. 2-(n-benzylanilino)ethyl 5-(5,5-dimethyl-2-oxo-1,3,2lambda5-dioxaphosphinan-2-yl)-2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3-carboxylate;hydrochloride

10. 3-pyridinecarboxylic Acid, 5-(5,5-dimethyl-2-oxido-1,3,2-dioxaphosphorinan-2-yl)-1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-, 2-(phenyl(phenylmethyl)amino)ethyl Ester, Monohydrochloride

11. Ccris 4065

12. Unii-3br983k69o

13. Efonidipine Hydrochloride [jan]

14. Schembl332377

15. Dtxsid20911942

16. Act06292

17. Bcp16454

18. Ex-a3999

19. Hy-12502b

20. Efonidipine Hydrochloride [mi]

21. Akos025294085

22. Cs-3624

23. Efonidipine Hydrochloride [mart.]

24. Ac-36442

25. Efonidipine Hydrochloride [who-dd]

26. A921491

27. J-002504

28. Q27257012

29. (+/-)-2-[benzyl(phenyl)amino]ethyl-1,4-dihydro-2,6-dimethyl-5-(5,5-dimethyl-2-oxo-1,3,2-dioxaphosphorinan-2-yl)-4-(3-nitrophenyl)-3-pyridinecarboxylate Hydrochloride

30. 2-(benzyl(phenyl)amino)ethyl 5-(5,5-dimethyl-2-oxido-1,3,2-dioxaphosphinan-2-yl)-2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3-carboxylate Hydrochloride

31. 2-(benzyl(phenyl)amino)ethyl5-(5,5-dimethyl-2-oxido-1,3,2-dioxaphosphinan-2-yl)-2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3-carboxylatehydrochloride

32. 2-(n-benzylanilino)ethyl (+/-)-1,4-dihydro-2,6-dimethyl-4-(m-nitrophenyl)-5-phosphononicotinate, Cyclic 2,2-dimethyltrimethylene Ester, Hydrochloride

33. 2-(n-benzylanilino)ethyl 5-(5,5-dimethyl-2-oxo-1,3,2$l^{5-dioxaphosphinan-2-yl)-2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3-carboxylate;hydrochloride

34. 2-[benzyl(phenyl)amino]ethyl 5-(5,5-dimethyl-2-oxo-1,3,2lambda~5~-dioxaphosphinan-2-yl)-2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3-carboxylate--hydrogen Chloride (1/1)

35. 3-pyridinecarboxylic Acid, 5-(5,5-dimethyl-2-oxido-1,3,2-dioxaphosphorinan-2-yl)-1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-, 2-(phenyl(phenylmethyl)amino)ethyl Ester, Hydrochloride (1:1)

2.4 Create Date

2005-06-24

3 Chemical and Physical Properties

Molecular Formula	C₃₄H₃₉ClN₃O₇P
Molecular Weight	668.1 g/mol
Hydrogen Bond Donor Count	2
Hydrogen Bond Acceptor Count	9
Rotatable Bond Count	10
Exact Mass	667.2214153 g/mol
Monoisotopic Mass	667.2214153 g/mol
Topological Polar Surface Area	123 Å²
Heavy Atom Count	46
Formal Charge	0
Complexity	1170
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	1
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently Bonded Unit Count	2

4 Pharmacology and Biochemistry

4.1 MeSH Pharmacological Classification

Antihypertensive Agents

Drugs used in the treatment of acute or chronic vascular HYPERTENSION regardless of pharmacological mechanism. Among the antihypertensive agents are DIURETICS; (especially DIURETICS, THIAZIDE); ADRENERGIC BETA-ANTAGONISTS; ADRENERGIC ALPHA-ANTAGONISTS; ANGIOTENSIN-CONVERTING ENZYME INHIBITORS; CALCIUM CHANNEL BLOCKERS; GANGLIONIC BLOCKERS; and VASODILATOR AGENTS. (See all compounds classified as Antihypertensive Agents.)

Calcium Channel Blockers

A class of drugs that act by selective inhibition of calcium influx through cellular membranes. (See all compounds classified as Calcium Channel Blockers.)

Diuretics

Agents that promote the excretion of urine through their effects on kidney function. (See all compounds classified as Diuretics.)

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ABOUT THIS PAGE

Efonidipine Hydrochloride Manufacturers

A Efonidipine Hydrochloride manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Efonidipine Hydrochloride, including repackagers and relabelers. The FDA regulates Efonidipine Hydrochloride manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Efonidipine Hydrochloride API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

click here to find a list of Efonidipine Hydrochloride manufacturers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PhamaCompass.

Efonidipine Hydrochloride Suppliers

A Efonidipine Hydrochloride supplier is an individual or a company that provides Efonidipine Hydrochloride active pharmaceutical ingredient (API) or Efonidipine Hydrochloride finished formulations upon request. The Efonidipine Hydrochloride suppliers may include Efonidipine Hydrochloride API manufacturers, exporters, distributors and traders.

click here to find a list of Efonidipine Hydrochloride suppliers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PharmaCompass.

Efonidipine Hydrochloride GMP

Efonidipine Hydrochloride Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

PharmaCompass offers a list of Efonidipine Hydrochloride GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Efonidipine Hydrochloride GMP manufacturer or Efonidipine Hydrochloride GMP API supplier for your needs.

Efonidipine Hydrochloride CoA

A Efonidipine Hydrochloride CoA (Certificate of Analysis) is a formal document that attests to Efonidipine Hydrochloride's compliance with Efonidipine Hydrochloride specifications and serves as a tool for batch-level quality control.

Efonidipine Hydrochloride CoA mostly includes findings from lab analyses of a specific batch. For each Efonidipine Hydrochloride CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

Efonidipine Hydrochloride may be tested according to a variety of international standards, such as European Pharmacopoeia (Efonidipine Hydrochloride EP), Efonidipine Hydrochloride JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Efonidipine Hydrochloride USP).

Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.