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Chemistry

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Also known as: Ipi-549, 1693758-51-8, Eganelisib [usan], Pi3k-gamma inhibitor ipi-549, Fof5155fmz, Ipi549
Molecular Formula
C30H24N8O2
Molecular Weight
528.6  g/mol
InChI Key
XUMALORDVCFWKV-IBGZPJMESA-N
FDA UNII
FOF5155FMZ

Eganelisib
Eganelisib is an orally bioavailable, highly selective small molecule inhibitor of the gamma isoform of phosphoinositide-3 kinase (PI3K-gamma) with potential immunomodulating and antineoplastic activities. Upon administration, eganelisib prevents the activation of the PI3K-gamma-mediated signaling pathways, which may lead to a reduction in cellular proliferation in PI3K-gamma-expressing tumor cells. In addition, this agent is able to modulate anti-tumor immune responses and inhibit tumor-mediated immunosuppression. Unlike other isoforms of PI3K, the gamma isoform is overexpressed in certain tumor cell types and immune cells; its expression increases tumor cell proliferation and survival. By selectively targeting the gamma isoform, PI3K signaling in normal, non-neoplastic cells is minimally or not affected, which results in a reduced side effect profile.
1 2D Structure

Eganelisib

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
2-amino-N-[(1S)-1-[8-[2-(1-methylpyrazol-4-yl)ethynyl]-1-oxo-2-phenylisoquinolin-3-yl]ethyl]pyrazolo[1,5-a]pyrimidine-3-carboxamide
2.1.2 InChI
InChI=1S/C30H24N8O2/c1-19(34-29(39)26-27(31)35-37-15-7-14-32-28(26)37)24-16-22-9-6-8-21(13-12-20-17-33-36(2)18-20)25(22)30(40)38(24)23-10-4-3-5-11-23/h3-11,14-19H,1-2H3,(H2,31,35)(H,34,39)/t19-/m0/s1
2.1.3 InChI Key
XUMALORDVCFWKV-IBGZPJMESA-N
2.1.4 Canonical SMILES
CC(C1=CC2=C(C(=CC=C2)C#CC3=CN(N=C3)C)C(=O)N1C4=CC=CC=C4)NC(=O)C5=C6N=CC=CN6N=C5N
2.1.5 Isomeric SMILES
C[C@@H](C1=CC2=C(C(=CC=C2)C#CC3=CN(N=C3)C)C(=O)N1C4=CC=CC=C4)NC(=O)C5=C6N=CC=CN6N=C5N
2.2 Other Identifiers
2.2.1 UNII
FOF5155FMZ
2.3 Synonyms
2.3.1 MeSH Synonyms

1. 2-amino-n-((1s)-1-(8-((1-methyl-1h-pyrazol-4-yl)ethynyl)-1-oxo-2-phenyl-1,2-dihydro-3-isoquinolinyl)ethyl)pyrazolo(1,5-a)pyrimidine-3-carboxamide

2. Ipi-549

2.3.2 Depositor-Supplied Synonyms

1. Ipi-549

2. 1693758-51-8

3. Eganelisib [usan]

4. Pi3k-gamma Inhibitor Ipi-549

5. Fof5155fmz

6. Ipi549

7. Chembl3984425

8. 2-amino-n-[(1s)-1-[8-[2-(1-methylpyrazol-4-yl)ethynyl]-1-oxo-2-phenylisoquinolin-3-yl]ethyl]pyrazolo[1,5-a]pyrimidine-3-carboxamide

9. (s)-2-amino-n-(1-(8-((1-methyl-1h-pyrazol-4-yl)ethynyl)-1-oxo-2-phenyl-1,2- Dihydroisoquinolin-3-yl)ethyl)pyrazolo(1,5-a)pyrimidine-3-carboxamide

10. 2-amino-n-[(1s)-1-{8-[(1-methyl-1h-pyrazol-4-yl)ethynyl]-1-oxo-2-phenyl-1,2-dihydroisoquinolin-3-yl}ethyl]pyrazolo[1,5-a]pyrimidine-3-carboxamide

11. Pyrazolo(1,5-a)pyrimidine-3-carboxamide, 2-amino-n-((1s)-1-(1,2-dihydro-8-(2-(1-methyl-1h-pyrazol-4-yl)ethynyl)-1-oxo-2-phenyl-3-isoquinolinyl)ethyl)-

12. Pyrazolo[1,5-a]pyrimidine-3-carboxamide, 2-amino-n-[(1s)-1-[1,2-dihydro-8-[2-(1-methyl-1h-pyrazol-4-yl)ethynyl]-1-oxo-2-phenyl-3-isoquinolinyl]ethyl]-

13. Eganelisib [inn]

14. Unii-fof5155fmz

15. Eganelisib [who-dd]

16. Gtpl9563

17. Schembl16629991

18. Dtxsid301336580

19. Ipi-549(ipi549)

20. Amy16733

21. Ex-a1057

22. V7y

23. Bdbm50192880

24. Mfcd30533720

25. Nsc795067

26. Nsc801002

27. S8330

28. Who 11571

29. Zinc584906867

30. Ccg-269905

31. Cs-6106

32. Nsc-795067

33. Nsc-801002

34. Compound 26 [pmid: 27660692]

35. Ac-29898

36. As-55938

37. Hy-100716

38. A16332

39. 2-amino-n-((1s)-1-(8-((1-methyl-1h-pyrazol-4-yl)ethynyl)-1-oxo-2-phenyl-1,2-dihydro-3-isoquinolinyl)ethyl)pyrazolo(1,5-a)pyrimidine-3-carboxamide

40. 2-amino-n-[(1s)-1-{8-[2-(1-methyl-1h-pyrazol-4-yl)ethynyl]-1-oxo-2-phenyl- 1,2-dihydroisoquinolin-3-yl}ethyl]pyrazolo[1,5-a]pyrimidine-3-carboxamide

2.4 Create Date
2015-10-12
3 Chemical and Physical Properties
Molecular Weight 528.6 g/mol
Molecular Formula C30H24N8O2
XLogP33.2
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count6
Rotatable Bond Count6
Exact Mass528.20222204 g/mol
Monoisotopic Mass528.20222204 g/mol
Topological Polar Surface Area123 Ų
Heavy Atom Count40
Formal Charge0
Complexity1060
Isotope Atom Count0
Defined Atom Stereocenter Count1
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count1

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ABOUT THIS PAGE

Eganelisib Manufacturers

A Eganelisib manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Eganelisib, including repackagers and relabelers. The FDA regulates Eganelisib manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Eganelisib API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

Eganelisib Suppliers

A Eganelisib supplier is an individual or a company that provides Eganelisib active pharmaceutical ingredient (API) or Eganelisib finished formulations upon request. The Eganelisib suppliers may include Eganelisib API manufacturers, exporters, distributors and traders.

Eganelisib GMP

Eganelisib Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

PharmaCompass offers a list of Eganelisib GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Eganelisib GMP manufacturer or Eganelisib GMP API supplier for your needs.

Eganelisib CoA

A Eganelisib CoA (Certificate of Analysis) is a formal document that attests to Eganelisib's compliance with Eganelisib specifications and serves as a tool for batch-level quality control.

Eganelisib CoA mostly includes findings from lab analyses of a specific batch. For each Eganelisib CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

Eganelisib may be tested according to a variety of international standards, such as European Pharmacopoeia (Eganelisib EP), Eganelisib JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Eganelisib USP).

Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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