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    Chemistry

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    Also known as: 177834-92-3, Eletriptan hbr, Relpax, Eletriptan hydrobromide [usan], Eletriptan (hydrobromide), (r)-3-((1-methylpyrrolidin-2-yl)methyl)-5-(2-(phenylsulfonyl)ethyl)-1h-indole hydrobromide
    Molecular Formula
    C22H27BrN2O2S
    Molecular Weight
    463.4  g/mol
    InChI Key
    UTINOWOSWSPFLJ-FSRHSHDFSA-N
    FDA UNII
    M41W832TA3
    Eletriptan Hydrobromide
    Eletriptan Hydrobromide is a triptan with specific affinity for the 5-hydroxytriptamine1B/1D receptor. Eletriptan hydrobromide binds to and acts at serotonin 5-HT1B receptors located on intracranial blood vessels which leads to vasoconstriction. This drug may also exerts its effects by binding to and activating 5-HT 1D receptors on sensory nerve endings in the trigeminal system, which results in the inhibition of pro-inflammatory neuropeptide release. Eletriptan hydrobromide is used to relieve pain or symptoms associated with migraine headaches.
    1 2D Structure

    Eletriptan Hydrobromide

    2 Identification
    2.1 Computed Descriptors
    2.1.1 IUPAC Name
    5-[2-(benzenesulfonyl)ethyl]-3-[[(2R)-1-methylpyrrolidin-2-yl]methyl]-1H-indole;hydrobromide
    2.1.2 InChI
    InChI=1S/C22H26N2O2S.BrH/c1-24-12-5-6-19(24)15-18-16-23-22-10-9-17(14-21(18)22)11-13-27(25,26)20-7-3-2-4-8-20;/h2-4,7-10,14,16,19,23H,5-6,11-13,15H2,1H3;1H/t19-;/m1./s1
    2.1.3 InChI Key
    UTINOWOSWSPFLJ-FSRHSHDFSA-N
    2.1.4 Canonical SMILES
    CN1CCCC1CC2=CNC3=C2C=C(C=C3)CCS(=O)(=O)C4=CC=CC=C4.Br
    2.1.5 Isomeric SMILES
    CN1CCC[C@@H]1CC2=CNC3=C2C=C(C=C3)CCS(=O)(=O)C4=CC=CC=C4.Br
    2.2 Other Identifiers
    2.2.1 UNII
    M41W832TA3
    2.3 Synonyms
    2.3.1 MeSH Synonyms

    1. (r)-3-((1-methyl-2-pyrrolidinyl)methyl)-5-(2-(phenylsulfonyl)ethyl)-1h-indole

    2. (r)-3-((1-methyl-2-pyrrolidinyl)methyl)-5-(2-(phenylsulfonyl)ethyl)-1h-indole Monohydrobromide

    3. 3-(1-methyl-2-pyrrolidinylmethyl)-5-(2-(phenylsulfonyl)ethyl)-1h-indole Hydrobromide

    4. Eletriptan

    5. Relpax

    6. Uk 166,044

    7. Uk 166044

    8. Uk-116,044-04

    9. Uk-116044-04

    10. Uk-166,044

    11. Uk-166044

    2.3.2 Depositor-Supplied Synonyms

    1. 177834-92-3

    2. Eletriptan Hbr

    3. Relpax

    4. Eletriptan Hydrobromide [usan]

    5. Eletriptan (hydrobromide)

    6. (r)-3-((1-methylpyrrolidin-2-yl)methyl)-5-(2-(phenylsulfonyl)ethyl)-1h-indole Hydrobromide

    7. Eletriptan Monohydrobromide

    8. Uk 116044-04

    9. Chebi:61176

    10. M41w832ta3

    11. Uk-116,044-04

    12. (r)-3-((1-methyl-2-pyrrolidinyl)methyl)-5-(2-(phenylsulfonyl)ethyl)-1h-indole Monohydrobromide

    13. 5-[2-(benzenesulfonyl)ethyl]-3-[[(2r)-1-methylpyrrolidin-2-yl]methyl]-1h-indole;hydrobromide

    14. Nsc-759258

    15. 3-(((r)-1-methyl-2-pyrrolidinyl)methyl)-5-(2-(phenylsulfonyl)ethyl)indole, Monohydrobromide

    16. 5-[2-(phenylsulfonyl)ethyl]-3-[(2r)-pyrrolidin-2-ylmethyl]-1h-indole Hydrobromide

    17. C22h26n2o2s.hbr

    18. Unii-m41w832ta3

    19. Relpax (tn)

    20. Schembl317370

    21. Chembl1201003

    22. Dtxsid001016113

    23. Hy-a0010

    24. Eletriptan Hydrobromide (jan/usan)

    25. Eletriptan Hydrobromide [mi]

    26. Tox21_500408

    27. Eletriptan Hydrobromide [jan]

    28. Mfcd08141806

    29. S3180

    30. Akos024262728

    31. Ac-3398

    32. Bcp9000640

    33. Ccg-221712

    34. Cs-0379

    35. Eletriptan Hydrobromide [mart.]

    36. Nsc 759258

    37. 3-[[(2r)-1-methyl-2-pyrrolidinyl]methyl]-5-[2-(phenylsulfonyl)ethyl]-1h-indole Hydrobromide

    38. Eletriptan Hydrobromide [usp-rs]

    39. Eletriptan Hydrobromide [who-dd]

    40. Ncgc00261093-01

    41. Bs-42146

    42. Eletriptan Hydrobromide, >=98% (hplc)

    43. Eletriptan Hydrobromide [orange Book]

    44. Sw220149-1

    45. D01973

    46. J-011323

    47. J-520433

    48. Q27130865

    49. 3-(n-methyl-2(r)-pyrrolidinyl Methyl)-5-[2-(phenyl Sulfonyl)ethyl]-1h-indole Hydrobromide

    50. 3-(n-methyl-2(r)-pyrrolidinylmethyl)-5-(2-phenylsulphonylethly)-1h-indole Hydrobromide

    51. 3-(n-methyl-2(r)-pyrrolidinylmethyl)-5-(2-phenylsulphonylethyl)-1h-indole Hydrobromide

    52. 3-(n-methyl-2(r)-pyrrolidinylmethyl)-5-[2-(phenyl Sulfonyl)ethyl]-1h-indole Hydrobromide

    53. 3-{[1-methylpyrrolidin-2(r)-yl]methyl}-5-(2-phenylsulphonylethyl)-1h-indole Hydrobromide

    54. (r)-3-[(1-methyl-2-pyrrolidinyl) Methyl]-5-[2-(phenylsulfonyl) Ethyl]-1h-indole Monohydrobromide

    55. 1h-indole, 3-(((2r)-1-methyl-2-pyrrolidinyl))methyl)-5-(2-(phenylsulfonyl)ethyl)-, Monohydrobromide

    56. 1h-indole, 3-[[(2r)-1-methyl-2-pyrrolidinyl]methyl]-5-[2-(phenylsulfonyl)ethyl]-, Hydrobromide (1:1)

    57. 3-[[(2r)-1-methyl-2-pyrrolidinyl]me Thyl]-5-[2-(phenylsulfonyl)ethyl]-1h-indole Hydrobromide

    58. 5-[2-(benzenesulfonyl)ethyl]-3-[[(2r)-1-methylpyrrolidin-2-yl]methyl]-1h-indol-1-ium;bromide

    2.4 Create Date
    2005-06-24
    3 Chemical and Physical Properties
    Molecular Weight 463.4 g/mol
    Molecular Formula C22H27BrN2O2S
    Hydrogen Bond Donor Count2
    Hydrogen Bond Acceptor Count3
    Rotatable Bond Count6
    Exact Mass462.09766 g/mol
    Monoisotopic Mass462.09766 g/mol
    Topological Polar Surface Area61.6 Ų
    Heavy Atom Count28
    Formal Charge0
    Complexity582
    Isotope Atom Count0
    Defined Atom Stereocenter Count1
    Undefined Atom Stereocenter Count0
    Defined Bond Stereocenter Count0
    Undefined Bond Stereocenter Count0
    Covalently Bonded Unit Count2
    4 Drug and Medication Information
    4.1 Drug Information
    1 of 2  
    Drug NameEletriptan hydrobromide
    Drug LabelRELPAX (eletriptan) Tablets contain eletriptan hydrobromide, which is a selective 5-hydroxytryptamine 1B/1D (5-HT1B/1D) receptor agonist. Eletriptan is chemically designated as (R)-3-[(1-Methyl-2-pyrrolidinyl)methyl]-5-[2-(phenylsulfonyl)ethyl]-1H-...
    Active IngredientEletriptan hydrobromide
    Dosage FormTablet
    Routeoral
    Strengtheq 40mg base; eq 20mg base; 40mg; 20mg
    Market StatusTentative Approval
    CompanyApotex; Teva Pharms Usa

    2 of 2  
    Drug NameEletriptan hydrobromide
    Drug LabelRELPAX (eletriptan) Tablets contain eletriptan hydrobromide, which is a selective 5-hydroxytryptamine 1B/1D (5-HT1B/1D) receptor agonist. Eletriptan is chemically designated as (R)-3-[(1-Methyl-2-pyrrolidinyl)methyl]-5-[2-(phenylsulfonyl)ethyl]-1H-...
    Active IngredientEletriptan hydrobromide
    Dosage FormTablet
    Routeoral
    Strengtheq 40mg base; eq 20mg base; 40mg; 20mg
    Market StatusTentative Approval
    CompanyApotex; Teva Pharms Usa

    5 Pharmacology and Biochemistry
    5.1 MeSH Pharmacological Classification

    Serotonin Receptor Agonists

    Endogenous compounds and drugs that bind to and activate SEROTONIN RECEPTORS. Many serotonin receptor agonists are used as ANTIDEPRESSANTS; ANXIOLYTICS; and in the treatment of MIGRAINE DISORDERS. (See all compounds classified as Serotonin Receptor Agonists.)

    5.2 FDA Pharmacological Classification
    5.2.1 Pharmacological Classes
    Serotonin 1d Receptor Agonists [MoA]; Serotonin-1b and Serotonin-1d Receptor Agonist [EPC]; Serotonin 1b Receptor Agonists [MoA]

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VAISHNODE","city":"AHMEDABAD","supplier":"F.I.S. FABBRICA ITALIANA SINTETICI","supplierCountry":"ITALY","foreign_port":"NA","customer":"ZYDUS LIFESCIENCES LIMITED","customerCountry":"INDIA","quantity":"15.00","actualQuantity":"15","unit":"KGS","unitRateFc":"6000","totalValueFC":"89684","currency":"USD","unitRateINR":"493800","date":"02-Feb-2023","totalValueINR":"7407000","totalValueInUsd":"89684","indian_port":"BOMBAY AIR","hs_no":"29339990","bill_no":"4451652","productDescription":"API","marketType":"REGULATED MARKET","country":"ITALY","selfForZScoreResived":"Pharma Grade","supplierPort":"NA","supplierAddress":"","customerAddress":"ZYDUS CORPORATE PARK, SCHEME NO 63, KHORAJ (GANDHINAGAR), NR. VAISHNODE"},{"dataSource":"API Import","activeIngredients":"","year":"2023","qtr":"Q1","strtotime":1678127400,"product":"ELETRIPTAN HYDROBROMIDE BETA FORM(USDMF GRADE)-09 DRUMS","address":"ZYDUS TOWER, SARKHEJ-GANDHINAGAR,H","city":"AHMEDABAD,GUJARAT","supplier":"M\/S.CHEMESS DWCLLC","supplierCountry":"ITALY","foreign_port":"N\/A","customer":"ZYDUS LIFESCIENCES LIMITED","customerCountry":"INDIA","quantity":"187.00","actualQuantity":"187","unit":"KGS","unitRateFc":"4944.6","totalValueFC":"938695.4","currency":"USD","unitRateINR":"412877.2","date":"07-Mar-2023","totalValueINR":"77208040","totalValueInUsd":"938695.4","indian_port":"Ahmedabad-ZIPL-SEZ","hs_no":"29339990","bill_no":"1000965","productDescription":"API","marketType":"REGULATED MARKET","country":"ITALY","selfForZScoreResived":"Pharma Grade","supplierPort":"N\/A","supplierAddress":"N\/A","customerAddress":"ZYDUS TOWER, SARKHEJ-GANDHINAGAR,H"},{"dataSource":"API Import","activeIngredients":"","year":"2023","qtr":"Q4","strtotime":1698949800,"product":"ELETRIPTAN HYDROBROMIDE-ELETRIPTAN HBR F-A ANH (ELE4) MM IH(UPLI)(FOR PHARMACEUTICAL. USE ONLY)","address":"564\/A\/22, ROAD NO.92","city":"HYDERABAD,ANDHRA PRADESH","supplier":"UPJOHN MANUFACTURING IRELAND UNLIMITED","supplierCountry":"IRELAND","foreign_port":"DUBLIN","customer":"VIATRIS","customerCountry":"INDIA","quantity":"158.91","actualQuantity":"158.91","unit":"KGS","unitRateFc":"5948.5","totalValueFC":"955259","currency":"USD","unitRateINR":"500568","date":"03-Nov-2023","totalValueINR":"79545253.94","totalValueInUsd":"955259","indian_port":"Bombay Air","hs_no":"29339990","bill_no":"8607476","productDescription":"API","marketType":"REGULATED MARKET","country":"IRELAND","selfForZScoreResived":"Pharma Grade","supplierPort":"DUBLIN","supplierAddress":"Company, Little Island, Cork, T45F627 Ireland.SDNF Ireland","customerAddress":"564\/A\/22, ROAD NO.92"},{"dataSource":"API Import","activeIngredients":"","year":"2023","qtr":"Q4","strtotime":1698949800,"product":"ELETRIPTAN HYDROBROMIDE-ELETRIPTAN HBR F-A ANH (ELE4) MM IH(UPLI)(FOR PHARMACEUTICAL. USE ONLY)","address":"564\/A\/22, ROAD NO.92","city":"HYDERABAD,ANDHRA PRADESH","supplier":"UPJOHN MANUFACTURING IRELAND UNLIMITED","supplierCountry":"IRELAND","foreign_port":"DUBLIN","customer":"VIATRIS","customerCountry":"INDIA","quantity":"397.94","actualQuantity":"397.94","unit":"KGS","unitRateFc":"5948.5","totalValueFC":"2392144.9","currency":"USD","unitRateINR":"500568","date":"03-Nov-2023","totalValueINR":"199196013.3","totalValueInUsd":"2392144.9","indian_port":"Bombay Air","hs_no":"29339990","bill_no":"8607476","productDescription":"API","marketType":"REGULATED MARKET","country":"IRELAND","selfForZScoreResived":"Pharma Grade","supplierPort":"DUBLIN","supplierAddress":"Company, Little Island, Cork, T45F627 Ireland.SDNF Ireland","customerAddress":"564\/A\/22, ROAD NO.92"}]
    28-Jan-2021
    11-Feb-2025
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    DOSAGE - TABLET;ORAL - EQ 20MG BASE

    USFDA APPLICATION NUMBER - 21016

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    ABOUT THIS PAGE

    Looking for 177834-92-3 / Eletriptan Hydrobromide API manufacturers, exporters & distributors?

    Eletriptan Hydrobromide manufacturers, exporters & distributors 1

    71

    PharmaCompass offers a list of Eletriptan Hydrobromide API manufacturers, exporters & distributors, which can be sorted by GMP, USDMF, JDMF, KDMF, CEP (COS), WC, Price,and more, enabling you to easily find the right Eletriptan Hydrobromide manufacturer or Eletriptan Hydrobromide supplier for your needs.

    Send us enquiries for free, and we will assist you in establishing a direct connection with your preferred Eletriptan Hydrobromide manufacturer or Eletriptan Hydrobromide supplier.

    PharmaCompass also assists you with knowing the Eletriptan Hydrobromide API Price utilized in the formulation of products. Eletriptan Hydrobromide API Price is not always fixed or binding as the Eletriptan Hydrobromide Price is obtained through a variety of data sources. The Eletriptan Hydrobromide Price can also vary due to multiple factors, including market conditions, regulatory modifications, or negotiated pricing deals.

    API | Excipient name

    Eletriptan Hydrobromide

    Synonyms

    177834-92-3, Eletriptan hbr, Relpax, Eletriptan hydrobromide [usan], Eletriptan (hydrobromide), (r)-3-((1-methylpyrrolidin-2-yl)methyl)-5-(2-(phenylsulfonyl)ethyl)-1h-indole hydrobromide

    Cas Number

    177834-92-3

    Unique Ingredient Identifier (UNII)

    M41W832TA3

    About Eletriptan Hydrobromide

    Eletriptan Hydrobromide is a triptan with specific affinity for the 5-hydroxytriptamine1B/1D receptor. Eletriptan hydrobromide binds to and acts at serotonin 5-HT1B receptors located on intracranial blood vessels which leads to vasoconstriction. This drug may also exerts its effects by binding to and activating 5-HT 1D receptors on sensory nerve endings in the trigeminal system, which results in the inhibition of pro-inflammatory neuropeptide release. Eletriptan hydrobromide is used to relieve pain or symptoms associated with migraine headaches.

    Eletriptan Manufacturers

    A Eletriptan manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Eletriptan, including repackagers and relabelers. The FDA regulates Eletriptan manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Eletriptan API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

    click here to find a list of Eletriptan manufacturers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PhamaCompass.

    Eletriptan Suppliers

    A Eletriptan supplier is an individual or a company that provides Eletriptan active pharmaceutical ingredient (API) or Eletriptan finished formulations upon request. The Eletriptan suppliers may include Eletriptan API manufacturers, exporters, distributors and traders.

    click here to find a list of Eletriptan suppliers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PharmaCompass.

    Eletriptan USDMF

    A Eletriptan DMF (Drug Master File) is a document detailing the whole manufacturing process of Eletriptan active pharmaceutical ingredient (API) in detail. Different forms of Eletriptan DMFs exist exist since differing nations have different regulations, such as Eletriptan USDMF, ASMF (EDMF), JDMF, CDMF, etc.

    A Eletriptan DMF submitted to regulatory agencies in the US is known as a USDMF. Eletriptan USDMF includes data on Eletriptan's chemical properties, information on the facilities and procedures used, and details about packaging and storage. The Eletriptan USDMF is kept confidential to protect the manufacturer’s intellectual property.

    click here to find a list of Eletriptan suppliers with USDMF on PharmaCompass.

    Eletriptan JDMF

    The Pharmaceuticals and Medical Devices Agency (PMDA) established the Japan Drug Master File (JDMF), also known as the Master File (MF), to permit Japanese and foreign manufacturers of drug substances, intermediates, excipients, raw materials, and packaging materials (‘Products’) to voluntarily register confidential information about the production and management of their products in Japan.

    The Eletriptan Drug Master File in Japan (Eletriptan JDMF) empowers Eletriptan API manufacturers to present comprehensive information (e.g., production methods, data, etc.) to the review authority, i.e., PMDA (Pharmaceuticals & Medical Devices Agency).

    PMDA reviews the Eletriptan JDMF during the approval evaluation for pharmaceutical products. At the time of Eletriptan JDMF registration, PMDA checks if the format is accurate, if the necessary items have been included (application), and if data has been attached.

    click here to find a list of Eletriptan suppliers with JDMF on PharmaCompass.

    Eletriptan KDMF

    In Korea, the Ministry of Food and Drug Safety (MFDS) is in charge of regulating pharmaceutical products and services.

    Pharmaceutical companies submit a Eletriptan Drug Master File in Korea (Eletriptan KDMF) to the MFDS, which includes comprehensive information about the production, processing, facilities, materials, packaging, and testing of Eletriptan. The MFDS reviews the Eletriptan KDMF as part of the drug registration process and uses the information provided in the Eletriptan KDMF to evaluate the safety and efficacy of the drug.

    After submitting a Eletriptan KDMF to the MFDS, the registered manufacturer can provide importers or distributors with the registration number without revealing confidential information to Korean business partners. Applicants seeking to register their Eletriptan API can apply through the Korea Drug Master File (KDMF).

    click here to find a list of Eletriptan suppliers with KDMF on PharmaCompass.

    Eletriptan WC

    A Eletriptan written confirmation (Eletriptan WC) is an official document issued by a regulatory agency to a Eletriptan manufacturer, verifying that the manufacturing facility of a Eletriptan active pharmaceutical ingredient (API) adheres to the Good Manufacturing Practices (GMP) regulations of the importing country. When exporting Eletriptan APIs or Eletriptan finished pharmaceutical products to another nation, regulatory agencies frequently require a Eletriptan WC (written confirmation) as part of the regulatory process.

    click here to find a list of Eletriptan suppliers with Written Confirmation (WC) on PharmaCompass.

    Eletriptan NDC

    National Drug Code is a comprehensive database maintained by the FDA that contains information on all drugs marketed in the US. This directory includes information about finished drug products, unfinished drug products, and compounded drug products, including those containing Eletriptan as an active pharmaceutical ingredient (API).

    Finished drug products

    The FDA updates the NDC directory daily. The NDC numbers for Eletriptan API and other APIs are published in this directory by the FDA.

    Unfinished drugs

    The NDC unfinished drugs database includes product listing information submitted for all unfinished drugs, such as active pharmaceutical ingredients (APIs), drugs intended for further processing and bulk drug substances for compounding.

    Pharmaceutical companies that manufacture Eletriptan as an active pharmaceutical ingredient (API) must furnish the FDA with an updated record of all drugs that they produce, prepare, propagate, compound, or process for commercial distribution in the US at their facilities.

    Compounded drug products

    The NDC directory also contains data on finished compounded human drug products that contain Eletriptan and are produced by outsourcing facilities. While these outsourcing facilities are not mandated to assign a Eletriptan NDC to their finished compounded human drug products, they may choose to do so.

    click here to find a list of Eletriptan suppliers with NDC on PharmaCompass.

    Eletriptan GMP

    Eletriptan Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

    GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

    PharmaCompass offers a list of Eletriptan GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Eletriptan GMP manufacturer or Eletriptan GMP API supplier for your needs.

    Eletriptan CoA

    A Eletriptan CoA (Certificate of Analysis) is a formal document that attests to Eletriptan's compliance with Eletriptan specifications and serves as a tool for batch-level quality control.

    Eletriptan CoA mostly includes findings from lab analyses of a specific batch. For each Eletriptan CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

    Eletriptan may be tested according to a variety of international standards, such as European Pharmacopoeia (Eletriptan EP), Eletriptan JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Eletriptan USP).

    Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
    For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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