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Chemistry

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Also known as: 9-ing-41, 1034895-42-5, Elraglusib, Elraglusib [usan], Nd1sof0dlu, Chembl483465
Molecular Formula
C22H13FN2O5
Molecular Weight
404.3  g/mol
InChI Key
FARXPFGGGGLENU-UHFFFAOYSA-N
FDA UNII
ND1SOF0DLU

Elraglusib
Elraglusib is a maleimide-based, small molecule inhibitor of glycogen synthase kinase-3 (GSK-3; serine/threonine-protein kinase GSK3) with potential antineoplastic activity. Upon intravenous administration, elraglusib binds to and competitively inhibits GSK-3, which may lead to downregulation of nuclear factor kappa B (NF-kappaB) and decreased expression of NF-kappaB target genes including cyclin D1, B-cell lymphoma 2 (Bcl-2), anti-apoptotic protein XIAP, and B-cell lymphoma extra-large (Bcl-XL). This may inhibit NF-kappaB-mediated survival and chemoresistance in certain tumor types. GSK-3, a constitutively active serine/threonine kinase that plays a role in numerous pathways involved in protein synthesis, cellular proliferation, differentiation, and metabolism, is aberrantly overexpressed in certain tumor types and may promote tumor cell survival and resistance to chemotherapy and radiotherapy.
1 2D Structure

Elraglusib

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
3-(5-fluoro-1-benzofuran-3-yl)-4-(5-methyl-[1,3]dioxolo[4,5-f]indol-7-yl)pyrrole-2,5-dione
2.1.2 InChI
InChI=1S/C22H13FN2O5/c1-25-7-13(11-5-17-18(6-15(11)25)30-9-29-17)19-20(22(27)24-21(19)26)14-8-28-16-3-2-10(23)4-12(14)16/h2-8H,9H2,1H3,(H,24,26,27)
2.1.3 InChI Key
FARXPFGGGGLENU-UHFFFAOYSA-N
2.1.4 Canonical SMILES
CN1C=C(C2=CC3=C(C=C21)OCO3)C4=C(C(=O)NC4=O)C5=COC6=C5C=C(C=C6)F
2.2 Other Identifiers
2.2.1 UNII
ND1SOF0DLU
2.3 Synonyms
2.3.1 Depositor-Supplied Synonyms

1. 9-ing-41

2. 1034895-42-5

3. Elraglusib

4. Elraglusib [usan]

5. Nd1sof0dlu

6. Chembl483465

7. 3-(5-fluoro-1-benzofuran-3-yl)-4-(5-methyl-[1,3]dioxolo[4,5-f]indol-7-yl)pyrrole-2,5-dione

8. 1h-pyrrole-2,5-dione, 3-(5-fluoro-3-benzofuranyl)-4-(5-methyl-5h-1,3-dioxolo(4,5-f)indol-7-yl)-

9. 3-(5-fluoro-benzofuran-3-yl)-4-(5-methyl-5h-(1,3)dioxolo(4,5-f)indol-7-yl)-pyrrole-2,5-dione

10. Unii-nd1sof0dlu

11. Elraglusib [inn]

12. Schembl3152351

13. Gtpl11412

14. 9-ing-41 [who-dd]

15. Ex-a4074

16. Bdbm50267716

17. S9602

18. Who 11553

19. Sb19735

20. Compound 26 [pmid: 19338355]

21. Hy-113914

22. Cs-0063319

23. E73486

24. 3-(5-fluoro-1-benzofuran-3-yl)-4-(5-methyl-5h- (1,3)dioxolo(4,5-f)indol-7-yl)-1h-pyrrole-2,5-dione

25. 3-(5-fluorobenzofuran-3-yl)-4-(5-methyl-5h-[1,3]dioxolo[4,5-f]indol-7-yl)pyrrole-2,5-dione

26. 4-(5-methyl-5h-[1,3]dioxolo[4,5-f]-indol-7-yl)-3-(5-fluoro-1-benzofuran-3-yl)-1 H-pyrrole-2,5-dione

2.4 Create Date
2010-01-26
3 Chemical and Physical Properties
Molecular Weight 404.3 g/mol
Molecular Formula C22H13FN2O5
XLogP33
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count6
Rotatable Bond Count2
Exact Mass404.08084968 g/mol
Monoisotopic Mass404.08084968 g/mol
Topological Polar Surface Area82.7 Ų
Heavy Atom Count30
Formal Charge0
Complexity802
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count1

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ABOUT THIS PAGE

Elraglusib Manufacturers

A Elraglusib manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Elraglusib, including repackagers and relabelers. The FDA regulates Elraglusib manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Elraglusib API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

Elraglusib Suppliers

A Elraglusib supplier is an individual or a company that provides Elraglusib active pharmaceutical ingredient (API) or Elraglusib finished formulations upon request. The Elraglusib suppliers may include Elraglusib API manufacturers, exporters, distributors and traders.

Elraglusib GMP

Elraglusib Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

PharmaCompass offers a list of Elraglusib GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Elraglusib GMP manufacturer or Elraglusib GMP API supplier for your needs.

Elraglusib CoA

A Elraglusib CoA (Certificate of Analysis) is a formal document that attests to Elraglusib's compliance with Elraglusib specifications and serves as a tool for batch-level quality control.

Elraglusib CoA mostly includes findings from lab analyses of a specific batch. For each Elraglusib CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

Elraglusib may be tested according to a variety of international standards, such as European Pharmacopoeia (Elraglusib EP), Elraglusib JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Elraglusib USP).

Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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