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Chemistry

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Also known as: Kpt-8602, 1642300-52-4, Eltanexor [inn], Eltanexor [usan], Eltanexor [who-dd], (e)-3-(3-(3,5-bis(trifluoromethyl)phenyl)-1h-1,2,4-triazol-1-yl)-2-(pyrimidin-5-yl)acrylamide
Molecular Formula
C17H10F6N6O
Molecular Weight
428.29  g/mol
InChI Key
JFBAVWVBLRIWHM-AWNIVKPZSA-N
FDA UNII
Q59IQJ9NTK

Eltanexor
Eltanexor is an orally bioavailable inhibitor of exportin-1 (XPO1; chromosome region maintenance 1 protein homolog; CRM1), with potential antineoplastic activity. Upon administration, eltanexor binds to the XPO1 cargo binding site, which prevents the XPO1-mediated nuclear export of cargo proteins such as tumor suppressor proteins (TSPs), including p53, p73, BRCA1/2, pRB, FOXO, and other growth regulatory proteins and leads to their selective accumulation in the nuclei of tumor cells. As a selective inhibitor of nuclear export (SINE), KPT-8602 restores the nuclear localization and function of tumor suppressing proteins which leads to the induction of apoptosis in tumor cells. XPO1, the major export factor that transports proteins from the nucleus to the cytoplasm, is overexpressed in a variety of cancer cell types while minimally expressed in normal, healthy cells. The export of tumor suppressor proteins into the cytoplasm prevents them from initiating apoptosis and leads to uncontrolled tumor cell proliferation.
1 2D Structure

Eltanexor

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
(E)-3-[3-[3,5-bis(trifluoromethyl)phenyl]-1,2,4-triazol-1-yl]-2-pyrimidin-5-ylprop-2-enamide
2.1.2 InChI
InChI=1S/C17H10F6N6O/c18-16(19,20)11-1-9(2-12(3-11)17(21,22)23)15-27-8-29(28-15)6-13(14(24)30)10-4-25-7-26-5-10/h1-8H,(H2,24,30)/b13-6+
2.1.3 InChI Key
JFBAVWVBLRIWHM-AWNIVKPZSA-N
2.1.4 Canonical SMILES
C1=C(C=C(C=C1C(F)(F)F)C(F)(F)F)C2=NN(C=N2)C=C(C3=CN=CN=C3)C(=O)N
2.1.5 Isomeric SMILES
C1=C(C=C(C=C1C(F)(F)F)C(F)(F)F)C2=NN(C=N2)/C=C(\C3=CN=CN=C3)/C(=O)N
2.2 Other Identifiers
2.2.1 UNII
Q59IQJ9NTK
2.3 Synonyms
2.3.1 MeSH Synonyms

1. (e)-3-(3-(3,5-bis(trifluoromethyl)phenyl)-1,2,4-triazol-1-yl)-2-pyrimidin-5-ylprop-2-enamide

2. Kpt-8602

2.3.2 Depositor-Supplied Synonyms

1. Kpt-8602

2. 1642300-52-4

3. Eltanexor [inn]

4. Eltanexor [usan]

5. Eltanexor [who-dd]

6. (e)-3-(3-(3,5-bis(trifluoromethyl)phenyl)-1h-1,2,4-triazol-1-yl)-2-(pyrimidin-5-yl)acrylamide

7. Q59iqj9ntk

8. Kpt8602

9. (e)-3-[3-[3,5-bis(trifluoromethyl)phenyl]-1,2,4-triazol-1-yl]-2-pyrimidin-5-ylprop-2-enamide

10. (2e)-3-(3-(3,5-bis(trifluoromethyl)phenyl)-1h-1,2,4-triazol-1-yl)-2-(pyrimidin-5-yl)prop-2-enamide

11. Eltanexor (usan/inn)

12. Eltanexor [usan:inn]

13. Unii-q59iqj9ntk

14. Kpt-8602; Eltanexor

15. Chembl4297623

16. Schembl16324809

17. Gtpl10037

18. Ex-a2433

19. Nsc794443

20. S8397

21. Who 10496

22. Ccg-268977

23. Cs-5947

24. Nsc-794443

25. Ac-36070

26. Bs-15585

27. Hy-100423

28. C73170

29. D11499

30. 5-pyrimidineacetamide, .alpha.-((3-(3,5-bis(trifluoromethyl)phenyl)-1h-1,2,4-triazol-1-yl)methylene)-, (.alpha.e)-

31. 5-pyrimidineacetamide, Alpha-((3-(3,5-bis(trifluoromethyl)phenyl)-1h-1,2,4-triazol-1-yl)methylene)-, (alphae)-

2.4 Create Date
2015-01-12
3 Chemical and Physical Properties
Molecular Weight 428.29 g/mol
Molecular Formula C17H10F6N6O
XLogP32.5
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count11
Rotatable Bond Count4
Exact Mass428.08202794 g/mol
Monoisotopic Mass428.08202794 g/mol
Topological Polar Surface Area99.6 Ų
Heavy Atom Count30
Formal Charge0
Complexity626
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count1
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count1

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ABOUT THIS PAGE

Eltanexor Manufacturers

A Eltanexor manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Eltanexor, including repackagers and relabelers. The FDA regulates Eltanexor manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Eltanexor API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

Eltanexor Suppliers

A Eltanexor supplier is an individual or a company that provides Eltanexor active pharmaceutical ingredient (API) or Eltanexor finished formulations upon request. The Eltanexor suppliers may include Eltanexor API manufacturers, exporters, distributors and traders.

Eltanexor GMP

Eltanexor Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

PharmaCompass offers a list of Eltanexor GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Eltanexor GMP manufacturer or Eltanexor GMP API supplier for your needs.

Eltanexor CoA

A Eltanexor CoA (Certificate of Analysis) is a formal document that attests to Eltanexor's compliance with Eltanexor specifications and serves as a tool for batch-level quality control.

Eltanexor CoA mostly includes findings from lab analyses of a specific batch. For each Eltanexor CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

Eltanexor may be tested according to a variety of international standards, such as European Pharmacopoeia (Eltanexor EP), Eltanexor JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Eltanexor USP).

Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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