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Chemistry

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Also known as: Eltanolone, 128-20-1, 3alpha-hydroxy-5beta-pregnan-20-one, Pregnan-3alpha-ol-20-one, Pregnanolone ii, Eltanolona
Molecular Formula
C21H34O2
Molecular Weight
318.5  g/mol
InChI Key
AURFZBICLPNKBZ-YZRLXODZSA-N
FDA UNII
BXO86P3XXW

Allopregnanolone
A pregnane found in the urine of pregnant women and sows. It has anesthetic, hypnotic, and sedative properties.
1 2D Structure

Allopregnanolone

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
1-[(3R,5R,8R,9S,10S,13S,14S,17S)-3-hydroxy-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl]ethanone
2.1.2 InChI
InChI=1S/C21H34O2/c1-13(22)17-6-7-18-16-5-4-14-12-15(23)8-10-20(14,2)19(16)9-11-21(17,18)3/h14-19,23H,4-12H2,1-3H3/t14-,15-,16+,17-,18+,19+,20+,21-/m1/s1
2.1.3 InChI Key
AURFZBICLPNKBZ-YZRLXODZSA-N
2.1.4 Canonical SMILES
CC(=O)C1CCC2C1(CCC3C2CCC4C3(CCC(C4)O)C)C
2.1.5 Isomeric SMILES
CC(=O)[C@H]1CC[C@@H]2[C@@]1(CC[C@H]3[C@H]2CC[C@H]4[C@@]3(CC[C@H](C4)O)C)C
2.2 Other Identifiers
2.2.1 UNII
BXO86P3XXW
2.3 Synonyms
2.3.1 MeSH Synonyms

1. 3 Alpha Hydroxy 5 Alpha Pregnan 20 One

2. 3 Alpha Hydroxy 5 Beta Pregnan 20 One

3. 3 Alpha, 5 Beta Tetrahydroprogesterone

4. 3 Alpha, 5 Beta-tetrahydroprogesterone

5. 3 Alpha-hydroxy-5 Alpha-pregnan-20-one

6. 3 Alpha-hydroxy-5 Beta-pregnan-20-one

7. 3 Hydroxypregnan 20 One

8. 3-hydroxypregnan-20-one

9. 3beta Hydroxy 5alpha Pregnan 20 One

10. 3beta-hydroxy-5alpha-pregnan-20-one

11. Allopregnan 3 Beta Ol 20 One

12. Allopregnan-3 Beta-ol-20-one

13. Allopregnanolone

14. Alpha-hydroxy-5 Alpha-pregnan-20-one, 3

15. Alpha-hydroxy-5 Beta-pregnan-20-one, 3

16. Alpha-pregnan-20-one, 3 Alpha-hydroxy-5

17. Beta-ol-20-one, Allopregnan-3

18. Beta-pregnan-20-one, 3 Alpha-hydroxy-5

19. Eltanolone

20. Epipregnanolone

21. Pregnan 3alpha Ol 20 One

22. Pregnan-3alpha-ol-20-one

23. Pregnanolone, (3alpha)-isomer

24. Pregnanolone, (3alpha, 5beta, 17-alpha)-isomer

25. Pregnanolone, (3alpha,5alpha)-isomer

26. Pregnanolone, (3alpha,5beta)-isomer

27. Pregnanolone, (3beta)-isomer

28. Pregnanolone, (3beta, 5alpha)-isomer

29. Pregnanolone, (3beta, 5alpha, 17alpha)-isomer

30. Pregnanolone, (3beta, 5alpha, 8alpha, 17beta)-isomer

31. Pregnanolone, (3beta, 5beta)-isomer

32. Pregnanolone, (3beta, 5beta, 17alpha)-isomer

33. Pregnanolone, (3beta, 5beta,14beta)-isomer

34. Pregnanolone, (5alpha)-isomer

35. Sepranolone

2.3.2 Depositor-Supplied Synonyms

1. Eltanolone

2. 128-20-1

3. 3alpha-hydroxy-5beta-pregnan-20-one

4. Pregnan-3alpha-ol-20-one

5. Pregnanolone Ii

6. Eltanolona

7. Eltanolonum

8. Eltanolone [inn]

9. Skf 6455

10. Allopregnanolone

11. Nsc 82867

12. 5beta-pregnan-3alpha-ol-20-one

13. (3alpha,5beta)-3-hydroxypregnan-20-one

14. Kabi 2213

15. Kabi-2213

16. 3alpha-hydroxy-5beta-pregnane-20-one

17. Pregnan-20-one, 3-hydroxy-, (3alpha,5beta)-

18. Pregnan-3.alpha.-ol-20-one

19. Nsc-82867

20. Bxo86p3xxw

21. 3.alpha.-hydroxy-5.beta.-pregnan-20-one

22. Chebi:1712

23. 5.beta.-pregnan-20-one, 3.alpha.-hydroxy-

24. Skf-6455

25. 1-[(3r,5r,8r,9s,10s,13s,14s,17s)-3-hydroxy-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1h-cyclopenta[a]phenanthren-17-yl]ethanone

26. 3.alpha.,5.beta.-epimeric Pregnanolone

27. 3.alpha.-hydroxy-5.beta.-tetrahydroprogesterone

28. Pregnan-20-one, 3-hydroxy-, (3.alpha.,5.beta.)-

29. Eltanolonum [inn-latin]

30. Eltanolona [inn-spanish]

31. 1-((3r,5r,8r,9s,10s,13s,14s,17s)-3-hydroxy-10,13-dimethylhexadecahydro-1h-cyclopenta[a]phenanthren-17-yl)ethan-1-one

32. Allopregnan-3 Beta-ol-20-one

33. 3alpha-hydroxy-5beta-tetrahydroprogesterone

34. 3alpha,5beta-epimeric Pregnanolone

35. Pregnan-3a-ol-20-one

36. Mls002694512

37. Unii-bxo86p3xxw

38. Pregnanolone, (3alpha,5beta)-isomer

39. 3 Hydroxypregnan 20 One

40. Pregnan 3alpha Ol 20 One

41. 3 Alpha, 5 Beta-tetrahydroprogesterone

42. Brn 4785659

43. 3 Alpha-hydroxy-5 Beta-pregnan-20-one

44. 3-alpha-hydroxy-5-beta-pregnan-20-one

45. 3 Alpha-hydroxy-5 Alpha-pregnan-20-one

46. Pregnanolone, (3beta)-isomer

47. Pregnanolone, (3alpha)-isomer

48. Pregnanolone, (5alpha)-isomer

49. Allopregnan 3 Beta Ol 20 One

50. Beta-ol-20-one, Allopregnan-3

51. (3?,5?)-3-hydroxy-pregnan-20-one

52. 3alpha,5beta-thp

53. 3beta Hydroxy 5alpha Pregnan 20 One

54. Pregnanolone, (3alpha,5alpha)-isomer

55. Pregnanolone, (3beta, 5beta)-isomer

56. Pregnanolone, (3beta, 5alpha)-isomer

57. 3 Alpha, 5 Beta Tetrahydroprogesterone

58. Wln: L E5 B666tj A1 E1 Fv1 Oq

59. 3 Alpha Hydroxy 5 Beta Pregnan 20 One

60. 5beta-pregnan-20-one, 3alpha-hydroxy-

61. 3 Alpha Hydroxy 5 Alpha Pregnan 20 One

62. Alpha-hydroxy-5 Beta-pregnan-20-one, 3

63. Beta-pregnan-20-one, 3 Alpha-hydroxy-5

64. 5-beta-pregnan-20-one, 3-alpha-hydroxy-

65. Alpha-hydroxy-5 Alpha-pregnan-20-one, 3

66. Alpha-pregnan-20-one, 3 Alpha-hydroxy-5

67. Kabi2213

68. Pregnan-20-one, 3-hydroxy-, (3a,5b)-

69. Pregnanolone, (3beta, 5beta,14beta)-isomer

70. Pregnanolone, (3beta, 5beta, 17alpha)-isomer

71. Eltanolone [mart.]

72. Pregnanolone, (3beta, 5alpha, 17alpha)-isomer

73. Pregnanolone, (3alpha, 5beta, 17-alpha)-isomer

74. Schembl56664

75. 3-hydroxy-5-pregnan-20-one

76. 5?-pregnan-3?-ol-20-one

77. Chembl210952

78. 3.alpha.,5.beta.-pregnanolone

79. 3a-hydroxy-5b-pregnan-20-one

80. Dtxsid1046342

81. Pregnanolone, (3beta, 5alpha, 8alpha, 17beta)-isomer

82. Gtpl11534

83. Skf6455

84. 3alpha,5beta-tetrahydroprogesterone

85. Nsc82867

86. Zinc3800039

87. (3a,5b)-3-hydroxypregnan-20-one

88. Lmst02030175

89. Db12308

90. 5 Beta -pregnan-3 Alpha -ol-20-one

91. 5.beta.-pregnan-3.alpha.-ol-20-one

92. Pregnan-20-one, (3.alpha.,5.beta.)-

93. (3alpha,5beta)-3-hydroxy-pregnan-20-one

94. Pregnan-3.alpha.-ol-20-one [mi]

95. B7455

96. C05480

97. 128p201

98. 3-hydroxypregnan-20-one, (3.alpha.,5.beta.)-

99. J-005571

100. Q18344323

101. 1-((3r,5r,8r,9s,10s,13s,14s,17s)-3-hydroxy-10,13-dimethylhexadecahydro-1h-cyclopenta[a]phenanthren-17-yl)ethanone

102. 110350-90-8

103. P9n

2.4 Create Date
2004-09-16
3 Chemical and Physical Properties
Molecular Weight 318.5 g/mol
Molecular Formula C21H34O2
XLogP34.9
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count2
Rotatable Bond Count1
Exact Mass318.255880323 g/mol
Monoisotopic Mass318.255880323 g/mol
Topological Polar Surface Area37.3 Ų
Heavy Atom Count23
Formal Charge0
Complexity500
Isotope Atom Count0
Defined Atom Stereocenter Count8
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count1
4 Drug and Medication Information
4.1 Drug Indication

Treatment of postpartum depression


5 Pharmacology and Biochemistry
5.1 MeSH Pharmacological Classification

Anesthetics

Agents capable of inducing a total or partial loss of sensation, especially tactile sensation and pain. They may act to induce general ANESTHESIA, in which an unconscious state is achieved, or may act locally to induce numbness or lack of sensation at a targeted site. (See all compounds classified as Anesthetics.)


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ABOUT THIS PAGE

Eltanolone Manufacturers

A Eltanolone manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Eltanolone, including repackagers and relabelers. The FDA regulates Eltanolone manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Eltanolone API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

Eltanolone Suppliers

A Eltanolone supplier is an individual or a company that provides Eltanolone active pharmaceutical ingredient (API) or Eltanolone finished formulations upon request. The Eltanolone suppliers may include Eltanolone API manufacturers, exporters, distributors and traders.

click here to find a list of Eltanolone suppliers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PharmaCompass.

Eltanolone USDMF

A Eltanolone DMF (Drug Master File) is a document detailing the whole manufacturing process of Eltanolone active pharmaceutical ingredient (API) in detail. Different forms of Eltanolone DMFs exist exist since differing nations have different regulations, such as Eltanolone USDMF, ASMF (EDMF), JDMF, CDMF, etc.

A Eltanolone DMF submitted to regulatory agencies in the US is known as a USDMF. Eltanolone USDMF includes data on Eltanolone's chemical properties, information on the facilities and procedures used, and details about packaging and storage. The Eltanolone USDMF is kept confidential to protect the manufacturer’s intellectual property.

click here to find a list of Eltanolone suppliers with USDMF on PharmaCompass.

Eltanolone NDC

National Drug Code is a comprehensive database maintained by the FDA that contains information on all drugs marketed in the US. This directory includes information about finished drug products, unfinished drug products, and compounded drug products, including those containing Eltanolone as an active pharmaceutical ingredient (API).

Finished drug products

The FDA updates the NDC directory daily. The NDC numbers for Eltanolone API and other APIs are published in this directory by the FDA.

Unfinished drugs

The NDC unfinished drugs database includes product listing information submitted for all unfinished drugs, such as active pharmaceutical ingredients (APIs), drugs intended for further processing and bulk drug substances for compounding.

Pharmaceutical companies that manufacture Eltanolone as an active pharmaceutical ingredient (API) must furnish the FDA with an updated record of all drugs that they produce, prepare, propagate, compound, or process for commercial distribution in the US at their facilities.

Compounded drug products

The NDC directory also contains data on finished compounded human drug products that contain Eltanolone and are produced by outsourcing facilities. While these outsourcing facilities are not mandated to assign a Eltanolone NDC to their finished compounded human drug products, they may choose to do so.

click here to find a list of Eltanolone suppliers with NDC on PharmaCompass.

Eltanolone GMP

Eltanolone Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

PharmaCompass offers a list of Eltanolone GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Eltanolone GMP manufacturer or Eltanolone GMP API supplier for your needs.

Eltanolone CoA

A Eltanolone CoA (Certificate of Analysis) is a formal document that attests to Eltanolone's compliance with Eltanolone specifications and serves as a tool for batch-level quality control.

Eltanolone CoA mostly includes findings from lab analyses of a specific batch. For each Eltanolone CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

Eltanolone may be tested according to a variety of international standards, such as European Pharmacopoeia (Eltanolone EP), Eltanolone JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Eltanolone USP).

Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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