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    Chemistry

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    Also known as: 496775-62-3, Revolade, Promacta, Eltrombopag (olamine), Unii-4u07f515lg, Sb-497115-gr
    Molecular Formula
    C29H36N6O6
    Molecular Weight
    564.6  g/mol
    InChI Key
    DJMJHIKGMVJYCW-UHFFFAOYSA-N
    FDA UNII
    4U07F515LG
    Eltrombopag
    Eltrombopag Olamine is the orally active ethanolamine salt of eltrombopag, a small-molecule, nonpeptide thrombopoietin receptor agonist with megakaryopoiesis-stimulating activity. Eltrombopag binds to and stimulates the transmembrane domain of the platelet thrombopoietin receptor (TPO-R or CD110), a member of the hematopoietin receptor superfamily. Activation of TPO-R leads to the proliferation and differentiation of cells in the megakaryocytic lineage and an increase in platelet production.
    1 2D Structure

    Eltrombopag

    2 Identification
    2.1 Computed Descriptors
    2.1.1 IUPAC Name
    2-aminoethanol;3-[3-[[2-(3,4-dimethylphenyl)-5-methyl-3-oxo-1H-pyrazol-4-yl]diazenyl]-2-hydroxyphenyl]benzoic acid
    2.1.2 InChI
    InChI=1S/C25H22N4O4.2C2H7NO/c1-14-10-11-19(12-15(14)2)29-24(31)22(16(3)28-29)27-26-21-9-5-8-20(23(21)30)17-6-4-7-18(13-17)25(32)33;2*3-1-2-4/h4-13,28,30H,1-3H3,(H,32,33);2*4H,1-3H2
    2.1.3 InChI Key
    DJMJHIKGMVJYCW-UHFFFAOYSA-N
    2.1.4 Canonical SMILES
    CC1=C(C=C(C=C1)N2C(=O)C(=C(N2)C)N=NC3=CC=CC(=C3O)C4=CC(=CC=C4)C(=O)O)C.C(CO)N.C(CO)N
    2.2 Other Identifiers
    2.2.1 UNII
    4U07F515LG
    2.3 Synonyms
    2.3.1 MeSH Synonyms

    1. (1,1'-biphenyl)-3-carboxylic Acid, 3'-((2z)-(1-(3,4-dimethylphenyl)-1,5-dihydro-3-methyl-5-oxo-4h-pyrazol-4-ylidene)hydrazino)-2'-hydroxy-

    2. Ddl-701

    3. Eltrombopag

    4. Promacta

    5. Revolade

    6. Sb-497 115

    7. Sb-497-115

    8. Sb497115

    2.3.2 Depositor-Supplied Synonyms

    1. 496775-62-3

    2. Revolade

    3. Promacta

    4. Eltrombopag (olamine)

    5. Unii-4u07f515lg

    6. Sb-497115-gr

    7. Eltrombopag Diethanolamine Salt

    8. 496775-62-3 (olamine)

    9. Eltrombopag (as Olamine)

    10. 4u07f515lg

    11. Sb-497115gr

    12. Eltrombopag Compd With 2-aminoethanol (1:2)

    13. Eltrombopag Diethanolamine Salt;sb-497115gr

    14. (z)-3'-(2-(1-(3,4-dimethylphenyl)-3-methyl-5-oxo-1,5-dihydro-4h-pyrazol-4-ylidene)hydrazinyl)-2'-hydroxy-[1,1'-biphenyl]-3-carboxyiic Acid;2-aminoethan-1-ol (1:2)

    15. 3'-((2z)-2-(1-(3,4-dimethylphenyl)-3-methyl-5-oxo-1,5-dihydro-4h-pyrazol-4-ylidene)diazanyl)-2'-hydroxybiphenyl-3-carboxylic Acid Compound With 2-aminoethanol (1:2)

    16. Promacta Olamine

    17. Eltrombopagolamine

    18. Eltrombopag Olamine [usan:jan]

    19. Promacta (tn)

    20. Sb 497115gr

    21. Schembl210183

    22. Amy267

    23. Chembl3989691

    24. Schembl16207741

    25. Schembl23458316

    26. Eltrombopag Olamine (jan/usan)

    27. Eltrombopag Olamine [jan]

    28. Eltrombopag Olamine [usan]

    29. Bcp07055

    30. Eltrombopag Olamine [mart.]

    31. Eltrombopag Olamine [who-dd]

    32. Hy-15306a

    33. Mfcd22380664

    34. S2229

    35. Akos025396658

    36. Akos037515856

    37. Ccg-270074

    38. Cs-1566

    39. Sb19102

    40. Eltrombopag Olamine [orange Book]

    41. 2-aminoethan-1-ol Hemi((e)-3'-(2-(2-(3,4-dimethylphenyl)-5-methyl-3-oxo-2,3-dihydro-1h-pyrazol-4-yl)hydrazono)-2'-oxo-2',3'-dihydro-[1,1'-biphenyl]-3-carboxylate)

    42. Ac-26286

    43. Bs-17370

    44. Ft-0773802

    45. D03978

    46. A904098

    47. Q27260489

    48. Eltrombopag Compd With 2-aminoethanol (1:2) [mi]

    49. (1,1'-biphenyl)-3-carboxylic Acid, 3'-((2z)-(1-(3,4-dimethylphenyl)-1,5-dihydro-3-methyl-5-oxo-4h-pyrazol-4-ylidene)hydrazino)-2'-hydroxy, Compound With 2-aminoethanol (1:2)

    50. (1,1'-biphenyl)-3-carboxylic Acid, 3'-((2z)-(1-(3,4-dimethylphenyl)-1,5-dihydro-3-methyl-5-oxo-4h-pyrazol-4-ylidene)hydrazino)-2'-hydroxy-, Compound With 2-aminoethanol (1:2)

    51. (1,1'-biphenyl)-3-carboxylic Acid, 3'-(2-(1-(3,4-dimethylphenyl)-4,5-dihydro-3-methyl-5-oxo-1h-pyrazol-4-yl)diazenyl)-2'-hydroxy-, Compd. With 2-aminoethanol (1:2)

    52. 2-aminoethan-1-ol Hemi((z)-3'-(2-(1-(3,4-dimethylphenyl)-3-methyl-5-oxo-1,5-dihydro-4h-pyrazol-4-ylidene)hydrazinyl)-2'-hydroxy-[1,1'-biphenyl]-3-carboxylate)

    53. 2-aminoethanol (e)-3'-(2-(1-(3,4-dimethylphenyl)-3-methyl-5-oxo-1h-pyrazol-4(5h)-ylidene)hydrazinyl)-2'-hydroxy-[1,1'-biphenyl]-3-carboxylate

    54. 2-aminoethanol;3-[3-[[2-(3,4-dimethylphenyl)-5-methyl-3-oxo-1h-pyrazol-4-yl]diazenyl]-2-hydroxyphenyl]benzoic Acid

    55. 3'-[(2z)-[1-(3,4-dimethylphenyl)-1,5-dihydro-3-methyl-5-oxo-4h-pyrazol-4-ylidene]hydrazino]-2'-hydroxy-[1,1'-biphenyl]-3-carboxylic Acid Bis-(monoethanolamine)

    56. 3'-[(2z)-[1-(3,4-dimethylphenyl)-1,5-dihydro-3-methyl-5-oxo-4h-pyrazol4-ylidene]hydrazino]-2'-hydroxy-[1,1'-biphenyl]-3-carboxylic Acid Bis-(monoethanolamine)

    57. 3'-{(2z)-2-[1-(3,4-dimethylphenyl)-3-methyl-5-oxo-1,5-dihydro-4h-pyrazol-4-ylidene]hydrazino}-2'-hydroxy-3-biphenylcarboxylic Acid 2-aminoethanol (1:2)

    2.4 Create Date
    2019-01-15
    3 Chemical and Physical Properties
    Molecular Weight 564.6 g/mol
    Molecular Formula C29H36N6O6
    Hydrogen Bond Donor Count7
    Hydrogen Bond Acceptor Count11
    Rotatable Bond Count7
    Exact Mass564.26963289 g/mol
    Monoisotopic Mass564.26963289 g/mol
    Topological Polar Surface Area207 Ų
    Heavy Atom Count41
    Formal Charge0
    Complexity822
    Isotope Atom Count0
    Defined Atom Stereocenter Count0
    Undefined Atom Stereocenter Count0
    Defined Bond Stereocenter Count0
    Undefined Bond Stereocenter Count0
    Covalently Bonded Unit Count3
    4 Drug and Medication Information
    4.1 Drug Indication

    Revolade is indicated for the treatment of adult patients with primary immune thrombocytopenia (ITP) who are refractory to other treatments (e. g. corticosteroids, immunoglobulins) (see sections 4. 2 and 5. 1).

    Revolade is indicated for the treatment of paediatric patients aged 1 year and above with primary immune thrombocytopenia (ITP) lasting 6 months or longer from diagnosis and who are refractory to other treatments (e. g. corticosteroids, immunoglobulins) (see sections 4. 2 and 5. 1).

    Revolade is indicated in adult patients with chronic hepatitis C virus (HCV) infection for the treatment of thrombocytopenia, where the degree of thrombocytopenia is the main factor preventing the initiation or limiting the ability to maintain optimal interferon-based therapy (see sections 4. 4 and 5. 1).

    Revolade is indicated in adult patients with acquired severe aplastic anaemia (SAA) who were either refractory to prior immunosuppressive therapy or heavily pretreated and are unsuitable for haematopoietic stem cell transplantation (see section 5. 1).

    5 Pharmacology and Biochemistry
    5.1 FDA Pharmacological Classification
    5.1.1 Pharmacological Classes
    Increased Megakaryocyte Maturation [PE]; Increased Platelet Production [PE]; Organic Anion Transporting Polypeptide 1B1 Inhibitors [MoA]; Thrombopoietin Receptor Agonist [EPC]; Thrombopoietin Receptor Agonists [MoA]; UGT1A1 Inhibitors [MoA]; UGT1A3 Inhibitors [MoA]; UGT1A4 Inhibitors [MoA]; UGT1A6 Inhibitors [MoA]; UGT1A9 Inhibitors [MoA]; UGT2B15 Inhibitors [MoA]; UGT2B7 Inhibitors [MoA]; Breast Cancer Resistance Protein Inhibitors [MoA]
    5.2 ATC Code

    B02BX05

    API Reference Price

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AP","customerAddress":""},{"dataSource":"API Export","activeIngredients":"","year":"2024","qtr":"Q4","strtotime":1734719400,"product":"ELTROMBOPAG OLAMINE IHS PHARMACEUTICAL RAW MATERIALS","address":"FLAT NO.302, BHANU ENCLAVE","city":"HYDERABAD.AP","supplier":"METROCHEM API PRIVATE LIMITED","supplierCountry":"INDIA","foreign_port":"CAIRO","customer":"EVA PHARMA","customerCountry":"EGYPT","quantity":"14.10","actualQuantity":"14.1","unit":"KGS","unitRateFc":"3000","totalValueFC":"41819.6","currency":"USD","unitRateINR":252011.89219858157,"date":"21-Dec-2024","totalValueINR":"3553367.68","totalValueInUsd":"41819.6","indian_port":"Hyderabad Air","hs_no":"29349990","bill_no":"6651058","productDescription":"API","marketType":"LESS REGULATED MARKET","country":"EGYPT","selfForZScoreResived":"Pharma Grade","supplierPort":"Hyderabad Air","supplierAddress":"FLAT NO.302, BHANU ENCLAVE, HYDERABAD.AP","customerAddress":""},{"dataSource":"API Export","activeIngredients":"","year":"2024","qtr":"Q4","strtotime":1735237800,"product":"ELTROMBOPAG OLAMINE IH","address":"7-2-A2, HETERO CORPORATE,","city":"HYDERABAD-A.P.","supplier":"HETERO DRUGS","supplierCountry":"INDIA","foreign_port":"RIYADH","customer":"SAUDI PHARMACEUTICAL INDUSTRIES ","customerCountry":"SAUDI ARABIA","quantity":"10.00","actualQuantity":"10","unit":"KGS","unitRateFc":"6000","totalValueFC":"59409.6","currency":"USD","unitRateINR":504797.09999999998,"date":"27-Dec-2024","totalValueINR":"5047971","totalValueInUsd":"59409.6","indian_port":"Hyderabad Air","hs_no":"29339990","bill_no":"6820722","productDescription":"API","marketType":"LESS REGULATED MARKET","country":"SAUDI ARABIA","selfForZScoreResived":"Pharma Grade","supplierPort":"Hyderabad Air","supplierAddress":"7-2-A2, HETERO CORPORATE,, HYDERABAD-A.P.","customerAddress":""},{"dataSource":"API Export","activeIngredients":"","year":"2024","qtr":"Q4","strtotime":1735497000,"product":"ELTROMBOPAG OLAMINE","address":"MSN HOUSE, PLOT NO. 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AP","customerAddress":""},{"dataSource":"API Import","activeIngredients":"ELTROMBOPAG OLAMINE","year":"2021","qtr":"Q2","strtotime":1620844200,"product":"ELTROMBOPAG OLAMINE (RE-IMPORT VIDE SB.NO:6255582 DT:31.10.2020","address":"8-3-167\/D\/16, KALYAN NAGAR - I,VENGAL RAO NAGAR","city":"HYDERABAD, A.P.","supplier":"NOVUGEN","supplierCountry":"INDIA","foreign_port":"KUALA LUMPUR - INT\\'L","customer":"MSN LABORATORIES","customerCountry":"INDIA","quantity":"4.60","actualQuantity":"4.6","unit":"KGS","unitRateFc":"10000","totalValueFC":"48294.9","currency":"USD","unitRateINR":"769036.1","date":"13-May-2021","totalValueINR":"3537566.18","totalValueInUsd":"48294.9","indian_port":"HYDERABAD AIR","hs_no":"29163110","bill_no":"3933356","productDescription":"Re-Import","marketType":"REGULATED MARKET","country":"INDIA","selfForZScoreResived":"Pharma Grade","supplierPort":"KUALA LUMPUR - INT\\'L","supplierAddress":"","customerAddress":"8-3-167\/D\/16, KALYAN NAGAR - I,VENGAL RAO NAGAR"},{"dataSource":"API Import","activeIngredients":"","year":"2021","qtr":"Q3","strtotime":1626719400,"product":"ELTROMBOPAG DRUG SUBSTANCE [DRUG LICENCE NO : TL\/HZ\/19\/000510 DT : 22.02.2019]","address":"SANDOZ BAUG, KOLSHETTHANE","city":"THANE,MAHARASHTRA","supplier":"NOVARTIS PHARMACEUTICALS CORPORATION","supplierCountry":"SWITZERLAND","foreign_port":"BASLE","customer":"NOVARTIS PHARMACEUTICALS CORPORATION","customerCountry":"INDIA","quantity":"0.15","actualQuantity":"150","unit":"GMS","unitRateFc":"168.1","totalValueFC":"28838","currency":"CHF","unitRateINR":"14328","date":"20-Jul-2021","totalValueINR":"2149198.84","totalValueInUsd":"28838","indian_port":"HYDERABAD AIR","hs_no":"29333990","bill_no":"4750707","productDescription":"API","marketType":"REGULATED MARKET","country":"SWITZERLAND","selfForZScoreResived":"Pharma Grade","supplierPort":"BASLE","supplierAddress":"","customerAddress":"SANDOZ BAUG, KOLSHETTHANE"},{"dataSource":"API Import","activeIngredients":"","year":"2021","qtr":"Q3","strtotime":1632853800,"product":"ELTROMBOPAG DRUG SUBSTANCE [DRUG LICENCE NO: TL\/HZ\/19\/000510 DT: 22.02.2019]","address":"SANDOZ BAUG, KOLSHETTHANE","city":"THANE,MAHARASHTRA","supplier":"NOVARTIS PHARMACEUTICALS CORPORATION","supplierCountry":"SWITZERLAND","foreign_port":"BASEL\/MULHOUSE","customer":"NOVARTIS PHARMACEUTICALS CORPORATION","customerCountry":"INDIA","quantity":"3.00","actualQuantity":"3000","unit":"GMS","unitRateFc":"168.1","totalValueFC":"559336.6","currency":"CHF","unitRateINR":"13714.3","date":"29-Sep-2021","totalValueINR":"41142814.97","totalValueInUsd":"559336.6","indian_port":"HYDERABAD AIR","hs_no":"29333990","bill_no":"5634848","productDescription":"API","marketType":"REGULATED MARKET","country":"SWITZERLAND","selfForZScoreResived":"Pharma Grade","supplierPort":"BASEL\/MULHOUSE","supplierAddress":"","customerAddress":"SANDOZ BAUG, KOLSHETTHANE"},{"dataSource":"API Import","activeIngredients":"","year":"2022","qtr":"Q3","strtotime":1660242600,"product":"ELTROMBOPAG OLAMINE MICRONIZED (BATCH NO.EPMX1301) (ELTROMBOPAG OLAMINE MICRONIZED) (FOR R&D PURPOSE ONLY)","address":"B\/2 MAHALAXMI CHAMBERS 22 BHULABHAI DESAI ROAD Contact No:","city":"MUMBAI","supplier":"CHEMO","supplierCountry":"SPAIN","foreign_port":"NA","customer":"GLENMARK PHARMACEUTICALS","customerCountry":"INDIA","quantity":"0.50","actualQuantity":"0.5","unit":"KGS","unitRateFc":"9200","totalValueFC":"4639.5","currency":"USD","unitRateINR":"738300","date":"12-Aug-2022","totalValueINR":"369150","totalValueInUsd":"4639.5","indian_port":"BOMBAY AIR","hs_no":"29147990","bill_no":"9976786","productDescription":"API","marketType":"REGULATED MARKET","country":"SPAIN","selfForZScoreResived":"Micronized","supplierPort":"NA","supplierAddress":"","customerAddress":"B\/2 MAHALAXMI CHAMBERS 22 BHULABHAI DESAI ROAD Contact No:"},{"dataSource":"API 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Import","activeIngredients":"","year":"2023","qtr":"Q1","strtotime":1678905000,"product":"ELTROMBOPAG OLAMINE MICRONIZED (BATCH NO.EPMA3302) (ELTROMBOPAG OLAMINE MICRONIZED)","address":"B\/2 MAHALAXMI CHAMBERS 22 BHULABHAI DESAI ROAD Contact No:","city":"MUMBAI","supplier":"CHEMO","supplierCountry":"SPAIN","foreign_port":"NA","customer":"GLENMARK PHARMACEUTICALS","customerCountry":"INDIA","quantity":"0.13","actualQuantity":"0.125","unit":"KGS","unitRateFc":"9200","totalValueFC":"1167.5","currency":"USD","unitRateINR":"768200","date":"16-Mar-2023","totalValueINR":"96025","totalValueInUsd":"1167.5","indian_port":"BOMBAY AIR","hs_no":"29147990","bill_no":"5072987","productDescription":"API","marketType":"REGULATED MARKET","country":"SPAIN","selfForZScoreResived":"Micronized","supplierPort":"NA","supplierAddress":"","customerAddress":"B\/2 MAHALAXMI CHAMBERS 22 BHULABHAI DESAI ROAD Contact No:"},{"dataSource":"API Import","activeIngredients":"","year":"2023","qtr":"Q3","strtotime":1689705000,"product":"ELTROMBOPAG OLAMINE MICRONIZED (BATCH NO.EPMA3304) (ELTROMBOPAG OLAMINE MICRONIZED) (FOR R&D PURPOSE ONLY)","address":"B\/2 MAHALAXMI CHAMBERS 22 BHULABHAI DESAI ROAD Contact No:","city":"MUMBAI","supplier":"CHEMO","supplierCountry":"SPAIN","foreign_port":"NA","customer":"GLENMARK PHARMACEUTICALS","customerCountry":"INDIA","quantity":"0.25","actualQuantity":"0.25","unit":"KGS","unitRateFc":"9200","totalValueFC":"2329.7","currency":"USD","unitRateINR":"765900.2","date":"19-Jul-2023","totalValueINR":"191475.046","totalValueInUsd":"2329.7","indian_port":"BOMBAY AIR","hs_no":"29147990","bill_no":"0","productDescription":"API","marketType":"REGULATED MARKET","country":"SPAIN","selfForZScoreResived":"Micronized","supplierPort":"NA","supplierAddress":"","customerAddress":"B\/2 MAHALAXMI CHAMBERS 22 BHULABHAI DESAI ROAD Contact No:"},{"dataSource":"API Import","activeIngredients":"","year":"2024","qtr":"Q1","strtotime":1704652200,"product":"ELTROMBOPAG OLAMINE MICRONIZED (BATCH NO.EPMA3304, EPMA3305,EPMA3306) (ELTROMBOPAG OLAMINE MICRONIZED)","address":"B\/2 MAHALAXMI CHAMBERS","city":"MUMBAI. MAHARASHTRA","supplier":"CHEMO","supplierCountry":"SPAIN","foreign_port":"MADRID","customer":"GLENMARK PHARMACEUTICALS","customerCountry":"INDIA","quantity":"22.65","actualQuantity":"22.65","unit":"KGS","unitRateFc":"9200","totalValueFC":"211234","currency":"USD","unitRateINR":"775100","date":"08-Jan-2024","totalValueINR":"17556015","totalValueInUsd":"211234","indian_port":"Bombay Air","hs_no":"29147990","bill_no":"9579204","productDescription":"API","marketType":"REGULATED MARKET","country":"SPAIN","selfForZScoreResived":"Micronized","supplierPort":"MADRID","supplierAddress":"MANUEL POMBO ANGULO, 28, 3RD FLOOR28050 MADRID SPAIN Madrid, , SpainSDNF Spain","customerAddress":"B\/2 MAHALAXMI CHAMBERS"},{"dataSource":"API Import","activeIngredients":"","year":"2024","qtr":"Q1","strtotime":1704738600,"product":"ELTROMBOPAG OLAMINE","address":"VILLAGE NAG KALAN,MAJITHA ROAD,MAJ","city":"AMRITSAR,PUNJAB","supplier":"M\/S. QUANZHOU FORTUNE TRADE CO. LTD.","supplierCountry":"CHINA","foreign_port":"HONG KONG","customer":"KWALITY PHARMACEUTICALS","customerCountry":"INDIA","quantity":"2.00","actualQuantity":"2","unit":"KGS","unitRateFc":"2800","totalValueFC":"5676.7","currency":"USD","unitRateINR":"235900","date":"09-Jan-2024","totalValueINR":"471800","totalValueInUsd":"5676.7","indian_port":"Delhi Air","hs_no":"29339990","bill_no":"9583864","productDescription":"API","marketType":"REGULATED MARKET","country":"CHINA","selfForZScoreResived":"Pharma Grade","supplierPort":"HONG KONG","supplierAddress":"ADD:ROOM2603, RONG TAI\\'AN BUILDINGNO.139 JINHUAI STREET,FENGZE ROAD,FENGZE DISTRICT QUANZHOU CITY FUJIA CHINA","customerAddress":"VILLAGE NAG KALAN,MAJITHA ROAD,MAJ"},{"dataSource":"API Import","activeIngredients":"","year":"2024","qtr":"Q1","strtotime":1708453800,"product":"ELTROMBOPAG OLAMINE MICRONIZED (BATCH NO.EPMA3303) (ELTROMBOPAG OLAMINE MICRONIZED)","address":"B\/2 MAHALAXMI CHAMBERS","city":"MUMBAI. MAHARASHTRA","supplier":"CHEMO","supplierCountry":"SPAIN","foreign_port":"MADRID","customer":"GLENMARK PHARMACEUTICALS","customerCountry":"INDIA","quantity":"1.20","actualQuantity":"1.2","unit":"KGS","unitRateFc":"9200","totalValueFC":"11163.2","currency":"USD","unitRateINR":"771880","date":"21-Feb-2024","totalValueINR":"926256","totalValueInUsd":"11163.2","indian_port":"Bombay Air","hs_no":"29147990","bill_no":"2236614","productDescription":"API","marketType":"REGULATED MARKET","country":"SPAIN","selfForZScoreResived":"Micronized","supplierPort":"MADRID","supplierAddress":"MANUEL POMBO ANGULO, 28, 3RD FLOOR28050 MADRID SPAIN Madrid, , SpainSDNF Spain","customerAddress":"B\/2 MAHALAXMI CHAMBERS"},{"dataSource":"API Import","activeIngredients":"","year":"2024","qtr":"Q2","strtotime":1717785000,"product":"(FOC) ELTROMBOPAG OLAMINE API","address":"21-22, KALPATARU SQUARE, KONDIVITA","city":"ANDHERI (E), MUMBAI,MAHARASHTRA","supplier":"ACTAVIS INC","supplierCountry":"INDIA","foreign_port":"MIAMI, FL","customer":"TEVA PHARMACEUTICAL INDUSTRIES","customerCountry":"INDIA","quantity":"0.01","actualQuantity":"5","unit":"GMS","unitRateFc":"76.5","totalValueFC":"463.5","currency":"USD","unitRateINR":"7738.7","date":"08-Jun-2024","totalValueINR":"38693.7","totalValueInUsd":"463.5","indian_port":"Bombay Air","hs_no":"29331930","bill_no":"3907450","productDescription":"Re-Import","marketType":"REGULATED MARKET","country":"INDIA","selfForZScoreResived":"Pharma Grade","supplierPort":"MIAMI, FL","supplierAddress":"2945 WEST CORPORATE LAKES BLVD WESTON, FLORIDA 33331 ., , United States United States","customerAddress":"21-22, KALPATARU SQUARE, KONDIVITA"},{"dataSource":"API Import","activeIngredients":"","year":"2024","qtr":"Q2","strtotime":1718389800,"product":"(FOC) ELTROMBOPAG CHOLINE API","address":"21-22, KALPATARU SQUARE, KONDIVITA","city":"ANDHERI (E), MUMBAI,MAHARASHTRA","supplier":"ACTAVIS INC","supplierCountry":"CROATIA","foreign_port":"MIAMI, FL","customer":"TEVA PHARMACEUTICAL INDUSTRIES","customerCountry":"INDIA","quantity":"0.01","actualQuantity":"10","unit":"GMS","unitRateFc":"76.5","totalValueFC":"927","currency":"USD","unitRateINR":"7738.7","date":"15-Jun-2024","totalValueINR":"77387.4","totalValueInUsd":"927","indian_port":"Bombay Air","hs_no":"29331930","bill_no":"4023891","productDescription":"API","marketType":"REGULATED MARKET","country":"CROATIA","selfForZScoreResived":"Pharma Grade","supplierPort":"MIAMI, FL","supplierAddress":"2945 WEST CORPORATE LAKES BLVD WESTON, FLORIDA 33331SDNF United States","customerAddress":"21-22, KALPATARU SQUARE, KONDIVITA"},{"dataSource":"API Import","activeIngredients":"","year":"2024","qtr":"Q4","strtotime":1730831400,"product":"7MP1042 4001328 ELTROMBOPAG OLAMINE (MICRONIZED)","address":"21-22, KALPATARU SQUARE, KONDIVITA","city":"ANDHERI (E), MUMBAI,MAHARASHTRA","supplier":"PLUSCHEM","supplierCountry":"CROATIA","foreign_port":"ZAGREB","customer":"TEVA PHARMACEUTICAL INDUSTRIES","customerCountry":"INDIA","quantity":"17.00","actualQuantity":"17","unit":"KGS","unitRateFc":"10000","totalValueFC":"205358.1","currency":"USD","unitRateINR":"1019400","date":"06-Nov-2024","totalValueINR":"17329800","totalValueInUsd":"205358.1","indian_port":"Bombay Air","hs_no":"29331999","bill_no":"6533523","productDescription":"API","marketType":"REGULATED MARKET","country":"CROATIA","selfForZScoreResived":"Micronized","supplierPort":"ZAGREB","supplierAddress":"BRANCH TEVA PHARMACEUTICALS INTL SC HLUESSELSTRASSE 12 JONA 8645, SDNF Switzerland","customerAddress":"21-22, KALPATARU SQUARE, KONDIVITA"}]
    25-Feb-2021
    30-Dec-2024
    KGS
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    Average Price (USD/KGS)

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    DRUG PRODUCT COMPOSITIONS

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    DOSAGE - TABLET;ORAL - EQ 100MG ACID **Federa...DOSAGE - TABLET;ORAL - EQ 100MG ACID **Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons**

    USFDA APPLICATION NUMBER - 22291

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    DOSAGE - TABLET;ORAL - EQ 12.5MG ACID

    USFDA APPLICATION NUMBER - 22291

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    DOSAGE - TABLET;ORAL - EQ 25MG ACID

    USFDA APPLICATION NUMBER - 22291

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    DOSAGE - TABLET;ORAL - EQ 50MG ACID

    USFDA APPLICATION NUMBER - 22291

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    DOSAGE - TABLET;ORAL - EQ 75MG ACID

    USFDA APPLICATION NUMBER - 22291

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    Grade : Oral

    Category : Fillers, Diluents & Binders

    Brand Name : Polyvinylpyrrolidone

    Application : Fillers, Diluents & Binders

    Excipient Details : Polyvinylpyrrolidone is used as a low viscosity wet binder in solid dosage forms such as tablets.

    Pharmacopoeia Ref : NA

    Technical Specs : NA

    Ingredient(s) : Polyvinylpyrrolidone

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    Faran Shimi Pharmaceutical

    Iran
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    Virtual BoothFaran Shimi: Leading producer of high-quality APIs & alkaloid opiates, serving major pharmaceutical companies across the Middle East.

    Dosage Form : Tablet

    Grade : Oral

    Category : Co-Processed Excipients

    Brand Name : Mannitol

    Application : Co-Processed Excipients

    Excipient Details : Mannitol is a co-processed excipient with superior compactibility, lower disintegration time, and hygroscopicity.

    Pharmacopoeia Ref : NA

    Technical Specs : NA

    Ingredient(s) : Mannitol

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    Boai NKY Pharmaceuticals Ltd

    China
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    Virtual BoothBoai NKY Pharmaceuticals Ltd. is one of the largest global PVP suppliers.

    Dosage Form : Capsule, Tablet

    Grade : Oral (Pharma Grade)

    Category : Fillers, Diluents & Binders

    Brand Name : KoVidone® K25

    Application : Fillers, Diluents & Binders

    Excipient Details : KoVidone® K25 is used as a low viscosity wet binder in solid dosage forms such as capsules and tablets.

    Pharmacopoeia Ref : USP/NF, EP, JP, KP, IP, BP

    Technical Specs : NA

    Ingredient(s) : Polyvinylpyrrolidone

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    Gangwal Healthcare

    India
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    Virtual BoothGangwal Healthcare is powered by innovation, driving health, wellness & healing.

    Brand Name : ProBlend®

    Application : Co-Processed Excipients, Direct Compression, Disintegrants & Superdisintegrants, Fillers, Diluents & Binders, Lubricants & Glidants

    Excipient Details : ProBlend (Microcrystalline Cellulose) is used as a filler, binder, glidant, DC & co-processed excipient in tablets, capsules, and MUPS formulations.

    Pharmacopoeia Ref : USP-NF

    Technical Specs : NA

    Ingredient(s) : Microcrystalline Cellulose

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    Gangwal Healthcare

    India
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    Brand Name : DiCOM-DC® SP204

    Application : Co-Processed Excipients, Direct Compression, Fillers, Diluents & Binders, Thickeners and Stabilizers

    Excipient Details : DiCOM-DC SP204 is used as a stabilizer, filler, binder, directly compressible, and co-processed excipient in tablets and capsules.

    Pharmacopoeia Ref : In-house

    Technical Specs : NA

    Ingredient(s) : Corn Starch, Pregelatinized

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    Nanjing Well Pharmaceutical

    China
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    Virtual BoothNanjing Well is focused on R&D, production & sales of Pharmaceutical Excipients & Synthetic Lubricating base oils.

    Brand Name : Polyethylene Glycol 400

    Application : Fillers, Diluents & Binders, Film Formers & Plasticizers, Parenteral, Surfactant & Foaming Agents, Thickeners and Stabilizers, Topical

    Excipient Details : PEG 400 is used as a suspending agent, stabilizer, plasticizer and filler in OSDs, liquids & semi-solids and as a solvent for parenteral formulations.

    Pharmacopoeia Ref : ChP/USP/EP

    Technical Specs : NA

    Ingredient(s) : Polyethylene Glycol 400

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    Pfanstiehl

    U.S.A
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    Virtual BoothPfanstiehl, a global leader in the manufacture of cGMP high purity, low endotoxin, low metals (HPLE-LM)TM injectable grade excipients.

    Brand Name : D-Mannitol

    Application : Fillers, Diluents & Binders, Parenteral, Thickeners and Stabilizers

    Excipient Details : D-mannitol protects proteins from denaturation & degradation. It is also used as a stabilizer in liquid formulations & as a bulking agent in tablets.

    Pharmacopoeia Ref : USP, NF, EP, JP, ChP

    Technical Specs : N/A

    Ingredient(s) : Mannitol

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    Direct Compression

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    SPI Pharma

    U.S.A
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    Virtual BoothSPI Pharma has been solving formulation challenges using superior functional materials.

    Brand Name : Pharmaburst 500

    Application : Chewable & Orodispersible Aids, Direct Compression, Fillers, Diluents & Binders, Taste Masking

    Excipient Details : Pharmaburst® 500 is a directly compressible pharmaceutical excipient used to create orally disintegrating tablets quickly and easily.

    Pharmacopoeia Ref : NA

    Technical Specs : NA

    Ingredient(s) : Mannitol

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    SPI Pharma

    U.S.A
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    Virtual BoothSPI Pharma has been solving formulation challenges using superior functional materials.

    Dosage Form : Tablet

    Grade : Oral

    Category : Direct Compression, Fillers, Diluents & Binders, Taste Masking

    Brand Name : Mannogem® XL Opal

    Application : Direct Compression, Fillers, Diluents & Binders, Taste Masking

    Excipient Details : Mannogem® XL Opal, directly compressible 160 µm spray-dried mannitol provides superior binding properties and tabletability.

    Pharmacopoeia Ref : NA

    Technical Specs : 160 µm Powder Mannitol

    Ingredient(s) : Mannitol

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    Gangwal Healthcare

    India
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    BIO Partnering at JPM
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    Virtual BoothGangwal Healthcare is powered by innovation, driving health, wellness & healing.

    Brand Name : DiCOM-DC® SP204

    Application : Co-Processed Excipients, Direct Compression, Fillers, Diluents & Binders, Thickeners and Stabilizers

    Excipient Details : DiCOM-DC SP204 is used as a stabilizer, filler, binder, directly compressible, and co-processed excipient in tablets and capsules.

    Pharmacopoeia Ref : In-house

    Technical Specs : NA

    Ingredient(s) : Corn Starch, Pregelatinized

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    Gangwal Healthcare

    India
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    Virtual BoothGangwal Healthcare is powered by innovation, driving health, wellness & healing.

    Brand Name : Solvostar™

    Application : Direct Compression, Disintegrants & Superdisintegrants

    Excipient Details : Solvostar (Sodium Starch Glycolate) is used as a superdisintegrant and directly compressible excipient in tablets, capsules, suspensions, and pellets.

    Pharmacopoeia Ref : IP/BP/EP/USP-NF

    Technical Specs : Solvostar 2% to 8%

    Ingredient(s) : Sodium Starch Glycolate

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    Gangwal Healthcare Solvostar™

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    SPI Pharma

    U.S.A
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    • fda
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    Virtual BoothSPI Pharma has been solving formulation challenges using superior functional materials.

    Brand Name : Advantol 300

    Application : Chewable & Orodispersible Aids, Direct Compression, Fillers, Diluents & Binders, Taste Masking

    Excipient Details : Advantol® 300 is a DC pharmaceutical excipient used to create soft chewable or soft melt oral dosage forms & enables rapid product development.

    Pharmacopoeia Ref : NA

    Technical Specs : NA

    Ingredient(s) : Mannitol

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    Gangwal Healthcare

    India
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    BIO Partnering at JPM
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    • fda
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    Virtual BoothGangwal Healthcare is powered by innovation, driving health, wellness & healing.

    Brand Name : ProBlend®

    Application : Co-Processed Excipients, Direct Compression, Disintegrants & Superdisintegrants, Fillers, Diluents & Binders, Lubricants & Glidants

    Excipient Details : ProBlend (Microcrystalline Cellulose) is used as a filler, binder, glidant, DC & co-processed excipient in tablets, capsules, and MUPS formulations.

    Pharmacopoeia Ref : USP-NF

    Technical Specs : NA

    Ingredient(s) : Microcrystalline Cellulose

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    SPI Pharma

    U.S.A
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    BIO Partnering at JPM
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    • fda
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    Virtual BoothSPI Pharma has been solving formulation challenges using superior functional materials.

    Brand Name : Compressol SM

    Application : Chewable & Orodispersible Aids, Co-Processed Excipients, Direct Compression, Fillers, Diluents & Binders, Taste Masking

    Excipient Details : Compressol® SM, co-processed polyol, is a DC excipient of mannitol & sorbitol with superior compactibility, lower disintegration time & hygroscopicity

    Pharmacopoeia Ref : NA

    Technical Specs : NA

    Ingredient(s) : Mannitol

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    Gangwal Healthcare

    India
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    Virtual BoothGangwal Healthcare is powered by innovation, driving health, wellness & healing.

    Brand Name : DiCOM-DC® PL009 P60

    Application : Co-Processed Excipients, Direct Compression, Fillers, Diluents & Binders

    Excipient Details : DiCOM-DC PL009 P60 is used as a filler, binder, directly compressible, and co-processed excipient in tablets and capsules.

    Pharmacopoeia Ref : IH

    Technical Specs : NA

    Ingredient(s) : Maize Starch

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    SPI Pharma

    U.S.A
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    Virtual BoothSPI Pharma has been solving formulation challenges using superior functional materials.

    Brand Name : Mannogem EZ Spray-Dried

    Application : Chewable & Orodispersible Aids, Direct Compression, Fillers, Diluents & Binders

    Excipient Details : Mannogem EZ Spray-Dried, a mannitol product, dissolves rapidly and can increase the rate of tablet disintegration, drug dissolution & drug release.

    Pharmacopoeia Ref : NA

    Technical Specs : NA

    Ingredient(s) : Mannitol

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    Gangwal Healthcare

    India
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    Virtual BoothGangwal Healthcare is powered by innovation, driving health, wellness & healing.

    Brand Name : DiCOM-DC® SR300

    Application : Co-Processed Excipients, Controlled & Modified Release, Direct Compression

    Excipient Details : DiCOM-DC SR300 is used as a directly compressible, rate-controlling, and co-processed excipient in sustained-release tablets and capsules.

    Pharmacopoeia Ref : In-house

    Technical Specs : NA

    Ingredient(s) : EthylCellulose

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    ABOUT THIS PAGE

    Eltrombopag Olamine Manufacturers

    A Eltrombopag Olamine manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Eltrombopag Olamine, including repackagers and relabelers. The FDA regulates Eltrombopag Olamine manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Eltrombopag Olamine API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

    click here to find a list of Eltrombopag Olamine manufacturers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PhamaCompass.

    Eltrombopag Olamine Suppliers

    A Eltrombopag Olamine supplier is an individual or a company that provides Eltrombopag Olamine active pharmaceutical ingredient (API) or Eltrombopag Olamine finished formulations upon request. The Eltrombopag Olamine suppliers may include Eltrombopag Olamine API manufacturers, exporters, distributors and traders.

    click here to find a list of Eltrombopag Olamine suppliers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PharmaCompass.

    Eltrombopag Olamine USDMF

    A Eltrombopag Olamine DMF (Drug Master File) is a document detailing the whole manufacturing process of Eltrombopag Olamine active pharmaceutical ingredient (API) in detail. Different forms of Eltrombopag Olamine DMFs exist exist since differing nations have different regulations, such as Eltrombopag Olamine USDMF, ASMF (EDMF), JDMF, CDMF, etc.

    A Eltrombopag Olamine DMF submitted to regulatory agencies in the US is known as a USDMF. Eltrombopag Olamine USDMF includes data on Eltrombopag Olamine's chemical properties, information on the facilities and procedures used, and details about packaging and storage. The Eltrombopag Olamine USDMF is kept confidential to protect the manufacturer’s intellectual property.

    click here to find a list of Eltrombopag Olamine suppliers with USDMF on PharmaCompass.

    Eltrombopag Olamine WC

    A Eltrombopag Olamine written confirmation (Eltrombopag Olamine WC) is an official document issued by a regulatory agency to a Eltrombopag Olamine manufacturer, verifying that the manufacturing facility of a Eltrombopag Olamine active pharmaceutical ingredient (API) adheres to the Good Manufacturing Practices (GMP) regulations of the importing country. When exporting Eltrombopag Olamine APIs or Eltrombopag Olamine finished pharmaceutical products to another nation, regulatory agencies frequently require a Eltrombopag Olamine WC (written confirmation) as part of the regulatory process.

    click here to find a list of Eltrombopag Olamine suppliers with Written Confirmation (WC) on PharmaCompass.

    Eltrombopag Olamine NDC

    National Drug Code is a comprehensive database maintained by the FDA that contains information on all drugs marketed in the US. This directory includes information about finished drug products, unfinished drug products, and compounded drug products, including those containing Eltrombopag Olamine as an active pharmaceutical ingredient (API).

    Finished drug products

    The FDA updates the NDC directory daily. The NDC numbers for Eltrombopag Olamine API and other APIs are published in this directory by the FDA.

    Unfinished drugs

    The NDC unfinished drugs database includes product listing information submitted for all unfinished drugs, such as active pharmaceutical ingredients (APIs), drugs intended for further processing and bulk drug substances for compounding.

    Pharmaceutical companies that manufacture Eltrombopag Olamine as an active pharmaceutical ingredient (API) must furnish the FDA with an updated record of all drugs that they produce, prepare, propagate, compound, or process for commercial distribution in the US at their facilities.

    Compounded drug products

    The NDC directory also contains data on finished compounded human drug products that contain Eltrombopag Olamine and are produced by outsourcing facilities. While these outsourcing facilities are not mandated to assign a Eltrombopag Olamine NDC to their finished compounded human drug products, they may choose to do so.

    click here to find a list of Eltrombopag Olamine suppliers with NDC on PharmaCompass.

    Eltrombopag Olamine GMP

    Eltrombopag Olamine Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

    GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

    PharmaCompass offers a list of Eltrombopag Olamine GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Eltrombopag Olamine GMP manufacturer or Eltrombopag Olamine GMP API supplier for your needs.

    Eltrombopag Olamine CoA

    A Eltrombopag Olamine CoA (Certificate of Analysis) is a formal document that attests to Eltrombopag Olamine's compliance with Eltrombopag Olamine specifications and serves as a tool for batch-level quality control.

    Eltrombopag Olamine CoA mostly includes findings from lab analyses of a specific batch. For each Eltrombopag Olamine CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

    Eltrombopag Olamine may be tested according to a variety of international standards, such as European Pharmacopoeia (Eltrombopag Olamine EP), Eltrombopag Olamine JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Eltrombopag Olamine USP).

    Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
    For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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