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Chemistry

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Also known as: 1650550-25-6, Ag-221 mesylate, Enasidenib mesilate, Enasidenib methanesulfonate, Enasidenib (mesylate), Uf6pc17xav
Molecular Formula
C20H21F6N7O4S
Molecular Weight
569.5  g/mol
InChI Key
ORZHZQZYWXEDDL-UHFFFAOYSA-N
FDA UNII
UF6PC17XAV

UNII-UF6PC17XAV
Enasidenib Mesylate is the mesylate salt form of enasidenib, an orally available inhibitor of specific mutant forms of the mitochondrial enzyme isocitrate dehydrogenase type 2 (IDH2), with potential antineoplastic activity. Upon administration, enasidenib specifically inhibits various mutant forms of IDH2, including the IDH2 variants R140Q, R172S, and R172K, which inhibits the formation of 2-hydroxyglutarate (2HG). This may lead to both an induction of cellular differentiation and an inhibition of cellular proliferation in IDH2-expressing tumor cells. IDH2, an enzyme in the citric acid cycle, is mutated in a variety of cancers; it initiates and drives cancer growth by blocking differentiation and the production of the oncometabolite 2HG.
1 2D Structure

UNII-UF6PC17XAV

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
methanesulfonic acid;2-methyl-1-[[4-[6-(trifluoromethyl)pyridin-2-yl]-6-[[2-(trifluoromethyl)pyridin-4-yl]amino]-1,3,5-triazin-2-yl]amino]propan-2-ol
2.1.2 InChI
InChI=1S/C19H17F6N7O.CH4O3S/c1-17(2,33)9-27-15-30-14(11-4-3-5-12(29-11)18(20,21)22)31-16(32-15)28-10-6-7-26-13(8-10)19(23,24)25;1-5(2,3)4/h3-8,33H,9H2,1-2H3,(H2,26,27,28,30,31,32);1H3,(H,2,3,4)
2.1.3 InChI Key
ORZHZQZYWXEDDL-UHFFFAOYSA-N
2.1.4 Canonical SMILES
CC(C)(CNC1=NC(=NC(=N1)C2=NC(=CC=C2)C(F)(F)F)NC3=CC(=NC=C3)C(F)(F)F)O.CS(=O)(=O)O
2.2 Other Identifiers
2.2.1 UNII
UF6PC17XAV
2.3 Synonyms
2.3.1 Depositor-Supplied Synonyms

1. 1650550-25-6

2. Ag-221 Mesylate

3. Enasidenib Mesilate

4. Enasidenib Methanesulfonate

5. Enasidenib (mesylate)

6. Uf6pc17xav

7. Enasidenib Mesylate [usan]

8. Cc-90007

9. 1650550-25-6 (mesylate)

10. Enasidenib Mesylate (usan)

11. 2-propanol, 2-methyl-1-((4-(6-(trifluoromethyl)-2-pyridinyl)-6-((2-(trifluoromethyl)-4-pyridinyl)amino)-1,3,5-triazin-2-yl)amino)-, Methanesulfonate (1:1)

12. 2-methyl-1-[4-(6-trifluoromethyl-pyridin-2-yl)-6-(2-trifluoromethyl-pyridin-4-ylamino)-[1,3,5]triazin-2-ylamino]-propan-2-ol Mesylate

13. Methanesulfonic Acid;2-methyl-1-[[4-[6-(trifluoromethyl)pyridin-2-yl]-6-[[2-(trifluoromethyl)pyridin-4-yl]amino]-1,3,5-triazin-2-yl]amino]propan-2-ol

14. Unii-uf6pc17xav

15. Idhifa (tn)

16. Chembl3989931

17. Enasidenib Mesylate [mi]

18. Schembl16448052

19. Dtxsid501027943

20. Bcp26166

21. Ex-a1972

22. Enasidenib Mesylate [who-dd]

23. Hy-18690a

24. S4929

25. Enasidenib Mesylate; Ag-221 Mesylate

26. At36098

27. Cs-7541

28. Enasidenib Mesylate [orange Book]

29. Ac-31319

30. D11044

31. Q27291054

32. 2-methyl-1-((4-(6-(trifluoromethyl)pyridin-2-yl)- 6-((2-(trifluoromethyl)pyridin-4-yl)amino)-1,3,5-triazin- 2-yl)amino)propan-2-ol Methanesulfonate

2.4 Create Date
2015-02-23
3 Chemical and Physical Properties
Molecular Weight 569.5 g/mol
Molecular Formula C20H21F6N7O4S
Hydrogen Bond Donor Count4
Hydrogen Bond Acceptor Count17
Rotatable Bond Count6
Exact Mass569.12799232 g/mol
Monoisotopic Mass569.12799232 g/mol
Topological Polar Surface Area172 Ų
Heavy Atom Count38
Formal Charge0
Complexity727
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count2
4 Pharmacology and Biochemistry
4.1 FDA Pharmacological Classification
4.1.1 Pharmacological Classes
Isocitrate Dehydrogenase 2 Inhibitors [MoA]; Isocitrate Dehydrogenase 2 Inhibitor [EPC]

ABOUT THIS PAGE

Looking for 1650550-25-6 / UNII-UF6PC17XAV API manufacturers, exporters & distributors?

UNII-UF6PC17XAV manufacturers, exporters & distributors 1

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PharmaCompass offers a list of UNII-UF6PC17XAV API manufacturers, exporters & distributors, which can be sorted by GMP, USDMF, JDMF, KDMF, CEP (COS), WC, Price,and more, enabling you to easily find the right UNII-UF6PC17XAV manufacturer or UNII-UF6PC17XAV supplier for your needs.

Send us enquiries for free, and we will assist you in establishing a direct connection with your preferred UNII-UF6PC17XAV manufacturer or UNII-UF6PC17XAV supplier.

PharmaCompass also assists you with knowing the UNII-UF6PC17XAV API Price utilized in the formulation of products. UNII-UF6PC17XAV API Price is not always fixed or binding as the UNII-UF6PC17XAV Price is obtained through a variety of data sources. The UNII-UF6PC17XAV Price can also vary due to multiple factors, including market conditions, regulatory modifications, or negotiated pricing deals.

API | Excipient name

UNII-UF6PC17XAV

Synonyms

1650550-25-6, Ag-221 mesylate, Enasidenib mesilate, Enasidenib methanesulfonate, Enasidenib (mesylate), Uf6pc17xav

Cas Number

1650550-25-6

Unique Ingredient Identifier (UNII)

UF6PC17XAV

About UNII-UF6PC17XAV

Enasidenib Mesylate is the mesylate salt form of enasidenib, an orally available inhibitor of specific mutant forms of the mitochondrial enzyme isocitrate dehydrogenase type 2 (IDH2), with potential antineoplastic activity. Upon administration, enasidenib specifically inhibits various mutant forms of IDH2, including the IDH2 variants R140Q, R172S, and R172K, which inhibits the formation of 2-hydroxyglutarate (2HG). This may lead to both an induction of cellular differentiation and an inhibition of cellular proliferation in IDH2-expressing tumor cells. IDH2, an enzyme in the citric acid cycle, is mutated in a variety of cancers; it initiates and drives cancer growth by blocking differentiation and the production of the oncometabolite 2HG.

Enasidenib (mesylate) Manufacturers

A Enasidenib (mesylate) manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Enasidenib (mesylate), including repackagers and relabelers. The FDA regulates Enasidenib (mesylate) manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Enasidenib (mesylate) API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

Enasidenib (mesylate) Suppliers

A Enasidenib (mesylate) supplier is an individual or a company that provides Enasidenib (mesylate) active pharmaceutical ingredient (API) or Enasidenib (mesylate) finished formulations upon request. The Enasidenib (mesylate) suppliers may include Enasidenib (mesylate) API manufacturers, exporters, distributors and traders.

Enasidenib (mesylate) GMP

Enasidenib (mesylate) Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

PharmaCompass offers a list of Enasidenib (mesylate) GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Enasidenib (mesylate) GMP manufacturer or Enasidenib (mesylate) GMP API supplier for your needs.

Enasidenib (mesylate) CoA

A Enasidenib (mesylate) CoA (Certificate of Analysis) is a formal document that attests to Enasidenib (mesylate)'s compliance with Enasidenib (mesylate) specifications and serves as a tool for batch-level quality control.

Enasidenib (mesylate) CoA mostly includes findings from lab analyses of a specific batch. For each Enasidenib (mesylate) CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

Enasidenib (mesylate) may be tested according to a variety of international standards, such as European Pharmacopoeia (Enasidenib (mesylate) EP), Enasidenib (mesylate) JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Enasidenib (mesylate) USP).

Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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