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Encainide

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ACTIVE PHARMA INGREDIENTS

2 API Suppliers, 2 USDMF

2 API Suppliers
2 USDMF

Synopsis

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Chemistry

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Also known as: 66794-74-9, Encainide hcl, Enkaid, Encainide (hydrochloride), Encainide hydrochloride [usan], Mj 9067-1

Molecular Formula

C₂₂H₂₉ClN₂O₂

Molecular Weight

388.9 g/mol

InChI Key

OJIIZIWOLTYOBS-UHFFFAOYSA-N

FDA UNII

4CH7J36N9S

One of the ANTI-ARRHYTHMIA AGENTS, it blocks VOLTAGE-GATED SODIUM CHANNELS and slows conduction within the His-Purkinje system and MYOCARDIUM.

1 2D Structure

Encainide

2 Identification

2.1 Computed Descriptors

2.1.1 IUPAC Name

4-methoxy-N-[2-[2-(1-methylpiperidin-2-yl)ethyl]phenyl]benzamide;hydrochloride

2.1.2 InChI

InChI=1S/C22H28N2O2.ClH/c1-24-16-6-5-8-19(24)13-10-17-7-3-4-9-21(17)23-22(25)18-11-14-20(26-2)15-12-18;/h3-4,7,9,11-12,14-15,19H,5-6,8,10,13,16H2,1-2H3,(H,23,25);1H

2.1.3 InChI Key

OJIIZIWOLTYOBS-UHFFFAOYSA-N

2.1.4 Canonical SMILES

CN1CCCCC1CCC2=CC=CC=C2NC(=O)C3=CC=C(C=C3)OC.Cl

2.2 Other Identifiers

2.2.1 UNII

4CH7J36N9S

2.3 Synonyms

2.3.1 MeSH Synonyms

1. Encainide

2. Encainide Hydrochloride, (+-)-isomer

3. Encainide, (+)-isomer

4. Encainide, (-)-isomer

5. Enkaid

6. Mj 9067

7. Mj-9067

8. Mj9067

2.3.2 Depositor-Supplied Synonyms

1. 66794-74-9

2. Encainide Hcl

3. Enkaid

4. Encainide (hydrochloride)

5. Encainide Hydrochloride [usan]

6. Mj 9067-1

7. Mj-9067

8. Encainidehydrochloride

9. 4-methoxy-2'-(2-(1-methyl-2-piperidyl)ethyl)benzanilide Hydrochloride

10. (+-)-2'-(2-(1-methyl-2-piperidyl)ethyl)-p-anisanilide Monohydrochloride

11. 4ch7j36n9s

12. Chebi:59880

13. 4-methoxy-n-[2-[2-(1-methylpiperidin-2-yl)ethyl]phenyl]benzamide;hydrochloride

14. (+/-)-4-methoxy-n-[2-[2-(1-methyl-2-piperidinyl)ethyl]phenyl]benzamide Hydrochloride

15. Mj-9067-1

16. Encainide Hydrochloride (usan)

17. 2-(2-{2-[(4-methoxybenzoyl)amino]phenyl}ethyl)-1-methylpiperidinium Chloride

18. 4-methoxy-n-{2-[2-(1-methylpiperidin-2-yl)ethyl]phenyl}benzamide Hydrochloride

19. Enkade; Enkaid;benzamide, 4-methoxy-n-[2-[2-(1-methyl-2-piperidinyl)ethyl]phenyl]-, Monohydrochloride (9ci); Benzamide, 4-methoxy-n-[2-[2-(1-methyl-2-piperidinyl)ethyl]phenyl]-, Monohydrochloride, (+/-)-

20. Ncgc00185765-01

21. Unii-4ch7j36n9s

22. Mfcd01667688

23. Dsstox_cid_28930

24. Dsstox_rid_83196

25. Dsstox_gsid_49004

26. Mls004712064

27. Schembl121261

28. Chembl2106155

29. Dtxsid2049004

30. Encainide Hydrochloride [mi]

31. Tox21_113498

32. Nsc299238

33. Akos025311581

34. Encainide Hydrochloride [mart.]

35. Encainide Hydrochloride [vandf]

36. Nsc-299238

37. Encainide Hydrochloride [who-dd]

38. Benzamide, 4-methoxy-n-(2-(2-(1-methyl-2-piperidinyl)ethyl)phenyl)-, Monohydrochloride, (+-)-

39. Hy-12531

40. Smr002529683

41. Cas-66794-74-9

42. Cs-0011988

43. D03991

44. H11012

45. Encainide Hydrochloride, >=98% (hplc), Powder

46. Q27126935

47. 4-methoxy-2' -[2-(1-methyl- 2-piperidyl)athyl]benzanilid-hydrochlorid

48. (+/-)-2'-(2-(1-methyl-2-piperidyl)ethyl)-p-anisanilide Monohydrochloride

49. Benzamide, 4-methoxy-n-(2-(2-(1-methyl-2-piperidinyl)ethyl)phenyl)-, Monohydrochloride, (+/-)-

2.4 Create Date

2005-08-08

3 Chemical and Physical Properties

Molecular Formula	C₂₂H₂₉ClN₂O₂
Molecular Weight	388.9 g/mol
Hydrogen Bond Donor Count	2
Hydrogen Bond Acceptor Count	3
Rotatable Bond Count	6
Exact Mass	388.1917559 g/mol
Monoisotopic Mass	388.1917559 g/mol
Topological Polar Surface Area	41.6 Å²
Heavy Atom Count	27
Formal Charge	0
Complexity	434
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	1
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently Bonded Unit Count	2

4 Pharmacology and Biochemistry

4.1 MeSH Pharmacological Classification

Anti-Arrhythmia Agents

Agents used for the treatment or prevention of cardiac arrhythmias. They may affect the polarization-repolarization phase of the action potential, its excitability or refractoriness, or impulse conduction or membrane responsiveness within cardiac fibers. Anti-arrhythmia agents are often classed into four main groups according to their mechanism of action: sodium channel blockade, beta-adrenergic blockade, repolarization prolongation, or calcium channel blockade. (See all compounds classified as Anti-Arrhythmia Agents.)

Voltage-Gated Sodium Channel Blockers

A class of drugs that inhibit the activation of VOLTAGE-GATED SODIUM CHANNELS. (See all compounds classified as Voltage-Gated Sodium Channel Blockers.)

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