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Enclomiphene Citrate

Octavius Clomiphene Citrate

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Valsynthese, part of the SSE Group, is a CDMO focused on highly energetic and highly hazardous chemistry.

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Suanfarma Clomiphene Citrate

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Bloomage is a one-stop source for CEP Sodium Hyaluronate and Hyaluronic Acid// FDA-inspected & GMP-certified.

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ACTIVE PHARMA INGREDIENTS

22 API Suppliers, 10 USDMF, 2 CEP/COS, 1 JDMF, 1 EU WC, 28 NDC API, 13 Listed Suppliers, $ API Reference Price

22 API Suppliers
10 USDMF
2 CEP/COS
1 JDMF
1 EU WC
28 NDC API
13 Listed Suppliers
$ API Reference Price

DEVELOPMENTS

1 Drugs in Development

1 Drugs in Development

INTERMEDIATES

2 Intermediates Suppliers

2 Intermediates Suppliers

FINISHED DOSAGE FORMULATIONS

32 FDF Dossiers, 6 FDA Orange Book, 3 Europe, 1 Australia, 5 South Africa, 17 Listed Dossiers

32 FDF Dossiers
6 FDA Orange Book
3 Europe
1 Australia
5 South Africa
17 Listed Dossiers

RELATED EXCIPIENT COMPANIES

4 SPI Pharma, 1 DKSH, 3 Faran Shimi Pharmaceutical, 11 Gangwal Healthcare, 1 Nanjing Well Pharmaceutical, 1 Pfanstiehl, 1 Actylis, 5 Anhui Sunhere Pharmaceutical Excipients Co.,Ltd, 2 BASF, 5 DFE Pharma, 5 Gangwal Chemicals, 1 Ideal Cures Pvt Ltd, 3 Ingredion Pharma Solutions, 20 Kerry, 9 Microlex e.U, 2 Pharmatrans-Sanaq, 3 Pluviaendo, 3 Prachin Chemical, 15 Roquette, 1 Seppic, 3 Shanghai Shenmei Pharmaceutical Technology Co., Ltd, 10 Sigachi Industries, 3 Vasa Pharmachem

EXCIPIENTS BY APPLICATIONS

51 Fillers, Diluents & Binders, 26 Direct Compression, 18 Disintegrants & Superdisintegrants, 15 Thickeners and Stabilizers, 14 Co-Processed Excipients, 12 Granulation, 12 Lubricants & Glidants, 7 Taste Masking, 6 Controlled & Modified Release, 6 Coating Systems & Additives, 5 Chewable & Orodispersible Aids, 3 Emulsifying Agents, 2 Parenteral, 1 Film Formers & Plasticizers, 1 API Stability Enhancers, 1 Rheology Modifiers

excipientsByApplications
51 Fillers, Diluents & Binders
26 Direct Compression
18 Disintegrants & Superdisintegrants
15 Thickeners and Stabilizers
14 Co-Processed Excipients
12 Granulation
12 Lubricants & Glidants
7 Taste Masking
6 Controlled & Modified Release
6 Coating Systems & Additives
5 Chewable & Orodispersible Aids
3 Emulsifying Agents
2 Parenteral
1 Film Formers & Plasticizers
1 API Stability Enhancers
1 Rheology Modifiers

DIGITAL CONTENT

7 NEWS #PharmaBuzz

media
7 NEWS #PharmaBuzz

GLOBAL SALES INFORMATION

2 US Medicaid Prescriptions, 5 Finished Drug Prices

globalSalesInformation
2 US Medicaid Prescriptions
5 Finished Drug Prices

MARKET PLACE

13 APIs

marketPlace
13 APIs

REF. STANDARDS & IMPURITIES

2 EDQM , 1 USP , 3 JP , 2 Others

otherSolutions
2 EDQM
1 USP
3 JP
2 Others

Octavius Clomiphene Citrate

Synopsis

ACTIVE PHARMA INGREDIENTS

22

API Suppliers

10

USDMF

2

CEP/COS

CEP/COS Certifications

1

JDMF

1

EU WC

0

KDMF

28

NDC API

0

VMF

13

Listed Suppliers

API REF. PRICE (USD/KG)

$

$ 160

MARKET PLACE

13

API

0

FDF

2INTERMEDIATES

FINISHED DOSAGE FORMULATIONS

32

FDF Dossiers

6

FDA Orange Book

FDA (Orange Book)

3

Europe

0

Canada

1

Australia

5

South Africa

17

Listed Dossiers

1DRUGS IN DEVELOPMENT

DRUG PRODUCT COMPOSITIONS

REF. STANDARDS OR IMPURITIES

2

EDQM

1

USP

3

JP

2

Others

PATENTS & EXCLUSIVITIES

0

US Patents

0

US Exclusivities

0

Health Canada Patents

DIGITAL CONTENT

0

Data Compilation #PharmaFlow

0

Stock Recap #PipelineProspector

0

Weekly News Recap #Phispers

7

News #PharmaBuzz

GLOBAL SALES INFORMATION

US Medicaid (USD)

224,386

Annual Reports (USD Million)

NA

Finished Drug Prices

112 RELATED EXCIPIENT COMPANIES

180EXCIPIENTS BY APPLICATIONS

Chemistry

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Also known as: Clomiphene citrate, 50-41-9, Zuclomiphene citrate, Cis-clomiphene citrate, Clomid, Zuclomid

Molecular Formula

C₃₂H₃₆ClNO₈

Molecular Weight

598.1 g/mol

InChI Key

PYTMYKVIJXPNBD-OQKDUQJOSA-N

FDA UNII

UY5X264QZV

Clomiphene Citrate

A triphenyl ethylene stilbene derivative which is an estrogen agonist or antagonist depending on the target tissue. Note that ENCLOMIPHENE and ZUCLOMIPHENE are the (E) and (Z) isomers of Clomiphene respectively.

1 2D Structure

Clomiphene Citrate

2 Identification

2.1 Computed Descriptors

2.1.1 IUPAC Name

2-[4-[(Z)-2-chloro-1,2-diphenylethenyl]phenoxy]-N,N-diethylethanamine;2-hydroxypropane-1,2,3-tricarboxylic acid

2.1.2 InChI

InChI=1S/C26H28ClNO.C6H8O7/c1-3-28(4-2)19-20-29-24-17-15-22(16-18-24)25(21-11-7-5-8-12-21)26(27)23-13-9-6-10-14-23;7-3(8)1-6(13,5(11)12)2-4(9)10/h5-18H,3-4,19-20H2,1-2H3;13H,1-2H2,(H,7,8)(H,9,10)(H,11,12)/b26-25-;

2.1.3 InChI Key

PYTMYKVIJXPNBD-OQKDUQJOSA-N

2.1.4 Canonical SMILES

CCN(CC)CCOC1=CC=C(C=C1)C(=C(C2=CC=CC=C2)Cl)C3=CC=CC=C3.C(C(=O)O)C(CC(=O)O)(C(=O)O)O

2.1.5 Isomeric SMILES

CCN(CC)CCOC1=CC=C(C=C1)/C(=C(/C2=CC=CC=C2)\Cl)/C3=CC=CC=C3.C(C(=O)O)C(CC(=O)O)(C(=O)O)O

2.2 Other Identifiers

2.2.1 UNII

UY5X264QZV

2.3 Synonyms

2.3.1 MeSH Synonyms

1. Chloramiphene

2. Citrate, Clomiphene

3. Clomid

4. Clomide

5. Clomifen

6. Clomifene

7. Clomiphene

8. Clomiphene Citrate

9. Clomiphene Hydrochloride

10. Clostilbegit

11. Dyneric

12. Gravosan

13. Hydrochloride, Clomiphene

14. Klostilbegit

15. Serophene

2.3.2 Depositor-Supplied Synonyms

1. Clomiphene Citrate

2. 50-41-9

3. Zuclomiphene Citrate

4. Cis-clomiphene Citrate

5. Clomid

6. Zuclomid

7. Clomiphene A Citrate

8. 7619-53-6

9. Clomiphene Citrate Salt

10. Milophene

11. Serophene

12. (z)-clomiphene Citrate

13. Chloramiphene

14. Omifin

15. Rmi 16289

16. Clomivid

17. Clomphid

18. Dyneric

19. Genozym

20. Ikaclomin

21. Clomifene Citrate (serophene)

22. Zuclomiphene (citrate)

23. Uy5x264qzv

24. Mrl 41

25. Nsc-151466

26. 2-(4-(2-chloro-1,2-diphenylvinyl)phenoxy)-n,n-diethylethanamine 2-hydroxypropane-1,2,3-tricarboxylate

27. Nsc 35770

28. Rmi 16312

29. 2-[4-[(z)-2-chloro-1,2-diphenylethenyl]phenoxy]-n,n-diethylethanamine;2-hydroxypropane-1,2,3-tricarboxylic Acid

30. Ethanamine, 2-(4-((1z)-2-chloro-1,2-diphenylethenyl)phenoxy)-n,n-diethyl-, 2-hydroxy-1,2,3-propanetricarboxylate (1:1)

31. Ethanamine, 2-[4-(2-chloro-1,2-diphenylethenyl)phenoxy]-n,n-diethyl-,2-hydroxy-1,2,3-propanetricarboxylate (1:1)

32. Mer-41

33. Mrl-41

34. Unii-uy5x264qzv

35. Nsc 151466

36. Nsc-35770

37. Cas-50-41-9

38. Clomiphene Citrate, Cis-

39. Triethylamine, 2-(p-(2-chloro-1,2-diphenylvinyl)phenoxy)-, Citrate (1:1), (z)-

40. Mls001332629

41. Mls002207099

42. Schembl223472

43. Spectrum1500196

44. Sgcut00109

45. Chembl1213137

46. Hms501h04

47. Hy-b1617a

48. Hms1920o19

49. Hms2091g06

50. Hms2232d12

51. Pharmakon1600-01500196

52. Amy33425

53. Bcp03057

54. To_000032

55. Ccg-39553

56. Nsc151466

57. Nsc756698

58. S2561

59. Akos005111131

60. Bcp9000541

61. Ds-6814

62. Fd12066

63. Nsc-756698

64. Ncgc00017008-01

65. Ncgc00017008-02

66. Ncgc00017008-03

67. Ncgc00094626-01

68. Ncgc00094626-02

69. Ncgc00164385-01

70. Ac-19685

71. Ac-32011

72. Ethanamine, 2-(4-(2-chloro-1,2-diphenylethenyl)phenoxy)-n,n-diethyl-, (z)-, 2-hydroxy-1,2,3-propanetricarboxylate (1:1)

73. Bcp0726000214

74. Cs-0111663

75. Sw196898-3

76. C08161

77. Triethylamine,2-diphenylvinyl)phenoxy]-, Citrate

78. Sr-05000001591

79. Sr-05000001591-1

80. Q27291328

81. Triethylamine,2-diphenylvinyl)phenoxy]-, Citrate (1:1)

82. Triethylamine,2-diphenylvinyl)phenoxy]-, Citrate (1:1), (z)-

83. (2)2-[p-(2-chloro-1,2-diphenylvinyl)phenoxy]triethylamine Citrate (1:1)

84. 2-(4-[2-chloro-1,2-diphenylethenyl]phenoxy)-n,n-diethylethanamine Citrate Salt

85. {2-[4-(2-chloro-1,2-diphenylvinyl)phenoxy]ethyl}diethylamine 2-hydroxypropane-1,2,3-tricarboxylic Acid Salt

86. 2-({4-[(z)-2-chloro-1,2-diphenylethenyl]phenyl}oxy)-n,n-diethylethanamine 2-hydroxypropane-1,2,3-tricarboxylate (salt)

87. Ethanamine,2-diphenylethenyl)phenoxy]-n,n-diethyl-, (z)-, 2-hydroxy-1,2,3-propanetricarboxylate (1:1)

88. Ethanamine,2-diphenylethenyl)phenoxy]-n,n-diethyl-, 2-hydroxy-1,2,3-propanetricarboxylate (1:1)

2.4 Create Date

2005-03-26

3 Chemical and Physical Properties

Molecular Formula	C₃₂H₃₆ClNO₈
Molecular Weight	598.1 g/mol
Hydrogen Bond Donor Count	4
Hydrogen Bond Acceptor Count	9
Rotatable Bond Count	14
Exact Mass	597.2129448 g/mol
Monoisotopic Mass	597.2129448 g/mol
Topological Polar Surface Area	145 Å²
Heavy Atom Count	42
Formal Charge	0
Complexity	708
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	1
Undefined Bond Stereocenter Count	0
Covalently Bonded Unit Count	2

4 Drug and Medication Information

4.1 Drug Information

1 of 6
Drug Name	Clomid
PubMed Health	Clomiphene (By mouth)
Drug Classes	Endocrine-Metabolic Agent, Female Reproductive Agent
Drug Label	Clomiphene citrate tablets, USP is an orally administered, nonsteroidal, ovulatory stimulant designated chemically as 2-[p-(2chloro-1,2-diphenylvinyl)phenoxy] triethylamine citrate (1:1). It has the molecular formula of C26H28CINO C6H8O7 and a mo...
Active Ingredient	Clomiphene citrate
Dosage Form	Tablet
Route	Oral
Strength	50mg
Market Status	Prescription
Company	Sanofi Aventis Us

2 of 6
Drug Name	Clomiphene citrate
PubMed Health	Clomiphene (By mouth)
Drug Classes	Endocrine-Metabolic Agent, Female Reproductive Agent
Drug Label	ClomiPHENE citrate is an orally administered, nonsteroidal, ovulatory stimulant designated chemically as 2-[p-(2-chloro-1,2-diphenylvinyl) phenoxy] triethylamine citrate (1:1). It has a molecular formula of C26H28CINO C6H8O7 and a molecular weig...
Active Ingredient	Clomiphene citrate
Dosage Form	Tablet
Route	Oral
Strength	50mg
Market Status	Prescription
Company	Par Pharm

3 of 6
Drug Name	Serophene
Active Ingredient	Clomiphene citrate
Dosage Form	Tablet
Route	Oral
Strength	50mg
Market Status	Prescription
Company	Emd Serono

4 of 6
Drug Name	Clomid
PubMed Health	Clomiphene (By mouth)
Drug Classes	Endocrine-Metabolic Agent, Female Reproductive Agent
Drug Label	Clomiphene citrate tablets, USP is an orally administered, nonsteroidal, ovulatory stimulant designated chemically as 2-[p-(2chloro-1,2-diphenylvinyl)phenoxy] triethylamine citrate (1:1). It has the molecular formula of C26H28CINO C6H8O7 and a mo...
Active Ingredient	Clomiphene citrate
Dosage Form	Tablet
Route	Oral
Strength	50mg
Market Status	Prescription
Company	Sanofi Aventis Us

5 of 6
Drug Name	Clomiphene citrate
PubMed Health	Clomiphene (By mouth)
Drug Classes	Endocrine-Metabolic Agent, Female Reproductive Agent
Drug Label	ClomiPHENE citrate is an orally administered, nonsteroidal, ovulatory stimulant designated chemically as 2-[p-(2-chloro-1,2-diphenylvinyl) phenoxy] triethylamine citrate (1:1). It has a molecular formula of C26H28CINO C6H8O7 and a molecular weig...
Active Ingredient	Clomiphene citrate
Dosage Form	Tablet
Route	Oral
Strength	50mg
Market Status	Prescription
Company	Par Pharm

6 of 6
Drug Name	Serophene
Active Ingredient	Clomiphene citrate
Dosage Form	Tablet
Route	Oral
Strength	50mg
Market Status	Prescription
Company	Emd Serono

5 Pharmacology and Biochemistry

5.1 MeSH Pharmacological Classification

Fertility Agents, Female

Compounds which increase the capacity to conceive in females. (See all compounds classified as Fertility Agents, Female.)

Estrogen Antagonists

Compounds which inhibit or antagonize the action or biosynthesis of estrogenic compounds. (See all compounds classified as Estrogen Antagonists.)

Selective Estrogen Receptor Modulators

A structurally diverse group of compounds distinguished from ESTROGENS by their ability to bind and activate ESTROGEN RECEPTORS but act as either an agonist or antagonist depending on the tissue type and hormonal milieu. They are classified as either first generation because they demonstrate estrogen agonist properties in the ENDOMETRIUM or second generation based on their patterns of tissue specificity. (Horm Res 1997;48:155-63) (See all compounds classified as Selective Estrogen Receptor Modulators.)

5.2 FDA Pharmacological Classification

5.2.1 Pharmacological Classes

Selective Estrogen Receptor Modulators [MoA]; Estrogen Agonist/Antagonist [EPC]

API SUPPLIERS

01

Octavius Pharma Pvt. Ltd

India

USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

Octavius has been empowering lives since 1980 by providing quality products like DC granules, APIs and FDFs.

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Suanfarma

Spain

USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

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Seqens

France

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Egis Pharmaceuticals PLC

Hungary

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Egis is a Hungarian generic pharma company with 110 years history. Our activities incorporate all areas of the pharma value chain.

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Jai Radhe Sales

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API Reference Price

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Number of Transactions

Total Quantity (KGS)

Total Value (USD)

Quantity (KGS) & Unit rate (USD/KGS) over time

API Imports and Exports

Importing Country	Total Quantity (KGS)	Average Price (USD/KGS)	Number of Transactions

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Drugs in Development

01

Mangoceuticals

U.S.A

DDL Conference

Not Confirmed

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INTERMEDIATES SUPPLIERS

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FDF Dossiers

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FDA Orange Book

01

SANOFI AVENTIS US

France

CPHI Middle east

Not Confirmed

Sanofi is a pioneer in Diabetes Solutions, Human Vaccines, Innovative Drugs, Consumer Healthcare, and the new Genzyme.

Contact Supplier

Contact Supplier

France

Digital Content

RLD : Yes

TE Code :

CLOMIPHENE CITRATE

Brand Name : CLOMID

Dosage Form : TABLET;ORAL

Dosage Strength : 50MG **Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons**

Approval Date : 1982-01-01

Application Number : 16131

RX/OTC/DISCN : DISCN

RLD : Yes

TE Code :

Sanofi Company Banner

Portfolio PDF

Product Web Link

Digital Content

02

APPCO

U.S.A

CPHI Middle east

Not Confirmed

03

COSETTE

U.S.A

CPHI Middle east

Not Confirmed

04

EMD SERONO

U.S.A

CPHI Middle east

Not Confirmed

05

GRANATA BIO

U.S.A

CPHI Middle east

Not Confirmed

06

RUBICON

India

CPHI Middle east

Not Confirmed

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Europe

01

Merck & Co.

U.S.A

CPHI Middle east

Not Confirmed

02

Merck AB

France

CPHI Middle east

Not Confirmed

03

BRUNO FARMACEUTICI SpA

Country

CPHI Middle east

Not Confirmed

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Australia

01

sanofi-aventis Australia Pty Ltd

France

CPHI Middle east

Not Confirmed

Sanofi is a pioneer in Diabetes Solutions, Human Vaccines, Innovative Drugs, Consumer Healthcare, and the new Genzyme.

Contact Supplier

Contact Supplier

France

Digital Content

Regulatory Info :

Registration Country : Australia

Brand Name : Clomid

Dosage Form :

Dosage Strength :

Packaging : 10

Approval Date :

Application Number :

Regulatory Info :

Registration Country : Australia

Sanofi Company Banner

Portfolio PDF

Product Web Link

Digital Content

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South Africa

01

Adcock Ingram Limited

South Africa

CPHI Middle east

Not Confirmed

02

Cipla Medpro (Pty) Ltd

South Africa

CPHI Middle east

Not Confirmed

03

Gulf Drug Company (Pty) Ltd

South Africa

CPHI Middle east

Not Confirmed

04

Gulf Drug Company (Pty) Ltd

South Africa

CPHI Middle east

Not Confirmed

05

Sandoz SA (Pty) Ltd

Switzerland

CPHI Middle east

Not Confirmed

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Listed Dossiers

01

Octavius Pharma Pvt. Ltd

India

Octavius has been empowering lives since 1980 by providing quality products like DC granules, APIs and FDFs.

Contact Supplier

Contact Supplier

India

Digital Content

Regulatory Info :

Registration Country : India

Clomiphene Citrate

Brand Name :

Dosage Form : Tablet

Dosage Strength : 50MG

Packaging :

Approval Date :

Application Number :

Regulatory Info :

Registration Country : India

Octavius Pharma

Product Web Link

Digital Content

02

Octavius Pharma Pvt. Ltd

India

Octavius has been empowering lives since 1980 by providing quality products like DC granules, APIs and FDFs.

Contact Supplier

Contact Supplier

India

Digital Content

Regulatory Info : DMF Available|FDF Compliance-B...

Registration Country : India

Clomiphene Citrate

Brand Name :

Dosage Form : DC Granules

Dosage Strength : 25MG

Packaging :

Approval Date :

Application Number :

Regulatory Info : DMF Available|FDF Compliance-B...

Registration Country : India

Octavius Pharma

Product Web Link

Digital Content

03

Octavius Pharma Pvt. Ltd

India

Octavius has been empowering lives since 1980 by providing quality products like DC granules, APIs and FDFs.

Contact Supplier

Contact Supplier

India

Digital Content

Regulatory Info : DMF Available|FDF Compliance-B...

Registration Country : India

Clomiphene Citrate

Brand Name :

Dosage Form : DC Granules

Dosage Strength : 50MG

Packaging :

Approval Date :

Application Number :

Regulatory Info : DMF Available|FDF Compliance-B...

Registration Country : India

Octavius Pharma

Product Web Link

Digital Content

04

Octavius Pharma Pvt. Ltd

India

Octavius has been empowering lives since 1980 by providing quality products like DC granules, APIs and FDFs.

Contact Supplier

Contact Supplier

India

Digital Content

Regulatory Info : DMF Available|FDF Compliance-B...

Registration Country : India

Clomiphene Citrate

Brand Name :

Dosage Form : DC Granules

Dosage Strength : 100MG

Packaging :

Approval Date :

Application Number :

Regulatory Info : DMF Available|FDF Compliance-B...

Registration Country : India

Octavius Pharma

Product Web Link

Digital Content

05

AMN Life Science

India

CPHI Middle east

Not Confirmed

06

Bio Labs

Pakistan

CPHI Middle east

Not Confirmed

07

Gracure Pharmaceuticals Limited

India

CPHI Middle east

Not Confirmed

08

Hochster Pharmaceutical Industries

Egypt

CPHI Middle east

Not Confirmed

09

Prime Pharmaceuticals

India

CPHI Middle east

Not Confirmed

10

Ram Pharma

Jordan

CPHI Middle east

Not Confirmed

Only 10 entries up to this point, click to access all

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